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Protein

Glutathione hydrolase 6

Gene

GGT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves glutathione conjugates.By similarity

Catalytic activityi

A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid.
Glutathione + H2O = L-cysteinylglycine + L-glutamate.

Pathwayi: glutathione metabolism

This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processGlutathione biosynthesis

Enzyme and pathway databases

ReactomeiR-HSA-174403 Glutathione synthesis and recycling
R-HSA-5423646 Aflatoxin activation and detoxification
UniPathwayiUPA00204

Protein family/group databases

MEROPSiT03.024

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione hydrolase 6 (EC:3.4.19.13)
Alternative name(s):
Gamma-glutamyltransferase 6 (EC:2.3.2.2)
Short name:
GGT 6
Gamma-glutamyltranspeptidase 6
Cleaved into the following 2 chains:
Gene namesi
Name:GGT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000167741.10
HGNCiHGNC:26891 GGT6
MIMi612341 gene
neXtProtiNX_Q6P531

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 54CytoplasmicSequence analysisAdd BLAST54
Transmembranei55 – 75Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini76 – 493ExtracellularSequence analysisAdd BLAST418

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167741
PharmGKBiPA142671739

Polymorphism and mutation databases

BioMutaiGGT6
DMDMi166221586

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000314955? – 493Glutathione hydrolase 6 light chain
ChainiPRO_00003149541 – ?Glutathione hydrolase 6 heavy chain

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ6P531
PeptideAtlasiQ6P531
PRIDEiQ6P531
ProteomicsDBi66987
66988 [Q6P531-2]

PTM databases

iPTMnetiQ6P531
PhosphoSitePlusiQ6P531

Expressioni

Gene expression databases

BgeeiENSG00000167741
CleanExiHS_GGT6
ExpressionAtlasiQ6P531 baseline and differential
GenevisibleiQ6P531 HS

Organism-specific databases

HPAiHPA023362
HPA027213

Interactioni

Subunit structurei

Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity).By similarity

Protein-protein interaction databases

BioGridi125906, 1 interactor
IntActiQ6P531, 10 interactors
STRINGi9606.ENSP00000458307

Structurei

3D structure databases

ProteinModelPortaliQ6P531
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 30Poly-Glu10

Sequence similaritiesi

Belongs to the gamma-glutamyltransferase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2410 Eukaryota
COG0405 LUCA
GeneTreeiENSGT00550000074591
HOGENOMiHOG000112719
HOVERGENiHBG055504
InParanoidiQ6P531
KOiK00681
PhylomeDBiQ6P531
TreeFamiTF338758

Family and domain databases

InterProiView protein in InterPro
IPR000101 GGT_peptidase
IPR029055 Ntn_hydrolases_N
PANTHERiPTHR11686 PTHR11686, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P531-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA
60 70 80 90 100
GGLPGTWARV VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH
110 120 130 140 150
GPGVYHHGAI ISPAGRELLV AGGNVVDAGV GAALCLAVVH PHATGLGAMF
160 170 180 190 200
WGLFHDSSSG NSTALTSGPA QTLAPGLGLP AALPTLHLLH ARFGRLPWPR
210 220 230 240 250
LLVGPTTLAQ EGFLVDTPLA RALVARGTEG LCPLLCHADG TPLGAGARAT
260 270 280 290 300
NPQLAAVLRS AALAPTSDLA GDALLSLLAG DLGVEVPSAV PRPTLEPAEQ
310 320 330 340 350
LPVPQGILFT TPSPSAGPEL LALLEAALRS GAPIPDPCPP FLQTAVSPES
360 370 380 390 400
SALAAVDSSG SVLLLTSSLN CSFGSAHLSP STGVLLSNLV AKSTTSAWAC
410 420 430 440 450
PLILRGSLDD TEADVLGLVA SGTPDVARAM THTLLRHLAA RPPTQAQHQH
460 470 480 490
QGQQEPTEHP STCGQGTLLQ VAAHTEHAHV SSVPHACCPF QGF
Length:493
Mass (Da):50,509
Last modified:January 15, 2008 - v2
Checksum:iBBC8ECC544C0D1A2
GO
Isoform 2 (identifier: Q6P531-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-147: Missing.

Show »
Length:461
Mass (Da):47,490
Checksum:i6979651CA49D8C5E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03813840R → W1 PublicationCorresponds to variant dbSNP:rs7216284Ensembl.1
Natural variantiVAR_03813958A → V3 PublicationsCorresponds to variant dbSNP:rs11657054Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030451116 – 147Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074646 mRNA Translation: BAC11110.1
AK300648 mRNA Translation: BAG62336.1
CH471108 Genomic DNA Translation: EAW90433.1
BC063111 mRNA Translation: AAH63111.1
CCDSiCCDS11047.1 [Q6P531-2]
CCDS45582.1 [Q6P531-1]
RefSeqiNP_001116362.1, NM_001122890.2 [Q6P531-1]
NP_001275631.1, NM_001288702.1
NP_001275632.1, NM_001288703.1
NP_001275633.1, NM_001288704.1
NP_699169.2, NM_153338.3 [Q6P531-2]
UniGeneiHs.130749

Genome annotation databases

EnsembliENST00000301395; ENSP00000301395; ENSG00000167741 [Q6P531-2]
ENST00000574154; ENSP00000458307; ENSG00000167741 [Q6P531-1]
GeneIDi124975
KEGGihsa:124975
UCSCiuc002fyc.6 human [Q6P531-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGGT6_HUMAN
AccessioniPrimary (citable) accession number: Q6P531
Secondary accession number(s): B4DUH4, Q8NCM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

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