UniProtKB - Q6P531 (GGT6_HUMAN)
Glutathione hydrolase 6
GGT6
Functioni
Hydrolyzes and transfers gamma-glutamyl moieties from glutathione and other gamma-glutamyl compounds to acceptors.
By similarityCatalytic activityi
- an α-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-α-aminoacyl-[peptide]By similarityEC:2.3.2.2By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:3.4.19.13By similarityThis reaction proceeds in the forwardBy similarity direction.
- EC:3.4.19.13By similarityThis reaction proceeds in the forwardBy similarity direction.
: glutathione metabolism Pathwayi
This protein is involved in the pathway glutathione metabolism, which is part of Sulfur metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway glutathione metabolism and in Sulfur metabolism.
GO - Molecular functioni
- glutathione hydrolase activity Source: UniProtKB-EC
- hypoglycin A gamma-glutamyl transpeptidase activity Source: UniProtKB-EC
- leukotriene C4 gamma-glutamyl transferase activity Source: UniProtKB-EC
GO - Biological processi
- glutathione biosynthetic process Source: UniProtKB-KW
- leukotriene D4 biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Acyltransferase, Hydrolase, Transferase |
Biological process | Glutathione biosynthesis |
Enzyme and pathway databases
PathwayCommonsi | Q6P531 |
Reactomei | R-HSA-174403, Glutathione synthesis and recycling R-HSA-5423646, Aflatoxin activation and detoxification |
SignaLinki | Q6P531 |
UniPathwayi | UPA00204 |
Protein family/group databases
MEROPSi | T03.024 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutathione hydrolase 61 Publication (EC:3.4.19.13By similarity)Alternative name(s): Gamma-glutamyltranspeptidase 6 Cleaved into the following 2 chains: |
Gene namesi | Name:GGT6Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26891, GGT6 |
MIMi | 612341, gene |
neXtProti | NX_Q6P531 |
VEuPathDBi | HostDB:ENSG00000167741 |
Subcellular locationi
Other locations
- Membrane By similarity; Single-pass type II membrane protein By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 54 | CytoplasmicBy similarityAdd BLAST | 54 | |
Transmembranei | 55 – 75 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 76 – 493 | ExtracellularBy similarityAdd BLAST | 418 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 124975 |
OpenTargetsi | ENSG00000167741 |
PharmGKBi | PA142671739 |
Miscellaneous databases
Pharosi | Q6P531, Tbio |
Genetic variation databases
BioMutai | GGT6 |
DMDMi | 166221586 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000314954 | 1 – ? | Glutathione hydrolase 6 heavy chain | ||
ChainiPRO_0000314955 | ? – 493 | Glutathione hydrolase 6 light chain |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 161 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 370 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, ZymogenProteomic databases
jPOSTi | Q6P531 |
MassIVEi | Q6P531 |
PaxDbi | Q6P531 |
PeptideAtlasi | Q6P531 |
PRIDEi | Q6P531 |
ProteomicsDBi | 66987 [Q6P531-1] 66988 [Q6P531-2] |
PTM databases
GlyGeni | Q6P531, 2 sites |
iPTMneti | Q6P531 |
PhosphoSitePlusi | Q6P531 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167741, Expressed in upper arm skin and 123 other tissues |
ExpressionAtlasi | Q6P531, baseline and differential |
Genevisiblei | Q6P531, HS |
Organism-specific databases
HPAi | ENSG00000167741, Tissue enhanced (esophagus, intestine, salivary gland, skin) |
Interactioni
Subunit structurei
Heterodimer composed of the light and heavy chains. The active site is located in the light chain.
By similarityBinary interactionsi
Q6P531
Protein-protein interaction databases
BioGRIDi | 125906, 12 interactors |
IntActi | Q6P531, 10 interactors |
STRINGi | 9606.ENSP00000370962 |
Miscellaneous databases
RNActi | Q6P531, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 52 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 83 – 105 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 442 – 464 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 47 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 444 – 464 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2410, Eukaryota |
GeneTreei | ENSGT00940000161883 |
InParanoidi | Q6P531 |
OrthoDBi | 1209764at2759 |
PhylomeDBi | Q6P531 |
TreeFami | TF338758 |
Family and domain databases
Gene3Di | 3.60.20.40, 1 hit |
InterProi | View protein in InterPro IPR043137, GGT_ssub IPR029055, Ntn_hydrolases_N |
SUPFAMi | SSF56235, SSF56235, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERAEEPVVY QKLLPWEPSL ESEEEVEEEE TSEALVLNPR RHQDSSRNKA
60 70 80 90 100
GGLPGTWARV VAALLLLAVG CSLAVRQLQN QGRSTGSLGS VAPPPGGHSH
110 120 130 140 150
GPGVYHHGAI ISPAGRELLV AGGNVVDAGV GAALCLAVVH PHATGLGAMF
160 170 180 190 200
WGLFHDSSSG NSTALTSGPA QTLAPGLGLP AALPTLHLLH ARFGRLPWPR
210 220 230 240 250
LLVGPTTLAQ EGFLVDTPLA RALVARGTEG LCPLLCHADG TPLGAGARAT
260 270 280 290 300
NPQLAAVLRS AALAPTSDLA GDALLSLLAG DLGVEVPSAV PRPTLEPAEQ
310 320 330 340 350
LPVPQGILFT TPSPSAGPEL LALLEAALRS GAPIPDPCPP FLQTAVSPES
360 370 380 390 400
SALAAVDSSG SVLLLTSSLN CSFGSAHLSP STGVLLSNLV AKSTTSAWAC
410 420 430 440 450
PLILRGSLDD TEADVLGLVA SGTPDVARAM THTLLRHLAA RPPTQAQHQH
460 470 480 490
QGQQEPTEHP STCGQGTLLQ VAAHTEHAHV SSVPHACCPF QGF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPJ0 | J3KPJ0_HUMAN | Glutathione hydrolase 6 | GGT6 | 499 | Annotation score: | ||
B4DPG6 | B4DPG6_HUMAN | Glutathione hydrolase 6 | GGT6 | 345 | Annotation score: | ||
I3L2G6 | I3L2G6_HUMAN | Glutathione hydrolase 6 | GGT6 | 180 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038138 | 40 | R → W1 PublicationCorresponds to variant dbSNP:rs7216284Ensembl. | 1 | |
Natural variantiVAR_038139 | 58 | A → V3 PublicationsCorresponds to variant dbSNP:rs11657054Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030451 | 116 – 147 | Missing in isoform 2. 1 PublicationAdd BLAST | 32 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074646 mRNA Translation: BAC11110.1 AK300648 mRNA Translation: BAG62336.1 CH471108 Genomic DNA Translation: EAW90433.1 BC063111 mRNA Translation: AAH63111.1 |
CCDSi | CCDS11047.1 [Q6P531-2] CCDS45582.1 [Q6P531-1] |
RefSeqi | NP_001116362.1, NM_001122890.2 [Q6P531-1] NP_001275631.1, NM_001288702.1 NP_001275632.1, NM_001288703.1 NP_001275633.1, NM_001288704.1 NP_699169.2, NM_153338.3 [Q6P531-2] |
Genome annotation databases
Ensembli | ENST00000301395.7; ENSP00000301395.3; ENSG00000167741.11 [Q6P531-2] ENST00000574154.5; ENSP00000458307.1; ENSG00000167741.11 |
GeneIDi | 124975 |
KEGGi | hsa:124975 |
UCSCi | uc002fyc.6, human [Q6P531-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074646 mRNA Translation: BAC11110.1 AK300648 mRNA Translation: BAG62336.1 CH471108 Genomic DNA Translation: EAW90433.1 BC063111 mRNA Translation: AAH63111.1 |
CCDSi | CCDS11047.1 [Q6P531-2] CCDS45582.1 [Q6P531-1] |
RefSeqi | NP_001116362.1, NM_001122890.2 [Q6P531-1] NP_001275631.1, NM_001288702.1 NP_001275632.1, NM_001288703.1 NP_001275633.1, NM_001288704.1 NP_699169.2, NM_153338.3 [Q6P531-2] |
3D structure databases
AlphaFoldDBi | Q6P531 |
SMRi | Q6P531 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125906, 12 interactors |
IntActi | Q6P531, 10 interactors |
STRINGi | 9606.ENSP00000370962 |
Protein family/group databases
MEROPSi | T03.024 |
PTM databases
GlyGeni | Q6P531, 2 sites |
iPTMneti | Q6P531 |
PhosphoSitePlusi | Q6P531 |
Genetic variation databases
BioMutai | GGT6 |
DMDMi | 166221586 |
Proteomic databases
jPOSTi | Q6P531 |
MassIVEi | Q6P531 |
PaxDbi | Q6P531 |
PeptideAtlasi | Q6P531 |
PRIDEi | Q6P531 |
ProteomicsDBi | 66987 [Q6P531-1] 66988 [Q6P531-2] |
Protocols and materials databases
Antibodypediai | 11242, 127 antibodies from 15 providers |
DNASUi | 124975 |
Genome annotation databases
Ensembli | ENST00000301395.7; ENSP00000301395.3; ENSG00000167741.11 [Q6P531-2] ENST00000574154.5; ENSP00000458307.1; ENSG00000167741.11 |
GeneIDi | 124975 |
KEGGi | hsa:124975 |
UCSCi | uc002fyc.6, human [Q6P531-1] |
Organism-specific databases
CTDi | 124975 |
DisGeNETi | 124975 |
GeneCardsi | GGT6 |
HGNCi | HGNC:26891, GGT6 |
HPAi | ENSG00000167741, Tissue enhanced (esophagus, intestine, salivary gland, skin) |
MIMi | 612341, gene |
neXtProti | NX_Q6P531 |
OpenTargetsi | ENSG00000167741 |
PharmGKBi | PA142671739 |
VEuPathDBi | HostDB:ENSG00000167741 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2410, Eukaryota |
GeneTreei | ENSGT00940000161883 |
InParanoidi | Q6P531 |
OrthoDBi | 1209764at2759 |
PhylomeDBi | Q6P531 |
TreeFami | TF338758 |
Enzyme and pathway databases
UniPathwayi | UPA00204 |
PathwayCommonsi | Q6P531 |
Reactomei | R-HSA-174403, Glutathione synthesis and recycling R-HSA-5423646, Aflatoxin activation and detoxification |
SignaLinki | Q6P531 |
Miscellaneous databases
BioGRID-ORCSi | 124975, 16 hits in 1070 CRISPR screens |
GenomeRNAii | 124975 |
Pharosi | Q6P531, Tbio |
PROi | PR:Q6P531 |
RNActi | Q6P531, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167741, Expressed in upper arm skin and 123 other tissues |
ExpressionAtlasi | Q6P531, baseline and differential |
Genevisiblei | Q6P531, HS |
Family and domain databases
Gene3Di | 3.60.20.40, 1 hit |
InterProi | View protein in InterPro IPR043137, GGT_ssub IPR029055, Ntn_hydrolases_N |
SUPFAMi | SSF56235, SSF56235, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GGT6_HUMAN | |
Accessioni | Q6P531Primary (citable) accession number: Q6P531 Secondary accession number(s): B4DUH4, Q8NCM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | January 15, 2008 | |
Last modified: | May 25, 2022 | |
This is version 134 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families