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Protein

Lysosomal-associated transmembrane protein 4A

Gene

Laptm4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment.By similarity

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosomal-associated transmembrane protein 4A
Gene namesi
Name:Laptm4a
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi735179 Laptm4a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Transmembranei160 – 180HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002497171 – 233Lysosomal-associated transmembrane protein 4AAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6P501
PRIDEiQ6P501

PTM databases

iPTMnetiQ6P501
PhosphoSitePlusiQ6P501

Expressioni

Gene expression databases

BgeeiENSRNOG00000006865 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ6P501 baseline and differential
GenevisibleiQ6P501 RN

Interactioni

Protein-protein interaction databases

BioGridi256045, 1 interactor
STRINGi10116.ENSRNOP00000009665

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi226 – 229Poly-Pro4

Domaini

The C-terminal domain is necessary for retention within intracellular membranes.By similarity

Sequence similaritiesi

Belongs to the LAPTM4/LAPTM5 transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEGH Eukaryota
ENOG4111K1Z LUCA
GeneTreeiENSGT00390000013359
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ6P501
KOiK12387
OMAiFTISAMM
OrthoDBiEOG091G0MA5
PhylomeDBiQ6P501

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
PfamiView protein in Pfam
PF03821 Mtp, 2 hits
TIGRFAMsiTIGR00799 mtp, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P501-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSMTFKRSR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE
60 70 80 90 100
VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG
110 120 130 140 150
AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK
160 170 180 190 200
DDLLALDSSC LLFIVLVFFV VFIIFKAYLI NCVWNCYKYI NNRNVPEIAV
210 220 230
YPAFEAPPQY VLPTYEMAVK IPEKEPPPPY LPA
Length:233
Mass (Da):26,784
Last modified:July 5, 2004 - v1
Checksum:iBF60C9667BD8FBDB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JWU5A0A0G2JWU5_RAT
Lysosomal-associated transmembrane ...
Laptm4a
207Annotation score:
A0A0G2KAV0A0A0G2KAV0_RAT
Lysosomal-associated transmembrane ...
Laptm4a
231Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063179 mRNA Translation: AAH63179.1
RefSeqiNP_955416.1, NM_199384.2
UniGeneiRn.108012

Genome annotation databases

EnsembliENSRNOT00000009665; ENSRNOP00000009665; ENSRNOG00000006865
GeneIDi298875
KEGGirno:298875

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063179 mRNA Translation: AAH63179.1
RefSeqiNP_955416.1, NM_199384.2
UniGeneiRn.108012

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi256045, 1 interactor
STRINGi10116.ENSRNOP00000009665

PTM databases

iPTMnetiQ6P501
PhosphoSitePlusiQ6P501

Proteomic databases

PaxDbiQ6P501
PRIDEiQ6P501

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009665; ENSRNOP00000009665; ENSRNOG00000006865
GeneIDi298875
KEGGirno:298875

Organism-specific databases

CTDi9741
RGDi735179 Laptm4a

Phylogenomic databases

eggNOGiENOG410IEGH Eukaryota
ENOG4111K1Z LUCA
GeneTreeiENSGT00390000013359
HOGENOMiHOG000007698
HOVERGENiHBG000908
InParanoidiQ6P501
KOiK12387
OMAiFTISAMM
OrthoDBiEOG091G0MA5
PhylomeDBiQ6P501

Miscellaneous databases

PROiPR:Q6P501

Gene expression databases

BgeeiENSRNOG00000006865 Expressed in 10 organ(s), highest expression level in lung
ExpressionAtlasiQ6P501 baseline and differential
GenevisibleiQ6P501 RN

Family and domain databases

InterProiView protein in InterPro
IPR004687 LAPTM4/5
IPR018396 LAPTM_4A/5
PfamiView protein in Pfam
PF03821 Mtp, 2 hits
TIGRFAMsiTIGR00799 mtp, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLAP4A_RAT
AccessioniPrimary (citable) accession number: Q6P501
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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