UniProtKB - Q6P4Z5 (1433Z_XENTR)
Protein
14-3-3 protein zeta
Gene
ywhaz
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
GO - Biological processi
- regulation of ERK1 and ERK2 cascade Source: UniProtKB
Enzyme and pathway databases
Reactomei | R-XTR-111447, Activation of BAD and translocation to mitochondria R-XTR-3769402, Deactivation of the beta-catenin transactivating complex R-XTR-392517, Rap1 signalling R-XTR-430116, GP1b-IX-V activation signalling R-XTR-450604, KSRP (KHSRP) binds and destabilizes mRNA R-XTR-5625740, RHO GTPases activate PKNs R-XTR-5628897, TP53 Regulates Metabolic Genes R-XTR-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-XTR-9614399, Regulation of localization of FOXO transcription factors |
Names & Taxonomyi
Protein namesi | Recommended name: 14-3-3 protein zeta |
Gene namesi | Name:ywhaz ORF Names:TTpA004p03.1 |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-970616, ywhaz |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000058634 | 1 – 245 | 14-3-3 protein zetaAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q6P4Z5 |
PRIDEi | Q6P4Z5 |
Interactioni
Subunit structurei
Homodimer.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 56 | Interaction with phosphoserine on interacting proteinBy similarity | 1 | |
Sitei | 127 | Interaction with phosphoserine on interacting proteinBy similarity | 1 |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000013608 |
Family & Domainsi
Sequence similaritiesi
Belongs to the 14-3-3 family.Curated
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | Q6P4Z5 |
OrthoDBi | 1176818at2759 |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
Q6P4Z5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDKNELVQKA KLAEQAERYD DMAACMKRVT EEGGELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VVSSIEQKTE GAEKKQEMSR EYREKIEAEL REICNDVLNL
110 120 130 140 150
LDKFLIANAS QPESKVFYLK MKGDYYRYLA EVASGDAKAD IVAQSQKAYQ
160 170 180 190 200
DAFDISKTEM QPTHPIRLGL ALNFSVFYYE ILNCPEKACS LAKAAFDEAI
210 220 230 240
AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEQG EGGEN
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG8JLT6 | G8JLT6_XENTR | 14-3-3 protein zeta | abca3 ywhaz | 1,625 | Annotation score: | ||
A0A6I8RDN6 | A0A6I8RDN6_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,696 | Annotation score: | ||
F6U7N4 | F6U7N4_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,672 | Annotation score: | ||
A0A6I8RC95 | A0A6I8RC95_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,704 | Annotation score: | ||
A0A6I8Q306 | A0A6I8Q306_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,662 | Annotation score: | ||
A0A6I8RCW2 | A0A6I8RCW2_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,656 | Annotation score: | ||
A0A6I8RYU9 | A0A6I8RYU9_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,649 | Annotation score: | ||
A0A6I8SLW4 | A0A6I8SLW4_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,695 | Annotation score: | ||
A0A6I8SWU5 | A0A6I8SWU5_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,676 | Annotation score: | ||
A0A6I8SZA6 | A0A6I8SZA6_XENTR | ATP-binding cassette subfamily A me... | abca3 | 1,605 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR926430 mRNA Translation: CAJ82916.1 BC063188 mRNA Translation: AAH63188.1 |
RefSeqi | NP_989173.1, NM_203842.1 XP_017950074.1, XM_018094585.1 |
Genome annotation databases
Ensembli | ENSXETT00000013608; ENSXETP00000013608; ENSXETG00000026459 |
GeneIDi | 394780 |
KEGGi | xtr:394780 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR926430 mRNA Translation: CAJ82916.1 BC063188 mRNA Translation: AAH63188.1 |
RefSeqi | NP_989173.1, NM_203842.1 XP_017950074.1, XM_018094585.1 |
3D structure databases
SMRi | Q6P4Z5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000013608 |
Proteomic databases
PaxDbi | Q6P4Z5 |
PRIDEi | Q6P4Z5 |
Genome annotation databases
Ensembli | ENSXETT00000013608; ENSXETP00000013608; ENSXETG00000026459 |
GeneIDi | 394780 |
KEGGi | xtr:394780 |
Organism-specific databases
CTDi | 7534 |
Xenbasei | XB-GENE-970616, ywhaz |
Phylogenomic databases
eggNOGi | KOG0841, Eukaryota |
GeneTreei | ENSGT01000000214500 |
HOGENOMi | CLU_058290_1_0_1 |
InParanoidi | Q6P4Z5 |
OrthoDBi | 1176818at2759 |
Enzyme and pathway databases
Reactomei | R-XTR-111447, Activation of BAD and translocation to mitochondria R-XTR-3769402, Deactivation of the beta-catenin transactivating complex R-XTR-392517, Rap1 signalling R-XTR-430116, GP1b-IX-V activation signalling R-XTR-450604, KSRP (KHSRP) binds and destabilizes mRNA R-XTR-5625740, RHO GTPases activate PKNs R-XTR-5628897, TP53 Regulates Metabolic Genes R-XTR-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-XTR-9614399, Regulation of localization of FOXO transcription factors |
Family and domain databases
Gene3Di | 1.20.190.20, 1 hit |
InterProi | View protein in InterPro IPR000308, 14-3-3 IPR023409, 14-3-3_CS IPR036815, 14-3-3_dom_sf IPR023410, 14-3-3_domain |
PANTHERi | PTHR18860, PTHR18860, 1 hit |
Pfami | View protein in Pfam PF00244, 14-3-3, 1 hit |
PIRSFi | PIRSF000868, 14-3-3, 1 hit |
PRINTSi | PR00305, 1433ZETA |
SMARTi | View protein in SMART SM00101, 14_3_3, 1 hit |
SUPFAMi | SSF48445, SSF48445, 1 hit |
PROSITEi | View protein in PROSITE PS00796, 1433_1, 1 hit PS00797, 1433_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 1433Z_XENTR | |
Accessioni | Q6P4Z5Primary (citable) accession number: Q6P4Z5 Secondary accession number(s): Q28CE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families