UniProtKB - Q6P4W7 (RIC8A_XENTR)
Protein
Synembryn-A
Gene
ric8a
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (By similarity).By similarity
GO - Molecular functioni
- G-protein alpha-subunit binding Source: GO_Central
- GTPase activator activity Source: GO_Central
- guanyl-nucleotide exchange factor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Names & Taxonomyi
Protein namesi | Recommended name: Synembryn-AAlternative name(s): Protein Ric-8A |
Gene namesi | Name:ric8a |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-5745094, ric8a |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235898 | 1 – 539 | Synembryn-AAdd BLAST | 539 |
Proteomic databases
PaxDbi | Q6P4W7 |
Expressioni
Gene expression databases
Bgeei | ENSXETG00000002868, Expressed in brain and 43 other tissues |
Interactioni
Subunit structurei
Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma (By similarity).
By similarityGO - Molecular functioni
- G-protein alpha-subunit binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000006281 |
Family & Domainsi
Sequence similaritiesi
Belongs to the synembryn family.Curated
Phylogenomic databases
eggNOGi | KOG4464, Eukaryota |
HOGENOMi | CLU_018602_1_0_1 |
InParanoidi | Q6P4W7 |
OMAi | CLCNIVY |
OrthoDBi | 1110075at2759 |
TreeFami | TF314907 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR019318, Gua_nucleotide_exch_fac_Ric8 IPR008376, Synembryn |
PANTHERi | PTHR12425, PTHR12425, 1 hit |
Pfami | View protein in Pfam PF10165, Ric8, 1 hit |
PRINTSi | PR01802, SYNEMBRYN |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q6P4W7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDPGTLLDKL ESGDQELVQK ALAEYNQENS QCFFFNAEQR EERKKLGELV
60 70 80 90 100
IKFLNRDLQP SCQMACLETI RILSRDKHAL SPFTGRSAIQ TLAQYAGLDY
110 120 130 140 150
SEEMEMPSIP DGESAVEALK GLCNIIYNSV EAQEVAKELR LVCGLARRLK
160 170 180 190 200
LYNETRSSHE SKFFDLRLLF LLTALSVDMR KQLAQELRGV SLLTDALEST
210 220 230 240 250
LALKWSDIYE VVTDRLAPPL GKEETERVME ILKTLFNITF DISRREVDEE
260 270 280 290 300
DAALYRHLAA ILRHCLLRQC DGEDRTEEFH GHTVNLLVNL PLMCLDVLLT
310 320 330 340 350
PKVEQGSVEY MGMNMDTVEV LIQFLDRRLD RGHKLRETLT PVLNLLTESS
360 370 380 390 400
RVHRETRKFL RAKVLPPLRD VKNRPEVGNT LRNKLVRLMT HVDTDVKHCA
410 420 430 440 450
AEFLFVLCKE NVSRFVKYTG YGNAAGLLAA RGLLAGGRGE GRYSEDEDTD
460 470 480 490 500
TEEYREAKPN INPVTGRVEE KQPNPMDGMT EEQKEYEAMK LVNMFDKLSR
510 520 530
EQIIQPMGVT SDGRLEPLDE AAQKMLQRQE SSDLESDSD
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8PX81 | A0A6I8PX81_XENTR | Synembryn-A | ric8a | 539 | Annotation score: | ||
A0A6I8S1J1 | A0A6I8S1J1_XENTR | Synembryn-A | ric8a | 579 | Annotation score: | ||
A0A5S6K9R0 | A0A5S6K9R0_XENTR | Synembryn-A | ric8a | 542 | Annotation score: | ||
A0A6I8QG17 | A0A6I8QG17_XENTR | Synembryn-A | ric8a | 508 | Annotation score: | ||
A0A6I8T1R0 | A0A6I8T1R0_XENTR | Synembryn-A | ric8a | 501 | Annotation score: | ||
A0A6I8PZR0 | A0A6I8PZR0_XENTR | Synembryn-A | ric8a | 573 | Annotation score: | ||
A0A6I8RAL2 | A0A6I8RAL2_XENTR | Synembryn-A | ric8a | 497 | Annotation score: | ||
A0A6I8RKQ7 | A0A6I8RKQ7_XENTR | Synembryn-A | ric8a | 497 | Annotation score: | ||
A0A6I8SIW6 | A0A6I8SIW6_XENTR | Synembryn-A | ric8a | 563 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC063218 mRNA Translation: AAH63218.1 |
RefSeqi | NP_989159.1, NM_203828.1 |
Genome annotation databases
GeneIDi | 394766 |
KEGGi | xtr:394766 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC063218 mRNA Translation: AAH63218.1 |
RefSeqi | NP_989159.1, NM_203828.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000006281 |
Proteomic databases
PaxDbi | Q6P4W7 |
Genome annotation databases
GeneIDi | 394766 |
KEGGi | xtr:394766 |
Organism-specific databases
CTDi | 60626 |
Xenbasei | XB-GENE-5745094, ric8a |
Phylogenomic databases
eggNOGi | KOG4464, Eukaryota |
HOGENOMi | CLU_018602_1_0_1 |
InParanoidi | Q6P4W7 |
OMAi | CLCNIVY |
OrthoDBi | 1110075at2759 |
TreeFami | TF314907 |
Gene expression databases
Bgeei | ENSXETG00000002868, Expressed in brain and 43 other tissues |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR019318, Gua_nucleotide_exch_fac_Ric8 IPR008376, Synembryn |
PANTHERi | PTHR12425, PTHR12425, 1 hit |
Pfami | View protein in Pfam PF10165, Ric8, 1 hit |
PRINTSi | PR01802, SYNEMBRYN |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIC8A_XENTR | |
Accessioni | Q6P4W7Primary (citable) accession number: Q6P4W7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families