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Protein

Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

Gene

inpp5d

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processImmunity

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC:3.1.3.86)
Alternative name(s):
SH2 domain-containing inositol 5'-phosphatase 1
Short name:
SH2 domain-containing inositol phosphatase 1
Short name:
SHIP-1
Gene namesi
Name:inpp5d
Synonyms:ship, ship1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6071368 inpp5d

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028691 – 1019Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1Add BLAST1019

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1007PhosphotyrosineBy similarity1

Post-translational modificationi

Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6P4S2

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ6P4S2
SMRiQ6P4S2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 101SH2PROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi120 – 125SH3-binding 16
Motifi966 – 971SH3-binding 26
Motifi1004 – 1007NPXY motif4

Domaini

The SH2 domain interacts with tyrosine phosphorylated forms of proteins.By similarity
The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, SH2 domain, SH3-binding

Phylogenomic databases

HOVERGENiHBG106726
KOiK03084

Family and domain databases

Gene3Di3.30.505.10, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR000300 IPPc
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P4S2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYGWYHGNI TRSKAEDLLS QAGKDGSYLV RDSESVCRAY ALCVLNQNCV
60 70 80 90 100
HTYRILQNAE HQLSVQASEG VPMRFFTNLV ELIEFYRREN VGLVTHLQYP
110 120 130 140 150
IEKEEEGPEE PDEEQEPAPP NVPPRNFAFT PPSETKECQT AIERAPAANA
160 170 180 190 200
SLLLSETLLQ RFQDTDSRCI PEEHLQAICD YFSLHIVSDC DMVRTGSQTL
210 220 230 240 250
PQFKKLLMTL CTGLHRELTR TLPTLESLQV AIDPQLSPGF KQRSPLPGDS
260 270 280 290 300
ATNNMVNKLT HLTSMVSNLE EKVKTVLMEG AAVKHRRSLI PPIIFEVKAD
310 320 330 340 350
SIGISQKTHL KVDVETGKLI IKKSKDGPDD KFYPSKKILQ LIKSQKFPHK
360 370 380 390 400
LVIVLETEKE KTQRKEYVFA DSKKREGFCQ LLQQMKNKHS GQSEPDMLSI
410 420 430 440 450
FIGTWNMGDA PPPKNITPWF QCKGQGKTRD DTADYIEHDI YVIGTQEDPL
460 470 480 490 500
SEKEWTDTLI HSLREITSVE YKVITTQTLW NIRIVVLAKP EHAHRISHVC
510 520 530 540 550
TNSVKTGIAN TLGNKGAVGA SFMFNGTSFG FINSHLTSGS EKKLRRNQNY
560 570 580 590 600
FNILRFLVLG DKKLSPFNFT HRFNHLFWLG DLNYRLQLPN TEAENIIQKI
610 620 630 640 650
KQQQHQELLP HDQLNLERRE SLIFFQFHEE EITFPPTYRY ERGSRERYCY
660 670 680 690 700
TKQKATGIKY NLPSWCDRIL WKSYPQMHIL CQSYGCTDDI TTSDHSPVFG
710 720 730 740 750
TFQVGVTSQF VSKNNPGDSG DLEAQGHIEL MNCKATLYTK SHTKFYIEFH
760 770 780 790 800
SPCLENMVKS SEAEDQEGNN GTLVVKFGVL PKLTPIISDL EYLLDQHLLI
810 820 830 840 850
CIKSSDTDES YGEGCIALRK EDTEQQFPFC TILTHHGEET GLFCGEICLP
860 870 880 890 900
ASGGKQREKL YDFVKIEKDE TVAQKQLKHP YSQSMEQSRI MKSISEKSAM
910 920 930 940 950
IARMRAAPET QNSMDHTASV AAISSQAKQS PPTTPPGFRG SEPRQKPGSP
960 970 980 990 1000
VQGRGDTPIT SPPRTTLSTQ KFSHSNTNRT APAARPQDSL QITVPSDPHE
1010
MVDNPLYGPV NNTLYPPTA
Length:1,019
Mass (Da):115,297
Last modified:July 5, 2004 - v1
Checksum:i6FF3E53E0658E27A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063273 mRNA Translation: AAH63273.1
RefSeqiNP_001083668.1, NM_001090199.1
UniGeneiXl.34826

Genome annotation databases

GeneIDi399051
KEGGixla:399051

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063273 mRNA Translation: AAH63273.1
RefSeqiNP_001083668.1, NM_001090199.1
UniGeneiXl.34826

3D structure databases

ProteinModelPortaliQ6P4S2
SMRiQ6P4S2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6P4S2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399051
KEGGixla:399051

Organism-specific databases

CTDi399051
XenbaseiXB-GENE-6071368 inpp5d

Phylogenomic databases

HOVERGENiHBG106726
KOiK03084

Family and domain databases

Gene3Di3.30.505.10, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR000300 IPPc
IPR000980 SH2
IPR036860 SH2_dom_sf
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SM00252 SH2, 1 hit
SUPFAMiSSF55550 SSF55550, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSHIP1_XENLA
AccessioniPrimary (citable) accession number: Q6P4S2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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