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UniProtKB - Q6P4R8 (NFRKB_HUMAN)

Entry version 150 (29 Sep 2021)
Sequence version 2 (21 Mar 2006)
Previous versions | rss
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Protein

Nuclear factor related to kappa-B-binding protein

Gene

NFRKB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'.

1 Publication

Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Modulates the deubiquitinase activity of UCHL5 in the INO80 complex.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P4R8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5689603, UCH proteinases
R-HSA-5696394, DNA Damage Recognition in GG-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear factor related to kappa-B-binding protein
Alternative name(s):
DNA-binding protein R kappa-B
INO80 complex subunit G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NFRKB
Synonyms:INO80G
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7802, NFRKB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164013, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P4R8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170322

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4798

Open Targets

More...OpenTargetsi		ENSG00000170322

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31606

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P4R8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		NFRKB

Domain mapping of disease mutations (DMDM)

More...DMDMi		90101417

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002278071 – 1299Nuclear factor related to kappa-B-binding proteinAdd BLAST1299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei228PhosphoserineCombined sources1
Modified residuei298PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki327Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei351PhosphoserineCombined sources1
Cross-linki469Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki488Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1237N6-acetyllysineCombined sources1
Modified residuei1291PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P4R8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P4R8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P4R8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P4R8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P4R8

PeptideAtlas

More...PeptideAtlasi		Q6P4R8

PRoteomics IDEntifications database

More...PRIDEi		Q6P4R8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66983 [Q6P4R8-1]
66984 [Q6P4R8-2]
66985 [Q6P4R8-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q6P4R8

GlyConnect protein glycosylation platform

More...GlyConnecti		2888, 1 O-Linked glycan (2 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6P4R8, 30 sites, 2 O-linked glycans (30 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P4R8

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q6P4R8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P4R8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in thymus, brain, testes, spleen and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170322, Expressed in buccal mucosa cell and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P4R8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P4R8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170322, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80.

Interacts with UCHL5; NFRKB competes with ADRM1 for interaction with UCHL5.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110864, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-846, INO80 chromatin remodeling complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q6P4R8

Protein interaction database and analysis system

More...IntActi		Q6P4R8, 40 interactors

Molecular INTeraction database

More...MINTi		Q6P4R8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000436926

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P4R8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P4R8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q6P4R8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 156DEUBADPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni163 – 187DisorderedSequence analysisAdd BLAST25
Regioni204 – 232DisorderedSequence analysisAdd BLAST29
Regioni370 – 495Winged-helix like domainAdd BLAST126
Regioni669 – 760DisorderedSequence analysisAdd BLAST92
Regioni882 – 902DisorderedSequence analysisAdd BLAST21
Regioni1017 – 1043DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi210 – 224Polar residuesSequence analysisAdd BLAST15
Compositional biasi682 – 717Polar residuesSequence analysisAdd BLAST36
Compositional biasi718 – 738Pro residuesSequence analysisAdd BLAST21
Compositional biasi742 – 760Polar residuesSequence analysisAdd BLAST19
Compositional biasi1026 – 1043Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NFRKB seems to be mostly disordered. The wing-helix like domain doesn't bind DNA.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NFRKB family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1927, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016213

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007638_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P4R8

Identification of Orthologs from Complete Genome Data

More...OMAi		VKCPPVP

Database of Orthologous Groups

More...OrthoDBi		140291at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P4R8

TreeFam database of animal gene trees

More...TreeFami		TF324944

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.2430, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR044867, DEUBAD_dom
IPR024867, NFRKB
IPR025220, NFRKB_winged_dom
IPR038106, NFRKB_winged_sf

The PANTHER Classification System

More...PANTHERi		PTHR13052, PTHR13052, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14465, NFRKB_winged, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51916, DEUBAD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P4R8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSLDHMLTD PLELGPCGDG HGTRIMEDCL LGGTRVSLPE DLLEDPEIFF 
        60         70         80         90        100
DVVSLSTWQE VLSDSQREHL QQFLPQFPED SAEQQNELIL ALFSGENFRF 
       110        120        130        140        150
GNPLHIAQKL FRDGHFNPEV VKYRQLCFKS QYKRYLNSQQ QYFHRLLKQI 
       160        170        180        190        200
LASRSDLLEM ARRSGPALPF RQKRPSPSRT PEEREWRTQQ RYLKVLREVK 
       210        220        230        240        250
EECGDTALSS DEEDLSSWLP SSPARSPSPA VPLRVVPTLS TTDMKTADKV 
       260        270        280        290        300
ELGDSDLKIM LKKHHEKRKH QPDHPDLLTG DLTLNDIMTR VNAGRKGSLA 
       310        320        330        340        350
ALYDLAVLKK KVKEKEEKKK KKIKTIKSEA EDLAEPLSST EGVAPLSQAP 
       360        370        380        390        400
SPLAIPAIKE EPLEDLKPCL GINEISSSFF SLLLEILLLE SQASLPMLEE 
       410        420        430        440        450
RVLDWQSSPA SSLNSWFSAA PNWAELVLPA LQYLAGESRA VPSSFSPFVE 
       460        470        480        490        500
FKEKTQQWKL LGQSQDNEKE LAALFQLWLE TKDQAFCKQE NEDSSDATTP 
       510        520        530        540        550
VPRVRTDYVV RPSTGEEKRV FQEQERYRYS QPHKAFTFRM HGFESVVGPV 
       560        570        580        590        600
KGVFDKETSL NKAREHSLLR SDRPAYVTIL SLVRDAAARL PNGEGTRAEI 
       610        620        630        640        650
CELLKDSQFL APDVTSTQVN TVVSGALDRL HYEKDPCVKY DIGRKLWIYL 
       660        670        680        690        700
HRDRSEEEFE RIHQAQAAAA KARKALQQKP KPPSKVKSSS KESSIKVLSS 
       710        720        730        740        750
GPSEQSQMSL SDSSMPPTPV TPVTPTTPAL PAIPISPPPV SAVNKSGPST 
       760        770        780        790        800
VSEPAKSSSG VLLVSSPTMP HLGTMLSPAS SQTAPSSQAA ARVVSHSGSA 
       810        820        830        840        850
GLSQVRVVAQ PSLPAVPQQS GGPAQTLPQM PAGPQIRVPA TATQTKVVPQ 
       860        870        880        890        900
TVMATVPVKA QTTAATVQRP GPGQTGLTVT SLPATASPVS KPATSSPGTS 
       910        920        930        940        950
APSASTAAVI QNVTGQNIIK QVAITGQLGV KPQTGNSIPL TATNFRIQGK 
       960        970        980        990       1000
DVLRLPPSSI TTDAKGQTVL RITPDMMATL AKSQVTTVKL TQDLFGTGGN 
      1010       1020       1030       1040       1050
TTGKGISATL HVTSNPVHAA DSPAKASSAS APSSTPTGTT VVKVTPDLKP 
      1060       1070       1080       1090       1100
TEASSSAFRL MPALGVSVAD QKGKSTVASS EAKPAATIRI VQGLGVMPPK 
      1110       1120       1130       1140       1150
AGQTITVATH AKQGASVASG SGTVHTSAVS LPSMNAAVSK TVAVASGAAS 
      1160       1170       1180       1190       1200
TPISISTGAP TVRQVPVSTT VVSTSQAGKL PTRITVPLSV ISQPMKGKSV 
      1210       1220       1230       1240       1250
VTAPIIKGNL GANLSGLGRN IILTTMPAGT KLIAGNKPVS FLTAQQLQQL 
      1260       1270       1280       1290 
QQQGQATQVR IQTVPASHLQ QGTASGSSKA VSTVVVTTAP SPKQAPEQQ
Length:1,299
Mass (Da):139,001
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i087B212E283C3820
GO
Isoform 2 (identifier: Q6P4R8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MHVFVQSTCGEETM
     213-213: E → EATLDLQEQFSFE

Show »
Length:1,324
Mass (Da):141,860
Checksum:i52A003376E91C5D9
GO
Isoform 3 (identifier: Q6P4R8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     687-687: Missing.

Show »
Length:1,298
Mass (Da):138,873
Checksum:iAE550B9B7DF44736
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQ59E9PQ59_HUMAN
Nuclear factor-related to kappa-B-b...
NFRKB
987Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJG2E9PJG2_HUMAN
Nuclear factor-related to kappa-B-b...
NFRKB
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQB0E9PQB0_HUMAN
Nuclear factor-related to kappa-B-b...
NFRKB
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJU3E9PJU3_HUMAN
Nuclear factor-related to kappa-B-b...
NFRKB
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PM88E9PM88_HUMAN
Nuclear factor-related to kappa-B-b...
NFRKB
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJE1E9PJE1_HUMAN
Nuclear factor-related to kappa-B-b...
NFRKB
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA17871 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1178G → E in AAH63280 (PubMed:15489334).Curated1
Sequence conflicti1213N → D in AAH63280 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0175921M → MHVFVQSTCGEETM in isoform 2. 2 Publications1
Alternative sequenceiVSP_017593213E → EATLDLQEQFSFE in isoform 2. 2 Publications1
Alternative sequenceiVSP_017594687Missing in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U08191 mRNA Translation: AAA17871.1 Sequence problems.
X80878 mRNA Translation: CAA56846.1
BC063280 mRNA Translation: AAH63280.1
AL512730 mRNA Translation: CAC21663.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44770.1 [Q6P4R8-1]
CCDS8483.1 [Q6P4R8-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S52863

NCBI Reference Sequences

More...RefSeqi		NP_001137307.1, NM_001143835.1 [Q6P4R8-1]
NP_006156.2, NM_006165.3 [Q6P4R8-2]
XP_011541153.1, XM_011542851.2 [Q6P4R8-2]
XP_011541154.1, XM_011542852.2 [Q6P4R8-2]
XP_016873285.1, XM_017017796.1 [Q6P4R8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000446488; ENSP00000400476; ENSG00000170322 [Q6P4R8-1]
ENST00000524746; ENSP00000433572; ENSG00000170322 [Q6P4R8-1]
ENST00000524794; ENSP00000436926; ENSG00000170322 [Q6P4R8-2]
ENST00000682444; ENSP00000506850; ENSG00000170322 [Q6P4R8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4798

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4798

UCSC genome browser

More...UCSCi		uc001qfg.4, human [Q6P4R8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08191 mRNA Translation: AAA17871.1 Sequence problems.
X80878 mRNA Translation: CAA56846.1
BC063280 mRNA Translation: AAH63280.1
AL512730 mRNA Translation: CAC21663.1
CCDSiCCDS44770.1 [Q6P4R8-1]
CCDS8483.1 [Q6P4R8-2]
PIRiS52863
RefSeqiNP_001137307.1, NM_001143835.1 [Q6P4R8-1]
NP_006156.2, NM_006165.3 [Q6P4R8-2]
XP_011541153.1, XM_011542851.2 [Q6P4R8-2]
XP_011541154.1, XM_011542852.2 [Q6P4R8-2]
XP_016873285.1, XM_017017796.1 [Q6P4R8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3U21X-ray2.18A/B370-495[»]
4UF5X-ray3.70B40-170[»]
4UF6X-ray3.69C/F/I/L40-101[»]
4WLPX-ray3.10B40-153[»]
SMRiQ6P4R8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110864, 58 interactors
ComplexPortaliCPX-846, INO80 chromatin remodeling complex
CORUMiQ6P4R8
IntActiQ6P4R8, 40 interactors
MINTiQ6P4R8
STRINGi9606.ENSP00000436926

PTM databases

CarbonylDBiQ6P4R8
GlyConnecti2888, 1 O-Linked glycan (2 sites)
GlyGeniQ6P4R8, 30 sites, 2 O-linked glycans (30 sites)
iPTMnetiQ6P4R8
MetOSiteiQ6P4R8
PhosphoSitePlusiQ6P4R8

Genetic variation databases

BioMutaiNFRKB
DMDMi90101417

Proteomic databases

EPDiQ6P4R8
jPOSTiQ6P4R8
MassIVEiQ6P4R8
MaxQBiQ6P4R8
PaxDbiQ6P4R8
PeptideAtlasiQ6P4R8
PRIDEiQ6P4R8
ProteomicsDBi66983 [Q6P4R8-1]
66984 [Q6P4R8-2]
66985 [Q6P4R8-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1820, 117 antibodies

The DNASU plasmid repository

More...DNASUi		4798

Genome annotation databases

EnsembliENST00000446488; ENSP00000400476; ENSG00000170322 [Q6P4R8-1]
ENST00000524746; ENSP00000433572; ENSG00000170322 [Q6P4R8-1]
ENST00000524794; ENSP00000436926; ENSG00000170322 [Q6P4R8-2]
ENST00000682444; ENSP00000506850; ENSG00000170322 [Q6P4R8-1]
GeneIDi4798
KEGGihsa:4798
UCSCiuc001qfg.4, human [Q6P4R8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4798
DisGeNETi4798

GeneCards: human genes, protein and diseases

More...GeneCardsi		NFRKB
HGNCiHGNC:7802, NFRKB
HPAiENSG00000170322, Low tissue specificity
MIMi164013, gene
neXtProtiNX_Q6P4R8
OpenTargetsiENSG00000170322
PharmGKBiPA31606
VEuPathDBiHostDB:ENSG00000170322

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1927, Eukaryota
GeneTreeiENSGT00390000016213
HOGENOMiCLU_007638_0_0_1
InParanoidiQ6P4R8
OMAiVKCPPVP
OrthoDBi140291at2759
PhylomeDBiQ6P4R8
TreeFamiTF324944

Enzyme and pathway databases

PathwayCommonsiQ6P4R8
ReactomeiR-HSA-5689603, UCH proteinases
R-HSA-5696394, DNA Damage Recognition in GG-NER

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4798, 311 hits in 1031 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NFRKB, human
EvolutionaryTraceiQ6P4R8

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		NFRKB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4798
PharosiQ6P4R8, Tbio

Protein Ontology

More...PROi		PR:Q6P4R8
RNActiQ6P4R8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170322, Expressed in buccal mucosa cell and 230 other tissues
ExpressionAtlasiQ6P4R8, baseline and differential
GenevisibleiQ6P4R8, HS

Family and domain databases

Gene3Di1.10.10.2430, 1 hit
InterProiView protein in InterPro
IPR044867, DEUBAD_dom
IPR024867, NFRKB
IPR025220, NFRKB_winged_dom
IPR038106, NFRKB_winged_sf
PANTHERiPTHR13052, PTHR13052, 1 hit
PfamiView protein in Pfam
PF14465, NFRKB_winged, 1 hit
PROSITEiView protein in PROSITE
PS51916, DEUBAD, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNFRKB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P4R8
Secondary accession number(s): Q12869, Q15312, Q9H048
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: September 29, 2021
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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