FAM173B

Functionⁱ

Mitochondrial protein-lysine N-methyltransferase that promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). Protein-lysine N-methyltransferase activity is dependent on S-adenosyl-L-methionine (PubMed:29444090). Target proteins are unknown (PubMed:29444090).1 Publication

GO - Molecular functionⁱ

protein-lysine N-methyltransferase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 29444090

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

peptidyl-lysine methylation
Source: UniProtKB
Inferred from direct assayⁱ
- 29444090
positive regulation of sensory perception of pain
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 29444090

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Methyltransferase, Transferase
Ligand	S-adenosyl-L-methionine

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein N-lysine methyltransferase FAM173BCurated (EC:2.1.1.-1 Publication) Short name: hFAM173B1 Publication
Gene namesⁱ	Name:FAM173B1 PublicationImported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000150756.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27029 FAM173B
neXtProtⁱ	NX_Q6P4H8

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	38 – 58	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	94	D → A: Abolished protein-lysine N-methyltransferase activity and ability to promote chronic pain. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	134145
Open Targets More...OpenTargetsⁱ	ENSG00000150756
PharmGKBⁱ	PA162387281

Polymorphism and mutation databases

BioMutaⁱ	FAM173B
DMDMⁱ	190360174

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000321536	1 – 233	Protein N-lysine methyltransferase FAM173BAdd BLAST		233

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q6P4H8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P4H8
PaxDbⁱ	Q6P4H8
PeptideAtlas More...PeptideAtlasⁱ	Q6P4H8
PRIDEⁱ	Q6P4H8
ProteomicsDBⁱ	66979

PTM databases

iPTMnetⁱ	Q6P4H8
PhosphoSitePlusⁱ	Q6P4H8

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000150756
CleanExⁱ	HS_FAM173B
ExpressionAtlasⁱ	Q6P4H8 baseline and differential
Genevisibleⁱ	Q6P4H8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA074513

HPAⁱ

HPA074513

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	126386, 1 interactor
IntActⁱ	Q6P4H8, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P4H8
SMRⁱ	Q6P4H8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FAM173 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4058 Eukaryota ENOG4111IHU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014771
HOGENOMⁱ	HOG000234394
HOVERGENⁱ	HBG056031
InParanoidⁱ	Q6P4H8
OMAⁱ	GVNTVWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0S3L
PhylomeDBⁱ	Q6P4H8
TreeFamⁱ	TF314984

Family and domain databases

InterProⁱ	View protein in InterPro IPR029063 SAM-dependent_MTases
SUPFAMⁱ	SSF53335 SSF53335, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6P4H8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA 
        60         70         80         90        100
VYAVATPFVT PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG 
       110        120        130        140        150
RIVIAAAKKG FTAVGYELNP WLVWYSRYRA WREGVHGSAK FYISDLWKVT 
       160        170        180        190        200
FSQYSNVVIF GVPQMMLQLE KKLERELEDD ARVIACRFPF PHWTPDHVTG 
       210        220        230 
EGIDTVWAYD ASTFRGREKR PCTSMHFQLP IQA

Length:233

Mass (Da):26,110

Last modified:February 26, 2008 - v2

Checksum:ⁱ7F4D1F9E3AC87854

GO

Isoform 2 (identifier: Q6P4H8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
149-165: Missing.

« Hide

        10         20         30         40         50
MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA 
        60         70         80         90        100
VYAVATPFVT PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG 
       110        120        130        140        150
RIVIAAAKKG FTAVGYELNP WLVWYSRYRA WREGVHGSAK FYISDLWKML 
       160        170        180        190        200
QLEKKLEREL EDDARVIACR FPFPHWTPDH VTGEGIDTVW AYDASTFRGR 
       210 
EKRPCTSMHF QLPIQA

Note: No experimental confirmation available.

Show »

Length:216

Mass (Da):24,212

Checksum:ⁱDF7D7AFA887C693A

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_039345	75	T → M2 PublicationsCorresponds to variant dbSNP:rs2438652Ensembl.	1
Natural variantⁱVAR_039346	105	A → V. Corresponds to variant dbSNP:rs16884350Ensembl.	1
Natural variantⁱVAR_039347	114	V → A. Corresponds to variant dbSNP:rs17360625Ensembl.	1
Natural variantⁱVAR_039348	229	L → M. Corresponds to variant dbSNP:rs15757Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_044724	149 – 165	Missing in isoform 2. 1 PublicationAdd BLAST		17

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK300042 mRNA Translation: BAG61853.1 AK302012 mRNA Translation: BAG63414.1 AC012640 Genomic DNA No translation available. AC034229 Genomic DNA No translation available. CH471102 Genomic DNA Translation: EAX08074.1 BC063406 mRNA Translation: AAH63406.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43301.1 [Q6P4H8-1] CCDS58942.1 [Q6P4H8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001245317.1, NM_001258388.1 [Q6P4H8-2] NP_954584.2, NM_199133.3 [Q6P4H8-1]
UniGeneⁱ	Hs.481569

Genome annotation databases

Ensemblⁱ	ENST00000510047; ENSP00000420876; ENSG00000150756 [Q6P4H8-2] ENST00000511437; ENSP00000422338; ENSG00000150756 [Q6P4H8-1]
GeneIDⁱ	134145
KEGGⁱ	hsa:134145
UCSC genome browser More...UCSCⁱ	uc003jeo.4 human [Q6P4H8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6P4H8	Family with sequence similarity 173 member B		PANPA		233
Family with sequence similarity 173 member B		GORGO		233
UPI000B7B60AA		PAPAN		233
cDNA, FLJ79216		HUMAN		233
Family with sequence similarity 173 member B		CERAT		233
+64

Protein	Similar proteins		Species	Score	Length
Q6P4H8	Family with sequence similarity 173 member B		GORGO		233
Family with sequence similarity 173 member B		CERAT		233
Family with sequence similarity 173 member B		MANLE		233
Family with sequence similarity 173 member B		PANPA		233
UPI000B7B60AA		PAPAN		233
+149

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK300042 mRNA Translation: BAG61853.1 AK302012 mRNA Translation: BAG63414.1 AC012640 Genomic DNA No translation available. AC034229 Genomic DNA No translation available. CH471102 Genomic DNA Translation: EAX08074.1 BC063406 mRNA Translation: AAH63406.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43301.1 [Q6P4H8-1] CCDS58942.1 [Q6P4H8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001245317.1, NM_001258388.1 [Q6P4H8-2] NP_954584.2, NM_199133.3 [Q6P4H8-1]
UniGeneⁱ	Hs.481569

3D structure databases

ProteinModelPortalⁱ	Q6P4H8
SMRⁱ	Q6P4H8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	126386, 1 interactor
IntActⁱ	Q6P4H8, 1 interactor

PTM databases

iPTMnetⁱ	Q6P4H8
PhosphoSitePlusⁱ	Q6P4H8

Polymorphism and mutation databases

BioMutaⁱ	FAM173B
DMDMⁱ	190360174

Proteomic databases

EPDⁱ	Q6P4H8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P4H8
PaxDbⁱ	Q6P4H8
PeptideAtlas More...PeptideAtlasⁱ	Q6P4H8
PRIDEⁱ	Q6P4H8
ProteomicsDBⁱ	66979

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	134145
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000510047; ENSP00000420876; ENSG00000150756 [Q6P4H8-2] ENST00000511437; ENSP00000422338; ENSG00000150756 [Q6P4H8-1]
GeneIDⁱ	134145
KEGGⁱ	hsa:134145
UCSC genome browser More...UCSCⁱ	uc003jeo.4 human [Q6P4H8-1]

Organism-specific databases

CTDⁱ	134145
DisGeNET More...DisGeNETⁱ	134145
EuPathDBⁱ	HostDB:ENSG00000150756.13
GeneCardsⁱ	FAM173B
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:27029 FAM173B
Human Protein Atlas More...HPAⁱ	HPA074513
neXtProtⁱ	NX_Q6P4H8
Open Targets More...OpenTargetsⁱ	ENSG00000150756
PharmGKBⁱ	PA162387281
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4058 Eukaryota ENOG4111IHU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014771
HOGENOMⁱ	HOG000234394
HOVERGENⁱ	HBG056031
InParanoidⁱ	Q6P4H8
OMAⁱ	GVNTVWF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0S3L
PhylomeDBⁱ	Q6P4H8
TreeFamⁱ	TF314984

Miscellaneous databases

GenomeRNAiⁱ	134145
Protein Ontology More...PROⁱ	PR:Q6P4H8

Gene expression databases

Bgeeⁱ	ENSG00000150756
CleanExⁱ	HS_FAM173B
ExpressionAtlasⁱ	Q6P4H8 baseline and differential
Genevisibleⁱ	Q6P4H8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029063 SAM-dependent_MTases
SUPFAMⁱ	SSF53335 SSF53335, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F173B_HUMAN
Accessionⁱ	Q6P4H8Primary (citable) accession number: Q6P4H8 Secondary accession number(s): B4DT41, B4DXK2, E9PBZ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	July 18, 2018
	This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q6P4H8 (F173B_HUMAN)

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Protein N-lysine methyltransferase FAM173B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ