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Protein

Protein N-lysine methyltransferase FAM173B

Gene

FAM173B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial protein-lysine N-methyltransferase that promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). Protein-lysine N-methyltransferase activity is dependent on S-adenosyl-L-methionine (PubMed:29444090). Target proteins are unknown (PubMed:29444090).1 Publication

GO - Molecular functioni

  • protein-lysine N-methyltransferase activity Source: UniProtKB

GO - Biological processi

  • peptidyl-lysine methylation Source: UniProtKB
  • positive regulation of sensory perception of pain Source: UniProtKB

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein N-lysine methyltransferase FAM173BCurated (EC:2.1.1.-1 Publication)
Short name:
hFAM173B1 Publication
Gene namesi
Name:FAM173B1 PublicationImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000150756.13
HGNCiHGNC:27029 FAM173B
neXtProtiNX_Q6P4H8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi94D → A: Abolished protein-lysine N-methyltransferase activity and ability to promote chronic pain. 1 Publication1

Organism-specific databases

DisGeNETi134145
OpenTargetsiENSG00000150756
PharmGKBiPA162387281

Polymorphism and mutation databases

BioMutaiFAM173B
DMDMi190360174

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003215361 – 233Protein N-lysine methyltransferase FAM173BAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ6P4H8
MaxQBiQ6P4H8
PaxDbiQ6P4H8
PeptideAtlasiQ6P4H8
PRIDEiQ6P4H8
ProteomicsDBi66979

PTM databases

iPTMnetiQ6P4H8
PhosphoSitePlusiQ6P4H8

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000150756 Expressed in 185 organ(s), highest expression level in corpus callosum
CleanExiHS_FAM173B
ExpressionAtlasiQ6P4H8 baseline and differential
GenevisibleiQ6P4H8 HS

Organism-specific databases

HPAiHPA074513

Interactioni

Protein-protein interaction databases

BioGridi126386, 1 interactor
IntActiQ6P4H8, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ6P4H8
SMRiQ6P4H8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM173 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4058 Eukaryota
ENOG4111IHU LUCA
GeneTreeiENSGT00390000014771
HOGENOMiHOG000234394
HOVERGENiHBG056031
InParanoidiQ6P4H8
OMAiGVNTVWF
OrthoDBiEOG091G0S3L
PhylomeDBiQ6P4H8
TreeFamiTF314984

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P4H8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA
60 70 80 90 100
VYAVATPFVT PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG
110 120 130 140 150
RIVIAAAKKG FTAVGYELNP WLVWYSRYRA WREGVHGSAK FYISDLWKVT
160 170 180 190 200
FSQYSNVVIF GVPQMMLQLE KKLERELEDD ARVIACRFPF PHWTPDHVTG
210 220 230
EGIDTVWAYD ASTFRGREKR PCTSMHFQLP IQA
Length:233
Mass (Da):26,110
Last modified:February 26, 2008 - v2
Checksum:i7F4D1F9E3AC87854
GO
Isoform 2 (identifier: Q6P4H8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-165: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,212
Checksum:iDF7D7AFA887C693A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RIE0D6RIE0_HUMAN
Protein N-lysine methyltransferase ...
FAM173B
149Annotation score:
D6RBE3D6RBE3_HUMAN
Protein N-lysine methyltransferase ...
FAM173B
109Annotation score:
J3KN90J3KN90_HUMAN
Protein N-lysine methyltransferase ...
FAM173B LOC134145, hCG_36858
69Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03934575T → M2 PublicationsCorresponds to variant dbSNP:rs2438652Ensembl.1
Natural variantiVAR_039346105A → V. Corresponds to variant dbSNP:rs16884350Ensembl.1
Natural variantiVAR_039347114V → A. Corresponds to variant dbSNP:rs17360625Ensembl.1
Natural variantiVAR_039348229L → M. Corresponds to variant dbSNP:rs15757Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044724149 – 165Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300042 mRNA Translation: BAG61853.1
AK302012 mRNA Translation: BAG63414.1
AC012640 Genomic DNA No translation available.
AC034229 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08074.1
BC063406 mRNA Translation: AAH63406.1
CCDSiCCDS43301.1 [Q6P4H8-1]
CCDS58942.1 [Q6P4H8-2]
RefSeqiNP_001245317.1, NM_001258388.1 [Q6P4H8-2]
NP_954584.2, NM_199133.3 [Q6P4H8-1]
UniGeneiHs.481569

Genome annotation databases

EnsembliENST00000510047; ENSP00000420876; ENSG00000150756 [Q6P4H8-2]
ENST00000511437; ENSP00000422338; ENSG00000150756 [Q6P4H8-1]
GeneIDi134145
KEGGihsa:134145
UCSCiuc003jeo.4 human [Q6P4H8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK300042 mRNA Translation: BAG61853.1
AK302012 mRNA Translation: BAG63414.1
AC012640 Genomic DNA No translation available.
AC034229 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08074.1
BC063406 mRNA Translation: AAH63406.1
CCDSiCCDS43301.1 [Q6P4H8-1]
CCDS58942.1 [Q6P4H8-2]
RefSeqiNP_001245317.1, NM_001258388.1 [Q6P4H8-2]
NP_954584.2, NM_199133.3 [Q6P4H8-1]
UniGeneiHs.481569

3D structure databases

ProteinModelPortaliQ6P4H8
SMRiQ6P4H8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126386, 1 interactor
IntActiQ6P4H8, 1 interactor

PTM databases

iPTMnetiQ6P4H8
PhosphoSitePlusiQ6P4H8

Polymorphism and mutation databases

BioMutaiFAM173B
DMDMi190360174

Proteomic databases

EPDiQ6P4H8
MaxQBiQ6P4H8
PaxDbiQ6P4H8
PeptideAtlasiQ6P4H8
PRIDEiQ6P4H8
ProteomicsDBi66979

Protocols and materials databases

DNASUi134145
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000510047; ENSP00000420876; ENSG00000150756 [Q6P4H8-2]
ENST00000511437; ENSP00000422338; ENSG00000150756 [Q6P4H8-1]
GeneIDi134145
KEGGihsa:134145
UCSCiuc003jeo.4 human [Q6P4H8-1]

Organism-specific databases

CTDi134145
DisGeNETi134145
EuPathDBiHostDB:ENSG00000150756.13
GeneCardsiFAM173B
HGNCiHGNC:27029 FAM173B
HPAiHPA074513
neXtProtiNX_Q6P4H8
OpenTargetsiENSG00000150756
PharmGKBiPA162387281
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4058 Eukaryota
ENOG4111IHU LUCA
GeneTreeiENSGT00390000014771
HOGENOMiHOG000234394
HOVERGENiHBG056031
InParanoidiQ6P4H8
OMAiGVNTVWF
OrthoDBiEOG091G0S3L
PhylomeDBiQ6P4H8
TreeFamiTF314984

Miscellaneous databases

GenomeRNAii134145
PROiPR:Q6P4H8

Gene expression databases

BgeeiENSG00000150756 Expressed in 185 organ(s), highest expression level in corpus callosum
CleanExiHS_FAM173B
ExpressionAtlasiQ6P4H8 baseline and differential
GenevisibleiQ6P4H8 HS

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF173B_HUMAN
AccessioniPrimary (citable) accession number: Q6P4H8
Secondary accession number(s): B4DT41, B4DXK2, E9PBZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 12, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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