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Protein

Rho GTPase-activating protein 11A

Gene

ARHGAP11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Rho GTPase-activating protein 11A
Alternative name(s):
Rho-type GTPase-activating protein 11A
Gene namesi
Name:ARHGAP11A
Synonyms:KIAA0013
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000198826.10
HGNCiHGNC:15783 ARHGAP11A
MIMi610589 gene
neXtProtiNX_Q6P4F7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi9824
OpenTargetsiENSG00000198826
PharmGKBiPA134982615

Polymorphism and mutation databases

BioMutaiARHGAP11A
DMDMi119361641

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002672131 – 1023Rho GTPase-activating protein 11AAdd BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285PhosphoserineCombined sources1
Modified residuei306PhosphothreonineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei323PhosphothreonineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei508PhosphothreonineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei847PhosphoserineCombined sources1
Modified residuei866PhosphothreonineCombined sources1
Modified residuei868PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P4F7
MaxQBiQ6P4F7
PaxDbiQ6P4F7
PeptideAtlasiQ6P4F7
PRIDEiQ6P4F7
ProteomicsDBi66975

PTM databases

iPTMnetiQ6P4F7
PhosphoSitePlusiQ6P4F7

Expressioni

Gene expression databases

BgeeiENSG00000198826 Expressed in 103 organ(s), highest expression level in lung
CleanExiHS_ARHGAP11A
ExpressionAtlasiQ6P4F7 baseline and differential
GenevisibleiQ6P4F7 HS

Organism-specific databases

HPAiHPA040419
HPA040830

Interactioni

Protein-protein interaction databases

BioGridi115162, 29 interactors
IntActiQ6P4F7, 24 interactors
MINTiQ6P4F7
STRINGi9606.ENSP00000355090

Structurei

Secondary structure

11023
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6P4F7
SMRiQ6P4F7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6P4F7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 239Rho-GAPPROSITE-ProRule annotationAdd BLAST191

Phylogenomic databases

eggNOGiKOG2710 Eukaryota
ENOG410YVI5 LUCA
GeneTreeiENSGT00760000119123
HOGENOMiHOG000231616
HOVERGENiHBG062938
InParanoidiQ6P4F7
KOiK20635
OMAiERVWYKG
OrthoDBiEOG091G0F5G
PhylomeDBiQ6P4F7
TreeFamiTF332212

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P4F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP
60 70 80 90 100
FNALPHSAVP EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN
110 120 130 140 150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE
160 170 180 190 200
EKNKATLLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA
210 220 230 240 250
PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR VPDFILEKIP
260 270 280 290 300
AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN
310 320 330 340 350
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF
360 370 380 390 400
NFELLPSNLF NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR
410 420 430 440 450
RSKRIAGKKV CRVESGKAGC FSPKISHKEK VRRSLRLKFN LGKNGREVNG
460 470 480 490 500
CSGVNRYESV GWRLANQQSL KNRIESVKTG LLFSPDVDEK LPKKGSEKIS
510 520 530 540 550
KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM VENLEVENSL
560 570 580 590 600
EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ
610 620 630 640 650
KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT
660 670 680 690 700
IVESKEKYEH HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE
710 720 730 740 750
KDIHSNMPKD YLSKQEFSSD EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK
760 770 780 790 800
CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM RIAKQQSLET CEKTVSESSQ
810 820 830 840 850
MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ SVRRINSLLE
860 870 880 890 900
YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP
910 920 930 940 950
KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ
960 970 980 990 1000
KILSDGQVKV PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW
1010 1020
YKGSPKHPIG KTQLLPTSKP VDL
Length:1,023
Mass (Da):113,866
Last modified:December 12, 2006 - v2
Checksum:i053C89371B5F614F
GO
Isoform 2 (identifier: Q6P4F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-501: SEKISK → TFTYYC
     502-1023: Missing.

Note: No experimental confirmation available.
Show »
Length:501
Mass (Da):55,525
Checksum:i44930C9BA98F2E41
GO
Isoform 3 (identifier: Q6P4F7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: Missing.

Note: No experimental confirmation available.
Show »
Length:834
Mass (Da):92,697
Checksum:i4F00E8BB4175EE72
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR51H3BR51_HUMAN
Rho GTPase-activating protein 11A
ARHGAP11A
473Annotation score:
H3BQ41H3BQ41_HUMAN
Rho GTPase-activating protein 11A
ARHGAP11A
207Annotation score:

Sequence cautioni

The sequence BAA13442 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035546605E → K in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553701 – 189Missing in isoform 3. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_054102496 – 501SEKISK → TFTYYC in isoform 2. 1 Publication6
Alternative sequenceiVSP_054103502 – 1023Missing in isoform 2. 1 PublicationAdd BLAST522

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87717 mRNA Translation: BAA13442.2 Different initiation.
AK303025 mRNA Translation: BAG64151.1
AK316437 mRNA Translation: BAH14808.1
AC123768 Genomic DNA No translation available.
BC039563 mRNA Translation: AAH39563.1
BC063444 mRNA Translation: AAH63444.1
CCDSiCCDS10028.1 [Q6P4F7-1]
CCDS58349.1 [Q6P4F7-2]
CCDS66730.1 [Q6P4F7-3]
PIRiA59431
RefSeqiNP_001273408.1, NM_001286479.2 [Q6P4F7-3]
NP_001273409.1, NM_001286480.2 [Q6P4F7-3]
NP_055598.1, NM_014783.5 [Q6P4F7-1]
NP_955389.1, NM_199357.2 [Q6P4F7-2]
UniGeneiHs.591130

Genome annotation databases

EnsembliENST00000361627; ENSP00000355090; ENSG00000198826 [Q6P4F7-1]
ENST00000543522; ENSP00000440073; ENSG00000198826 [Q6P4F7-3]
ENST00000565905; ENSP00000455754; ENSG00000198826 [Q6P4F7-3]
ENST00000567348; ENSP00000454575; ENSG00000198826 [Q6P4F7-2]
ENST00000611363; ENSP00000480085; ENSG00000275568 [Q6P4F7-3]
ENST00000619401; ENSP00000479117; ENSG00000275568 [Q6P4F7-1]
ENST00000622253; ENSP00000481011; ENSG00000275568 [Q6P4F7-3]
ENST00000633634; ENSP00000488640; ENSG00000282168
GeneIDi9824
KEGGihsa:9824
UCSCiuc001zgw.4 human [Q6P4F7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87717 mRNA Translation: BAA13442.2 Different initiation.
AK303025 mRNA Translation: BAG64151.1
AK316437 mRNA Translation: BAH14808.1
AC123768 Genomic DNA No translation available.
BC039563 mRNA Translation: AAH39563.1
BC063444 mRNA Translation: AAH63444.1
CCDSiCCDS10028.1 [Q6P4F7-1]
CCDS58349.1 [Q6P4F7-2]
CCDS66730.1 [Q6P4F7-3]
PIRiA59431
RefSeqiNP_001273408.1, NM_001286479.2 [Q6P4F7-3]
NP_001273409.1, NM_001286480.2 [Q6P4F7-3]
NP_055598.1, NM_014783.5 [Q6P4F7-1]
NP_955389.1, NM_199357.2 [Q6P4F7-2]
UniGeneiHs.591130

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EAPX-ray2.30A/B/C/D1-253[»]
ProteinModelPortaliQ6P4F7
SMRiQ6P4F7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115162, 29 interactors
IntActiQ6P4F7, 24 interactors
MINTiQ6P4F7
STRINGi9606.ENSP00000355090

PTM databases

iPTMnetiQ6P4F7
PhosphoSitePlusiQ6P4F7

Polymorphism and mutation databases

BioMutaiARHGAP11A
DMDMi119361641

Proteomic databases

EPDiQ6P4F7
MaxQBiQ6P4F7
PaxDbiQ6P4F7
PeptideAtlasiQ6P4F7
PRIDEiQ6P4F7
ProteomicsDBi66975

Protocols and materials databases

DNASUi9824
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361627; ENSP00000355090; ENSG00000198826 [Q6P4F7-1]
ENST00000543522; ENSP00000440073; ENSG00000198826 [Q6P4F7-3]
ENST00000565905; ENSP00000455754; ENSG00000198826 [Q6P4F7-3]
ENST00000567348; ENSP00000454575; ENSG00000198826 [Q6P4F7-2]
ENST00000611363; ENSP00000480085; ENSG00000275568 [Q6P4F7-3]
ENST00000619401; ENSP00000479117; ENSG00000275568 [Q6P4F7-1]
ENST00000622253; ENSP00000481011; ENSG00000275568 [Q6P4F7-3]
ENST00000633634; ENSP00000488640; ENSG00000282168
GeneIDi9824
KEGGihsa:9824
UCSCiuc001zgw.4 human [Q6P4F7-1]

Organism-specific databases

CTDi9824
DisGeNETi9824
EuPathDBiHostDB:ENSG00000198826.10
GeneCardsiARHGAP11A
HGNCiHGNC:15783 ARHGAP11A
HPAiHPA040419
HPA040830
MIMi610589 gene
neXtProtiNX_Q6P4F7
OpenTargetsiENSG00000198826
PharmGKBiPA134982615
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2710 Eukaryota
ENOG410YVI5 LUCA
GeneTreeiENSGT00760000119123
HOGENOMiHOG000231616
HOVERGENiHBG062938
InParanoidiQ6P4F7
KOiK20635
OMAiERVWYKG
OrthoDBiEOG091G0F5G
PhylomeDBiQ6P4F7
TreeFamiTF332212

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSiARHGAP11A human
EvolutionaryTraceiQ6P4F7
GenomeRNAii9824
PROiPR:Q6P4F7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198826 Expressed in 103 organ(s), highest expression level in lung
CleanExiHS_ARHGAP11A
ExpressionAtlasiQ6P4F7 baseline and differential
GenevisibleiQ6P4F7 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHGBA_HUMAN
AccessioniPrimary (citable) accession number: Q6P4F7
Secondary accession number(s): B4DZN9, Q6PI96, Q9Y3S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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