UniProtKB - Q6P4F7 (RHGBA_HUMAN)

BLAST

>sp|Q6P4F7|RHGBA_HUMAN Rho GTPase-activating protein 11A OS=Homo sapiens OX=9606 GN=ARHGAP11A PE=1 SV=2
MWDQRLVRLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGGKIFGVPFNALPHSAVP
EYGHIPSFLVDACTSLEDHIHTEGLFRKSGSVIRLKALKNKVDHGEGCLSSAPPCDIAGL
LKQFFRELPEPILPADLHEALLKAQQLGTEEKNKATLLLSCLLADHTVHVLRYFFNFLRN
VSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGR
VPDFILEKIPAMLGIDGLCATPSLEGFEEGEYETPGEYKRKRRQSVGDFVSGALNKFKPN
RTPSITPQEERIAQLSESPVILTPNAKRTLPVDSSHGFSSKKRKSIKHNFNFELLPSNLF
NSSSTPVSVHIDTSSEGSSQSSLSPVLIGGNHLITAGVPRRSKRIAGKKVCRVESGKAGC
FSPKISHKEKVRRSLRLKFNLGKNGREVNGCSGVNRYESVGWRLANQQSLKNRIESVKTG
LLFSPDVDEKLPKKGSEKISKSEETLLTPERLVGTNYRMSWTGPNNSSFQEVDANEASSM
VENLEVENSLEPDIMVEKSPATSCELTPSNLNNKHNSNITSSPLSGDENNMTKETLVKVQ
KAFSESGSNLHALMNQRQSSVTNVGKVKLTEPSYLEDSPEENLFETNDLTIVESKEKYEH
HTGKGEKCFSERDFSPLQTQTFNRETTIKCYSTQMKMEHEKDIHSNMPKDYLSKQEFSSD
EEIKKQQSPKDKLNNKLKENENMMEGNLPKCAAHSKDEARSSFSQQSTCVVTNLSKPRPM
RIAKQQSLETCEKTVSESSQMTEHRKVSDHIQWFNKLSLNEPNRIKVKSPLKFQRTPVRQ
SVRRINSLLEYSRQPTGHKLASLGDTASPLVKSVSCDGALSSCIESASKDSSVSCIKSGP
KEQKSMSCEESNIGAISKSSMELPSKSFLKMRKHPDSVNASLRSTTVYKQKILSDGQVKV
PLDDLTNHDIVKPVVNNNMGISSGINNRVLRRPSERGRAWYKGSPKHPIGKTQLLPTSKP
VDL

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History
Entry version 124 (07 Nov 2018)
Sequence version 2 (12 Dec 2006)
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Protein

Rho GTPase-activating protein 11A

Gene

ARHGAP11A

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

GTPase activator activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of small GTPase mediated signal transduction Source: Reactome
signal transduction Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	GTPase activation

Molecular function

GTPase activation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-194840 Rho GTPase cycle

Reactomeⁱ

R-HSA-194840 Rho GTPase cycle

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Rho GTPase-activating protein 11A Alternative name(s): Rho-type GTPase-activating protein 11A
Gene namesⁱ	Name:ARHGAP11A Synonyms:KIAA0013
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198826.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15783 ARHGAP11A
MIMⁱ	610589 gene
neXtProtⁱ	NX_Q6P4F7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9824
Open Targets More...OpenTargetsⁱ	ENSG00000198826
PharmGKBⁱ	PA134982615

Polymorphism and mutation databases

BioMutaⁱ	ARHGAP11A
DMDMⁱ	119361641

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000267213	1 – 1023	Rho GTPase-activating protein 11AAdd BLAST		1023

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	285	PhosphoserineCombined sources	1
Modified residueⁱ	306	PhosphothreonineCombined sources	1
Modified residueⁱ	316	PhosphoserineCombined sources	1
Modified residueⁱ	318	PhosphoserineCombined sources	1
Modified residueⁱ	323	PhosphothreonineCombined sources	1
Modified residueⁱ	339	PhosphoserineCombined sources	1
Modified residueⁱ	340	PhosphoserineCombined sources	1
Modified residueⁱ	484	PhosphoserineCombined sources	1
Modified residueⁱ	508	PhosphothreonineCombined sources	1
Modified residueⁱ	582	PhosphoserineCombined sources	1
Modified residueⁱ	585	PhosphoserineCombined sources	1
Modified residueⁱ	638	PhosphoserineCombined sources	1
Modified residueⁱ	675	PhosphoserineCombined sources	1
Modified residueⁱ	847	PhosphoserineCombined sources	1
Modified residueⁱ	866	PhosphothreonineCombined sources	1
Modified residueⁱ	868	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6P4F7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P4F7
PaxDbⁱ	Q6P4F7
PeptideAtlas More...PeptideAtlasⁱ	Q6P4F7
PRIDEⁱ	Q6P4F7
ProteomicsDBⁱ	66975

PTM databases

iPTMnetⁱ	Q6P4F7
PhosphoSitePlusⁱ	Q6P4F7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000198826 Expressed in 103 organ(s), highest expression level in lung
CleanExⁱ	HS_ARHGAP11A
ExpressionAtlasⁱ	Q6P4F7 baseline and differential
Genevisibleⁱ	Q6P4F7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040419 HPA040830

HPAⁱ

HPA040419
HPA040830

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115162, 29 interactors
IntActⁱ	Q6P4F7, 24 interactors
Molecular INTeraction database More...MINTⁱ	Q6P4F7
STRINGⁱ	9606.ENSP00000355090

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	4 – 19	Combined sources	16
Helixⁱ	51 – 53	Combined sources	3
Beta strandⁱ	56 – 59	Combined sources	4
Turnⁱ	60 – 62	Combined sources	3
Beta strandⁱ	63 – 66	Combined sources	4
Helixⁱ	67 – 76	Combined sources	10
Helixⁱ	77 – 79	Combined sources	3
Helixⁱ	92 – 104	Combined sources	13
Helixⁱ	114 – 127	Combined sources	14
Beta strandⁱ	128 – 130	Combined sources	3
Helixⁱ	135 – 137	Combined sources	3
Helixⁱ	138 – 144	Combined sources	7
Helixⁱ	149 – 160	Combined sources	12
Helixⁱ	165 – 183	Combined sources	19
Helixⁱ	185 – 188	Combined sources	4
Helixⁱ	192 – 204	Combined sources	13
Helixⁱ	215 – 233	Combined sources	19
Helixⁱ	235 – 237	Combined sources	3
Helixⁱ	243 – 246	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6P4F7
SMRⁱ	Q6P4F7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q6P4F7

EvolutionaryTraceⁱ

Q6P4F7

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	49 – 239	Rho-GAPPROSITE-ProRule annotationAdd BLAST		191

Phylogenomic databases

eggNOGⁱ	KOG2710 Eukaryota ENOG410YVI5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119123
HOGENOMⁱ	HOG000231616
HOVERGENⁱ	HBG062938
InParanoidⁱ	Q6P4F7
KEGG Orthology (KO) More...KOⁱ	K20635
OMAⁱ	ERVWYKG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F5G
PhylomeDBⁱ	Q6P4F7
TreeFamⁱ	TF332212

Family and domain databases

Gene3Dⁱ	1.10.555.10, 1 hit
InterProⁱ	View protein in InterPro IPR008936 Rho_GTPase_activation_prot IPR000198 RhoGAP_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00620 RhoGAP, 1 hit
SMARTⁱ	View protein in SMART SM00324 RhoGAP, 1 hit
SUPFAMⁱ	SSF48350 SSF48350, 1 hit
PROSITEⁱ	View protein in PROSITE PS50238 RHOGAP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6P4F7-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP 
        60         70         80         90        100
FNALPHSAVP EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN 
       110        120        130        140        150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE 
       160        170        180        190        200
EKNKATLLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA 
       210        220        230        240        250
PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR VPDFILEKIP 
       260        270        280        290        300
AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN 
       310        320        330        340        350
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF 
       360        370        380        390        400
NFELLPSNLF NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR 
       410        420        430        440        450
RSKRIAGKKV CRVESGKAGC FSPKISHKEK VRRSLRLKFN LGKNGREVNG 
       460        470        480        490        500
CSGVNRYESV GWRLANQQSL KNRIESVKTG LLFSPDVDEK LPKKGSEKIS 
       510        520        530        540        550
KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM VENLEVENSL 
       560        570        580        590        600
EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ 
       610        620        630        640        650
KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT 
       660        670        680        690        700
IVESKEKYEH HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE 
       710        720        730        740        750
KDIHSNMPKD YLSKQEFSSD EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK 
       760        770        780        790        800
CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM RIAKQQSLET CEKTVSESSQ 
       810        820        830        840        850
MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ SVRRINSLLE 
       860        870        880        890        900
YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP 
       910        920        930        940        950
KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ 
       960        970        980        990       1000
KILSDGQVKV PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW 
      1010       1020 
YKGSPKHPIG KTQLLPTSKP VDL

Length:1,023

Mass (Da):113,866

Last modified:December 12, 2006 - v2

Checksum:ⁱ053C89371B5F614F

Isoform 2 (identifier: Q6P4F7-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
496-501: SEKISK → TFTYYC
502-1023: Missing.

« Hide

        10         20         30         40         50
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP 
        60         70         80         90        100
FNALPHSAVP EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN 
       110        120        130        140        150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE 
       160        170        180        190        200
EKNKATLLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA 
       210        220        230        240        250
PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR VPDFILEKIP 
       260        270        280        290        300
AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN 
       310        320        330        340        350
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF 
       360        370        380        390        400
NFELLPSNLF NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR 
       410        420        430        440        450
RSKRIAGKKV CRVESGKAGC FSPKISHKEK VRRSLRLKFN LGKNGREVNG 
       460        470        480        490        500
CSGVNRYESV GWRLANQQSL KNRIESVKTG LLFSPDVDEK LPKKGTFTYY 

C

Note: No experimental confirmation available.

Show »

Length:501

Mass (Da):55,525

Checksum:ⁱ44930C9BA98F2E41

Isoform 3 (identifier: Q6P4F7-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-189: Missing.

« Hide

        10         20         30         40         50
MDSSNLAVIF APNLLQTSEG HEKMSSNTEK KLRLQAAVVQ TLIDYASDIG 
        60         70         80         90        100
RVPDFILEKI PAMLGIDGLC ATPSLEGFEE GEYETPGEYK RKRRQSVGDF 
       110        120        130        140        150
VSGALNKFKP NRTPSITPQE ERIAQLSESP VILTPNAKRT LPVDSSHGFS 
       160        170        180        190        200
SKKRKSIKHN FNFELLPSNL FNSSSTPVSV HIDTSSEGSS QSSLSPVLIG 
       210        220        230        240        250
GNHLITAGVP RRSKRIAGKK VCRVESGKAG CFSPKISHKE KVRRSLRLKF 
       260        270        280        290        300
NLGKNGREVN GCSGVNRYES VGWRLANQQS LKNRIESVKT GLLFSPDVDE 
       310        320        330        340        350
KLPKKGSEKI SKSEETLLTP ERLVGTNYRM SWTGPNNSSF QEVDANEASS 
       360        370        380        390        400
MVENLEVENS LEPDIMVEKS PATSCELTPS NLNNKHNSNI TSSPLSGDEN 
       410        420        430        440        450
NMTKETLVKV QKAFSESGSN LHALMNQRQS SVTNVGKVKL TEPSYLEDSP 
       460        470        480        490        500
EENLFETNDL TIVESKEKYE HHTGKGEKCF SERDFSPLQT QTFNRETTIK 
       510        520        530        540        550
CYSTQMKMEH EKDIHSNMPK DYLSKQEFSS DEEIKKQQSP KDKLNNKLKE 
       560        570        580        590        600
NENMMEGNLP KCAAHSKDEA RSSFSQQSTC VVTNLSKPRP MRIAKQQSLE 
       610        620        630        640        650
TCEKTVSESS QMTEHRKVSD HIQWFNKLSL NEPNRIKVKS PLKFQRTPVR 
       660        670        680        690        700
QSVRRINSLL EYSRQPTGHK LASLGDTASP LVKSVSCDGA LSSCIESASK 
       710        720        730        740        750
DSSVSCIKSG PKEQKSMSCE ESNIGAISKS SMELPSKSFL KMRKHPDSVN 
       760        770        780        790        800
ASLRSTTVYK QKILSDGQVK VPLDDLTNHD IVKPVVNNNM GISSGINNRV 
       810        820        830 
LRRPSERGRA WYKGSPKHPI GKTQLLPTSK PVDL

Note: No experimental confirmation available.

Show »

Length:834

Mass (Da):92,697

Checksum:ⁱ4F00E8BB4175EE72

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BR51	H3BR51_HUMAN	Rho GTPase-activating protein 11A Rho GTPase-activating protein 11A	ARHGAP11A	473	Annotation score:
H3BQ41	H3BQ41_HUMAN	Rho GTPase-activating protein 11A Rho GTPase-activating protein 11A	ARHGAP11A	207	Annotation score:

Sequence cautionⁱ

The sequence BAA13442 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035546	605	E → K in a breast cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_055370	1 – 189	Missing in isoform 3. 1 PublicationAdd BLAST	189
Alternative sequenceⁱVSP_054102	496 – 501	SEKISK → TFTYYC in isoform 2. 1 Publication	6
Alternative sequenceⁱVSP_054103	502 – 1023	Missing in isoform 2. 1 PublicationAdd BLAST	522

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87717 mRNA Translation: BAA13442.2 Different initiation. AK303025 mRNA Translation: BAG64151.1 AK316437 mRNA Translation: BAH14808.1 AC123768 Genomic DNA No translation available. BC039563 mRNA Translation: AAH39563.1 BC063444 mRNA Translation: AAH63444.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10028.1 [Q6P4F7-1] CCDS58349.1 [Q6P4F7-2] CCDS66730.1 [Q6P4F7-3]
PIRⁱ	A59431
NCBI Reference Sequences More...RefSeqⁱ	NP_001273408.1, NM_001286479.2 [Q6P4F7-3] NP_001273409.1, NM_001286480.2 [Q6P4F7-3] NP_055598.1, NM_014783.5 [Q6P4F7-1] NP_955389.1, NM_199357.2 [Q6P4F7-2]
UniGeneⁱ	Hs.591130

Genome annotation databases

Ensemblⁱ	ENST00000361627; ENSP00000355090; ENSG00000198826 [Q6P4F7-1] ENST00000543522; ENSP00000440073; ENSG00000198826 [Q6P4F7-3] ENST00000565905; ENSP00000455754; ENSG00000198826 [Q6P4F7-3] ENST00000567348; ENSP00000454575; ENSG00000198826 [Q6P4F7-2] ENST00000611363; ENSP00000480085; ENSG00000275568 [Q6P4F7-3] ENST00000619401; ENSP00000479117; ENSG00000275568 [Q6P4F7-1] ENST00000622253; ENSP00000481011; ENSG00000275568 [Q6P4F7-3] ENST00000633634; ENSP00000488640; ENSG00000282168
GeneIDⁱ	9824
KEGGⁱ	hsa:9824
UCSC genome browser More...UCSCⁱ	uc001zgw.4 human [Q6P4F7-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q6P4F7	ARHGAP11A (Fragment)		HUMAN		1025	UniRef100_Q6P4F7
UPI0008F53880		GORGO		98
Isoform 3 of Rho GTPase-activating protein 11A		HUMAN		834

Protein	Similar proteins		Species	Score	Length	Source
Q6P4F7	ARHGAP11A (Fragment)		HUMAN		1025	UniRef90_Q6P4F7
Rho GTPase activating protein 11A		PANTR		1023
Uncharacterized protein		MACMU		1023
Uncharacterized protein		COLAP		1023
Uncharacterized protein		CERAT		1023
+33
Q6P4F7-2	Rho GTPase activating protein 11A		PANTR		501	UniRef90_Q6P4F7-2
Uncharacterized protein		MANLE		501

Protein	Similar proteins		Species	Score	Length	Source
Q6P4F7	ARHGAP11A (Fragment)		HUMAN		1025	UniRef50_Q6P4F7
Uncharacterized protein		MACMU		1023
Uncharacterized protein		NOMLE		1023
Uncharacterized protein		CERAT		1023
Uncharacterized protein		MANLE		1023
+153
Q6P4F7-2	Uncharacterized protein		MANLE		501	UniRef50_Q6P4F7-2
Rho GTPase activating protein 11A		PANTR		501
Uncharacterized protein		CAVPO		500
rho GTPase-activating protein 11A isoform X2		URSMA		501
Rho GTPase-activating protein 11A		MOUSE		457
+13

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D87717 mRNA Translation: BAA13442.2 Different initiation. AK303025 mRNA Translation: BAG64151.1 AK316437 mRNA Translation: BAH14808.1 AC123768 Genomic DNA No translation available. BC039563 mRNA Translation: AAH39563.1 BC063444 mRNA Translation: AAH63444.1
CCDSⁱ	CCDS10028.1 [Q6P4F7-1] CCDS58349.1 [Q6P4F7-2] CCDS66730.1 [Q6P4F7-3]
PIRⁱ	A59431
RefSeqⁱ	NP_001273408.1, NM_001286479.2 [Q6P4F7-3] NP_001273409.1, NM_001286480.2 [Q6P4F7-3] NP_055598.1, NM_014783.5 [Q6P4F7-1] NP_955389.1, NM_199357.2 [Q6P4F7-2]
UniGeneⁱ	Hs.591130

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3EAP	X-ray	2.30	A/B/C/D	1-253	[»]
ProteinModelPortalⁱ	Q6P4F7
SMRⁱ	Q6P4F7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115162, 29 interactors
IntActⁱ	Q6P4F7, 24 interactors
MINTⁱ	Q6P4F7
STRINGⁱ	9606.ENSP00000355090

PTM databases

iPTMnetⁱ	Q6P4F7
PhosphoSitePlusⁱ	Q6P4F7

Polymorphism and mutation databases

BioMutaⁱ	ARHGAP11A
DMDMⁱ	119361641

Proteomic databases

EPDⁱ	Q6P4F7
MaxQBⁱ	Q6P4F7
PaxDbⁱ	Q6P4F7
PeptideAtlasⁱ	Q6P4F7
PRIDEⁱ	Q6P4F7
ProteomicsDBⁱ	66975

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9824
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000361627; ENSP00000355090; ENSG00000198826 [Q6P4F7-1] ENST00000543522; ENSP00000440073; ENSG00000198826 [Q6P4F7-3] ENST00000565905; ENSP00000455754; ENSG00000198826 [Q6P4F7-3] ENST00000567348; ENSP00000454575; ENSG00000198826 [Q6P4F7-2] ENST00000611363; ENSP00000480085; ENSG00000275568 [Q6P4F7-3] ENST00000619401; ENSP00000479117; ENSG00000275568 [Q6P4F7-1] ENST00000622253; ENSP00000481011; ENSG00000275568 [Q6P4F7-3] ENST00000633634; ENSP00000488640; ENSG00000282168
GeneIDⁱ	9824
KEGGⁱ	hsa:9824
UCSCⁱ	uc001zgw.4 human [Q6P4F7-1]

Organism-specific databases

CTDⁱ	9824
DisGeNETⁱ	9824
EuPathDBⁱ	HostDB:ENSG00000198826.10
GeneCardsⁱ	ARHGAP11A
HGNCⁱ	HGNC:15783 ARHGAP11A
HPAⁱ	HPA040419 HPA040830
MIMⁱ	610589 gene
neXtProtⁱ	NX_Q6P4F7
OpenTargetsⁱ	ENSG00000198826
PharmGKBⁱ	PA134982615
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2710 Eukaryota ENOG410YVI5 LUCA
GeneTreeⁱ	ENSGT00760000119123
HOGENOMⁱ	HOG000231616
HOVERGENⁱ	HBG062938
InParanoidⁱ	Q6P4F7
KOⁱ	K20635
OMAⁱ	ERVWYKG
OrthoDBⁱ	EOG091G0F5G
PhylomeDBⁱ	Q6P4F7
TreeFamⁱ	TF332212

Enzyme and pathway databases

Reactomeⁱ	R-HSA-194840 Rho GTPase cycle

Reactomeⁱ

R-HSA-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRSⁱ	ARHGAP11A human
EvolutionaryTraceⁱ	Q6P4F7
GenomeRNAiⁱ	9824
Protein Ontology More...PROⁱ	PR:Q6P4F7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198826 Expressed in 103 organ(s), highest expression level in lung
CleanExⁱ	HS_ARHGAP11A
ExpressionAtlasⁱ	Q6P4F7 baseline and differential
Genevisibleⁱ	Q6P4F7 HS

Family and domain databases

Gene3Dⁱ	1.10.555.10, 1 hit
InterProⁱ	View protein in InterPro IPR008936 Rho_GTPase_activation_prot IPR000198 RhoGAP_dom
Pfamⁱ	View protein in Pfam PF00620 RhoGAP, 1 hit
SMARTⁱ	View protein in SMART SM00324 RhoGAP, 1 hit
SUPFAMⁱ	SSF48350 SSF48350, 1 hit
PROSITEⁱ	View protein in PROSITE PS50238 RHOGAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RHGBA_HUMAN
Accessionⁱ	Q6P4F7Primary (citable) accession number: Q6P4F7 Secondary accession number(s): B4DZN9, Q6PI96, Q9Y3S6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	December 12, 2006
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM

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UniProtKB - Q6P4F7 (RHGBA_HUMAN)

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Rho GTPase-activating protein 11A

ARHGAP11A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Gene expression databases

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ