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UniProtKB - Q6P4F7 (RHGBA_HUMAN)

Entry version 145 (25 May 2022)
Sequence version 2 (12 Dec 2006)
Previous versions | rss
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Protein

Rho GTPase-activating protein 11A

Gene

ARHGAP11A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P4F7

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8980692, RHOA GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6P4F7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q6P4F7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 11ACurated
Alternative name(s):
Rho-type GTPase-activating protein 11ACurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP11A1 PublicationImported
Synonyms:KIAA00131 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15783, ARHGAP11A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610589, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P4F7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198826

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9824

Open Targets

More...OpenTargetsi		ENSG00000198826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134982615

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P4F7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARHGAP11A

Domain mapping of disease mutations (DMDM)

More...DMDMi		119361641

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002672131 – 1023Rho GTPase-activating protein 11AAdd BLAST1023

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei285PhosphoserineCombined sources1
Modified residuei306PhosphothreonineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei323PhosphothreonineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1
Modified residuei508PhosphothreonineCombined sources1
Modified residuei582PhosphoserineCombined sources1
Modified residuei585PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei847PhosphoserineCombined sources1
Modified residuei866PhosphothreonineCombined sources1
Modified residuei868PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P4F7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P4F7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P4F7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P4F7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P4F7

PeptideAtlas

More...PeptideAtlasi		Q6P4F7

PRoteomics IDEntifications database

More...PRIDEi		Q6P4F7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5612
66975 [Q6P4F7-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P4F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P4F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198826, Expressed in subventricular zone (outer) (primate) and 126 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P4F7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P4F7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198826, Tissue enhanced (bone marrow, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115162, 67 interactors

Protein interaction database and analysis system

More...IntActi		Q6P4F7, 49 interactors

Molecular INTeraction database

More...MINTi		Q6P4F7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355090

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P4F7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11023
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6P4F7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P4F7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q6P4F7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 239Rho-GAPPROSITE-ProRule annotationAdd BLAST191

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni567 – 589DisorderedSequence analysisAdd BLAST23
Regioni714 – 734DisorderedSequence analysisAdd BLAST21
Regioni999 – 1023DisorderedSequence analysisAdd BLAST25

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2710, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155312

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_010134_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P4F7

Identification of Orthologs from Complete Genome Data

More...OMAi		RQPIRHK

Database of Orthologous Groups

More...OrthoDBi		213929at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P4F7

TreeFam database of animal gene trees

More...TreeFami		TF332212

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR042869, ARHGAP11A/B
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom

The PANTHER Classification System

More...PANTHERi		PTHR15670, PTHR15670, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00620, RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00324, RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50238, RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P4F7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP 
        60         70         80         90        100
FNALPHSAVP EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN 
       110        120        130        140        150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE 
       160        170        180        190        200
EKNKATLLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA 
       210        220        230        240        250
PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR VPDFILEKIP 
       260        270        280        290        300
AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN 
       310        320        330        340        350
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF 
       360        370        380        390        400
NFELLPSNLF NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR 
       410        420        430        440        450
RSKRIAGKKV CRVESGKAGC FSPKISHKEK VRRSLRLKFN LGKNGREVNG 
       460        470        480        490        500
CSGVNRYESV GWRLANQQSL KNRIESVKTG LLFSPDVDEK LPKKGSEKIS 
       510        520        530        540        550
KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM VENLEVENSL 
       560        570        580        590        600
EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ 
       610        620        630        640        650
KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT 
       660        670        680        690        700
IVESKEKYEH HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE 
       710        720        730        740        750
KDIHSNMPKD YLSKQEFSSD EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK 
       760        770        780        790        800
CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM RIAKQQSLET CEKTVSESSQ 
       810        820        830        840        850
MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ SVRRINSLLE 
       860        870        880        890        900
YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP 
       910        920        930        940        950
KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ 
       960        970        980        990       1000
KILSDGQVKV PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW 
      1010       1020 
YKGSPKHPIG KTQLLPTSKP VDL
Length:1,023
Mass (Da):113,866
Last modified:December 12, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i053C89371B5F614F
GO
Isoform 2 (identifier: Q6P4F7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     496-501: SEKISK → TFTYYC
     502-1023: Missing.

Show »
Length:501
Mass (Da):55,525
Checksum:i44930C9BA98F2E41
GO
Isoform 3 (identifier: Q6P4F7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-189: Missing.

Show »
Length:834
Mass (Da):92,697
Checksum:i4F00E8BB4175EE72
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BR51H3BR51_HUMAN
Rho GTPase-activating protein 11A
ARHGAP11A
473Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ41H3BQ41_HUMAN
Rho GTPase-activating protein 11A
ARHGAP11A
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA13442 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035546605E → K in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553701 – 189Missing in isoform 3. 1 PublicationAdd BLAST189
Alternative sequenceiVSP_054102496 – 501SEKISK → TFTYYC in isoform 2. 1 Publication6
Alternative sequenceiVSP_054103502 – 1023Missing in isoform 2. 1 PublicationAdd BLAST522

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D87717 mRNA Translation: BAA13442.2 Different initiation.
AK303025 mRNA Translation: BAG64151.1
AK316437 mRNA Translation: BAH14808.1
AC123768 Genomic DNA No translation available.
BC039563 mRNA Translation: AAH39563.1
BC063444 mRNA Translation: AAH63444.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10028.1 [Q6P4F7-1]
CCDS58349.1 [Q6P4F7-2]
CCDS66730.1 [Q6P4F7-3]

Protein sequence database of the Protein Information Resource

More...PIRi		A59431

NCBI Reference Sequences

More...RefSeqi		NP_001273408.1, NM_001286479.2 [Q6P4F7-3]
NP_001273409.1, NM_001286480.2 [Q6P4F7-3]
NP_055598.1, NM_014783.5 [Q6P4F7-1]
NP_955389.1, NM_199357.2 [Q6P4F7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361627.8; ENSP00000355090.3; ENSG00000198826.11
ENST00000543522.5; ENSP00000440073.1; ENSG00000198826.11 [Q6P4F7-3]
ENST00000565905.5; ENSP00000455754.1; ENSG00000198826.11 [Q6P4F7-3]
ENST00000567348.5; ENSP00000454575.1; ENSG00000198826.11 [Q6P4F7-2]
ENST00000611363.1; ENSP00000480085.1; ENSG00000275568.4 [Q6P4F7-3]
ENST00000619401.4; ENSP00000479117.1; ENSG00000275568.4
ENST00000622253.4; ENSP00000481011.1; ENSG00000275568.4 [Q6P4F7-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9824

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9824

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000361627.8; ENSP00000355090.3; NM_014783.6; NP_055598.1

UCSC genome browser

More...UCSCi		uc001zgw.4, human [Q6P4F7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87717 mRNA Translation: BAA13442.2 Different initiation.
AK303025 mRNA Translation: BAG64151.1
AK316437 mRNA Translation: BAH14808.1
AC123768 Genomic DNA No translation available.
BC039563 mRNA Translation: AAH39563.1
BC063444 mRNA Translation: AAH63444.1
CCDSiCCDS10028.1 [Q6P4F7-1]
CCDS58349.1 [Q6P4F7-2]
CCDS66730.1 [Q6P4F7-3]
PIRiA59431
RefSeqiNP_001273408.1, NM_001286479.2 [Q6P4F7-3]
NP_001273409.1, NM_001286480.2 [Q6P4F7-3]
NP_055598.1, NM_014783.5 [Q6P4F7-1]
NP_955389.1, NM_199357.2 [Q6P4F7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EAPX-ray2.30A/B/C/D1-253[»]
AlphaFoldDBiQ6P4F7
SMRiQ6P4F7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115162, 67 interactors
IntActiQ6P4F7, 49 interactors
MINTiQ6P4F7
STRINGi9606.ENSP00000355090

PTM databases

iPTMnetiQ6P4F7
PhosphoSitePlusiQ6P4F7

Genetic variation databases

BioMutaiARHGAP11A
DMDMi119361641

Proteomic databases

EPDiQ6P4F7
jPOSTiQ6P4F7
MassIVEiQ6P4F7
MaxQBiQ6P4F7
PaxDbiQ6P4F7
PeptideAtlasiQ6P4F7
PRIDEiQ6P4F7
ProteomicsDBi5612
66975 [Q6P4F7-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		51650, 86 antibodies from 18 providers

The DNASU plasmid repository

More...DNASUi		9824

Genome annotation databases

EnsembliENST00000361627.8; ENSP00000355090.3; ENSG00000198826.11
ENST00000543522.5; ENSP00000440073.1; ENSG00000198826.11 [Q6P4F7-3]
ENST00000565905.5; ENSP00000455754.1; ENSG00000198826.11 [Q6P4F7-3]
ENST00000567348.5; ENSP00000454575.1; ENSG00000198826.11 [Q6P4F7-2]
ENST00000611363.1; ENSP00000480085.1; ENSG00000275568.4 [Q6P4F7-3]
ENST00000619401.4; ENSP00000479117.1; ENSG00000275568.4
ENST00000622253.4; ENSP00000481011.1; ENSG00000275568.4 [Q6P4F7-3]
GeneIDi9824
KEGGihsa:9824
MANE-SelectiENST00000361627.8; ENSP00000355090.3; NM_014783.6; NP_055598.1
UCSCiuc001zgw.4, human [Q6P4F7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9824
DisGeNETi9824

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARHGAP11A
HGNCiHGNC:15783, ARHGAP11A
HPAiENSG00000198826, Tissue enhanced (bone marrow, lymphoid tissue)
MIMi610589, gene
neXtProtiNX_Q6P4F7
OpenTargetsiENSG00000198826
PharmGKBiPA134982615
VEuPathDBiHostDB:ENSG00000198826

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2710, Eukaryota
GeneTreeiENSGT00940000155312
HOGENOMiCLU_010134_1_0_1
InParanoidiQ6P4F7
OMAiRQPIRHK
OrthoDBi213929at2759
PhylomeDBiQ6P4F7
TreeFamiTF332212

Enzyme and pathway databases

PathwayCommonsiQ6P4F7
ReactomeiR-HSA-8980692, RHOA GTPase cycle
SignaLinkiQ6P4F7
SIGNORiQ6P4F7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9824, 186 hits in 1076 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARHGAP11A, human
EvolutionaryTraceiQ6P4F7

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9824
PharosiQ6P4F7, Tbio

Protein Ontology

More...PROi		PR:Q6P4F7
RNActiQ6P4F7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198826, Expressed in subventricular zone (outer) (primate) and 126 other tissues
ExpressionAtlasiQ6P4F7, baseline and differential
GenevisibleiQ6P4F7, HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR042869, ARHGAP11A/B
IPR008936, Rho_GTPase_activation_prot
IPR000198, RhoGAP_dom
PANTHERiPTHR15670, PTHR15670, 1 hit
PfamiView protein in Pfam
PF00620, RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324, RhoGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238, RHOGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHGBA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P4F7
Secondary accession number(s): B4DZN9, Q6PI96, Q9Y3S6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 12, 2006
Last modified: May 25, 2022
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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