UniProtKB - Q6P4F7 (RHGBA_HUMAN)
Protein
Rho GTPase-activating protein 11A
Gene
ARHGAP11A
Organism
Homo sapiens (Human)
Status
Functioni
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.1 Publication
GO - Molecular functioni
- GTPase activator activity Source: UniProtKB
GO - Biological processi
- positive regulation of GTPase activity Source: UniProtKB
- regulation of small GTPase mediated signal transduction Source: Reactome
- signal transduction Source: InterPro
Keywordsi
Molecular function | GTPase activation |
Enzyme and pathway databases
PathwayCommonsi | Q6P4F7 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q6P4F7 |
Names & Taxonomyi
Protein namesi | Recommended name: Rho GTPase-activating protein 11ACuratedAlternative name(s): Rho-type GTPase-activating protein 11ACurated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15783, ARHGAP11A |
MIMi | 610589, gene |
neXtProti | NX_Q6P4F7 |
VEuPathDBi | HostDB:ENSG00000198826.10 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9824 |
OpenTargetsi | ENSG00000198826 |
PharmGKBi | PA134982615 |
Miscellaneous databases
Pharosi | Q6P4F7, Tdark |
Genetic variation databases
BioMutai | ARHGAP11A |
DMDMi | 119361641 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000267213 | 1 – 1023 | Rho GTPase-activating protein 11AAdd BLAST | 1023 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 285 | PhosphoserineCombined sources | 1 | |
Modified residuei | 306 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 316 | PhosphoserineCombined sources | 1 | |
Modified residuei | 318 | PhosphoserineCombined sources | 1 | |
Modified residuei | 323 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 339 | PhosphoserineCombined sources | 1 | |
Modified residuei | 340 | PhosphoserineCombined sources | 1 | |
Modified residuei | 484 | PhosphoserineCombined sources | 1 | |
Modified residuei | 508 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 582 | PhosphoserineCombined sources | 1 | |
Modified residuei | 585 | PhosphoserineCombined sources | 1 | |
Modified residuei | 638 | PhosphoserineCombined sources | 1 | |
Modified residuei | 675 | PhosphoserineCombined sources | 1 | |
Modified residuei | 847 | PhosphoserineCombined sources | 1 | |
Modified residuei | 866 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 868 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6P4F7 |
jPOSTi | Q6P4F7 |
MassIVEi | Q6P4F7 |
MaxQBi | Q6P4F7 |
PaxDbi | Q6P4F7 |
PeptideAtlasi | Q6P4F7 |
PRIDEi | Q6P4F7 |
ProteomicsDBi | 5612 66975 [Q6P4F7-1] |
PTM databases
iPTMneti | Q6P4F7 |
PhosphoSitePlusi | Q6P4F7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198826, Expressed in subventricular zone (outer) (primate) and 125 other tissues |
ExpressionAtlasi | Q6P4F7, baseline and differential |
Genevisiblei | Q6P4F7, HS |
Organism-specific databases
HPAi | ENSG00000198826, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 115162, 66 interactors |
IntActi | Q6P4F7, 46 interactors |
MINTi | Q6P4F7 |
STRINGi | 9606.ENSP00000355090 |
Miscellaneous databases
RNActi | Q6P4F7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q6P4F7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6P4F7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 49 – 239 | Rho-GAPPROSITE-ProRule annotationAdd BLAST | 191 |
Phylogenomic databases
eggNOGi | KOG2710, Eukaryota |
GeneTreei | ENSGT00940000155312 |
HOGENOMi | CLU_010134_1_0_1 |
InParanoidi | Q6P4F7 |
OMAi | CSGVNRY |
OrthoDBi | 213929at2759 |
PhylomeDBi | Q6P4F7 |
TreeFami | TF332212 |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR042869, ARHGAP11A/B IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
PANTHERi | PTHR15670, PTHR15670, 1 hit |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6P4F7-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MWDQRLVRLA LLQHLRAFYG IKVKGVRGQC DRRRHETAAT EIGGKIFGVP
60 70 80 90 100
FNALPHSAVP EYGHIPSFLV DACTSLEDHI HTEGLFRKSG SVIRLKALKN
110 120 130 140 150
KVDHGEGCLS SAPPCDIAGL LKQFFRELPE PILPADLHEA LLKAQQLGTE
160 170 180 190 200
EKNKATLLLS CLLADHTVHV LRYFFNFLRN VSLRSSENKM DSSNLAVIFA
210 220 230 240 250
PNLLQTSEGH EKMSSNTEKK LRLQAAVVQT LIDYASDIGR VPDFILEKIP
260 270 280 290 300
AMLGIDGLCA TPSLEGFEEG EYETPGEYKR KRRQSVGDFV SGALNKFKPN
310 320 330 340 350
RTPSITPQEE RIAQLSESPV ILTPNAKRTL PVDSSHGFSS KKRKSIKHNF
360 370 380 390 400
NFELLPSNLF NSSSTPVSVH IDTSSEGSSQ SSLSPVLIGG NHLITAGVPR
410 420 430 440 450
RSKRIAGKKV CRVESGKAGC FSPKISHKEK VRRSLRLKFN LGKNGREVNG
460 470 480 490 500
CSGVNRYESV GWRLANQQSL KNRIESVKTG LLFSPDVDEK LPKKGSEKIS
510 520 530 540 550
KSEETLLTPE RLVGTNYRMS WTGPNNSSFQ EVDANEASSM VENLEVENSL
560 570 580 590 600
EPDIMVEKSP ATSCELTPSN LNNKHNSNIT SSPLSGDENN MTKETLVKVQ
610 620 630 640 650
KAFSESGSNL HALMNQRQSS VTNVGKVKLT EPSYLEDSPE ENLFETNDLT
660 670 680 690 700
IVESKEKYEH HTGKGEKCFS ERDFSPLQTQ TFNRETTIKC YSTQMKMEHE
710 720 730 740 750
KDIHSNMPKD YLSKQEFSSD EEIKKQQSPK DKLNNKLKEN ENMMEGNLPK
760 770 780 790 800
CAAHSKDEAR SSFSQQSTCV VTNLSKPRPM RIAKQQSLET CEKTVSESSQ
810 820 830 840 850
MTEHRKVSDH IQWFNKLSLN EPNRIKVKSP LKFQRTPVRQ SVRRINSLLE
860 870 880 890 900
YSRQPTGHKL ASLGDTASPL VKSVSCDGAL SSCIESASKD SSVSCIKSGP
910 920 930 940 950
KEQKSMSCEE SNIGAISKSS MELPSKSFLK MRKHPDSVNA SLRSTTVYKQ
960 970 980 990 1000
KILSDGQVKV PLDDLTNHDI VKPVVNNNMG ISSGINNRVL RRPSERGRAW
1010 1020
YKGSPKHPIG KTQLLPTSKP VDL
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BR51 | H3BR51_HUMAN | Rho GTPase-activating protein 11A | ARHGAP11A | 473 | Annotation score: | ||
H3BQ41 | H3BQ41_HUMAN | Rho GTPase-activating protein 11A | ARHGAP11A | 207 | Annotation score: |
Sequence cautioni
The sequence BAA13442 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035546 | 605 | E → K in a breast cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055370 | 1 – 189 | Missing in isoform 3. 1 PublicationAdd BLAST | 189 | |
Alternative sequenceiVSP_054102 | 496 – 501 | SEKISK → TFTYYC in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_054103 | 502 – 1023 | Missing in isoform 2. 1 PublicationAdd BLAST | 522 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87717 mRNA Translation: BAA13442.2 Different initiation. AK303025 mRNA Translation: BAG64151.1 AK316437 mRNA Translation: BAH14808.1 AC123768 Genomic DNA No translation available. BC039563 mRNA Translation: AAH39563.1 BC063444 mRNA Translation: AAH63444.1 |
CCDSi | CCDS10028.1 [Q6P4F7-1] CCDS58349.1 [Q6P4F7-2] CCDS66730.1 [Q6P4F7-3] |
PIRi | A59431 |
RefSeqi | NP_001273408.1, NM_001286479.2 [Q6P4F7-3] NP_001273409.1, NM_001286480.2 [Q6P4F7-3] NP_055598.1, NM_014783.5 [Q6P4F7-1] NP_955389.1, NM_199357.2 [Q6P4F7-2] |
Genome annotation databases
Ensembli | ENST00000361627; ENSP00000355090; ENSG00000198826 [Q6P4F7-1] ENST00000543522; ENSP00000440073; ENSG00000198826 [Q6P4F7-3] ENST00000565905; ENSP00000455754; ENSG00000198826 [Q6P4F7-3] ENST00000567348; ENSP00000454575; ENSG00000198826 [Q6P4F7-2] ENST00000611363; ENSP00000480085; ENSG00000275568 [Q6P4F7-3] ENST00000619401; ENSP00000479117; ENSG00000275568 [Q6P4F7-1] ENST00000622253; ENSP00000481011; ENSG00000275568 [Q6P4F7-3] |
GeneIDi | 9824 |
KEGGi | hsa:9824 |
UCSCi | uc001zgw.4, human [Q6P4F7-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D87717 mRNA Translation: BAA13442.2 Different initiation. AK303025 mRNA Translation: BAG64151.1 AK316437 mRNA Translation: BAH14808.1 AC123768 Genomic DNA No translation available. BC039563 mRNA Translation: AAH39563.1 BC063444 mRNA Translation: AAH63444.1 |
CCDSi | CCDS10028.1 [Q6P4F7-1] CCDS58349.1 [Q6P4F7-2] CCDS66730.1 [Q6P4F7-3] |
PIRi | A59431 |
RefSeqi | NP_001273408.1, NM_001286479.2 [Q6P4F7-3] NP_001273409.1, NM_001286480.2 [Q6P4F7-3] NP_055598.1, NM_014783.5 [Q6P4F7-1] NP_955389.1, NM_199357.2 [Q6P4F7-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3EAP | X-ray | 2.30 | A/B/C/D | 1-253 | [»] | |
SMRi | Q6P4F7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115162, 66 interactors |
IntActi | Q6P4F7, 46 interactors |
MINTi | Q6P4F7 |
STRINGi | 9606.ENSP00000355090 |
PTM databases
iPTMneti | Q6P4F7 |
PhosphoSitePlusi | Q6P4F7 |
Genetic variation databases
BioMutai | ARHGAP11A |
DMDMi | 119361641 |
Proteomic databases
EPDi | Q6P4F7 |
jPOSTi | Q6P4F7 |
MassIVEi | Q6P4F7 |
MaxQBi | Q6P4F7 |
PaxDbi | Q6P4F7 |
PeptideAtlasi | Q6P4F7 |
PRIDEi | Q6P4F7 |
ProteomicsDBi | 5612 66975 [Q6P4F7-1] |
Protocols and materials databases
Antibodypediai | 51650, 80 antibodies |
DNASUi | 9824 |
Genome annotation databases
Organism-specific databases
CTDi | 9824 |
DisGeNETi | 9824 |
GeneCardsi | ARHGAP11A |
HGNCi | HGNC:15783, ARHGAP11A |
HPAi | ENSG00000198826, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 610589, gene |
neXtProti | NX_Q6P4F7 |
OpenTargetsi | ENSG00000198826 |
PharmGKBi | PA134982615 |
VEuPathDBi | HostDB:ENSG00000198826.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2710, Eukaryota |
GeneTreei | ENSGT00940000155312 |
HOGENOMi | CLU_010134_1_0_1 |
InParanoidi | Q6P4F7 |
OMAi | CSGVNRY |
OrthoDBi | 213929at2759 |
PhylomeDBi | Q6P4F7 |
TreeFami | TF332212 |
Enzyme and pathway databases
PathwayCommonsi | Q6P4F7 |
Reactomei | R-HSA-194840, Rho GTPase cycle |
SIGNORi | Q6P4F7 |
Miscellaneous databases
BioGRID-ORCSi | 9824, 178 hits in 991 CRISPR screens |
ChiTaRSi | ARHGAP11A, human |
EvolutionaryTracei | Q6P4F7 |
GenomeRNAii | 9824 |
Pharosi | Q6P4F7, Tdark |
PROi | PR:Q6P4F7 |
RNActi | Q6P4F7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198826, Expressed in subventricular zone (outer) (primate) and 125 other tissues |
ExpressionAtlasi | Q6P4F7, baseline and differential |
Genevisiblei | Q6P4F7, HS |
Family and domain databases
Gene3Di | 1.10.555.10, 1 hit |
InterProi | View protein in InterPro IPR042869, ARHGAP11A/B IPR008936, Rho_GTPase_activation_prot IPR000198, RhoGAP_dom |
PANTHERi | PTHR15670, PTHR15670, 1 hit |
Pfami | View protein in Pfam PF00620, RhoGAP, 1 hit |
SMARTi | View protein in SMART SM00324, RhoGAP, 1 hit |
SUPFAMi | SSF48350, SSF48350, 1 hit |
PROSITEi | View protein in PROSITE PS50238, RHOGAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RHGBA_HUMAN | |
Accessioni | Q6P4F7Primary (citable) accession number: Q6P4F7 Secondary accession number(s): B4DZN9, Q6PI96, Q9Y3S6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | December 12, 2006 | |
Last modified: | April 7, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references