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Entry version 121 (17 Jun 2020)
Sequence version 2 (05 Jun 2019)
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Protein

Protein GOLM2

Gene

GOLM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein GOLM2Curated
Alternative name(s):
Cancer susceptibility candidate gene 4 protein
Short name:
CASC4
Golgi membrane protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLM2Imported
Synonyms:CASC4
ORF Names:UNQ2573/PRO6308
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166734.18

Human Gene Nomenclature Database

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HGNCi
HGNC:24892 GOLM2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P4E1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini36 – 436LumenalSequence analysisAdd BLAST401

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113201

Open Targets

More...
OpenTargetsi
ENSG00000166734

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672200

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P4E1 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CASC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737334

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002918431 – 436Protein GOLM2Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei233PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P4E1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P4E1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P4E1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P4E1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P4E1

PeptideAtlas

More...
PeptideAtlasi
Q6P4E1

PRoteomics IDEntifications database

More...
PRIDEi
Q6P4E1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
33815
66964 [Q6P4E1-2]
66965 [Q6P4E1-3]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1652

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P4E1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P4E1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166734 Expressed in epithelial cell of pancreas and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P4E1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P4E1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166734 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125233, 12 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P4E1, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299957

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P4E1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P4E1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili35 – 198Sequence analysisAdd BLAST164

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GOLM family.Curated

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHYU Eukaryota
ENOG4111SUN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063675

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_129925_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P4E1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVQVDTH

Database of Orthologous Groups

More...
OrthoDBi
913812at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P4E1

TreeFam database of animal gene trees

More...
TreeFami
TF331127

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026141 CASC4
IPR026139 GOLM1/CASC4

The PANTHER Classification System

More...
PANTHERi
PTHR15896 PTHR15896, 1 hit
PTHR15896:SF11 PTHR15896:SF11, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR02084 GOLM1CASC4

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q6P4E1-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVGFGANRRA GRLPSLVLVV LLVVIVVLAF NYWSISSRHV LLQEEVAELQ
60 70 80 90 100
GQVQRTEVAR GRLEKRNSDL LLLVDTHKKQ IDQKEADYGR LSSRLQAREG
110 120 130 140 150
LGKRCEDDKV KLQNNISYQM ADIHHLKEQL AELRQEFLRQ EDQLQDYRKN
160 170 180 190 200
NTYLVKRLEY ESFQCGQQMK ELRAQHEENI KKLADQFLEE QKQETQKIQS
210 220 230 240 250
NDGKELDINN QVVPKNIPKV AENVADKNEE PSSNHIPHGK EQIKRGGDAG
260 270 280 290 300
MPGIEENDLA KVDDLPPALR KPPISVSQHE SHQAISHLPT GQPLSPNMPP
310 320 330 340 350
DSHINHNGNP GTSKQNPSSP LQRLIPGSNL DSEPRIQTDI LKQATKDRVS
360 370 380 390 400
DFHKLKQSRF FDENESPVDP QHGSKLADYN GDDGNVGEYE ADKQAELAYN
410 420 430
EEEDGDGGEE DVQDDEEREL QMDPADYGKQ HFNDVL
Length:436
Mass (Da):49,498
Last modified:June 5, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE11DABFDD27CF70A
GO
Isoform 2 (identifier: Q6P4E1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-414: SRFFDENESPVDPQHGSKLADYNGDDGNVGEYEADKQAELAYNEEEDGDGGEEDVQD → N

Show »
Length:380
Mass (Da):43,333
Checksum:iB99B88414F734501
GO
Isoform 3 (identifier: Q6P4E1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-177: FQCGQQMKELRAQHE → KRPKRFNQMMERNWI
     178-436: Missing.

Show »
Length:177
Mass (Da):20,934
Checksum:iDF8452919A90949A
GO
Isoform 5 (identifier: Q6P4E1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MVGFGANRRAGRLPSLVLVVLL → M

Show »
Length:415
Mass (Da):47,308
Checksum:i0E65E3642D8E6316
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YMR0H0YMR0_HUMAN
Golgi membrane protein 2
GOLM2
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRW9A0A3B3IRW9_HUMAN
Golgi membrane protein 2
GOLM2
317Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YM51H0YM51_HUMAN
Golgi membrane protein 2
GOLM2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKJ7H0YKJ7_HUMAN
Golgi membrane protein 2
GOLM2
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN36H0YN36_HUMAN
Golgi membrane protein 2
GOLM2
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH63480 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti429K → E (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0601781 – 22MVGFG…LVVLL → M in isoform 5. Add BLAST22
Alternative sequenceiVSP_060179163 – 177FQCGQ…RAQHE → KRPKRFNQMMERNWI in isoform 3. Add BLAST15
Alternative sequenceiVSP_060180178 – 436Missing in isoform 3. Add BLAST259
Alternative sequenceiVSP_060181358 – 414SRFFD…EDVQD → N in isoform 2. Add BLAST57

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY358086 mRNA Translation: AAQ88453.1
AK298564 mRNA Translation: BAG60758.1
AL832333 mRNA No translation available.
AC025043 Genomic DNA No translation available.
AC090519 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77258.1
BC012124 mRNA Translation: AAH12124.1
BC063480 mRNA Translation: AAH63480.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10108.1 [Q6P4E1-4]
CCDS10109.1 [Q6P4E1-2]

NCBI Reference Sequences

More...
RefSeqi
NP_612432.2, NM_138423.3 [Q6P4E1-4]
NP_816929.1, NM_177974.2 [Q6P4E1-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299957; ENSP00000299957; ENSG00000166734 [Q6P4E1-4]
ENST00000345795; ENSP00000335063; ENSG00000166734 [Q6P4E1-2]
ENST00000557945; ENSP00000453720; ENSG00000166734 [Q6P4E1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113201

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113201

UCSC genome browser

More...
UCSCi
uc001ztp.4 human [Q6P4E1-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358086 mRNA Translation: AAQ88453.1
AK298564 mRNA Translation: BAG60758.1
AL832333 mRNA No translation available.
AC025043 Genomic DNA No translation available.
AC090519 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77258.1
BC012124 mRNA Translation: AAH12124.1
BC063480 mRNA Translation: AAH63480.1 Sequence problems.
CCDSiCCDS10108.1 [Q6P4E1-4]
CCDS10109.1 [Q6P4E1-2]
RefSeqiNP_612432.2, NM_138423.3 [Q6P4E1-4]
NP_816929.1, NM_177974.2 [Q6P4E1-2]

3D structure databases

SMRiQ6P4E1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125233, 12 interactors
IntActiQ6P4E1, 4 interactors
STRINGi9606.ENSP00000299957

PTM databases

GlyConnecti1652
iPTMnetiQ6P4E1
PhosphoSitePlusiQ6P4E1

Polymorphism and mutation databases

BioMutaiCASC4
DMDMi74737334

Proteomic databases

EPDiQ6P4E1
jPOSTiQ6P4E1
MassIVEiQ6P4E1
MaxQBiQ6P4E1
PaxDbiQ6P4E1
PeptideAtlasiQ6P4E1
PRIDEiQ6P4E1
ProteomicsDBi33815
66964 [Q6P4E1-2]
66965 [Q6P4E1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
55771 85 antibodies

The DNASU plasmid repository

More...
DNASUi
113201

Genome annotation databases

EnsembliENST00000299957; ENSP00000299957; ENSG00000166734 [Q6P4E1-4]
ENST00000345795; ENSP00000335063; ENSG00000166734 [Q6P4E1-2]
ENST00000557945; ENSP00000453720; ENSG00000166734 [Q6P4E1-3]
GeneIDi113201
KEGGihsa:113201
UCSCiuc001ztp.4 human [Q6P4E1-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113201
DisGeNETi113201
EuPathDBiHostDB:ENSG00000166734.18

GeneCards: human genes, protein and diseases

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GeneCardsi
CASC4
HGNCiHGNC:24892 GOLM2
HPAiENSG00000166734 Low tissue specificity
neXtProtiNX_Q6P4E1
OpenTargetsiENSG00000166734
PharmGKBiPA142672200

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHYU Eukaryota
ENOG4111SUN LUCA
GeneTreeiENSGT00530000063675
HOGENOMiCLU_129925_0_0_1
InParanoidiQ6P4E1
OMAiIVQVDTH
OrthoDBi913812at2759
PhylomeDBiQ6P4E1
TreeFamiTF331127

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
113201 4 hits in 789 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CASC4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
113201
PharosiQ6P4E1 Tdark

Protein Ontology

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PROi
PR:Q6P4E1
RNActiQ6P4E1 protein

Gene expression databases

BgeeiENSG00000166734 Expressed in epithelial cell of pancreas and 206 other tissues
ExpressionAtlasiQ6P4E1 baseline and differential
GenevisibleiQ6P4E1 HS

Family and domain databases

InterProiView protein in InterPro
IPR026141 CASC4
IPR026139 GOLM1/CASC4
PANTHERiPTHR15896 PTHR15896, 1 hit
PTHR15896:SF11 PTHR15896:SF11, 1 hit
PRINTSiPR02084 GOLM1CASC4

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOLM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P4E1
Secondary accession number(s): B4DPZ6
, G5E934, Q6UY45, Q96EM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 5, 2019
Last modified: June 17, 2020
This is version 121 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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