Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - Q6P4A8 (PLBL1_HUMAN)

Entry version 127 (25 May 2022)
Sequence version 2 (24 Nov 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Phospholipase B-like 1

Gene

PLBD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity).

Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.

By similarity1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

Optimum pH is 7.4.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • phospholipase activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.1.5, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P4A8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1483115, Hydrolysis of LPC

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6P4A8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipase B-like 1 (EC:3.1.1.-)
Alternative name(s):
LAMA-like protein 1
Lamina ancestor homolog 1
Phospholipase B domain-containing protein 1
Cleaved into the following 3 chains:
Phospholipase B-like 1 chain A
Phospholipase B-like 1 chain B
Phospholipase B-like 1 chain C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLBD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26215, PLBD1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618486, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P4A8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000121316

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79887

Open Targets

More...OpenTargetsi		ENSG00000121316

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164724597

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P4A8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLBD1

Domain mapping of disease mutations (DMDM)

More...DMDMi		269849630

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000028610639 – 553Phospholipase B-like 1Add BLAST515
ChainiPRO_000042542139 – 208Phospholipase B-like 1 chain AAdd BLAST170
ChainiPRO_000042542293 – 208Phospholipase B-like 1 chain CAdd BLAST116
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000425423209 – 227Removed in mature formBy similarityAdd BLAST19
ChainiPRO_0000425424228 – 553Phospholipase B-like 1 chain BAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi71N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi308N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi308N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi366N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi366N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1
Glycosylationi411N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi470 ↔ 475By similarity
Disulfide bondi474 ↔ 489By similarity
Glycosylationi526N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity1
Glycosylationi526N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P4A8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P4A8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P4A8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P4A8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P4A8

PeptideAtlas

More...PeptideAtlasi		Q6P4A8

PRoteomics IDEntifications database

More...PRIDEi		Q6P4A8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66958

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1603, 12 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6P4A8, 6 sites, 11 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P4A8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P4A8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neutrophils and monocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000121316, Expressed in bone marrow and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P4A8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P4A8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000121316, Tissue enhanced (bone)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a homodimer, each monomer is composed of a chain A and a chain B.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122972, 130 interactors

Protein interaction database and analysis system

More...IntActi		Q6P4A8, 15 interactors

Molecular INTeraction database

More...MINTi		Q6P4A8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000240617

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P4A8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6P4A8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P4A8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholipase B-like family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3774, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063509

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027106_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P4A8

Identification of Orthologs from Complete Genome Data

More...OMAi		MYDHFTN

Database of Orthologous Groups

More...OrthoDBi		724258at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P4A8

TreeFam database of animal gene trees

More...TreeFami		TF315042

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.439.20, 1 hit
2.10.70.60, 1 hit
3.60.60.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007000, PLipase_B-like
IPR043040, PLipase_B-like_dom1
IPR043041, PLipase_B-like_dom2
IPR043042, PLipase_B-like_dom3

The PANTHER Classification System

More...PANTHERi		PTHR12370, PTHR12370, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04916, Phospholip_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P4A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTRGGPGGRP GLPQPPPLLL LLLLLPLLLV TAEPPKPAGV YYATAYWMPA 
        60         70         80         90        100
EKTVQVKNVM DKNGDAYGFY NNSVKTTGWG ILEIRAGYGS QTLSNEIIMF 
       110        120        130        140        150
VAGFLEGYLT APHMNDHYTN LYPQLITKPS IMDKVQDFME KQDKWTRKNI 
       160        170        180        190        200
KEYKTDSFWR HTGYVMAQID GLYVGAKKRA ILEGTKPMTL FQIQFLNSVG 
       210        220        230        240        250
DLLDLIPSLS PTKNGSLKVF KRWDMGHCSA LIKVLPGFEN ILFAHSSWYT 
       260        270        280        290        300
YAAMLRIYKH WDFNVIDKDT SSSRLSFSSY PGFLESLDDF YILSSGLILL 
       310        320        330        340        350
QTTNSVFNKT LLKQVIPETL LSWQRVRVAN MMADSGKRWA DIFSKYNSGT 
       360        370        380        390        400
YNNQYMVLDL KKVKLNHSLD KGTLYIVEQI PTYVEYSEQT DVLRKGYWPS 
       410        420        430        440        450
YNVPFHEKIY NWSGYPLLVQ KLGLDYSYDL APRAKIFRRD QGKVTDTASM 
       460        470        480        490        500
KYIMRYNNYK KDPYSRGDPC NTICCREDLN SPNPSPGGCY DTKVADIYLA 
       510        520        530        540        550
SQYTSYAISG PTVQGGLPVF RWDRFNKTLH QGMPEVYNFD FITMKPILKL 

DIK
Length:553
Mass (Da):63,255
Last modified:November 24, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB4258DD2E1A16FE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H053F5H053_HUMAN
Phospholipase B-like
PLBD1
144Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GYQ3F5GYQ3_HUMAN
Phospholipase B-like 1
PLBD1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH00909 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15442 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18Missing in BAF83603 (PubMed:14702039).Curated1
Sequence conflicti18Missing in AAH63561 (PubMed:15489334).Curated1
Sequence conflicti241I → V in BAB15442 (PubMed:15489334).Curated1
Sequence conflicti302T → A in BAF83603 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032072265V → I2 PublicationsCorresponds to variant dbSNP:rs7957558Ensembl.1
Natural variantiVAR_032073377V → A. Corresponds to variant dbSNP:rs2287541Ensembl.1
Natural variantiVAR_032074534P → A1 PublicationCorresponds to variant dbSNP:rs1600Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK026315 mRNA Translation: BAB15442.1 Different initiation.
AK290914 mRNA Translation: BAF83603.1
AC008114 Genomic DNA No translation available.
BC000909 mRNA Translation: AAH00909.2 Different initiation.
BC063561 mRNA Translation: AAH63561.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31751.1

NCBI Reference Sequences

More...RefSeqi		NP_079105.4, NM_024829.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000240617.10; ENSP00000240617.5; ENSG00000121316.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79887

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79887

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000240617.10; ENSP00000240617.5; NM_024829.6; NP_079105.4

UCSC genome browser

More...UCSCi		uc001rcc.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026315 mRNA Translation: BAB15442.1 Different initiation.
AK290914 mRNA Translation: BAF83603.1
AC008114 Genomic DNA No translation available.
BC000909 mRNA Translation: AAH00909.2 Different initiation.
BC063561 mRNA Translation: AAH63561.1
CCDSiCCDS31751.1
RefSeqiNP_079105.4, NM_024829.5

3D structure databases

AlphaFoldDBiQ6P4A8
SMRiQ6P4A8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122972, 130 interactors
IntActiQ6P4A8, 15 interactors
MINTiQ6P4A8
STRINGi9606.ENSP00000240617

PTM databases

GlyConnecti1603, 12 N-Linked glycans (3 sites)
GlyGeniQ6P4A8, 6 sites, 11 N-linked glycans (3 sites)
iPTMnetiQ6P4A8
PhosphoSitePlusiQ6P4A8

Genetic variation databases

BioMutaiPLBD1
DMDMi269849630

Proteomic databases

EPDiQ6P4A8
jPOSTiQ6P4A8
MassIVEiQ6P4A8
MaxQBiQ6P4A8
PaxDbiQ6P4A8
PeptideAtlasiQ6P4A8
PRIDEiQ6P4A8
ProteomicsDBi66958

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23639, 63 antibodies from 13 providers

The DNASU plasmid repository

More...DNASUi		79887

Genome annotation databases

EnsembliENST00000240617.10; ENSP00000240617.5; ENSG00000121316.11
GeneIDi79887
KEGGihsa:79887
MANE-SelectiENST00000240617.10; ENSP00000240617.5; NM_024829.6; NP_079105.4
UCSCiuc001rcc.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79887
DisGeNETi79887

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLBD1
HGNCiHGNC:26215, PLBD1
HPAiENSG00000121316, Tissue enhanced (bone)
MIMi618486, gene
neXtProtiNX_Q6P4A8
OpenTargetsiENSG00000121316
PharmGKBiPA164724597
VEuPathDBiHostDB:ENSG00000121316

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3774, Eukaryota
GeneTreeiENSGT00530000063509
HOGENOMiCLU_027106_3_0_1
InParanoidiQ6P4A8
OMAiMYDHFTN
OrthoDBi724258at2759
PhylomeDBiQ6P4A8
TreeFamiTF315042

Enzyme and pathway databases

BRENDAi3.1.1.5, 2681
PathwayCommonsiQ6P4A8
ReactomeiR-HSA-1482788, Acyl chain remodelling of PC
R-HSA-1482839, Acyl chain remodelling of PE
R-HSA-1482922, Acyl chain remodelling of PI
R-HSA-1483115, Hydrolysis of LPC
SignaLinkiQ6P4A8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79887, 8 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLBD1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79887
PharosiQ6P4A8, Tdark

Protein Ontology

More...PROi		PR:Q6P4A8
RNActiQ6P4A8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000121316, Expressed in bone marrow and 218 other tissues
ExpressionAtlasiQ6P4A8, baseline and differential
GenevisibleiQ6P4A8, HS

Family and domain databases

Gene3Di1.10.439.20, 1 hit
2.10.70.60, 1 hit
3.60.60.20, 1 hit
InterProiView protein in InterPro
IPR007000, PLipase_B-like
IPR043040, PLipase_B-like_dom1
IPR043041, PLipase_B-like_dom2
IPR043042, PLipase_B-like_dom3
PANTHERiPTHR12370, PTHR12370, 1 hit
PfamiView protein in Pfam
PF04916, Phospholip_B, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLBL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P4A8
Secondary accession number(s): A8K4E9, Q9BVV3, Q9H625
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 24, 2009
Last modified: May 25, 2022
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again