UniProtKB - Q6P4A8 (PLBL1_HUMAN)
Phospholipase B-like 1
PLBD1
Functioni
In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity).
Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.
By similarity1 PublicationpH dependencei
GO - Molecular functioni
- phospholipase activity Source: GO_Central
GO - Biological processi
- phospholipid catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Enzyme and pathway databases
BRENDAi | 3.1.1.5, 2681 |
PathwayCommonsi | Q6P4A8 |
Reactomei | R-HSA-1482788, Acyl chain remodelling of PC R-HSA-1482839, Acyl chain remodelling of PE R-HSA-1482922, Acyl chain remodelling of PI R-HSA-1483115, Hydrolysis of LPC |
SignaLinki | Q6P4A8 |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipase B-like 1 (EC:3.1.1.-)Alternative name(s): LAMA-like protein 1 Lamina ancestor homolog 1 Phospholipase B domain-containing protein 1 Cleaved into the following 3 chains: |
Gene namesi | Name:PLBD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26215, PLBD1 |
MIMi | 618486, gene |
neXtProti | NX_Q6P4A8 |
VEuPathDBi | HostDB:ENSG00000121316 |
Subcellular locationi
Lysosome
- Lysosome By similarity
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: GO_Central
- extracellular space Source: UniProtKB
Lysosome
- lysosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
LysosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 79887 |
OpenTargetsi | ENSG00000121316 |
PharmGKBi | PA164724597 |
Miscellaneous databases
Pharosi | Q6P4A8, Tdark |
Genetic variation databases
BioMutai | PLBD1 |
DMDMi | 269849630 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 38 | Sequence analysisAdd BLAST | 38 | |
ChainiPRO_0000286106 | 39 – 553 | Phospholipase B-like 1Add BLAST | 515 | |
ChainiPRO_0000425421 | 39 – 208 | Phospholipase B-like 1 chain AAdd BLAST | 170 | |
ChainiPRO_0000425422 | 93 – 208 | Phospholipase B-like 1 chain CAdd BLAST | 116 | |
PropeptideiPRO_0000425423 | 209 – 227 | Removed in mature formBy similarityAdd BLAST | 19 | |
ChainiPRO_0000425424 | 228 – 553 | Phospholipase B-like 1 chain BAdd BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 71 | N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 71 | N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 308 | N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 308 | N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 366 | N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 366 | N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 411 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 470 ↔ 475 | By similarity | ||
Disulfide bondi | 474 ↔ 489 | By similarity | ||
Glycosylationi | 526 | N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity | 1 | |
Glycosylationi | 526 | N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q6P4A8 |
jPOSTi | Q6P4A8 |
MassIVEi | Q6P4A8 |
MaxQBi | Q6P4A8 |
PaxDbi | Q6P4A8 |
PeptideAtlasi | Q6P4A8 |
PRIDEi | Q6P4A8 |
ProteomicsDBi | 66958 |
PTM databases
GlyConnecti | 1603, 12 N-Linked glycans (3 sites) |
GlyGeni | Q6P4A8, 6 sites, 11 N-linked glycans (3 sites) |
iPTMneti | Q6P4A8 |
PhosphoSitePlusi | Q6P4A8 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000121316, Expressed in bone marrow and 218 other tissues |
ExpressionAtlasi | Q6P4A8, baseline and differential |
Genevisiblei | Q6P4A8, HS |
Organism-specific databases
HPAi | ENSG00000121316, Tissue enhanced (bone) |
Interactioni
Subunit structurei
May form a homodimer, each monomer is composed of a chain A and a chain B.
1 PublicationProtein-protein interaction databases
BioGRIDi | 122972, 130 interactors |
IntActi | Q6P4A8, 15 interactors |
MINTi | Q6P4A8 |
STRINGi | 9606.ENSP00000240617 |
Miscellaneous databases
RNActi | Q6P4A8, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3774, Eukaryota |
GeneTreei | ENSGT00530000063509 |
HOGENOMi | CLU_027106_3_0_1 |
InParanoidi | Q6P4A8 |
OMAi | MYDHFTN |
OrthoDBi | 724258at2759 |
PhylomeDBi | Q6P4A8 |
TreeFami | TF315042 |
Family and domain databases
Gene3Di | 1.10.439.20, 1 hit 2.10.70.60, 1 hit 3.60.60.20, 1 hit |
InterProi | View protein in InterPro IPR007000, PLipase_B-like IPR043040, PLipase_B-like_dom1 IPR043041, PLipase_B-like_dom2 IPR043042, PLipase_B-like_dom3 |
PANTHERi | PTHR12370, PTHR12370, 1 hit |
Pfami | View protein in Pfam PF04916, Phospholip_B, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTRGGPGGRP GLPQPPPLLL LLLLLPLLLV TAEPPKPAGV YYATAYWMPA
60 70 80 90 100
EKTVQVKNVM DKNGDAYGFY NNSVKTTGWG ILEIRAGYGS QTLSNEIIMF
110 120 130 140 150
VAGFLEGYLT APHMNDHYTN LYPQLITKPS IMDKVQDFME KQDKWTRKNI
160 170 180 190 200
KEYKTDSFWR HTGYVMAQID GLYVGAKKRA ILEGTKPMTL FQIQFLNSVG
210 220 230 240 250
DLLDLIPSLS PTKNGSLKVF KRWDMGHCSA LIKVLPGFEN ILFAHSSWYT
260 270 280 290 300
YAAMLRIYKH WDFNVIDKDT SSSRLSFSSY PGFLESLDDF YILSSGLILL
310 320 330 340 350
QTTNSVFNKT LLKQVIPETL LSWQRVRVAN MMADSGKRWA DIFSKYNSGT
360 370 380 390 400
YNNQYMVLDL KKVKLNHSLD KGTLYIVEQI PTYVEYSEQT DVLRKGYWPS
410 420 430 440 450
YNVPFHEKIY NWSGYPLLVQ KLGLDYSYDL APRAKIFRRD QGKVTDTASM
460 470 480 490 500
KYIMRYNNYK KDPYSRGDPC NTICCREDLN SPNPSPGGCY DTKVADIYLA
510 520 530 540 550
SQYTSYAISG PTVQGGLPVF RWDRFNKTLH QGMPEVYNFD FITMKPILKL
DIK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H053 | F5H053_HUMAN | Phospholipase B-like | PLBD1 | 144 | Annotation score: | ||
F5GYQ3 | F5GYQ3_HUMAN | Phospholipase B-like 1 | PLBD1 | 40 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | Missing in BAF83603 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 18 | Missing in AAH63561 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 241 | I → V in BAB15442 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 302 | T → A in BAF83603 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032072 | 265 | V → I2 PublicationsCorresponds to variant dbSNP:rs7957558Ensembl. | 1 | |
Natural variantiVAR_032073 | 377 | V → A. Corresponds to variant dbSNP:rs2287541Ensembl. | 1 | |
Natural variantiVAR_032074 | 534 | P → A1 PublicationCorresponds to variant dbSNP:rs1600Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026315 mRNA Translation: BAB15442.1 Different initiation. AK290914 mRNA Translation: BAF83603.1 AC008114 Genomic DNA No translation available. BC000909 mRNA Translation: AAH00909.2 Different initiation. BC063561 mRNA Translation: AAH63561.1 |
CCDSi | CCDS31751.1 |
RefSeqi | NP_079105.4, NM_024829.5 |
Genome annotation databases
Ensembli | ENST00000240617.10; ENSP00000240617.5; ENSG00000121316.11 |
GeneIDi | 79887 |
KEGGi | hsa:79887 |
MANE-Selecti | ENST00000240617.10; ENSP00000240617.5; NM_024829.6; NP_079105.4 |
UCSCi | uc001rcc.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK026315 mRNA Translation: BAB15442.1 Different initiation. AK290914 mRNA Translation: BAF83603.1 AC008114 Genomic DNA No translation available. BC000909 mRNA Translation: AAH00909.2 Different initiation. BC063561 mRNA Translation: AAH63561.1 |
CCDSi | CCDS31751.1 |
RefSeqi | NP_079105.4, NM_024829.5 |
3D structure databases
AlphaFoldDBi | Q6P4A8 |
SMRi | Q6P4A8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122972, 130 interactors |
IntActi | Q6P4A8, 15 interactors |
MINTi | Q6P4A8 |
STRINGi | 9606.ENSP00000240617 |
PTM databases
GlyConnecti | 1603, 12 N-Linked glycans (3 sites) |
GlyGeni | Q6P4A8, 6 sites, 11 N-linked glycans (3 sites) |
iPTMneti | Q6P4A8 |
PhosphoSitePlusi | Q6P4A8 |
Genetic variation databases
BioMutai | PLBD1 |
DMDMi | 269849630 |
Proteomic databases
EPDi | Q6P4A8 |
jPOSTi | Q6P4A8 |
MassIVEi | Q6P4A8 |
MaxQBi | Q6P4A8 |
PaxDbi | Q6P4A8 |
PeptideAtlasi | Q6P4A8 |
PRIDEi | Q6P4A8 |
ProteomicsDBi | 66958 |
Protocols and materials databases
Antibodypediai | 23639, 63 antibodies from 13 providers |
DNASUi | 79887 |
Genome annotation databases
Ensembli | ENST00000240617.10; ENSP00000240617.5; ENSG00000121316.11 |
GeneIDi | 79887 |
KEGGi | hsa:79887 |
MANE-Selecti | ENST00000240617.10; ENSP00000240617.5; NM_024829.6; NP_079105.4 |
UCSCi | uc001rcc.2, human |
Organism-specific databases
CTDi | 79887 |
DisGeNETi | 79887 |
GeneCardsi | PLBD1 |
HGNCi | HGNC:26215, PLBD1 |
HPAi | ENSG00000121316, Tissue enhanced (bone) |
MIMi | 618486, gene |
neXtProti | NX_Q6P4A8 |
OpenTargetsi | ENSG00000121316 |
PharmGKBi | PA164724597 |
VEuPathDBi | HostDB:ENSG00000121316 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3774, Eukaryota |
GeneTreei | ENSGT00530000063509 |
HOGENOMi | CLU_027106_3_0_1 |
InParanoidi | Q6P4A8 |
OMAi | MYDHFTN |
OrthoDBi | 724258at2759 |
PhylomeDBi | Q6P4A8 |
TreeFami | TF315042 |
Enzyme and pathway databases
BRENDAi | 3.1.1.5, 2681 |
PathwayCommonsi | Q6P4A8 |
Reactomei | R-HSA-1482788, Acyl chain remodelling of PC R-HSA-1482839, Acyl chain remodelling of PE R-HSA-1482922, Acyl chain remodelling of PI R-HSA-1483115, Hydrolysis of LPC |
SignaLinki | Q6P4A8 |
Miscellaneous databases
BioGRID-ORCSi | 79887, 8 hits in 1078 CRISPR screens |
ChiTaRSi | PLBD1, human |
GenomeRNAii | 79887 |
Pharosi | Q6P4A8, Tdark |
PROi | PR:Q6P4A8 |
RNActi | Q6P4A8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121316, Expressed in bone marrow and 218 other tissues |
ExpressionAtlasi | Q6P4A8, baseline and differential |
Genevisiblei | Q6P4A8, HS |
Family and domain databases
Gene3Di | 1.10.439.20, 1 hit 2.10.70.60, 1 hit 3.60.60.20, 1 hit |
InterProi | View protein in InterPro IPR007000, PLipase_B-like IPR043040, PLipase_B-like_dom1 IPR043041, PLipase_B-like_dom2 IPR043042, PLipase_B-like_dom3 |
PANTHERi | PTHR12370, PTHR12370, 1 hit |
Pfami | View protein in Pfam PF04916, Phospholip_B, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLBL1_HUMAN | |
Accessioni | Q6P4A8Primary (citable) accession number: Q6P4A8 Secondary accession number(s): A8K4E9, Q9BVV3, Q9H625 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | November 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 127 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families