PLBD1

Functionⁱ

In view of the small size of the putative binding pocket, it has been proposed that it may act as an amidase or a peptidase (By similarity). Exhibits a weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids.By similarity1 Publication

pH dependenceⁱ

Optimum pH is 7.4.1 Publication

GO - Molecular functionⁱ

lysophospholipase activity Source: Reactome
phospholipase A2 activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid catabolic process Source: UniProtKB-KW
phosphatidylcholine acyl-chain remodeling Source: Reactome
phosphatidylethanolamine acyl-chain remodeling Source: Reactome
phosphatidylinositol acyl-chain remodeling Source: Reactome
phospholipid metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAⁱ	3.1.1.5 2681
Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1483115 Hydrolysis of LPC

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Phospholipase B-like 1 (EC:3.1.1.-) Alternative name(s): LAMA-like protein 1 Lamina ancestor homolog 1 Phospholipase B domain-containing protein 1 Cleaved into the following 3 chains: Phospholipase B-like 1 chain A Phospholipase B-like 1 chain B Phospholipase B-like 1 chain C
Gene namesⁱ	Name:PLBD1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121316.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26215 PLBD1
neXtProtⁱ	NX_Q6P4A8

Keywords - Cellular componentⁱ

Lysosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	79887
Open Targets More...OpenTargetsⁱ	ENSG00000121316
PharmGKBⁱ	PA164724597

Polymorphism and mutation databases

BioMutaⁱ	PLBD1
DMDMⁱ	269849630

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 38	Sequence analysisAdd BLAST	38
ChainⁱPRO_0000286106	39 – 553	Phospholipase B-like 1Add BLAST	515
ChainⁱPRO_0000425421	39 – 208	Phospholipase B-like 1 chain AAdd BLAST	170
ChainⁱPRO_0000425422	93 – 208	Phospholipase B-like 1 chain CAdd BLAST	116
PropeptideⁱPRO_0000425423	209 – 227	Removed in mature formBy similarityAdd BLAST	19
ChainⁱPRO_0000425424	228 – 553	Phospholipase B-like 1 chain BAdd BLAST	326

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	71	N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity	1
Glycosylationⁱ	71	N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity	1
Glycosylationⁱ	308	N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity	1
Glycosylationⁱ	308	N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity	1
Glycosylationⁱ	366	N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity	1
Glycosylationⁱ	366	N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity	1
Glycosylationⁱ	411	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	470 ↔ 475	By similarity
Disulfide bondⁱ	474 ↔ 489	By similarity
Glycosylationⁱ	526	N-linked (GlcNAc...) (high mannose) asparagine; alternateBy similarity	1
Glycosylationⁱ	526	N-linked (GlcNAc...) (hybrid) asparagine; alternateBy similarity	1

Post-translational modificationⁱ

The maturation cleavages that produces chains A and B are required to open the putative substrate binding pocket. Both chains A and B remain associated in the mature protein.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q6P4A8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P4A8
PaxDbⁱ	Q6P4A8
PeptideAtlas More...PeptideAtlasⁱ	Q6P4A8
PRIDEⁱ	Q6P4A8
ProteomicsDBⁱ	66958

PTM databases

iPTMnetⁱ	Q6P4A8
PhosphoSitePlusⁱ	Q6P4A8

Expressionⁱ

Tissue specificityⁱ

Expressed in neutrophils and monocytes.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000121316
ExpressionAtlasⁱ	Q6P4A8 baseline and differential
Genevisibleⁱ	Q6P4A8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040303

HPAⁱ

HPA040303

Interactionⁱ

Subunit structureⁱ

May form a homodimer, each monomer is composed of a chain A and a chain B.1 Publication

Protein-protein interaction databases

BioGridⁱ	122972, 16 interactors
IntActⁱ	Q6P4A8, 3 interactors
STRINGⁱ	9606.ENSP00000240617

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P4A8
SMRⁱ	Q6P4A8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the phospholipase B-like family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3774 Eukaryota ENOG410XQRV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063509
HOGENOMⁱ	HOG000006903
HOVERGENⁱ	HBG108264
InParanoidⁱ	Q6P4A8
OMAⁱ	MKYIMRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G9H
PhylomeDBⁱ	Q6P4A8
TreeFamⁱ	TF315042

Family and domain databases

InterProⁱ	View protein in InterPro IPR007000 PLipase_B-like
PANTHERⁱ	PTHR12370 PTHR12370, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04916 Phospholip_B, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6P4A8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTRGGPGGRP GLPQPPPLLL LLLLLPLLLV TAEPPKPAGV YYATAYWMPA 
        60         70         80         90        100
EKTVQVKNVM DKNGDAYGFY NNSVKTTGWG ILEIRAGYGS QTLSNEIIMF 
       110        120        130        140        150
VAGFLEGYLT APHMNDHYTN LYPQLITKPS IMDKVQDFME KQDKWTRKNI 
       160        170        180        190        200
KEYKTDSFWR HTGYVMAQID GLYVGAKKRA ILEGTKPMTL FQIQFLNSVG 
       210        220        230        240        250
DLLDLIPSLS PTKNGSLKVF KRWDMGHCSA LIKVLPGFEN ILFAHSSWYT 
       260        270        280        290        300
YAAMLRIYKH WDFNVIDKDT SSSRLSFSSY PGFLESLDDF YILSSGLILL 
       310        320        330        340        350
QTTNSVFNKT LLKQVIPETL LSWQRVRVAN MMADSGKRWA DIFSKYNSGT 
       360        370        380        390        400
YNNQYMVLDL KKVKLNHSLD KGTLYIVEQI PTYVEYSEQT DVLRKGYWPS 
       410        420        430        440        450
YNVPFHEKIY NWSGYPLLVQ KLGLDYSYDL APRAKIFRRD QGKVTDTASM 
       460        470        480        490        500
KYIMRYNNYK KDPYSRGDPC NTICCREDLN SPNPSPGGCY DTKVADIYLA 
       510        520        530        540        550
SQYTSYAISG PTVQGGLPVF RWDRFNKTLH QGMPEVYNFD FITMKPILKL 

DIK

Length:553

Mass (Da):63,255

Last modified:November 24, 2009 - v2

Checksum:ⁱB4258DD2E1A16FE0

GO

Sequence cautionⁱ

The sequence AAH00909 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAB15442 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	18	Missing in BAF83603 (PubMed:14702039).Curated	1
Sequence conflictⁱ	18	Missing in AAH63561 (PubMed:15489334).Curated	1
Sequence conflictⁱ	241	I → V in BAB15442 (PubMed:15489334).Curated	1
Sequence conflictⁱ	302	T → A in BAF83603 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_032072	265	V → I2 PublicationsCorresponds to variant dbSNP:rs7957558Ensembl.	1
Natural variantⁱVAR_032073	377	V → A. Corresponds to variant dbSNP:rs2287541Ensembl.	1
Natural variantⁱVAR_032074	534	P → A1 PublicationCorresponds to variant dbSNP:rs1600Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK026315 mRNA Translation: BAB15442.1 Different initiation. AK290914 mRNA Translation: BAF83603.1 AC008114 Genomic DNA No translation available. BC000909 mRNA Translation: AAH00909.2 Different initiation. BC063561 mRNA Translation: AAH63561.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31751.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079105.4, NM_024829.5
UniGeneⁱ	Hs.131933

Genome annotation databases

Ensemblⁱ	ENST00000240617; ENSP00000240617; ENSG00000121316
GeneIDⁱ	79887
KEGGⁱ	hsa:79887
UCSC genome browser More...UCSCⁱ	uc001rcc.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6P4A8	Phospholipase B-like (Fragment)		HUMAN		144
Phospholipase B-like		Cebus capucinus imitator		564
Phospholipase B-like		NOMLE		556
Phospholipase B-like		PANTR		554
Phospholipase B-like		PANPA		554
+7

Protein	Similar proteins		Species	Score	Length
Q6P4A8	Phospholipase B-like (Fragment)		HUMAN		144
Phospholipase B-like		Cebus capucinus imitator		564
Phospholipase B-like		NOMLE		556
Phospholipase B-like		PANTR		554
Phospholipase B-like		PANPA		554
+119

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK026315 mRNA Translation: BAB15442.1 Different initiation. AK290914 mRNA Translation: BAF83603.1 AC008114 Genomic DNA No translation available. BC000909 mRNA Translation: AAH00909.2 Different initiation. BC063561 mRNA Translation: AAH63561.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31751.1
NCBI Reference Sequences More...RefSeqⁱ	NP_079105.4, NM_024829.5
UniGeneⁱ	Hs.131933

3D structure databases

ProteinModelPortalⁱ	Q6P4A8
SMRⁱ	Q6P4A8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122972, 16 interactors
IntActⁱ	Q6P4A8, 3 interactors
STRINGⁱ	9606.ENSP00000240617

PTM databases

iPTMnetⁱ	Q6P4A8
PhosphoSitePlusⁱ	Q6P4A8

Polymorphism and mutation databases

BioMutaⁱ	PLBD1
DMDMⁱ	269849630

Proteomic databases

EPDⁱ	Q6P4A8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P4A8
PaxDbⁱ	Q6P4A8
PeptideAtlas More...PeptideAtlasⁱ	Q6P4A8
PRIDEⁱ	Q6P4A8
ProteomicsDBⁱ	66958

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000240617; ENSP00000240617; ENSG00000121316
GeneIDⁱ	79887
KEGGⁱ	hsa:79887
UCSC genome browser More...UCSCⁱ	uc001rcc.2 human

Organism-specific databases

CTDⁱ	79887
DisGeNET More...DisGeNETⁱ	79887
EuPathDBⁱ	HostDB:ENSG00000121316.10
GeneCardsⁱ	PLBD1
H-InvDBⁱ	HIX0010454
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26215 PLBD1
Human Protein Atlas More...HPAⁱ	HPA040303
neXtProtⁱ	NX_Q6P4A8
Open Targets More...OpenTargetsⁱ	ENSG00000121316
PharmGKBⁱ	PA164724597
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3774 Eukaryota ENOG410XQRV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063509
HOGENOMⁱ	HOG000006903
HOVERGENⁱ	HBG108264
InParanoidⁱ	Q6P4A8
OMAⁱ	MKYIMRY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0G9H
PhylomeDBⁱ	Q6P4A8
TreeFamⁱ	TF315042

Enzyme and pathway databases

BRENDAⁱ	3.1.1.5 2681
Reactomeⁱ	R-HSA-1482788 Acyl chain remodelling of PC R-HSA-1482839 Acyl chain remodelling of PE R-HSA-1482922 Acyl chain remodelling of PI R-HSA-1483115 Hydrolysis of LPC

Miscellaneous databases

ChiTaRSⁱ	PLBD1 human
GenomeRNAiⁱ	79887
Protein Ontology More...PROⁱ	PR:Q6P4A8

Gene expression databases

Bgeeⁱ	ENSG00000121316
ExpressionAtlasⁱ	Q6P4A8 baseline and differential
Genevisibleⁱ	Q6P4A8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007000 PLipase_B-like
PANTHERⁱ	PTHR12370 PTHR12370, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04916 Phospholip_B, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLBL1_HUMAN
Accessionⁱ	Q6P4A8Primary (citable) accession number: Q6P4A8 Secondary accession number(s): A8K4E9, Q9BVV3, Q9H625
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
	Last sequence update:	November 24, 2009
	Last modified:	June 20, 2018
	This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q6P4A8 (PLBL1_HUMAN)

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Phospholipase B-like 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>pH dependencei

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Lysosome

Cytosol

Extracellular region or secreted

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

pH dependenceⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ