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UniProtKB - Q6P4A7 (SFXN4_HUMAN)

Entry version 154 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Sideroflexin-4

Gene

SFXN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial amino-acid transporter (By similarity).

Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (PubMed:30442778).

By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P4A7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6P4A7

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.54.1.3, the sideroflexin (sfxn) family (formerly the mitochondrial tricarboxylate carrier (mtc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sideroflexin-41 Publication
Alternative name(s):
Breast cancer resistance marker 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFXN41 PublicationImported
Synonyms:BCRM11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16088, SFXN4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615564, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P4A7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000183605

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Transmembranei133 – 153HelicalSequence analysisAdd BLAST21
Transmembranei165 – 185HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 18 (COXPD18)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder of mitochondrial dysfunction characterized by intrauterine growth retardation, hypotonia, visual impairment, speech delay, and lactic acidosis associated with decreased mitochondrial respiratory chain activity. Affected patients may also show hematologic abnormalities, mainly macrocytic anemia.
Related information in OMIM

Keywords - Diseasei

Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...DisGeNETi		119559

MalaCards human disease database

More...MalaCardsi		SFXN4
MIMi615578, phenotype

Open Targets

More...OpenTargetsi		ENSG00000183605

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		391348, Growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38093

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P4A7, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFXN4

Domain mapping of disease mutations (DMDM)

More...DMDMi		71153761

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001770412 – 337Sideroflexin-4Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei197N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P4A7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P4A7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P4A7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P4A7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P4A7

PeptideAtlas

More...PeptideAtlasi		Q6P4A7

PRoteomics IDEntifications database

More...PRIDEi		Q6P4A7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66955 [Q6P4A7-1]
66956 [Q6P4A7-2]
66957 [Q6P4A7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P4A7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P4A7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000183605, Expressed in muscle tissue and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P4A7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P4A7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000183605, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125645, 95 interactors

Protein interaction database and analysis system

More...IntActi		Q6P4A7, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P4A7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q6P4A7

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sideroflexin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3767, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234641

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_039425_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P4A7

Identification of Orthologs from Complete Genome Data

More...OMAi		SYTTCAG

Database of Orthologous Groups

More...OrthoDBi		881974at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P4A7

TreeFam database of animal gene trees

More...TreeFami		TF313205

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004686, Mtc
IPR028825, SFXN4

The PANTHER Classification System

More...PANTHERi		PTHR11153, PTHR11153, 1 hit
PTHR11153:SF3, PTHR11153:SF3, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03820, SFXNs, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P4A7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSLEQEEETQ PGRLLGRRDA VPAFIEPNVR FWITERQSFI RRFLQWTELL 
        60         70         80         90        100
DPTNVFISVE SIENSRQLLC TNEDVSSPAS ADQRIQEAWK RSLATVHPDS 
       110        120        130        140        150
SNLIPKLFRP AAFLPFMAPT VFLSMTPLKG IKSVILPQVF LCAYMAAFNS 
       160        170        180        190        200
INGNRSYTCK PLERSLLMAG AVASSTFLGV IPQFVQMKYG LTGPWIKRLL 
       210        220        230        240        250
PVIFLVQASG MNVYMSRSLE SIKGIAVMDK EGNVLGHSRI AGTKAVRETL 
       260        270        280        290        300
ASRIVLFGTS ALIPEVFTYF FKRTQYFRKN PGSLWILKLS CTVLAMGLMV 
       310        320        330 
PFSFSIFPQI GQIQYCSLEE KIQSPTEETE IFYHRGV
Length:337
Mass (Da):37,998
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77A08F150D241277
GO
Isoform 2 (identifier: Q6P4A7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-93: Missing.
     313-337: IQYCSLEEKIQSPTEETEIFYHRGV → VT

Show »
Length:305
Mass (Da):34,104
Checksum:iA0E3CFE491DDB508
GO
Isoform 3 (identifier: Q6P4A7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.

Show »
Length:221
Mass (Da):24,587
Checksum:iA6E9596C3E438E0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMV7B1AMV7_HUMAN
Sideroflexin-4
SFXN4
178Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1AMV8B1AMV8_HUMAN
Sideroflexin-4
SFXN4
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0146081 – 116Missing in isoform 3. 1 PublicationAdd BLAST116
Alternative sequenceiVSP_01460985 – 93Missing in isoform 2. 1 Publication9
Alternative sequenceiVSP_014610313 – 337IQYCS…YHRGV → VT in isoform 2. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF336980 mRNA Translation: AAP23066.1
AY269785 mRNA Translation: AAP97074.1
AL355598 Genomic DNA No translation available.
AL355861 Genomic DNA No translation available.
BC063562 mRNA Translation: AAH63562.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7610.1 [Q6P4A7-1]

NCBI Reference Sequences

More...RefSeqi		NP_998814.1, NM_213649.1 [Q6P4A7-1]
XP_005269583.1, XM_005269526.2 [Q6P4A7-3]
XP_005269584.1, XM_005269527.1 [Q6P4A7-3]
XP_011537584.1, XM_011539282.2 [Q6P4A7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000355697.7; ENSP00000347924.2; ENSG00000183605.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		119559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:119559

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000355697.7; ENSP00000347924.2; NM_213649.2; NP_998814.1

UCSC genome browser

More...UCSCi		uc001leb.4, human [Q6P4A7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF336980 mRNA Translation: AAP23066.1
AY269785 mRNA Translation: AAP97074.1
AL355598 Genomic DNA No translation available.
AL355861 Genomic DNA No translation available.
BC063562 mRNA Translation: AAH63562.1
CCDSiCCDS7610.1 [Q6P4A7-1]
RefSeqiNP_998814.1, NM_213649.1 [Q6P4A7-1]
XP_005269583.1, XM_005269526.2 [Q6P4A7-3]
XP_005269584.1, XM_005269527.1 [Q6P4A7-3]
XP_011537584.1, XM_011539282.2 [Q6P4A7-3]

3D structure databases

AlphaFoldDBiQ6P4A7
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

BioGRIDi125645, 95 interactors
IntActiQ6P4A7, 22 interactors
STRINGi9606.ENSP00000347924

Protein family/group databases

TCDBi2.A.54.1.3, the sideroflexin (sfxn) family (formerly the mitochondrial tricarboxylate carrier (mtc) family

PTM databases

iPTMnetiQ6P4A7
PhosphoSitePlusiQ6P4A7

Genetic variation databases

BioMutaiSFXN4
DMDMi71153761

Proteomic databases

EPDiQ6P4A7
jPOSTiQ6P4A7
MassIVEiQ6P4A7
MaxQBiQ6P4A7
PaxDbiQ6P4A7
PeptideAtlasiQ6P4A7
PRIDEiQ6P4A7
ProteomicsDBi66955 [Q6P4A7-1]
66956 [Q6P4A7-2]
66957 [Q6P4A7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18795, 125 antibodies from 20 providers

The DNASU plasmid repository

More...DNASUi		119559

Genome annotation databases

EnsembliENST00000355697.7; ENSP00000347924.2; ENSG00000183605.17
GeneIDi119559
KEGGihsa:119559
MANE-SelectiENST00000355697.7; ENSP00000347924.2; NM_213649.2; NP_998814.1
UCSCiuc001leb.4, human [Q6P4A7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		119559
DisGeNETi119559

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFXN4
HGNCiHGNC:16088, SFXN4
HPAiENSG00000183605, Low tissue specificity
MalaCardsiSFXN4
MIMi615564, gene
615578, phenotype
neXtProtiNX_Q6P4A7
OpenTargetsiENSG00000183605
Orphaneti391348, Growth and developmental delay-hypotonia-vision impairment-lactic acidosis syndrome
PharmGKBiPA38093
VEuPathDBiHostDB:ENSG00000183605

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3767, Eukaryota
GeneTreeiENSGT01030000234641
HOGENOMiCLU_039425_3_0_1
InParanoidiQ6P4A7
OMAiSYTTCAG
OrthoDBi881974at2759
PhylomeDBiQ6P4A7
TreeFamiTF313205

Enzyme and pathway databases

PathwayCommonsiQ6P4A7
SignaLinkiQ6P4A7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		119559, 18 hits in 1079 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SFXN4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		119559
PharosiQ6P4A7, Tbio

Protein Ontology

More...PROi		PR:Q6P4A7
RNActiQ6P4A7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000183605, Expressed in muscle tissue and 212 other tissues
ExpressionAtlasiQ6P4A7, baseline and differential
GenevisibleiQ6P4A7, HS

Family and domain databases

InterProiView protein in InterPro
IPR004686, Mtc
IPR028825, SFXN4
PANTHERiPTHR11153, PTHR11153, 1 hit
PTHR11153:SF3, PTHR11153:SF3, 1 hit
PfamiView protein in Pfam
PF03820, SFXNs, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFXN4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P4A7
Secondary accession number(s): Q6WSU4, Q86TD9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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