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Entry version 116 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

NIPA-like protein 3

Gene

NIPAL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • magnesium ion transport Source: GO_Central

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5223345 Miscellaneous transport and binding events

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.7.25.3 the drug/metabolite transporter (dmt) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NIPA-like protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NIPAL3
Synonyms:NPAL3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000001461.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25233 NIPAL3

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P499

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57185

Open Targets

More...
OpenTargetsi
ENSG00000001461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164723927

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NIPAL3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002421501 – 406NIPA-like protein 3Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi166N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei372PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P499

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P499

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P499

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P499

PeptideAtlas

More...
PeptideAtlasi
Q6P499

PRoteomics IDEntifications database

More...
PRIDEi
Q6P499

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66952
66953 [Q6P499-2]
66954 [Q6P499-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P499

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P499

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000001461 Expressed in 226 organ(s), highest expression level in brain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P499 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P499 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039978

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EDAQ928385EBI-10252783,EBI-529425

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121434, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P499, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000363520

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6P499

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 21Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NIPA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2922 Eukaryota
ENOG410XNR8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158233

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230865

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG069791

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P499

KEGG Orthology (KO)

More...
KOi
K22733

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDALHIC

Database of Orthologous Groups

More...
OrthoDBi
754939at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P499

TreeFam database of animal gene trees

More...
TreeFami
TF313214

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008521 Mg_trans_NIPA

The PANTHER Classification System

More...
PANTHERi
PTHR12570 PTHR12570, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05653 Mg_trans_NIPA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P499-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGSHSAALK LQQLPPTSSS SAVSEASFSY KENLIGALLA IFGHLVVSIA
60 70 80 90 100
LNLQKYCHIR LAGSKDPRAY FKTKTWWLGL FLMLLGELGV FASYAFAPLS
110 120 130 140 150
LIVPLSAVSV IASAIIGIIF IKEKWKPKDF LRRYVLSFVG CGLAVVGTYL
160 170 180 190 200
LVTFAPNSHE KMTGENVTRH LVSWPFLLYM LVEIILFCLL LYFYKEKNAN
210 220 230 240 250
NIVVILLLVA LLGSMTVVTV KAVAGMLVLS IQGNLQLDYP IFYVMFVCMV
260 270 280 290 300
ATAVYQAAFL SQASQMYDSS LIASVGYILS TTIAITAGAI FYLDFIGEDV
310 320 330 340 350
LHICMFALGC LIAFLGVFLI TRNRKKPIPF EPYISMDAMP GMQNMHDKGM
360 370 380 390 400
TVQPELKASF SYGALENNDN ISEIYAPATL PVMQEEHGSR SASGVPYRVL

EHTKKE
Length:406
Mass (Da):44,742
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42E87B84B01E7C88
GO
Isoform 2 (identifier: Q6P499-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.

Note: No experimental confirmation available.
Show »
Length:324
Mass (Da):35,764
Checksum:iD6F51AF9CA50C347
GO
Isoform 3 (identifier: Q6P499-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     213-226: GSMTVVTVKAVAGM → VLLCHPGWSAVVQS
     227-406: Missing.

Note: No experimental confirmation available.
Show »
Length:226
Mass (Da):24,994
Checksum:iDE2A2780573E9AE0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NN97A6NN97_HUMAN
NIPA-like protein 3
NIPAL3
368Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4I9H0Y4I9_HUMAN
NIPA-like protein 3
NIPAL3
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0194451 – 82Missing in isoform 2. 1 PublicationAdd BLAST82
Alternative sequenceiVSP_019446213 – 226GSMTV…AVAGM → VLLCHPGWSAVVQS in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_019447227 – 406Missing in isoform 3. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK312433 mRNA Translation: BAG35342.1
BX640883 mRNA Translation: CAE45938.1
AL031431 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95130.1
BC001265 mRNA Translation: AAH01265.1
BC063583 mRNA Translation: AAH63583.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30631.1 [Q6P499-1]
CCDS81280.1 [Q6P499-3]
CCDS81282.1 [Q6P499-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001309783.1, NM_001322854.1 [Q6P499-1]
NP_001309784.1, NM_001322855.1 [Q6P499-1]
NP_001309785.1, NM_001322856.1 [Q6P499-1]
NP_001309786.1, NM_001322857.1 [Q6P499-1]
NP_001309791.1, NM_001322862.1 [Q6P499-2]
NP_001309792.1, NM_001322863.1 [Q6P499-2]
NP_001309794.1, NM_001322865.1 [Q6P499-3]
NP_065181.1, NM_020448.4 [Q6P499-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.523442

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000003912; ENSP00000003912; ENSG00000001461 [Q6P499-2]
ENST00000358028; ENSP00000350722; ENSG00000001461 [Q6P499-3]
ENST00000374399; ENSP00000363520; ENSG00000001461 [Q6P499-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57185

UCSC genome browser

More...
UCSCi
uc001bjh.4 human [Q6P499-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312433 mRNA Translation: BAG35342.1
BX640883 mRNA Translation: CAE45938.1
AL031431 Genomic DNA No translation available.
CH471134 Genomic DNA Translation: EAW95130.1
BC001265 mRNA Translation: AAH01265.1
BC063583 mRNA Translation: AAH63583.1
CCDSiCCDS30631.1 [Q6P499-1]
CCDS81280.1 [Q6P499-3]
CCDS81282.1 [Q6P499-2]
RefSeqiNP_001309783.1, NM_001322854.1 [Q6P499-1]
NP_001309784.1, NM_001322855.1 [Q6P499-1]
NP_001309785.1, NM_001322856.1 [Q6P499-1]
NP_001309786.1, NM_001322857.1 [Q6P499-1]
NP_001309791.1, NM_001322862.1 [Q6P499-2]
NP_001309792.1, NM_001322863.1 [Q6P499-2]
NP_001309794.1, NM_001322865.1 [Q6P499-3]
NP_065181.1, NM_020448.4 [Q6P499-1]
UniGeneiHs.523442

3D structure databases

ProteinModelPortaliQ6P499
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121434, 4 interactors
IntActiQ6P499, 10 interactors
STRINGi9606.ENSP00000363520

Protein family/group databases

TCDBi2.A.7.25.3 the drug/metabolite transporter (dmt) superfamily

PTM databases

iPTMnetiQ6P499
PhosphoSitePlusiQ6P499

Polymorphism and mutation databases

BioMutaiNIPAL3
DMDMi74737314

Proteomic databases

EPDiQ6P499
jPOSTiQ6P499
MaxQBiQ6P499
PaxDbiQ6P499
PeptideAtlasiQ6P499
PRIDEiQ6P499
ProteomicsDBi66952
66953 [Q6P499-2]
66954 [Q6P499-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000003912; ENSP00000003912; ENSG00000001461 [Q6P499-2]
ENST00000358028; ENSP00000350722; ENSG00000001461 [Q6P499-3]
ENST00000374399; ENSP00000363520; ENSG00000001461 [Q6P499-1]
GeneIDi57185
KEGGihsa:57185
UCSCiuc001bjh.4 human [Q6P499-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57185
DisGeNETi57185
EuPathDBiHostDB:ENSG00000001461.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NIPAL3

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0000263
HGNCiHGNC:25233 NIPAL3
HPAiHPA039978
neXtProtiNX_Q6P499
OpenTargetsiENSG00000001461
PharmGKBiPA164723927

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2922 Eukaryota
ENOG410XNR8 LUCA
GeneTreeiENSGT00940000158233
HOGENOMiHOG000230865
HOVERGENiHBG069791
InParanoidiQ6P499
KOiK22733
OMAiEDALHIC
OrthoDBi754939at2759
PhylomeDBiQ6P499
TreeFamiTF313214

Enzyme and pathway databases

ReactomeiR-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NIPAL3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57185

Protein Ontology

More...
PROi
PR:Q6P499

Gene expression databases

BgeeiENSG00000001461 Expressed in 226 organ(s), highest expression level in brain
ExpressionAtlasiQ6P499 baseline and differential
GenevisibleiQ6P499 HS

Family and domain databases

InterProiView protein in InterPro
IPR008521 Mg_trans_NIPA
PANTHERiPTHR12570 PTHR12570, 1 hit
PfamiView protein in Pfam
PF05653 Mg_trans_NIPA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNPAL3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P499
Secondary accession number(s): A2A298, Q6MZT9, Q9BVE6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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