Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative pyridoxal-dependent decarboxylase domain-containing protein 2

Gene

PDXDC2P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

Caution

Could be the product of a pseudogene.Curated

Cofactori

GO - Molecular functioni

  • carboxy-lyase activity Source: UniProtKB-KW
  • pyridoxal phosphate binding Source: GO_Central
  • sphinganine-1-phosphate aldolase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxal-dependent decarboxylase domain-containing protein 2 (EC:4.1.1.-)
Alternative name(s):
pyridoxal-dependent decarboxylase domain-containing 2 pseudogene
Gene namesi
Name:PDXDC2P
Synonyms:PDXDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27559 PDXDC2P
neXtProtiNX_Q6P474

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi218512123

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003112161 – 469Putative pyridoxal-dependent decarboxylase domain-containing protein 2Add BLAST469

Proteomic databases

EPDiQ6P474
MaxQBiQ6P474
PeptideAtlasiQ6P474
PRIDEiQ6P474
ProteomicsDBi66949

PTM databases

iPTMnetiQ6P474
PhosphoSitePlusiQ6P474

Expressioni

Gene expression databases

CleanExiHS_PDXDC2

Organism-specific databases

HPAiHPA047369
HPA049121

Structurei

3D structure databases

ProteinModelPortaliQ6P474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 40Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0630 Eukaryota
ENOG410XYFU LUCA
HOGENOMiHOG000115485
HOVERGENiHBG062459
InParanoidiQ6P474
PhylomeDBiQ6P474

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P474-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QRRTEEENGK KLISRDIPGP
60 70 80 90 100
LQGSGQDMVS ILQLVQNLMH GDEDEEPQSP RIQNIGEQGH VAVLGHSLGA
110 120 130 140 150
YILTLDEEKL RKLTTRILSD TTLWLCRIFR YENGCAYFHE EEREGLAKIC
160 170 180 190 200
RLAIHSQYED FVVDGFSGLY NKKPVIYLSA AARPGLGQYL CNQLGLPFPC
210 220 230 240 250
LCRVPCNTMF GSQHQMDVAF LEKLIKDDIE RGRLPLLLVA NAGTAAVGHT
260 270 280 290 300
DKIGRLKELC EQYGIWLHVE GVNLATLALG YVSSSVLAAA KCDSMTMTPG
310 320 330 340 350
PWLGLPAVPA VTLYKHDPAL TLVAGLISNK PTDKLRALPL WLSLQYLGLD
360 370 380 390 400
GFVERIKHAC QLSQWLQESL KKVNYIKILV EDELSSPVVV FRFFQELPGS
410 420 430 440 450
DPVFKAVPVP NMTPSAVGRE RHSCDALNLW LGEQLKQLVP ASGLTVMDLE
460
AEGTCLRFSP LMTAAGMIS
Length:469
Mass (Da):51,810
Last modified:December 16, 2008 - v3
Checksum:i07734D8C8DA0A772
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037159209M → V. Corresponds to variant dbSNP:rs3169319Ensembl.1
Natural variantiVAR_037160429L → F. Corresponds to variant dbSNP:rs11648231Ensembl.1
Natural variantiVAR_037161429L → R. Corresponds to variant dbSNP:rs929843Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292860 mRNA Translation: BAF85549.1
AC009022 Genomic DNA No translation available.
AC026468 Genomic DNA No translation available.
UniGeneiHs.513695

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292860 mRNA Translation: BAF85549.1
AC009022 Genomic DNA No translation available.
AC026468 Genomic DNA No translation available.
UniGeneiHs.513695

3D structure databases

ProteinModelPortaliQ6P474
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ6P474
PhosphoSitePlusiQ6P474

Polymorphism and mutation databases

DMDMi218512123

Proteomic databases

EPDiQ6P474
MaxQBiQ6P474
PeptideAtlasiQ6P474
PRIDEiQ6P474
ProteomicsDBi66949

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPDXDC2P
HGNCiHGNC:27559 PDXDC2P
HPAiHPA047369
HPA049121
neXtProtiNX_Q6P474
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0630 Eukaryota
ENOG410XYFU LUCA
HOGENOMiHOG000115485
HOVERGENiHBG062459
InParanoidiQ6P474
PhylomeDBiQ6P474

Miscellaneous databases

ChiTaRSiPDXDC2P human

Gene expression databases

CleanExiHS_PDXDC2

Family and domain databases

Gene3Di3.40.640.10, 1 hit
InterProiView protein in InterPro
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPDXD2_HUMAN
AccessioniPrimary (citable) accession number: Q6P474
Secondary accession number(s): A8K9Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 99 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again