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Entry version 119 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

DEAH (Asp-Glu-Ala-His) box polypeptide 38

Gene

dhx38

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
DEAH (Asp-Glu-Ala-His) box polypeptide 38Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dhx38Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040426-1144 dhx38

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini573 – 736Helicase ATP-bindingInterPro annotationAdd BLAST164
Domaini758 – 933Helicase C-terminalInterPro annotationAdd BLAST176

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni28 – 47DisorderedSequence analysisAdd BLAST20
Regioni56 – 348DisorderedSequence analysisAdd BLAST293

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili385 – 405Sequence analysisAdd BLAST21
Coiled coili1186 – 1220Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 87PolyampholyteSequence analysisAdd BLAST32
Compositional biasi94 – 111PolyampholyteSequence analysisAdd BLAST18
Compositional biasi123 – 248PolyampholyteSequence analysisAdd BLAST126
Compositional biasi256 – 287PolyampholyteSequence analysisAdd BLAST32
Compositional biasi304 – 332PolyampholyteSequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0924 Eukaryota
COG1643 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000175261

KEGG Orthology (KO)

More...
KOi
K12815

Database of Orthologous Groups

More...
OrthoDBi
354219at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P404

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P404-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDDSSLHRL EGSDPSVQVG GLIVKKKSAA TEQHVFRAPA PRTSLLGLDL
60 70 80 90 100
LAAQKRKERE GKERLDDQPK KSKVSSYKDW EEGKSDSGSD DENQEDGESR
110 120 130 140 150
NGKKERKYRV TGSETPSNPG GVSEEFKRKH QQREKDRREH GVYASSKEDK
160 170 180 190 200
SKDKNRSRDR EHDRHRDRER RKDRDERESS RSRGSSSSRS ERSEGSVRSE
210 220 230 240 250
RSQREGCSER MSRGTRREEP ESPRNKPKDL ATPSRCSWDE DDSGYASSRH
260 270 280 290 300
SHWESPSPAP SHRENDRSER SQRSVRDSER RDRSSKPQYP TDTPLPTPSY
310 320 330 340 350
KYNEWANDRK HFGSTPRLSR GKGEKREEGE GGIQFDDEDE KEQWEEDQRQ
360 370 380 390 400
ADRDWYMMDE GYDEFHNPLT SSSDEYVKKR EQILQKQTQK RISAQKRQIN
410 420 430 440 450
EDNERWETNR MLTSGVVQRL EVDEDFEEDN AARVHLLVHN LVPPFLDGRI
460 470 480 490 500
VFTKQPEPVI PVKDATSDMA IISRKGSQLV RRHREQKERK KAQHKHWELA
510 520 530 540 550
GTKLGDIMGI QKKEDGGDSK AVGEDGKVDY RAEQKFADHM KEKSEASSDF
560 570 580 590 600
AKKKTLLEQR QYLPIFAVRQ QLLNIIRDNN IVIVVGETGS GKTTQLTQYL
610 620 630 640 650
HEDGYTSYGM VGCTQPRRVA AMSVAKRVSE EMNSNLGEEV GYAIRFEDCT
660 670 680 690 700
SEKTMIKYMT DGILLRESLR ESDLDHYSAV IMDEAHERSL NTDVLFGLLR
710 720 730 740 750
EVVSRRSDLK LIVTSATMDS DKFASFFGNV PIFHIPGRTF PVDILFSKTP
760 770 780 790 800
QEDYVEAAVK QALQIHLSGM VGDILIFMPG QEDIEVTSDQ IVERLADLEN
810 820 830 840 850
APALAVLPIY SQLPSDLQAK IFQKAPDGVR KCIVATNIAE TSLTVDGIMF
860 870 880 890 900
VVDSGYCKLK VFNPRIGMDA LQVYPISQAN ANQRAGRAGR TGPGQCYRLY
910 920 930 940 950
TQSAFKNEML TTTIPEIQRT NLANVVLLLK SLGVQDLLLF HFMDPPPEDN
960 970 980 990 1000
MLNSMYQLWI LGALDNTGAL TPTGRLMVEF PLDPALSKML IVSCDMSCSA
1010 1020 1030 1040 1050
DILIIVSMLS VPSIFYRPKG REEESDQVRE KFSVPESDHL TYLNVYLQWK
1060 1070 1080 1090 1100
NNNYSSIWCN DHFIHTKAMR KVREVRAQLK DIMVQQKMNL ISCGSDWDVI
1110 1120 1130 1140 1150
RKCICAAYFH QAAKLKGIGE YVNVRTGMPC HLHPTSALFG MGYTPDYIIY
1160 1170 1180 1190 1200
HELVMTTKEY MQCVTAVDGE WLAELGPMFY SIKHAGKSRQ ENRRRAKEEI
1210 1220 1230 1240 1250
TNMEEEMSLA QEQIRARKEE QDRKNNLGSV RAVKICTPGR KEEMTPMTPK

RTPARFGL
Length:1,258
Mass (Da):143,730
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36A42A6158531D7C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC063744 mRNA Translation: AAH63744.1

NCBI Reference Sequences

More...
RefSeqi
NP_957170.1, NM_200876.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
393850

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:393850

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063744 mRNA Translation: AAH63744.1
RefSeqiNP_957170.1, NM_200876.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi393850
KEGGidre:393850

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9785
ZFINiZDB-GENE-040426-1144 dhx38

Phylogenomic databases

eggNOGiKOG0924 Eukaryota
COG1643 LUCA
HOGENOMiHOG000175261
KOiK12815
OrthoDBi354219at2759
PhylomeDBiQ6P404

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6P404_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P404
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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