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Protein

Zinc finger protein 280C

Gene

Znf280c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcription factor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1Add BLAST23
Zinc fingeri360 – 383C2H2-type 2Add BLAST24
Zinc fingeri390 – 413C2H2-type 3Add BLAST24
Zinc fingeri420 – 443C2H2-type 4Add BLAST24
Zinc fingeri477 – 499C2H2-type 5Add BLAST23

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA-binding transcription factor activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 280C
Alternative name(s):
Suppressor of hairy wing homolog 3
Gene namesi
Name:Znf280c
Synonyms:Kiaa1584, Suhw3, Zfp280c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2387585 Zfp280c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279761 – 742Zinc finger protein 280CAdd BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki23Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki42Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki85Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki135Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki186Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki193Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki580Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6P3Y5
PeptideAtlasiQ6P3Y5
PRIDEiQ6P3Y5

PTM databases

iPTMnetiQ6P3Y5
PhosphoSitePlusiQ6P3Y5

Expressioni

Gene expression databases

BgeeiENSMUSG00000036916 Expressed in 262 organ(s), highest expression level in humerus cartilage element
CleanExiMM_ZFP280C
GenevisibleiQ6P3Y5 MM

Interactioni

Protein-protein interaction databases

IntActiQ6P3Y5, 1 interactor
MINTiQ6P3Y5
STRINGi10090.ENSMUSP00000075933

Structurei

3D structure databases

ProteinModelPortaliQ6P3Y5
SMRiQ6P3Y5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 37Poly-Glu8
Compositional biasi62 – 244Ser-richAdd BLAST183

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1Add BLAST23
Zinc fingeri360 – 383C2H2-type 2Add BLAST24
Zinc fingeri390 – 413C2H2-type 3Add BLAST24
Zinc fingeri420 – 443C2H2-type 4Add BLAST24
Zinc fingeri477 – 499C2H2-type 5Add BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063300
HOGENOMiHOG000013047
HOVERGENiHBG060885
InParanoidiQ6P3Y5
OMAiHMKHCCP
OrthoDBiEOG091G01UE
PhylomeDBiQ6P3Y5
TreeFamiTF331707

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P3Y5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDKDNSVQEK GLFLSSWKLD NSKMAELFME CEEEELEPWQ QKVEESQSKD
60 70 80 90 100
DDDELIFVGE ISSSKPAISN ILNRCSPGSS SKGLKNGSFN PAISNIFKPT
110 120 130 140 150
SQHYRNPSSN ALVALPSFHP ALKSSESSDG QTVSKLDFTK TSPQEDSGAC
160 170 180 190 200
SVSQSDSTQD IPSSNILQPR TGVDQTLGLK HPSTSKVNSV NPKKPKTSAS
210 220 230 240 250
ISETRPCSSS SSQTAPSGAS SQTVLSNVNT SSVQSAPGSS SLRSCPKCNV
260 270 280 290 300
KFRLLDPLKC HMKRCCPDMI NKFLETLKSE NSKAVSKATT DSDKEKLIML
310 320 330 340 350
VSDFYYGRHE GTIEESQKTH TTFKCFSCTK VLKNNIRFMN HMKHHLELEK
360 370 380 390 400
QNNETWESHT TCQHCYRQYP NPFQLQCHIE STHTPHDFST ICKICELSFE
410 420 430 440 450
TEHMLLQHMK DTHKPGEMPY ICQVCQFRSS IFSDVETHFR SSHENTKNLL
460 470 480 490 500
CPFCLKVSRM ATPYMNHYMR HQKKGIYRCP KCRLQFLTSK EKTEHKLEHR
510 520 530 540 550
TFIKPKELEG LPPGTKVIIR ASLGSSQSRA SSPPSSTIPS TSLQLSVPKS
560 570 580 590 600
KSTTTKNNSK VSANKATTTS PQTVATTTGK PSASKPGTGT TKSKAKPSYK
610 620 630 640 650
QKRQRTRKNK FSIDLKNLRC HQGSHMCIEC RSKIKDFSSH FSTHINCDFC
660 670 680 690 700
KYTTNCNKAF TNHMSSHNDH PSKQLYIFKK QSRARRGITL VCLKCDFLAD
710 720 730 740
TSGLDRMAKH LNQRKTHTCQ VVIENVTERA VTSESASDGL FK
Length:742
Mass (Da):83,146
Last modified:July 5, 2004 - v1
Checksum:i04A82F753CAD6C10
GO
Isoform 2 (identifier: Q6P3Y5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     686-693: RGITLVCL → SYRKSRNF
     694-742: Missing.

Note: No experimental confirmation available.
Show »
Length:693
Mass (Da):77,895
Checksum:i0253B2C5564DB87F
GO
Isoform 3 (identifier: Q6P3Y5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-19: Missing.

Note: No experimental confirmation available.
Show »
Length:733
Mass (Da):82,114
Checksum:i865EA149FF38A4B6
GO

Sequence cautioni

The sequence BAC98209 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01761911 – 19Missing in isoform 3. 1 Publication9
Alternative sequenceiVSP_017620686 – 693RGITLVCL → SYRKSRNF in isoform 2. 1 Publication8
Alternative sequenceiVSP_017621694 – 742Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129399 mRNA Translation: BAC98209.1 Different initiation.
AK141491 mRNA Translation: BAE24700.1
AL669901 Genomic DNA No translation available.
BC028839 mRNA Translation: AAH28839.1
BC051397 mRNA Translation: AAH51397.1
BC063775 mRNA Translation: AAH63775.1
CCDSiCCDS30111.1 [Q6P3Y5-1]
CCDS53064.1 [Q6P3Y5-3]
CCDS53065.1 [Q6P3Y5-2]
RefSeqiNP_001160120.1, NM_001166648.1 [Q6P3Y5-1]
NP_001160121.1, NM_001166649.1 [Q6P3Y5-3]
NP_001160122.1, NM_001166650.1 [Q6P3Y5-2]
NP_705760.2, NM_153532.3 [Q6P3Y5-1]
XP_006541521.1, XM_006541458.3 [Q6P3Y5-1]
XP_006541522.1, XM_006541459.3 [Q6P3Y5-1]
XP_006541524.1, XM_006541461.3 [Q6P3Y5-1]
XP_006541528.1, XM_006541465.3 [Q6P3Y5-2]
UniGeneiMm.293819

Genome annotation databases

EnsembliENSMUST00000072292; ENSMUSP00000072138; ENSMUSG00000036916 [Q6P3Y5-3]
ENSMUST00000076635; ENSMUSP00000075933; ENSMUSG00000036916 [Q6P3Y5-1]
ENSMUST00000088898; ENSMUSP00000086288; ENSMUSG00000036916 [Q6P3Y5-1]
ENSMUST00000114940; ENSMUSP00000110590; ENSMUSG00000036916 [Q6P3Y5-2]
GeneIDi208968
KEGGimmu:208968
UCSCiuc009tcj.1 mouse [Q6P3Y5-2]
uc009tck.1 mouse [Q6P3Y5-1]
uc009tcm.2 mouse [Q6P3Y5-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129399 mRNA Translation: BAC98209.1 Different initiation.
AK141491 mRNA Translation: BAE24700.1
AL669901 Genomic DNA No translation available.
BC028839 mRNA Translation: AAH28839.1
BC051397 mRNA Translation: AAH51397.1
BC063775 mRNA Translation: AAH63775.1
CCDSiCCDS30111.1 [Q6P3Y5-1]
CCDS53064.1 [Q6P3Y5-3]
CCDS53065.1 [Q6P3Y5-2]
RefSeqiNP_001160120.1, NM_001166648.1 [Q6P3Y5-1]
NP_001160121.1, NM_001166649.1 [Q6P3Y5-3]
NP_001160122.1, NM_001166650.1 [Q6P3Y5-2]
NP_705760.2, NM_153532.3 [Q6P3Y5-1]
XP_006541521.1, XM_006541458.3 [Q6P3Y5-1]
XP_006541522.1, XM_006541459.3 [Q6P3Y5-1]
XP_006541524.1, XM_006541461.3 [Q6P3Y5-1]
XP_006541528.1, XM_006541465.3 [Q6P3Y5-2]
UniGeneiMm.293819

3D structure databases

ProteinModelPortaliQ6P3Y5
SMRiQ6P3Y5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P3Y5, 1 interactor
MINTiQ6P3Y5
STRINGi10090.ENSMUSP00000075933

PTM databases

iPTMnetiQ6P3Y5
PhosphoSitePlusiQ6P3Y5

Proteomic databases

PaxDbiQ6P3Y5
PeptideAtlasiQ6P3Y5
PRIDEiQ6P3Y5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072292; ENSMUSP00000072138; ENSMUSG00000036916 [Q6P3Y5-3]
ENSMUST00000076635; ENSMUSP00000075933; ENSMUSG00000036916 [Q6P3Y5-1]
ENSMUST00000088898; ENSMUSP00000086288; ENSMUSG00000036916 [Q6P3Y5-1]
ENSMUST00000114940; ENSMUSP00000110590; ENSMUSG00000036916 [Q6P3Y5-2]
GeneIDi208968
KEGGimmu:208968
UCSCiuc009tcj.1 mouse [Q6P3Y5-2]
uc009tck.1 mouse [Q6P3Y5-1]
uc009tcm.2 mouse [Q6P3Y5-3]

Organism-specific databases

CTDi208968
MGIiMGI:2387585 Zfp280c
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063300
HOGENOMiHOG000013047
HOVERGENiHBG060885
InParanoidiQ6P3Y5
OMAiHMKHCCP
OrthoDBiEOG091G01UE
PhylomeDBiQ6P3Y5
TreeFamiTF331707

Miscellaneous databases

ChiTaRSiZfp280c mouse
PROiPR:Q6P3Y5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036916 Expressed in 262 organ(s), highest expression level in humerus cartilage element
CleanExiMM_ZFP280C
GenevisibleiQ6P3Y5 MM

Family and domain databases

InterProiView protein in InterPro
IPR025243 DUF4195
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF13836 DUF4195, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZ280C_MOUSE
AccessioniPrimary (citable) accession number: Q6P3Y5
Secondary accession number(s): B1AU28
, B1AU29, Q6ZPM2, Q8K145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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