Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 135 (03 Jul 2019)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein

Tetratricopeptide repeat protein 27

Gene

TTC27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 27
Short name:
TPR repeat protein 27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25986 TTC27

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P3X3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000018699

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145007326

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74758258

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002950961 – 843Tetratricopeptide repeat protein 27Add BLAST843

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P3X3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P3X3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P3X3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P3X3

PeptideAtlas

More...
PeptideAtlasi
Q6P3X3

PRoteomics IDEntifications database

More...
PRIDEi
Q6P3X3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66938

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P3X3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P3X3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000018699 Expressed in 193 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P3X3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P3X3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA031246

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
LRRK2Q5S0073EBI-1057046,EBI-5323863

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120761, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P3X3, 19 interactors

Molecular INTeraction database

More...
MINTi
Q6P3X3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000313953

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P3X3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati453 – 486TPR 1Add BLAST34
Repeati492 – 525TPR 2Add BLAST34
Repeati527 – 560TPR 3Add BLAST34
Repeati561 – 594TPR 4Add BLAST34
Repeati596 – 628TPR 5Add BLAST33
Repeati629 – 662TPR 6Add BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTC27 family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1128 Eukaryota
ENOG410XNXB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00500000044929

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000067764

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P3X3

Identification of Orthologs from Complete Genome Data

More...
OMAi
MWAEAAL

Database of Orthologous Groups

More...
OrthoDBi
1039489at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P3X3

TreeFam database of animal gene trees

More...
TreeFami
TF105894

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR013105 TPR_2
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07719 TPR_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6P3X3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTPELAILR GFPTEAERQQ WKQEGVVGSE SGSFLQLLLE GNYEAIFLNS
60 70 80 90 100
MTQNIFNSTT TAEEKIDSYL EKQVVTFLDY STDLDTTERQ QLIFLLGVSS
110 120 130 140 150
LQLFVQSNWT GPPVDLHPQD FLSSVLFQQF SEVKGLDAFV LSLLTLDGES
160 170 180 190 200
IYSLTSKPIL LLLARIILVN VRHKLTAIQS LPWWTLRCVN IHQHLLEERS
210 220 230 240 250
PLLFTLAENC IDQVMKLQNL FVDDSGRYLA IQFHLECAYV FLYYYEYRKA
260 270 280 290 300
KDQLDIAKDI SQLQIDLTGA LGKRTRFQEN YVAQLILDVR REGDVLSNCE
310 320 330 340 350
FTPAPTPQEH LTKNLELNDD TILNDIKLAD CEQFQMPDLC AEEIAIILGI
360 370 380 390 400
CTNFQKNNPV HTLTEVELLA FTSCLLSQPK FWAIQTSALI LRTKLEKGST
410 420 430 440 450
RRVERAMRQT QALADQFEDK TTSVLERLKI FYCCQVPPHW AIQRQLASLL
460 470 480 490 500
FELGCTSSAL QIFEKLEMWE DVVICYERAG QHGKAEEILR QELEKKETPS
510 520 530 540 550
LYCLLGDVLG DHSCYDKAWE LSRYRSARAQ RSKALLHLRN KEFQECVECF
560 570 580 590 600
ERSVKINPMQ LGVWFSLGCA YLALEDYQGS AKAFQRCVTL EPDNAEAWNN
610 620 630 640 650
LSTSYIRLKQ KVKAFRTLQE ALKCNYEHWQ IWENYILTST DVGEFSEAIK
660 670 680 690 700
AYHRLLDLRD KYKDVQVLKI LVRAVIDGMT DRSGDVATGL KGKLQELFGR
710 720 730 740 750
VTSRVTNDGE IWRLYAHVYG NGQSEKPDEN EKAFQCLSKA YKCDTQSNCW
760 770 780 790 800
EKDITSFKEV VQRALGLAHV AIKCSKNKSS SQEAVQMLSS VRLNLRGLLS
810 820 830 840
KAKQLFTDVA TGEMSRELAD DITAMDTLVT ELQDLSNQFR NQY
Length:843
Mass (Da):96,632
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7008E0BC278718C7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C3A3H7C3A3_HUMAN
Tetratricopeptide repeat protein 27
TTC27
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C178H7C178_HUMAN
Tetratricopeptide repeat protein 27
TTC27
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JVS4C9JVS4_HUMAN
Tetratricopeptide repeat protein 27
TTC27
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCH1F8WCH1_HUMAN
Tetratricopeptide repeat protein 27
TTC27
41Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C329H7C329_HUMAN
Tetratricopeptide repeat protein 27
TTC27
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IS02A0A3B3IS02_HUMAN
Tetratricopeptide repeat protein 27
TTC27
350Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA91315 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti563V → A in BAA91315 (PubMed:14702039).Curated1
Sequence conflicti627E → G in BAB55206 (PubMed:14702039).Curated1
Sequence conflicti756S → P in BAB55206 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033207476Y → C. Corresponds to variant dbSNP:rs2273660Ensembl.1
Natural variantiVAR_061905498T → M. Corresponds to variant dbSNP:rs34188947Ensembl.1
Natural variantiVAR_033208525R → H1 PublicationCorresponds to variant dbSNP:rs2273664Ensembl.1
Natural variantiVAR_052628586R → H. Corresponds to variant dbSNP:rs17012268Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK000279 mRNA Translation: BAA91048.1 Different initiation.
AK000665 mRNA Translation: BAA91315.1 Different initiation.
AK027570 mRNA Translation: BAB55206.1
AL133246 Genomic DNA No translation available.
BC001248 mRNA Translation: AAH01248.2
BC063791 mRNA Translation: AAH63791.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33176.1

NCBI Reference Sequences

More...
RefSeqi
NP_001180438.1, NM_001193509.1
NP_060205.3, NM_017735.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317907; ENSP00000313953; ENSG00000018699

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55622

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55622

UCSC genome browser

More...
UCSCi
uc002rom.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000279 mRNA Translation: BAA91048.1 Different initiation.
AK000665 mRNA Translation: BAA91315.1 Different initiation.
AK027570 mRNA Translation: BAB55206.1
AL133246 Genomic DNA No translation available.
BC001248 mRNA Translation: AAH01248.2
BC063791 mRNA Translation: AAH63791.1
CCDSiCCDS33176.1
RefSeqiNP_001180438.1, NM_001193509.1
NP_060205.3, NM_017735.4

3D structure databases

SMRiQ6P3X3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120761, 48 interactors
IntActiQ6P3X3, 19 interactors
MINTiQ6P3X3
STRINGi9606.ENSP00000313953

PTM databases

iPTMnetiQ6P3X3
PhosphoSitePlusiQ6P3X3

Polymorphism and mutation databases

BioMutaiTTC27
DMDMi74758258

Proteomic databases

EPDiQ6P3X3
jPOSTiQ6P3X3
MaxQBiQ6P3X3
PaxDbiQ6P3X3
PeptideAtlasiQ6P3X3
PRIDEiQ6P3X3
ProteomicsDBi66938

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317907; ENSP00000313953; ENSG00000018699
GeneIDi55622
KEGGihsa:55622
UCSCiuc002rom.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55622

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTC27
HGNCiHGNC:25986 TTC27
HPAiHPA031246
neXtProtiNX_Q6P3X3
OpenTargetsiENSG00000018699
PharmGKBiPA145007326

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1128 Eukaryota
ENOG410XNXB LUCA
GeneTreeiENSGT00500000044929
HOGENOMiHOG000067764
InParanoidiQ6P3X3
OMAiMWAEAAL
OrthoDBi1039489at2759
PhylomeDBiQ6P3X3
TreeFamiTF105894

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTC27 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55622

Protein Ontology

More...
PROi
PR:Q6P3X3

Gene expression databases

BgeeiENSG00000018699 Expressed in 193 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ6P3X3 baseline and differential
GenevisibleiQ6P3X3 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR013105 TPR_2
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF07719 TPR_2, 1 hit
SMARTiView protein in SMART
SM00028 TPR, 4 hits
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50005 TPR, 4 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P3X3
Secondary accession number(s): A6NKJ0
, Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: July 3, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again