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Entry version 73 (08 May 2019)
Sequence version 2 (01 Jul 2008)
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Protein

Tetratricopeptide repeat protein 41

Gene

Ttc41

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 41By similarity
Short name:
TPR repeat protein 41By similarity
Alternative name(s):
Grp94-neighboring nucleotidaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ttc41By similarity
Synonyms:GnnBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
1302940 LOC362863

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003425511 – 1309Tetratricopeptide repeat protein 41Add BLAST1309

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q6P3V7

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P3V7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati399 – 432TPR 1Add BLAST34
Repeati651 – 684TPR 2Add BLAST34
Repeati817 – 851TPR 3Add BLAST35
Repeati859 – 892TPR 4Add BLAST34
Repeati989 – 1024TPR 5Add BLAST36
Repeati1042 – 1079TPR 6Add BLAST38

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000172545

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P3V7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05729 NACHT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P3V7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIEEAIETAQ RYNSQPILKR QKPIRPYICS TIDFQDERDF LAKTIFPQLN
60 70 80 90 100
DFCSSRGTYF KAVDLRWSAL KAHKSFTNNQ FRQYSCLHSQ HLKLCLDYVN
110 120 130 140 150
RCFPFFICLL GQTYGDFLPD YTPFLLSKVK DLESLSKGEQ NLYVAAKNGY
160 170 180 190 200
PWVLKTPNCS LTEFEIIQAA FRKKSQFQFF YFRTSNSLLR TFSEEEEEEE
210 220 230 240 250
EKLSSGYQVD RQGKVKVGKL KAKIIGKGLP VRFYRDLDEL GDMVLKDWSA
260 270 280 290 300
VVEELYPVTM IMENIDYKHS FENLYHEEFV ENCKQVFVIS KESNRTFEML
310 320 330 340 350
ERFAIKDLEL NSDSTVAGAG LDSILRINSL PTCKSILLLC GERGCGKSTL
360 370 380 390 400
IANWVDDFKS RHPGVLMVPY FVGSTCESCD IMSVMHYFIM ELQHRANGPQ
410 420 430 440 450
LEMDFLNEDS NVLVFSLLIE VFMAAISLKP CILVLDGIEE LVGIYGISGQ
460 470 480 490 500
KAKDFSWLPR SLPPHCKFIL SSVSSSLSCK SLCARPDVKT VELNSLGDED
510 520 530 540 550
TKFSIFRQHL SAPDQERFGQ SKPILRKKPN LNPLKLTLIA SELQECRIYR
560 570 580 590 600
NEFQCLREYL EVASVQELWE LILKRWVEDY SWPLKHKETT VDNVISGACG
610 620 630 640 650
WVVDVLCLLC ISHCGLAEDE LLQILDMMGY RDHHKVTAVH WAAFRNATKN
660 670 680 690 700
WIQEKPNGLL YFQHQSLRNA VEHKMLGVTI SVRESNPNVS QNSTNHKKVH
710 720 730 740 750
FHQVLMKYFQ RQTIFWRVYQ ELPWHMKMSG YWEGLCGFIT SPIITDFISK
760 770 780 790 800
IQNPSLWTRL HLVHYWDVLL EAGSDVLEAF LLSAAKIEAE DSQKLKKRTT
810 820 830 840 850
LSGMTVCPEA LQATKFLTFL LFLWGFLTLL GNRRANNLFS GAAPFLVSVQ
860 870 880 890 900
SPSMTEMLLK AQNAIGELYL DIGMMQKGLT YFQKAWSNLL RFTLSDLKIS
910 920 930 940 950
QELMKQKVKV MNNLAKSASE EFLKENHVLE YATEVSKYVM DNPRDQATMR
960 970 980 990 1000
YTEGVLIPVG RVFALQGHSY SLLPILRRAL GDRLSNKCMS YFSSAVLMEF
1010 1020 1030 1040 1050
LFSRSQRKQA IEYYKQVIKI KEKADSVATC KLVRKQLNIS LSDTLCKLAG
1060 1070 1080 1090 1100
QLLSGDFCHH ATMEAVSYLY RSLDLRAAHL GPSHASIEGI LHLLREIQRS
1110 1120 1130 1140 1150
RGRRSWPQGM NQLYPEGSSC GFSLWENLPK LNFHSAQSSD TVNTAMCMNI
1160 1170 1180 1190 1200
HRFQRAKSTE PSLVSDKAKY FPGRGKKTLT PILSMSAEEK AQNSQIRNSL
1210 1220 1230 1240 1250
RKQPPRKKGV YPLKTYSLID KNGSVRLSRQ RVFSAELGSG RSLINSIYRQ
1260 1270 1280 1290 1300
PLRAPLSADN PWKSISELVS EKWLFHTPHY CFTPQKSVFP RRSQIETKML

KTSHDFDKE
Length:1,309
Mass (Da):150,287
Last modified:July 1, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAEDA8C7022E6CFA
GO
Isoform 2 (identifier: Q6P3V7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     399-399: P → T
     400-1309: Missing.

Note: No experimental confirmation available.
Show »
Length:399
Mass (Da):46,223
Checksum:i80B571701FAADADD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WG20F8WG20_RAT
First gene upstream of Nt5dc3
LOC362863
1,310Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LQV7F1LQV7_RAT
First gene upstream of Nt5dc3
LOC362863
1,307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2K9F1A0A0G2K9F1_RAT
First gene upstream of Nt5dc3
LOC362863
397Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32I → M in AAH63813 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034502399P → T in isoform 2. 1 Publication1
Alternative sequenceiVSP_034503400 – 1309Missing in isoform 2. 1 PublicationAdd BLAST910

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR03057641 Genomic DNA No translation available.
AABR03059265 Genomic DNA No translation available.
AABR03060536 Genomic DNA No translation available.
AABR03060891 Genomic DNA No translation available.
AABR03061268 Genomic DNA No translation available.
AABR03061651 Genomic DNA No translation available.
BC063813 mRNA Translation: AAH63813.1

Genome annotation databases

UCSC genome browser

More...
UCSCi
RGD:1302940 rat [Q6P3V7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03057641 Genomic DNA No translation available.
AABR03059265 Genomic DNA No translation available.
AABR03060536 Genomic DNA No translation available.
AABR03060891 Genomic DNA No translation available.
AABR03061268 Genomic DNA No translation available.
AABR03061651 Genomic DNA No translation available.
BC063813 mRNA Translation: AAH63813.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

PhosphoSitePlusiQ6P3V7

Proteomic databases

PRIDEiQ6P3V7

Genome annotation databases

UCSCiRGD:1302940 rat [Q6P3V7-1]

Organism-specific databases

RGDi1302940 LOC362863

Phylogenomic databases

HOGENOMiHOG000172545
InParanoidiQ6P3V7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6P3V7

Family and domain databases

InterProiView protein in InterPro
IPR007111 NACHT_NTPase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF05729 NACHT, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC41_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P3V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: May 8, 2019
This is version 73 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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