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UniProtKB - Q6P3V2 (Z585A_HUMAN)

Entry version 152 (10 Feb 2021)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

Zinc finger protein 585A

Gene

ZNF585A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri746 – 768C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6P3V2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 585A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF585A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26305, ZNF585A

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P3V2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196967.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		199704

Open Targets

More...OpenTargetsi		ENSG00000196967

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134905518

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P3V2, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF585A

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242848

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476771 – 769Zinc finger protein 585AAdd BLAST769

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P3V2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P3V2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P3V2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P3V2

PeptideAtlas

More...PeptideAtlasi		Q6P3V2

PRoteomics IDEntifications database

More...PRIDEi		Q6P3V2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66932 [Q6P3V2-1]
66933 [Q6P3V2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P3V2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P3V2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196967, Expressed in buccal mucosa cell and 198 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P3V2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P3V2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196967, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		128264, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q6P3V2, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000292841

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P3V2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P3V2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 97KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri746 – 768C2H2-type 22PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P3V2

Identification of Orthologs from Complete Genome Data

More...OMAi		YQSCPEE

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P3V2

TreeFam database of animal gene trees

More...TreeFami		TF343410

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 19 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 21 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 13 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 21 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P3V2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPANWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDPSQRN 
        60         70         80         90        100
LYRDVMLETY SHLLSVGYQV PEAEVVMLEQ GKEPWALQGE RPRQSCPGEK 
       110        120        130        140        150
LWDHNQCRKI LSYKQVSSQP QKMYPGEKAY ECAKFEKIFT QKSQLKVHLK 
       160        170        180        190        200
VLAGEKLYVC IECGKAFVQK PEFIIHQKTH MREKPFKCNE CGKSFFQVSS 
       210        220        230        240        250
LFRHQRIHTG EKLYECSQCG KGFSYNSDLS IHEKIHTGER HHECTDCGKA 
       260        270        280        290        300
FTQKSTLKMH QKIHTGERSY ICIECGQAFI QKTHLIAHRR IHTGEKPYEC 
       310        320        330        340        350
SNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LVTHKKVQSR 
       360        370        380        390        400
EKSSICTECG KAFTYRSELI IHQRIHTGEK PYECSDCGKA FTQKSALTVH 
       410        420        430        440        450
QRIHTGEKSY ICMKCGLAFI QKAHLIAHQI IHTGEKPHKC GHCGKLFTSK 
       460        470        480        490        500
SQLHVHKRIH TGEKPYMCNK CGKAFTNRSN LITHQKTHTG EKSYICSKCG 
       510        520        530        540        550
KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSHLNIH QKIHTGERQY 
       560        570        580        590        600
ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH 
       610        620        630        640        650
TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS 
       660        670        680        690        700
KHQKTHTGEK PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT 
       710        720        730        740        750
KKSQLQVHQR IHTGEKPYVC AECGKAFTDR SNLNKHQTTH TGDKPYKCGI 
       760 
CGKGFVQKSV FSVHQSSHA
Length:769
Mass (Da):87,974
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE8E19B5D5F95AF7
GO
Isoform 2 (identifier: Q6P3V2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-55: Missing.
     367-674: Missing.

Show »
Length:406
Mass (Da):46,686
Checksum:i1BAB9BC5DF908886
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EN80K7EN80_HUMAN
Zinc finger protein 585A
ZNF585A
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ELR3K7ELR3_HUMAN
Zinc finger protein 585A
ZNF585A
25Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DFY4A0A0C4DFY4_HUMAN
Zinc finger protein 585A
ZNF585A
714Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85057 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti763V → I in AAH63820 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0160171 – 55Missing in isoform 2. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_016018367 – 674Missing in isoform 2. 1 PublicationAdd BLAST308

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056389 mRNA Translation: BAB71174.1
AK074345 mRNA Translation: BAB85057.1 Different initiation.
AC012309 Genomic DNA No translation available.
BC063820 mRNA Translation: AAH63820.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS74353.1 [Q6P3V2-1]

NCBI Reference Sequences

More...RefSeqi		NP_001275729.1, NM_001288800.1 [Q6P3V2-1]
NP_689868.1, NM_152655.3
NP_954577.1, NM_199126.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000292841; ENSP00000292841; ENSG00000196967 [Q6P3V2-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		199704

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:199704

UCSC genome browser

More...UCSCi		uc002ofm.3, human [Q6P3V2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056389 mRNA Translation: BAB71174.1
AK074345 mRNA Translation: BAB85057.1 Different initiation.
AC012309 Genomic DNA No translation available.
BC063820 mRNA Translation: AAH63820.1
CCDSiCCDS74353.1 [Q6P3V2-1]
RefSeqiNP_001275729.1, NM_001288800.1 [Q6P3V2-1]
NP_689868.1, NM_152655.3
NP_954577.1, NM_199126.2

3D structure databases

SMRiQ6P3V2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128264, 2 interactors
IntActiQ6P3V2, 2 interactors
STRINGi9606.ENSP00000292841

PTM databases

iPTMnetiQ6P3V2
PhosphoSitePlusiQ6P3V2

Genetic variation databases

BioMutaiZNF585A
DMDMi116242848

Proteomic databases

EPDiQ6P3V2
MassIVEiQ6P3V2
MaxQBiQ6P3V2
PaxDbiQ6P3V2
PeptideAtlasiQ6P3V2
PRIDEiQ6P3V2
ProteomicsDBi66932 [Q6P3V2-1]
66933 [Q6P3V2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		73626, 10 antibodies

Genome annotation databases

EnsembliENST00000292841; ENSP00000292841; ENSG00000196967 [Q6P3V2-1]
GeneIDi199704
KEGGihsa:199704
UCSCiuc002ofm.3, human [Q6P3V2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		199704
DisGeNETi199704

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF585A
HGNCiHGNC:26305, ZNF585A
HPAiENSG00000196967, Low tissue specificity
neXtProtiNX_Q6P3V2
OpenTargetsiENSG00000196967
PharmGKBiPA134905518
VEuPathDBiHostDB:ENSG00000196967.10

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000161781
HOGENOMiCLU_002678_44_5_1
InParanoidiQ6P3V2
OMAiYQSCPEE
OrthoDBi1318335at2759
PhylomeDBiQ6P3V2
TreeFamiTF343410

Enzyme and pathway databases

PathwayCommonsiQ6P3V2
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		199704, 6 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF585A, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		199704
PharosiQ6P3V2, Tdark

Protein Ontology

More...PROi		PR:Q6P3V2
RNActiQ6P3V2, protein

Gene expression databases

BgeeiENSG00000196967, Expressed in buccal mucosa cell and 198 other tissues
ExpressionAtlasiQ6P3V2, baseline and differential
GenevisibleiQ6P3V2, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 21 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 13 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 21 hits
PS50157, ZINC_FINGER_C2H2_2, 23 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ585A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P3V2
Secondary accession number(s): Q8TE95, Q96MV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 17, 2006
Last modified: February 10, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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