UniProtKB - Q6P3V2 (Z585A_HUMAN)
Protein
Zinc finger protein 585A
Gene
ZNF585A
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 158 – 180 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 186 – 208 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 214 – 236 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 544 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 550 – 572 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 606 – 628 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 634 – 656 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 662 – 684 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 690 – 712 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 718 – 740 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 746 – 768 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6P3V2 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 585A |
Gene namesi | Name:ZNF585A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26305, ZNF585A |
neXtProti | NX_Q6P3V2 |
VEuPathDBi | HostDB:ENSG00000196967.10 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 199704 |
OpenTargetsi | ENSG00000196967 |
PharmGKBi | PA134905518 |
Miscellaneous databases
Pharosi | Q6P3V2, Tdark |
Genetic variation databases
BioMutai | ZNF585A |
DMDMi | 116242848 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047677 | 1 – 769 | Zinc finger protein 585AAdd BLAST | 769 |
Proteomic databases
EPDi | Q6P3V2 |
MassIVEi | Q6P3V2 |
MaxQBi | Q6P3V2 |
PaxDbi | Q6P3V2 |
PeptideAtlasi | Q6P3V2 |
PRIDEi | Q6P3V2 |
ProteomicsDBi | 66932 [Q6P3V2-1] 66933 [Q6P3V2-2] |
PTM databases
iPTMneti | Q6P3V2 |
PhosphoSitePlusi | Q6P3V2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196967, Expressed in buccal mucosa cell and 198 other tissues |
ExpressionAtlasi | Q6P3V2, baseline and differential |
Genevisiblei | Q6P3V2, HS |
Organism-specific databases
HPAi | ENSG00000196967, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 128264, 2 interactors |
IntActi | Q6P3V2, 2 interactors |
STRINGi | 9606.ENSP00000292841 |
Miscellaneous databases
RNActi | Q6P3V2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 97 | KRABPROSITE-ProRule annotationAdd BLAST | 71 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 158 – 180 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 186 – 208 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 214 – 236 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 242 – 264 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 270 – 292 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 298 – 320 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 326 – 348 | C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 354 – 376 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 382 – 404 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 410 – 432 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 438 – 460 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 522 – 544 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 550 – 572 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 578 – 600 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 606 – 628 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 634 – 656 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 662 – 684 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 690 – 712 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 718 – 740 | C2H2-type 21PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 746 – 768 | C2H2-type 22PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161781 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q6P3V2 |
OMAi | YQSCPEE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6P3V2 |
TreeFami | TF343410 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 19 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 21 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 13 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 21 hits PS50157, ZINC_FINGER_C2H2_2, 23 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6P3V2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPANWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDPSQRN
60 70 80 90 100
LYRDVMLETY SHLLSVGYQV PEAEVVMLEQ GKEPWALQGE RPRQSCPGEK
110 120 130 140 150
LWDHNQCRKI LSYKQVSSQP QKMYPGEKAY ECAKFEKIFT QKSQLKVHLK
160 170 180 190 200
VLAGEKLYVC IECGKAFVQK PEFIIHQKTH MREKPFKCNE CGKSFFQVSS
210 220 230 240 250
LFRHQRIHTG EKLYECSQCG KGFSYNSDLS IHEKIHTGER HHECTDCGKA
260 270 280 290 300
FTQKSTLKMH QKIHTGERSY ICIECGQAFI QKTHLIAHRR IHTGEKPYEC
310 320 330 340 350
SNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LVTHKKVQSR
360 370 380 390 400
EKSSICTECG KAFTYRSELI IHQRIHTGEK PYECSDCGKA FTQKSALTVH
410 420 430 440 450
QRIHTGEKSY ICMKCGLAFI QKAHLIAHQI IHTGEKPHKC GHCGKLFTSK
460 470 480 490 500
SQLHVHKRIH TGEKPYMCNK CGKAFTNRSN LITHQKTHTG EKSYICSKCG
510 520 530 540 550
KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSHLNIH QKIHTGERQY
560 570 580 590 600
ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
610 620 630 640 650
TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS
660 670 680 690 700
KHQKTHTGEK PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT
710 720 730 740 750
KKSQLQVHQR IHTGEKPYVC AECGKAFTDR SNLNKHQTTH TGDKPYKCGI
760
CGKGFVQKSV FSVHQSSHA
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EN80 | K7EN80_HUMAN | Zinc finger protein 585A | ZNF585A | 113 | Annotation score: | ||
K7ELR3 | K7ELR3_HUMAN | Zinc finger protein 585A | ZNF585A | 25 | Annotation score: | ||
A0A0C4DFY4 | A0A0C4DFY4_HUMAN | Zinc finger protein 585A | ZNF585A | 714 | Annotation score: |
Sequence cautioni
The sequence BAB85057 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 763 | V → I in AAH63820 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016017 | 1 – 55 | Missing in isoform 2. 1 PublicationAdd BLAST | 55 | |
Alternative sequenceiVSP_016018 | 367 – 674 | Missing in isoform 2. 1 PublicationAdd BLAST | 308 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056389 mRNA Translation: BAB71174.1 AK074345 mRNA Translation: BAB85057.1 Different initiation. AC012309 Genomic DNA No translation available. BC063820 mRNA Translation: AAH63820.1 |
CCDSi | CCDS74353.1 [Q6P3V2-1] |
RefSeqi | NP_001275729.1, NM_001288800.1 [Q6P3V2-1] NP_689868.1, NM_152655.3 NP_954577.1, NM_199126.2 |
Genome annotation databases
Ensembli | ENST00000292841; ENSP00000292841; ENSG00000196967 [Q6P3V2-1] |
GeneIDi | 199704 |
KEGGi | hsa:199704 |
UCSCi | uc002ofm.3, human [Q6P3V2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056389 mRNA Translation: BAB71174.1 AK074345 mRNA Translation: BAB85057.1 Different initiation. AC012309 Genomic DNA No translation available. BC063820 mRNA Translation: AAH63820.1 |
CCDSi | CCDS74353.1 [Q6P3V2-1] |
RefSeqi | NP_001275729.1, NM_001288800.1 [Q6P3V2-1] NP_689868.1, NM_152655.3 NP_954577.1, NM_199126.2 |
3D structure databases
SMRi | Q6P3V2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128264, 2 interactors |
IntActi | Q6P3V2, 2 interactors |
STRINGi | 9606.ENSP00000292841 |
PTM databases
iPTMneti | Q6P3V2 |
PhosphoSitePlusi | Q6P3V2 |
Genetic variation databases
BioMutai | ZNF585A |
DMDMi | 116242848 |
Proteomic databases
EPDi | Q6P3V2 |
MassIVEi | Q6P3V2 |
MaxQBi | Q6P3V2 |
PaxDbi | Q6P3V2 |
PeptideAtlasi | Q6P3V2 |
PRIDEi | Q6P3V2 |
ProteomicsDBi | 66932 [Q6P3V2-1] 66933 [Q6P3V2-2] |
Protocols and materials databases
Antibodypediai | 73626, 10 antibodies |
Genome annotation databases
Ensembli | ENST00000292841; ENSP00000292841; ENSG00000196967 [Q6P3V2-1] |
GeneIDi | 199704 |
KEGGi | hsa:199704 |
UCSCi | uc002ofm.3, human [Q6P3V2-1] |
Organism-specific databases
CTDi | 199704 |
DisGeNETi | 199704 |
GeneCardsi | ZNF585A |
HGNCi | HGNC:26305, ZNF585A |
HPAi | ENSG00000196967, Low tissue specificity |
neXtProti | NX_Q6P3V2 |
OpenTargetsi | ENSG00000196967 |
PharmGKBi | PA134905518 |
VEuPathDBi | HostDB:ENSG00000196967.10 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161781 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q6P3V2 |
OMAi | YQSCPEE |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6P3V2 |
TreeFami | TF343410 |
Enzyme and pathway databases
PathwayCommonsi | Q6P3V2 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 199704, 6 hits in 874 CRISPR screens |
ChiTaRSi | ZNF585A, human |
GenomeRNAii | 199704 |
Pharosi | Q6P3V2, Tdark |
PROi | PR:Q6P3V2 |
RNActi | Q6P3V2, protein |
Gene expression databases
Bgeei | ENSG00000196967, Expressed in buccal mucosa cell and 198 other tissues |
ExpressionAtlasi | Q6P3V2, baseline and differential |
Genevisiblei | Q6P3V2, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 19 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 21 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 13 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 21 hits PS50157, ZINC_FINGER_C2H2_2, 23 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Z585A_HUMAN | |
Accessioni | Q6P3V2Primary (citable) accession number: Q6P3V2 Secondary accession number(s): Q8TE95, Q96MV3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 25, 2005 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 152 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM