We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - Q6P3U7 (Q6P3U7_HUMAN)
Protein
Submitted name:
RXRA protein
Gene
RXRA
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- steroid hormone receptor activity Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation, ReceptorUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: RXRA proteinImported |
Gene namesi | Name:RXRAImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- nucleoplasm Source: UniProt
Keywords - Cellular componenti
NucleusUniRule annotationARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 186 – 261 | Nuclear receptorInterPro annotationAdd BLAST | 76 | |
Domaini | 281 – 512 | NR LBDInterPro annotationAdd BLAST | 232 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 47 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 71 – 161 | DisorderedSequence analysisAdd BLAST | 91 | |
Regioni | 260 – 282 | DisorderedSequence analysisAdd BLAST | 23 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 10 – 36 | Basic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 100 – 117 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 125 – 157 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 260 – 276 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 912470at2759 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q6P3U7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ATFATTRRAA ASARRRRHRS RRLPAARARA GRAGGRRARR PLPAPPAGHE
60 70 80 90 100
LVADMDTKHF LPLDFSTQVN SSLTSPTGRG SMAAPSLHPS LGPGIGSPGQ
110 120 130 140 150
LHSPISTLSS PINGMGPPFS VISSPMGPHS MSVPTTPTLG FSTGSPQLSS
160 170 180 190 200
PMNPVSSSED IKPPLGLNGV LKVPAHPSGN MASFTKHICA ICGDRSSGKH
210 220 230 240 250
YGVYSCEGCK GFFKRTVRKD LTYTCRDNKD CLIDKRQRNR CQYCRYQKCL
260 270 280 290 300
AMGMKREAVQ EERQRGKDRN ENEVESTSSA NEDMPVERIL EAELAVEPKT
310 320 330 340 350
ETYVEANMGL NPSSPNDPVT NICQAADKQL FTLVEWAKRI PHFSELPLDD
360 370 380 390 400
QVILLRAGWN ELLIASFSHR SIAVKDGILL ATGLHVHRNS AHSAGVGAIF
410 420 430 440 450
DRVLTELVSK MRDMQMDKTE LGCLRAIVLF NPDSKGLSNP AEVEALREKV
460 470 480 490 500
YASLEAYCKH KYPEQPGRFA KLLLRLPALR SIGLKCLEHL FFFKLIGDTP
510
IDTFLMEMLE APHQMT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC063827 mRNA Translation: AAH63827.1 |
RefSeqi | NP_001278849.1, NM_001291920.1 NP_001278850.1, NM_001291921.1 NP_002948.1, NM_002957.5 |
Genome annotation databases
GeneIDi | 6256 |
KEGGi | hsa:6256 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC063827 mRNA Translation: AAH63827.1 |
RefSeqi | NP_001278849.1, NM_001291920.1 NP_001278850.1, NM_001291921.1 NP_002948.1, NM_002957.5 |
3D structure databases
SMRi | Q6P3U7 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | Q6P3U7 |
Protocols and materials databases
DNASUi | 6256 |
Genome annotation databases
GeneIDi | 6256 |
KEGGi | hsa:6256 |
Organism-specific databases
CTDi | 6256 |
PharmGKBi | PA34890 |
Phylogenomic databases
OrthoDBi | 912470at2759 |
Miscellaneous databases
BioGRID-ORCSi | 6256, 52 hits in 1110 CRISPR screens |
ChiTaRSi | RXRA, human |
GenomeRNAii | 6256 |
Gene expression databases
Genevisiblei | Q6P3U7, HS |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR021780, Nuc_recep-AF1 IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000003, Retinoid-X_rcpt/HNF4 IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF11825, Nuc_recep-AF1, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00545, RETINOIDXR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6P3U7_HUMAN | |
Accessioni | Q6P3U7Primary (citable) accession number: Q6P3U7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |