RXRA

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	186 – 261	Nuclear receptorPROSITE-ProRule annotationAdd BLAST		76

GO - Molecular functionⁱ

DNA binding transcription factor activity Source: InterPro
sequence-specific DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: RXRA proteinImported
Gene namesⁱ	Name:RXRAImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA34890

PharmGKBⁱ

PA34890

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	Q6P3U7

PRIDEⁱ

Q6P3U7

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q6P3U7 HS

Genevisibleⁱ

Q6P3U7 HS

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P3U7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	186 – 261	Nuclear receptorInterPro annotationAdd BLAST		76
Domainⁱ	281 – 512	NR LBDInterPro annotationAdd BLAST		232

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
HOGENOMⁱ	HOG000260821
HOVERGENⁱ	HBG005606
KEGG Orthology (KO) More...KOⁱ	K08524

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR021780 Nuc_recep-AF1 IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR000003 Retinoid-X_rcpt/HNF4 IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF11825 Nuc_recep-AF1, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00545 RETINOIDXR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q6P3U7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
ATFATTRRAA ASARRRRHRS RRLPAARARA GRAGGRRARR PLPAPPAGHE 
        60         70         80         90        100
LVADMDTKHF LPLDFSTQVN SSLTSPTGRG SMAAPSLHPS LGPGIGSPGQ 
       110        120        130        140        150
LHSPISTLSS PINGMGPPFS VISSPMGPHS MSVPTTPTLG FSTGSPQLSS 
       160        170        180        190        200
PMNPVSSSED IKPPLGLNGV LKVPAHPSGN MASFTKHICA ICGDRSSGKH 
       210        220        230        240        250
YGVYSCEGCK GFFKRTVRKD LTYTCRDNKD CLIDKRQRNR CQYCRYQKCL 
       260        270        280        290        300
AMGMKREAVQ EERQRGKDRN ENEVESTSSA NEDMPVERIL EAELAVEPKT 
       310        320        330        340        350
ETYVEANMGL NPSSPNDPVT NICQAADKQL FTLVEWAKRI PHFSELPLDD 
       360        370        380        390        400
QVILLRAGWN ELLIASFSHR SIAVKDGILL ATGLHVHRNS AHSAGVGAIF 
       410        420        430        440        450
DRVLTELVSK MRDMQMDKTE LGCLRAIVLF NPDSKGLSNP AEVEALREKV 
       460        470        480        490        500
YASLEAYCKH KYPEQPGRFA KLLLRLPALR SIGLKCLEHL FFFKLIGDTP 
       510 
IDTFLMEMLE APHQMT

Length:516

Mass (Da):56,672

Last modified:July 5, 2004 - v1

Checksum:ⁱC18FB97552E55929

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC063827 mRNA Translation: AAH63827.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001278849.1, NM_001291920.1 NP_001278850.1, NM_001291921.1 NP_002948.1, NM_002957.5
UniGeneⁱ	Hs.590886

Genome annotation databases

GeneIDⁱ	6256
KEGGⁱ	hsa:6256

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q6P3U7	Retinoic acid receptor RXR-alpha	)	HUMAN		462
Retinoic acid receptor RXR-alpha		MACMU		462
Retinoid X nuclear receptor alpha		HUMAN		462

Protein	Similar proteins		Species	Score	Length
Q6P3U7	Retinoic acid receptor RXR-alpha	)	HUMAN		462
Retinoic acid receptor RXR-alpha		MACMU		462
UPI00084D6AF8		XENLA		463
Retinoid X nuclear receptor alpha		HUMAN		462

Protein	Similar proteins		Species	Score	Length
Q6P3U7	Retinoic acid receptor RXR-alpha	)	HUMAN		462
Retinoic acid receptor RXR-alpha		MACMU		462
UPI00084D6AF8		XENLA		463
UPI0004DFE50F		URSMA		496
Retinoic acid receptor RXR-gamma-A		HETGA		616
+1

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC063827 mRNA Translation: AAH63827.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001278849.1, NM_001291920.1 NP_001278850.1, NM_001291921.1 NP_002948.1, NM_002957.5
UniGeneⁱ	Hs.590886

3D structure databases

ProteinModelPortalⁱ	Q6P3U7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q6P3U7

PRIDEⁱ

Q6P3U7

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6256
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	6256
KEGGⁱ	hsa:6256

Organism-specific databases

CTDⁱ	6256
PharmGKBⁱ	PA34890

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
HOGENOMⁱ	HOG000260821
HOVERGENⁱ	HBG005606
KEGG Orthology (KO) More...KOⁱ	K08524

Miscellaneous databases

ChiTaRSⁱ	RXRA human
GenomeRNAiⁱ	6256

Gene expression databases

Genevisibleⁱ	Q6P3U7 HS

Genevisibleⁱ

Q6P3U7 HS

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR021780 Nuc_recep-AF1 IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR000003 Retinoid-X_rcpt/HNF4 IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF11825 Nuc_recep-AF1, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00545 RETINOIDXR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6P3U7_HUMAN
Accessionⁱ	Q6P3U7Primary (citable) accession number: Q6P3U7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 5, 2004
	Last sequence update:	July 5, 2004
	Last modified:	May 23, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q6P3U7 (Q6P3U7_HUMAN)

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RXRA protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ