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Protein
Submitted name:

RXRA protein

Gene

RXRA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi186 – 261Nuclear receptorPROSITE-ProRule annotationAdd BLAST76

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation, ReceptorUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
RXRA proteinImported
Gene namesi
Name:RXRAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34890

PTM / Processingi

Proteomic databases

PRIDEiQ6P3U7

Expressioni

Gene expression databases

GenevisibleiQ6P3U7 HS

Structurei

3D structure databases

ProteinModelPortaliQ6P3U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 261Nuclear receptorInterPro annotationAdd BLAST76
Domaini281 – 512NR LBDInterPro annotationAdd BLAST232

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000260821
HOVERGENiHBG005606
KOiK08524

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR021780 Nuc_recep-AF1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF11825 Nuc_recep-AF1, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Fragment.

Q6P3U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ATFATTRRAA ASARRRRHRS RRLPAARARA GRAGGRRARR PLPAPPAGHE
60 70 80 90 100
LVADMDTKHF LPLDFSTQVN SSLTSPTGRG SMAAPSLHPS LGPGIGSPGQ
110 120 130 140 150
LHSPISTLSS PINGMGPPFS VISSPMGPHS MSVPTTPTLG FSTGSPQLSS
160 170 180 190 200
PMNPVSSSED IKPPLGLNGV LKVPAHPSGN MASFTKHICA ICGDRSSGKH
210 220 230 240 250
YGVYSCEGCK GFFKRTVRKD LTYTCRDNKD CLIDKRQRNR CQYCRYQKCL
260 270 280 290 300
AMGMKREAVQ EERQRGKDRN ENEVESTSSA NEDMPVERIL EAELAVEPKT
310 320 330 340 350
ETYVEANMGL NPSSPNDPVT NICQAADKQL FTLVEWAKRI PHFSELPLDD
360 370 380 390 400
QVILLRAGWN ELLIASFSHR SIAVKDGILL ATGLHVHRNS AHSAGVGAIF
410 420 430 440 450
DRVLTELVSK MRDMQMDKTE LGCLRAIVLF NPDSKGLSNP AEVEALREKV
460 470 480 490 500
YASLEAYCKH KYPEQPGRFA KLLLRLPALR SIGLKCLEHL FFFKLIGDTP
510
IDTFLMEMLE APHQMT
Length:516
Mass (Da):56,672
Last modified:July 5, 2004 - v1
Checksum:iC18FB97552E55929
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC063827 mRNA Translation: AAH63827.1
RefSeqiNP_001278849.1, NM_001291920.1
NP_001278850.1, NM_001291921.1
NP_002948.1, NM_002957.5
UniGeneiHs.590886

Genome annotation databases

GeneIDi6256
KEGGihsa:6256

Similar proteinsi

Entry informationi

Entry nameiQ6P3U7_HUMAN
AccessioniPrimary (citable) accession number: Q6P3U7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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