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Protein

F-box only protein 42

Gene

FBXO42

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.1 Publication

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 42
Alternative name(s):
Just one F-box and Kelch domain-containing protein
Gene namesi
Name:FBXO42
Synonyms:FBX42, JFK, KIAA1332
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000037637.10
HGNCiHGNC:29249 FBXO42
MIMi609109 gene
neXtProtiNX_Q6P3S6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000037637
PharmGKBiPA134951560

Polymorphism and mutation databases

BioMutaiFBXO42
DMDMi51701398

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199421 – 717F-box only protein 42Add BLAST717

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei365PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1
Modified residuei378PhosphothreonineCombined sources1
Modified residuei552PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P3S6
MaxQBiQ6P3S6
PaxDbiQ6P3S6
PeptideAtlasiQ6P3S6
PRIDEiQ6P3S6
ProteomicsDBi66931

PTM databases

iPTMnetiQ6P3S6
PhosphoSitePlusiQ6P3S6

Expressioni

Gene expression databases

BgeeiENSG00000037637 Expressed in 230 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_FBXO42
ExpressionAtlasiQ6P3S6 baseline and differential
GenevisibleiQ6P3S6 HS

Organism-specific databases

HPAiHPA025071

Interactioni

Subunit structurei

Component of some SCF complex, composed of CUL1, SKP1, RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPJQ063303EBI-2506081,EBI-632552

Protein-protein interaction databases

BioGridi119962, 15 interactors
IntActiQ6P3S6, 3 interactors
MINTiQ6P3S6
STRINGi9606.ENSP00000364742

Structurei

3D structure databases

ProteinModelPortaliQ6P3S6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 93F-boxPROSITE-ProRule annotationAdd BLAST50
Repeati132 – 184Kelch 1Add BLAST53
Repeati186 – 242Kelch 2Add BLAST57
Repeati244 – 293Kelch 3Add BLAST50
Repeati295 – 342Kelch 4Add BLAST48

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00440000039706
HOVERGENiHBG051582
InParanoidiQ6P3S6
KOiK10317
OMAiIDLNWDL
OrthoDBiEOG091G0DN3
PhylomeDBiQ6P3S6
TreeFamiTF324505

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF07646 Kelch_2, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF117281 SSF117281, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6P3S6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSSDSEDD SFMAVDQEET VLEGTMDQDE EPHPVLEAEE TRHNRSMSEL
60 70 80 90 100
PEEVLEYILS FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG
110 120 130 140 150
NIQWESRTYP YPGTPITQRF SHSACYYDAN QSMYVFGGCT QSSCNAAFND
160 170 180 190 200
LWRLDLNSKE WIRPLASGSY PSPKAGATLV VYKDLLVLFG GWTRPSPYPL
210 220 230 240 250
HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI DDKMIVFGGS
260 270 280 290 300
LGSRQMSNDV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDATILILG
310 320 330 340 350
GCGGPNALFK DAWLLHMHSG PWAWQPLKVE NEEHGAPELW CHPACRVGQC
360 370 380 390 400
VVVFSQAPSG RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE
410 420 430 440 450
APCVNGRWGT LRPRAQRQTP SGSREGSLSP ARGDGSPILN GGSLSPGTAA
460 470 480 490 500
VGGSSLDSPV QAISPSTPSA PEGYDLKIGL SLAPRRGSLP DQKDLRLGSI
510 520 530 540 550
DLNWDLKPAS SSNPMDGMDN RTVGGSMRHP PEQTNGVHTP PHVASALAGA
560 570 580 590 600
VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPGSPGS QSLSSGETVP
610 620 630 640 650
IPRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD
660 670 680 690 700
IKDTKEKGRV KWKVFNSSSV VGPPETSLHT VVQGRGELII FGGLMDKKQN
710
VKYYPKTNAL YFVRAKR
Length:717
Mass (Da):77,839
Last modified:July 5, 2004 - v1
Checksum:i938D0A018FC3DCBD
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6RKU3X6RKU3_HUMAN
F-box only protein 42
FBXO42
298Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti454Missing in AAH43410 (PubMed:15489334).Curated1
Sequence conflicti509A → T in CAD38731 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024447471P → A3 PublicationsCorresponds to variant dbSNP:rs12069239Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055598 mRNA Translation: BAG51542.1
AL109627 Genomic DNA No translation available.
AL358794 Genomic DNA No translation available.
BC006174 mRNA Translation: AAH06174.1
BC032439 mRNA Translation: AAH32439.1
BC043410 mRNA Translation: AAH43410.1
BC063864 mRNA Translation: AAH63864.1
AB037753 mRNA Translation: BAA92570.1
AL833874 mRNA Translation: CAD38731.1
CCDSiCCDS30613.1
RefSeqiNP_061867.1, NM_018994.2
XP_006710761.1, XM_006710698.3
UniGeneiHs.522384

Genome annotation databases

EnsembliENST00000375592; ENSP00000364742; ENSG00000037637
GeneIDi54455
KEGGihsa:54455
UCSCiuc001ayg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055598 mRNA Translation: BAG51542.1
AL109627 Genomic DNA No translation available.
AL358794 Genomic DNA No translation available.
BC006174 mRNA Translation: AAH06174.1
BC032439 mRNA Translation: AAH32439.1
BC043410 mRNA Translation: AAH43410.1
BC063864 mRNA Translation: AAH63864.1
AB037753 mRNA Translation: BAA92570.1
AL833874 mRNA Translation: CAD38731.1
CCDSiCCDS30613.1
RefSeqiNP_061867.1, NM_018994.2
XP_006710761.1, XM_006710698.3
UniGeneiHs.522384

3D structure databases

ProteinModelPortaliQ6P3S6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119962, 15 interactors
IntActiQ6P3S6, 3 interactors
MINTiQ6P3S6
STRINGi9606.ENSP00000364742

PTM databases

iPTMnetiQ6P3S6
PhosphoSitePlusiQ6P3S6

Polymorphism and mutation databases

BioMutaiFBXO42
DMDMi51701398

Proteomic databases

EPDiQ6P3S6
MaxQBiQ6P3S6
PaxDbiQ6P3S6
PeptideAtlasiQ6P3S6
PRIDEiQ6P3S6
ProteomicsDBi66931

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375592; ENSP00000364742; ENSG00000037637
GeneIDi54455
KEGGihsa:54455
UCSCiuc001ayg.4 human

Organism-specific databases

CTDi54455
EuPathDBiHostDB:ENSG00000037637.10
GeneCardsiFBXO42
HGNCiHGNC:29249 FBXO42
HPAiHPA025071
MIMi609109 gene
neXtProtiNX_Q6P3S6
OpenTargetsiENSG00000037637
PharmGKBiPA134951560
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379 Eukaryota
ENOG410Y5WM LUCA
GeneTreeiENSGT00440000039706
HOVERGENiHBG051582
InParanoidiQ6P3S6
KOiK10317
OMAiIDLNWDL
OrthoDBiEOG091G0DN3
PhylomeDBiQ6P3S6
TreeFamiTF324505

Miscellaneous databases

ChiTaRSiFBXO42 human
GenomeRNAii54455
PROiPR:Q6P3S6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000037637 Expressed in 230 organ(s), highest expression level in saliva-secreting gland
CleanExiHS_FBXO42
ExpressionAtlasiQ6P3S6 baseline and differential
GenevisibleiQ6P3S6 HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR015915 Kelch-typ_b-propeller
IPR011498 Kelch_2
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF07646 Kelch_2, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF117281 SSF117281, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBX42_HUMAN
AccessioniPrimary (citable) accession number: Q6P3S6
Secondary accession number(s): B3KP30
, Q5TEU8, Q86XI0, Q8N3N4, Q8N5F8, Q9BRM0, Q9P2L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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