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Entry version 131 (31 Jul 2019)
Sequence version 2 (16 Mar 2016)
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Protein

DENN domain-containing protein 1B

Gene

DENND1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells (PubMed:20154091, PubMed:20937701, PubMed:24520163, PubMed:26774822). Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form (PubMed:20154091, PubMed:20937701). Plays a role in clathrin-mediated endocytosis (PubMed:20154091). Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity (PubMed:26774822). Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells (PubMed:26774822).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein 1BImported
Alternative name(s):
Connecdenn 21 Publication
Protein FAM31BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DENND1BImported
Synonyms:C1orf218Imported, FAM31BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28404 DENND1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613292 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P3S1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Asthma (ASTHMA)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. Asthma susceptibility is probably caused by decreased TCR down-modulation and recycling in TH2 cells, causing prolonged TCR signaling and increased cytokine production in TH2 lymphocytes (PubMed:26774822).1 Publication
Disease descriptionThe most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi.
Related information in OMIM

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi489K → A: Causes only a slight reduction in AP2B1-binding. 1 Publication1
Mutagenesisi500K → A: Greatly reduce AP2B1-binding. 1 Publication1
Mutagenesisi501R → A: No effect. 1 Publication1
Mutagenesisi502K → A: Almost completely abolishes AP2B1-binding. 1 Publication1
Mutagenesisi507R → A: No effect. 1 Publication1
Mutagenesisi509K → A: Greatly reduce AP2B1-binding. 1 Publication1

Keywords - Diseasei

Asthma

Organism-specific databases

DisGeNET

More...
DisGeNETi
163486
MIMi600807 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000213047

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134951951

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DENND1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749089

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003046741 – 775DENN domain-containing protein 1BAdd BLAST775

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei520PhosphotyrosineBy similarity1
Modified residuei535PhosphoserineBy similarity1
Modified residuei536PhosphoserineBy similarity1
Modified residuei549PhosphoserineBy similarity1
Modified residuei552PhosphoserineBy similarity1
Modified residuei652PhosphoserineCombined sources1
Modified residuei653PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P3S1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P3S1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P3S1

PeptideAtlas

More...
PeptideAtlasi
Q6P3S1

PRoteomics IDEntifications database

More...
PRIDEi
Q6P3S1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66926 [Q6P3S1-1]
66927 [Q6P3S1-2]
66928 [Q6P3S1-3]
66929 [Q6P3S1-4]
66930 [Q6P3S1-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P3S1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P3S1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in dendritic and natural killer cells and at lower levels in other myeloid lineage cells and in pituitary. Significantly up-regulated in effector memory T-cells as compared with naive T-cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000213047 Expressed in 222 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P3S1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P3S1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042586

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RAB35 (PubMed:24520163, PubMed:22065758).

Interacts with clathrin heavy chain/CLTC (PubMed:20154091).

Interacts with components of the adapter protein complex 2 (AP-2) AP2A2 and AP2B1 (PubMed:20154091).

Interacts with CD3E (By similarity).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127867, 3 interactors

Protein interaction database and analysis system

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IntActi
Q6P3S1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000479816

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1775
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P3S1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 143uDENNPROSITE-ProRule annotationAdd BLAST130
Domaini180 – 316cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini318 – 395dDENNPROSITE-ProRule annotationAdd BLAST78

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi398 – 402FXDXF motif1 Publication5
Motifi566 – 575Clathrin box1 Publication10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FXDXF motif mediates interaction the AP-2 complex.By similarity
The clathrin box motif mediates interaction with clathrin.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3569 Eukaryota
ENOG410XT3N LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000155446

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P3S1

KEGG Orthology (KO)

More...
KOi
K20160

Identification of Orthologs from Complete Genome Data

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OMAi
MHSYFIA

Database of Orthologous Groups

More...
OrthoDBi
189322at2759

TreeFam database of animal gene trees

More...
TreeFami
TF320336

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR040032 DENND1A/B/C
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR13196 PTHR13196, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211 DENN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 5 (identifier: Q6P3S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDCRTKANPD RTFDLVLKVK CHASENEDPV VLWKFPEDFG DQEILQSVPK
60 70 80 90 100
FCFPFDVERV SQNQVGQHFT FVLTDIESKQ RFGFCRLTSG GTICLCILSY
110 120 130 140 150
LPWFEVYYKL LNTLADYLAK ELENDLNETL RSLYNHPVPK ANTPVNLSVN
160 170 180 190 200
QEIFIACEQV LKDQPALVPH SYFIAPDVTG LPTIPESRNL TEYFVAVDVN
210 220 230 240 250
NMLQLYASML HERRIVIISS KLSTLTACIH GSAALLYPMY WQHIYIPVLP
260 270 280 290 300
PHLLDYCCAP MPYLIGIHSS LIERVKNKSL EDVVMLNVDT NTLESPFSDL
310 320 330 340 350
NNLPSDVVSA LKNKLKKQST ATGDGVARAF LRAQAALFGS YRDALRYKPG
360 370 380 390 400
EPITFCEESF VKHRSSVMKQ FLETAINLQL FKQFIDGRLA KLNAGRGFSD
410 420 430 440 450
VFEEEITSGG FCGGNPRSYQ QWVHTVKKGG ALFNTAMTKA TPAVRTAYKF
460 470 480 490 500
AKNHAKLGLK EVKSKLKHKE NEEDYGTCSS SVQYTPVYKL HNEKGGNSEK
510 520 530 540 550
RKLAQARLKR PLKSLDGALY DDEDDDDIER ASKLSSEDGE EASAYLYESD
560 570 580 590 600
DSVETRVKTP YSGEMDLLGE ILDTLSTHSS DQGKLAAAKS LDFFRSMDDI
610 620 630 640 650
DYKPTNKSNA PSENNLAFLC GGSGDQAEWN LGQDDSALHG KHLPPSPRKR
660 670 680 690 700
VSSSGLTDSL FILKEENSNK HLGADNVSDP TSGLDFQLTS PEVSQTDKGK
710 720 730 740 750
TEKRETLSQI SDDLLIPGLG RHSSTFVPWE KEGKEAKETS EDIGLLHEVV
760 770
SLCHMTSDFQ QSLNISDKNT NGNQT
Length:775
Mass (Da):86,552
Last modified:March 16, 2016 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED44D8F693DF3983
GO
Isoform 2 (identifier: Q6P3S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-169: Missing.
     415-775: NPRSYQQWVH...SDKNTNGNQT → KDKLQYDYPFSQ

Show »
Length:406
Mass (Da):46,023
Checksum:iF447B1AC261D9D1C
GO
Isoform 3 (identifier: Q6P3S1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     150-169: Missing.
     310-315: ALKNKL → MKAIQW
     316-775: Missing.

Note: No experimental confirmation available.
Show »
Length:295
Mass (Da):33,701
Checksum:iAEE0F8F8B6791EF4
GO
Isoform 4 (identifier: Q6P3S1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MDCRTKANPDRTFDLVLKVKCHASENED → MAAAPREEKRWPQPVFSN
     150-169: Missing.
     415-775: NPRSYQQWVH...SDKNTNGNQT → KDKLQYDYPFSQ

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):44,901
Checksum:iEE50301A6487BABF
GO
Isoform 1 (identifier: Q6P3S1-5) [UniParc]FASTAAdd to basket
Also known as: DENND1B-S

The sequence of this isoform differs from the canonical sequence as follows:
     415-775: NPRSYQQWVH...SDKNTNGNQT → KDKLQYDYPFSQ

Show »
Length:426
Mass (Da):48,260
Checksum:i811670F3F2F6897F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KR95B3KR95_HUMAN
DENN domain-containing protein 1B
DENND1B hCG_2039668
352Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7ZBL5B7ZBL5_HUMAN
DENN domain-containing protein 1B
DENND1B
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH74735 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA90918 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15024 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW91280 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti340S → Y in AAH22561 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035055216V → M. Corresponds to variant dbSNP:rs7546381Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0280821 – 28MDCRT…SENED → MAAAPREEKRWPQPVFSN in isoform 4. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_028083150 – 169Missing in isoform 2, isoform 3 and isoform 4. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_028084310 – 315ALKNKL → MKAIQW in isoform 3. 1 Publication6
Alternative sequenceiVSP_028085316 – 775Missing in isoform 3. 1 PublicationAdd BLAST460
Alternative sequenceiVSP_034515415 – 775NPRSY…NGNQT → KDKLQYDYPFSQ in isoform 4, isoform 2 and isoform 1. 2 PublicationsAdd BLAST361

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AL139136 Genomic DNA No translation available.
AL365258 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91280.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91281.1
CH471067 Genomic DNA Translation: EAW91285.1
BC022561 mRNA Translation: AAH22561.1
BC063877 mRNA Translation: AAH63877.1
BC074735 mRNA Translation: AAH74735.2 Different initiation.
AL831839 mRNA Translation: CAD38548.1
AK000061 mRNA Translation: BAA90918.1 Different initiation.
AK024832 mRNA Translation: BAB15024.1 Different initiation.
BK006960 mRNA Translation: DAA12502.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS41452.2 [Q6P3S1-5]
CCDS72996.1 [Q6P3S1-4]
CCDS72997.1 [Q6P3S1-1]

NCBI Reference Sequences

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RefSeqi
NP_001182144.1, NM_001195215.1 [Q6P3S1-1]
NP_001182145.1, NM_001195216.1
NP_001287787.1, NM_001300858.1 [Q6P3S1-4]
NP_659414.2, NM_144977.4 [Q6P3S1-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000235453; ENSP00000235453; ENSG00000213047 [Q6P3S1-4]
ENST00000367396; ENSP00000356366; ENSG00000213047 [Q6P3S1-5]
ENST00000620048; ENSP00000479816; ENSG00000213047 [Q6P3S1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
163486

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:163486

UCSC genome browser

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UCSCi
uc001gue.4 human [Q6P3S1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139136 Genomic DNA No translation available.
AL365258 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91280.1 Sequence problems.
CH471067 Genomic DNA Translation: EAW91281.1
CH471067 Genomic DNA Translation: EAW91285.1
BC022561 mRNA Translation: AAH22561.1
BC063877 mRNA Translation: AAH63877.1
BC074735 mRNA Translation: AAH74735.2 Different initiation.
AL831839 mRNA Translation: CAD38548.1
AK000061 mRNA Translation: BAA90918.1 Different initiation.
AK024832 mRNA Translation: BAB15024.1 Different initiation.
BK006960 mRNA Translation: DAA12502.1
CCDSiCCDS41452.2 [Q6P3S1-5]
CCDS72996.1 [Q6P3S1-4]
CCDS72997.1 [Q6P3S1-1]
RefSeqiNP_001182144.1, NM_001195215.1 [Q6P3S1-1]
NP_001182145.1, NM_001195216.1
NP_001287787.1, NM_001300858.1 [Q6P3S1-4]
NP_659414.2, NM_144977.4 [Q6P3S1-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TW8X-ray2.10A/C1-410[»]
SMRiQ6P3S1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127867, 3 interactors
IntActiQ6P3S1, 2 interactors
STRINGi9606.ENSP00000479816

PTM databases

iPTMnetiQ6P3S1
PhosphoSitePlusiQ6P3S1

Polymorphism and mutation databases

BioMutaiDENND1B
DMDMi74749089

Proteomic databases

jPOSTiQ6P3S1
MaxQBiQ6P3S1
PaxDbiQ6P3S1
PeptideAtlasiQ6P3S1
PRIDEiQ6P3S1
ProteomicsDBi66926 [Q6P3S1-1]
66927 [Q6P3S1-2]
66928 [Q6P3S1-3]
66929 [Q6P3S1-4]
66930 [Q6P3S1-5]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
163486
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000235453; ENSP00000235453; ENSG00000213047 [Q6P3S1-4]
ENST00000367396; ENSP00000356366; ENSG00000213047 [Q6P3S1-5]
ENST00000620048; ENSP00000479816; ENSG00000213047 [Q6P3S1-1]
GeneIDi163486
KEGGihsa:163486
UCSCiuc001gue.4 human [Q6P3S1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
163486
DisGeNETi163486

GeneCards: human genes, protein and diseases

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GeneCardsi
DENND1B
HGNCiHGNC:28404 DENND1B
HPAiHPA042586
MIMi600807 phenotype
613292 gene
neXtProtiNX_Q6P3S1
OpenTargetsiENSG00000213047
PharmGKBiPA134951951

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3569 Eukaryota
ENOG410XT3N LUCA
GeneTreeiENSGT00940000155446
InParanoidiQ6P3S1
KOiK20160
OMAiMHSYFIA
OrthoDBi189322at2759
TreeFamiTF320336

Enzyme and pathway databases

ReactomeiR-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DENND1B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
163486

Protein Ontology

More...
PROi
PR:Q6P3S1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213047 Expressed in 222 organ(s), highest expression level in blood
ExpressionAtlasiQ6P3S1 baseline and differential
GenevisibleiQ6P3S1 HS

Family and domain databases

InterProiView protein in InterPro
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR040032 DENND1A/B/C
IPR037516 Tripartite_DENN
IPR005113 uDENN_dom
PANTHERiPTHR13196 PTHR13196, 1 hit
PfamiView protein in Pfam
PF03455 dDENN, 1 hit
PF02141 DENN, 1 hit
PF03456 uDENN, 1 hit
SMARTiView protein in SMART
SM00801 dDENN, 1 hit
SM00799 DENN, 1 hit
SM00800 uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDEN1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P3S1
Secondary accession number(s): B5MD89
, D3PFD5, Q5T3B8, Q5T3B9, Q5T3C1, Q5TAI8, Q6B0I8, Q8NDT1, Q8TBE6, Q9H774, Q9NXU2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: March 16, 2016
Last modified: July 31, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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