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Protein

Serine/threonine-protein kinase Nek5

Gene

NEK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6P3R8

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek5 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 5
Short name:
NimA-related protein kinase 5
Gene namesi
Name:NEK5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000197168.11
HGNCiHGNC:7748 NEK5
neXtProtiNX_Q6P3R8

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197168
PharmGKBiPA31549

Chemistry databases

ChEMBLiCHEMBL5044

Polymorphism and mutation databases

BioMutaiNEK5
DMDMi74758252

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002597651 – 708Serine/threonine-protein kinase Nek5Add BLAST708

Proteomic databases

EPDiQ6P3R8
PaxDbiQ6P3R8
PeptideAtlasiQ6P3R8
PRIDEiQ6P3R8
ProteomicsDBi66925

PTM databases

iPTMnetiQ6P3R8
PhosphoSitePlusiQ6P3R8

Expressioni

Gene expression databases

BgeeiENSG00000197168 Expressed in 126 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_NEK5
ExpressionAtlasiQ6P3R8 baseline and differential

Organism-specific databases

HPAiHPA035565
HPA041399

Interactioni

Protein-protein interaction databases

BioGridi131150, 1 interactor
IntActiQ6P3R8, 1 interactor
STRINGi9606.ENSP00000347767

Chemistry databases

BindingDBiQ6P3R8

Structurei

3D structure databases

ProteinModelPortaliQ6P3R8
SMRiQ6P3R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 259Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00760000118997
HOGENOMiHOG000113763
InParanoidiQ6P3R8
KOiK08857
OMAiWPAEYLQ
OrthoDBiEOG091G0GU4
PhylomeDBiQ6P3R8
TreeFamiTF106472

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6P3R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKYDVIKAI GQGAFGKAYL AKGKSDSKHC VIKEINFEKM PIQEKEASKK
60 70 80 90 100
EVILLEKMKH PNIVAFFNSF QENGRLFIVM EYCDGGDLMK RINRQRGVLF
110 120 130 140 150
SEDQILGWFV QISLGLKHIH DRKILHRDIK AQNIFLSKNG MVAKLGDFGI
160 170 180 190 200
ARVLNNSMEL ARTCIGTPYY LSPEICQNKP YNNKTDIWSL GCVLYELCTL
210 220 230 240 250
KHPFEGNNLQ QLVLKICQAH FAPISPGFSR ELHSLISQLF QVSPRDRPSI
260 270 280 290 300
NSILKRPFLE NLIPKYLTPE VIQEEFSHML ICRAGAPASR HAGKVVQKCK
310 320 330 340 350
IQKVRFQGKC PPRSRISVPI KRNAILHRNE WRPPAGAQKA RSIKMIERPK
360 370 380 390 400
IAAVCGHYDY YYAQLDMLRR RAHKPSYHPI PQENTGVEDY GQETRHGPSP
410 420 430 440 450
SQWPAEYLQR KFEAQQYKLK VEKQLGLRPS SAEPNYNQRQ ELRSNGEEPR
460 470 480 490 500
FQELPFRKNE MKEQEYWKQL EEIRQQYHND MKEIRKKMGR EPEENSKISH
510 520 530 540 550
KTYLVKKSNL PVHQDASEGE APVQMEFRSC CPGWSAMARS WLTATSASQD
560 570 580 590 600
IEKDLKQMRL QNTKESKNPE QKYKAKKGVK FEINLDKCIS DENILQEEEA
610 620 630 640 650
MDIPNETLTF EDGMKFKEYE CVKEHGDYTD KAFEKLHCPE AGFSTQTVAA
660 670 680 690 700
VGNRRQWDGG APQTLLQMMA VADITSTCPT GPDSESVLSV SRQEGKTKDP

YSPVLILM
Length:708
Mass (Da):81,445
Last modified:July 5, 2004 - v1
Checksum:iD9A5B3606414D128
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIX7E9PIX7_HUMAN
Serine/threonine-protein kinase Nek...
NEK5
295Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051652255K → Q. Corresponds to variant dbSNP:rs34756139Ensembl.1
Natural variantiVAR_040922290R → H1 Publication1
Natural variantiVAR_040923531C → R1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139082 Genomic DNA No translation available.
BC063885 mRNA Translation: AAH63885.1
CCDSiCCDS31979.1
RefSeqiNP_954983.1, NM_199289.2
UniGeneiHs.672144

Genome annotation databases

EnsembliENST00000355568; ENSP00000347767; ENSG00000197168
ENST00000617045; ENSP00000477810; ENSG00000197168
GeneIDi341676
KEGGihsa:341676
UCSCiuc001vge.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL139082 Genomic DNA No translation available.
BC063885 mRNA Translation: AAH63885.1
CCDSiCCDS31979.1
RefSeqiNP_954983.1, NM_199289.2
UniGeneiHs.672144

3D structure databases

ProteinModelPortaliQ6P3R8
SMRiQ6P3R8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131150, 1 interactor
IntActiQ6P3R8, 1 interactor
STRINGi9606.ENSP00000347767

Chemistry databases

BindingDBiQ6P3R8
ChEMBLiCHEMBL5044

PTM databases

iPTMnetiQ6P3R8
PhosphoSitePlusiQ6P3R8

Polymorphism and mutation databases

BioMutaiNEK5
DMDMi74758252

Proteomic databases

EPDiQ6P3R8
PaxDbiQ6P3R8
PeptideAtlasiQ6P3R8
PRIDEiQ6P3R8
ProteomicsDBi66925

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355568; ENSP00000347767; ENSG00000197168
ENST00000617045; ENSP00000477810; ENSG00000197168
GeneIDi341676
KEGGihsa:341676
UCSCiuc001vge.4 human

Organism-specific databases

CTDi341676
EuPathDBiHostDB:ENSG00000197168.11
GeneCardsiNEK5
HGNCiHGNC:7748 NEK5
HPAiHPA035565
HPA041399
neXtProtiNX_Q6P3R8
OpenTargetsiENSG00000197168
PharmGKBiPA31549
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0589 Eukaryota
ENOG410Y7JF LUCA
GeneTreeiENSGT00760000118997
HOGENOMiHOG000113763
InParanoidiQ6P3R8
KOiK08857
OMAiWPAEYLQ
OrthoDBiEOG091G0GU4
PhylomeDBiQ6P3R8
TreeFamiTF106472

Enzyme and pathway databases

SignaLinkiQ6P3R8

Miscellaneous databases

ChiTaRSiNEK5 human
GenomeRNAii341676
PROiPR:Q6P3R8

Gene expression databases

BgeeiENSG00000197168 Expressed in 126 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_NEK5
ExpressionAtlasiQ6P3R8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEK5_HUMAN
AccessioniPrimary (citable) accession number: Q6P3R8
Secondary accession number(s): Q5TAP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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