UniProtKB - Q6P3E7 (HDA10_MOUSE)
Protein
Polyamine deacetylase HDAC10
Gene
Hdac10
Organism
Mus musculus (Mouse)
Status
Functioni
Polyamine deacetylase (PDAC), which acts preferentially on N8-acetylspermidine, and also on acetylcadaverine and acetylputrescine. Exhibits attenuated catalytic activity toward N1,N8-diacetylspermidine and very low activity, if any, toward N1-acetylspermidine. Histone deacetylase activity has been observed in vitro. Has also been shown to be involved in MSH2 deacetylation. The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak. May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells. May play a role in homologous recombination. May promote DNA mismatch repair.By similarity
Caution
Protein/histone deacetylase activity in vivo is uncertain. The 3D structure analysis of the zebrafish ortholog shows that a glutamate gatekeeper and a sterically constricted active site confer specificity for N8-acetylspermidine hydrolysis and disfavour acetyllysine hydrolysis. Supporting this observation, has been shown to exhibit only very low activity, if any, towards acetyl-lysine peptide substrates. However, histone deacetylase activity has been observed in vitro and HDAC10 has also been shown to be involved in MSH2 deacetylation.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 135 | By similarity | 1 |
GO - Molecular functioni
- acetylputrescine deacetylase activity Source: UniProtKB-EC
- acetylspermidine deacetylase activity Source: UniProtKB-EC
- deacetylase activity Source: UniProtKB
- enzyme binding Source: MGI
- histone deacetylase activity Source: MGI
- histone deacetylase binding Source: MGI
- protein deacetylase activity Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- DNA repair Source: UniProtKB-KW
- histone deacetylation Source: MGI
- homologous recombination Source: UniProtKB
- macroautophagy Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- peptidyl-lysine deacetylation Source: UniProtKB
- polyamine deacetylation Source: UniProtKB
- positive regulation of mismatch repair Source: UniProtKB
- regulation of transcription, DNA-templated Source: MGI
- spermidine deacetylation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Biological process | Autophagy, DNA damage, DNA recombination, DNA repair |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-3214815, HDACs deacetylate histones R-MMU-350054, Notch-HLH transcription pathway |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Hdac10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2158340, Hdac10 |
Subcellular locationi
Nucleus
- histone deacetylase complex Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000114713 | 1 – 666 | Polyamine deacetylase HDAC10Add BLAST | 666 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6P3E7 |
MaxQBi | Q6P3E7 |
PaxDbi | Q6P3E7 |
PRIDEi | Q6P3E7 |
PTM databases
PhosphoSitePlusi | Q6P3E7 |
Expressioni
Tissue specificityi
widely expressed.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000062906, Expressed in pancreas and 190 other tissues |
ExpressionAtlasi | Q6P3E7, baseline and differential |
Genevisiblei | Q6P3E7, MM |
Interactioni
Subunit structurei
Interacts with HDAC3.
Interacts with HDAC2 and NCOR2/SMRT.
Interacts with HSPA8/HSC70.
Interacts with MSH2.
By similarityGO - Molecular functioni
- enzyme binding Source: MGI
- histone deacetylase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 228438, 6 interactors |
IntActi | Q6P3E7, 2 interactors |
STRINGi | 10090.ENSMUSP00000080832 |
Chemistry databases
BindingDBi | Q6P3E7 |
Miscellaneous databases
RNActi | Q6P3E7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 323 | Histone deacetylaseAdd BLAST | 323 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1343, Eukaryota |
GeneTreei | ENSGT00940000160061 |
InParanoidi | Q6P3E7 |
OrthoDBi | 1484694at2759 |
TreeFami | TF106173 |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PRINTSi | PR01270, HDASUPER |
SUPFAMi | SSF52768, SSF52768, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6P3E7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL
60 70 80 90 100
SACEASEEEL GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LQLVDAVLTG AVHNGLALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ YIFNDDPSVL YFSWHRYEHG
210 220 230 240 250
SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ
360 370 380 390 400
TPYWTSLQQN VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL
410 420 430 440 450
CLRPAPPICT AVASTVPGAA LCLPPGVLHQ EGSVLREETE AWARLHKSRF
460 470 480 490 500
QDEDLATLGK ILCLLDGIMD GQIRNAIATT TALATAATLD VLIQRCLARR
510 520 530 540 550
AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF HFSTPLPQTT
560 570 580 590 600
GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG
610 620 630 640 650
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA
660
RLEARWKLLQ VAAPPP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3Z7T4 | D3Z7T4_MOUSE | Polyamine deacetylase HDAC10 | Hdac10 | 470 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 91 | N → D in AAH64018 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113069 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL04375.1 BC064018 mRNA Translation: AAH64018.1 |
CCDSi | CCDS27739.1 |
RefSeqi | NP_954668.2, NM_199198.2 |
Genome annotation databases
Ensembli | ENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906 |
GeneIDi | 170787 |
KEGGi | mmu:170787 |
UCSCi | uc007xfj.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113069 Genomic DNA No translation available. CH466550 Genomic DNA Translation: EDL04375.1 BC064018 mRNA Translation: AAH64018.1 |
CCDSi | CCDS27739.1 |
RefSeqi | NP_954668.2, NM_199198.2 |
3D structure databases
SMRi | Q6P3E7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 228438, 6 interactors |
IntActi | Q6P3E7, 2 interactors |
STRINGi | 10090.ENSMUSP00000080832 |
Chemistry databases
BindingDBi | Q6P3E7 |
ChEMBLi | CHEMBL3832944 |
PTM databases
PhosphoSitePlusi | Q6P3E7 |
Proteomic databases
EPDi | Q6P3E7 |
MaxQBi | Q6P3E7 |
PaxDbi | Q6P3E7 |
PRIDEi | Q6P3E7 |
Protocols and materials databases
Antibodypediai | 14233, 469 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906 |
GeneIDi | 170787 |
KEGGi | mmu:170787 |
UCSCi | uc007xfj.2, mouse |
Organism-specific databases
CTDi | 83933 |
MGIi | MGI:2158340, Hdac10 |
Phylogenomic databases
eggNOGi | KOG1343, Eukaryota |
GeneTreei | ENSGT00940000160061 |
InParanoidi | Q6P3E7 |
OrthoDBi | 1484694at2759 |
TreeFami | TF106173 |
Enzyme and pathway databases
Reactomei | R-MMU-3214815, HDACs deacetylate histones R-MMU-350054, Notch-HLH transcription pathway |
Miscellaneous databases
BioGRID-ORCSi | 170787, 1 hit in 19 CRISPR screens |
ChiTaRSi | Hdac10, mouse |
PROi | PR:Q6P3E7 |
RNActi | Q6P3E7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062906, Expressed in pancreas and 190 other tissues |
ExpressionAtlasi | Q6P3E7, baseline and differential |
Genevisiblei | Q6P3E7, MM |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PRINTSi | PR01270, HDASUPER |
SUPFAMi | SSF52768, SSF52768, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HDA10_MOUSE | |
Accessioni | Q6P3E7Primary (citable) accession number: Q6P3E7 Secondary accession number(s): G3X9I8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families