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Protein

Histone deacetylase 10

Gene

Hdac10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei135By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 10 (EC:3.5.1.98)
Short name:
HD10
Gene namesi
Name:Hdac10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2158340 Hdac10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3832944

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001147131 – 666Histone deacetylase 10Add BLAST666

Proteomic databases

MaxQBiQ6P3E7
PaxDbiQ6P3E7
PRIDEiQ6P3E7

PTM databases

PhosphoSitePlusiQ6P3E7

Expressioni

Gene expression databases

BgeeiENSMUSG00000062906 Expressed in 166 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_HDAC10
ExpressionAtlasiQ6P3E7 baseline and differential
GenevisibleiQ6P3E7 MM

Interactioni

Subunit structurei

Interacts with HDAC2, HDAC3 and NCOR2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228438, 6 interactors
IntActiQ6P3E7, 2 interactors
STRINGi10090.ENSMUSP00000080832

Structurei

3D structure databases

ProteinModelPortaliQ6P3E7
SMRiQ6P3E7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 323Histone deacetylaseAdd BLAST323

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOGENOMiHOG000225183
HOVERGENiHBG051892
InParanoidiQ6P3E7
KOiK18671
OrthoDBiEOG091G0210
TreeFamiTF106173

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6P3E7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTALVYHED MTATRLLWDD PECEIECPER LTAALDGLRQ RGLEERCLCL
60 70 80 90 100
SACEASEEEL GLVHSPEYIA LVQKTQTLDK EELHALSKQY NAVYFHPDTF
110 120 130 140 150
HCARLAAGAA LQLVDAVLTG AVHNGLALVR PPGHHSQRAA ANGFCVFNNV
160 170 180 190 200
ALAAKHAKQK YGLQRILIVD WDVHHGQGIQ YIFNDDPSVL YFSWHRYEHG
210 220 230 240 250
SFWPFLPESD ADAVGQGQGQ GFTVNLPWNQ VGMGNADYLA AFLHVLLPLA
260 270 280 290 300
FEFDPELVLV SAGFDSAIGD PEGQMQATPE CFAHLTQLLQ VLAGGRICAV
310 320 330 340 350
LEGGYHLESL AQSVCMMVQT LLGDPTPPLL GLMVPCQSAL ESIQSVQTAQ
360 370 380 390 400
TPYWTSLQQN VAPVLSSSTH SPEERSLRLL GESPTCAVAE DSLSPLLDQL
410 420 430 440 450
CLRPAPPICT AVASTVPGAA LCLPPGVLHQ EGSVLREETE AWARLHKSRF
460 470 480 490 500
QDEDLATLGK ILCLLDGIMD GQIRNAIATT TALATAATLD VLIQRCLARR
510 520 530 540 550
AQRVLCVALG QLDRPLDLAD DGRILWLNIR GKDAAIQSMF HFSTPLPQTT
560 570 580 590 600
GGFLSLILGL VLPLAYGFQP DMVLMALGPA HGLQNAQAAL LAAMLRSPVG
610 620 630 640 650
GRILAVVEEE SIRLLARSLA QALHGETPPS LGPFSKATPE EIQALMFLKA
660
RLEARWKLLQ VAAPPP
Length:666
Mass (Da):72,109
Last modified:October 3, 2012 - v2
Checksum:i1F011B546D5D9A17
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z7T4D3Z7T4_MOUSE
Histone deacetylase
Hdac10
470Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91N → D in AAH64018 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113069 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04375.1
BC064018 mRNA Translation: AAH64018.1
CCDSiCCDS27739.1
RefSeqiNP_954668.2, NM_199198.2
UniGeneiMm.203954

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906
GeneIDi170787
KEGGimmu:170787
UCSCiuc007xfj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113069 Genomic DNA No translation available.
CH466550 Genomic DNA Translation: EDL04375.1
BC064018 mRNA Translation: AAH64018.1
CCDSiCCDS27739.1
RefSeqiNP_954668.2, NM_199198.2
UniGeneiMm.203954

3D structure databases

ProteinModelPortaliQ6P3E7
SMRiQ6P3E7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228438, 6 interactors
IntActiQ6P3E7, 2 interactors
STRINGi10090.ENSMUSP00000080832

Chemistry databases

ChEMBLiCHEMBL3832944

PTM databases

PhosphoSitePlusiQ6P3E7

Proteomic databases

MaxQBiQ6P3E7
PaxDbiQ6P3E7
PRIDEiQ6P3E7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082197; ENSMUSP00000080832; ENSMUSG00000062906
GeneIDi170787
KEGGimmu:170787
UCSCiuc007xfj.2 mouse

Organism-specific databases

CTDi83933
MGIiMGI:2158340 Hdac10

Phylogenomic databases

eggNOGiKOG1343 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00530000062809
HOGENOMiHOG000225183
HOVERGENiHBG051892
InParanoidiQ6P3E7
KOiK18671
OrthoDBiEOG091G0210
TreeFamiTF106173

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones

Miscellaneous databases

ChiTaRSiHdac10 mouse
PROiPR:Q6P3E7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062906 Expressed in 166 organ(s), highest expression level in mesenteric lymph node
CleanExiMM_HDAC10
ExpressionAtlasiQ6P3E7 baseline and differential
GenevisibleiQ6P3E7 MM

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiHDA10_MOUSE
AccessioniPrimary (citable) accession number: Q6P3E7
Secondary accession number(s): G3X9I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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