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Protein

ADP-ribosylation factor-like protein 11

Gene

Arl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. May act as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

  • GTP binding Source: GO_Central

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • intracellular protein transport Source: GO_Central
  • vesicle-mediated transport Source: GO_Central

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 11
Gene namesi
Name:Arl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2444054 Arl11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074802 – 176ADP-ribosylation factor-like protein 11Add BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

MaxQBiQ6P3A9
PaxDbiQ6P3A9
PRIDEiQ6P3A9

PTM databases

iPTMnetiQ6P3A9
PhosphoSitePlusiQ6P3A9

Expressioni

Gene expression databases

BgeeiENSMUSG00000043157 Expressed in 24 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_ARL11

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055447

Structurei

3D structure databases

ProteinModelPortaliQ6P3A9
SMRiQ6P3A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ6P3A9
KOiK07959
OMAiWELRACS
OrthoDBiEOG091G0O0X
PhylomeDBiQ6P3A9
TreeFamiTF105471

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P3A9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSVNSRGHK AEAQVVMMGL DSAGKTTILY KLKGNQLVDT LPTVGFNVEP
60 70 80 90 100
LEAPGHVSLT LWDIGGQTQL RATWKDYLEG IDLLVYVLDS TDEARLPEAV
110 120 130 140 150
AELKEVLEDP NMAGVPFLVL ANKQEAPGAL PLLEIRNRLG LEGFQKHCWE
160 170
LRACSALTGQ GLQEALQSLL HLLKSR
Length:176
Mass (Da):19,212
Last modified:July 5, 2004 - v1
Checksum:i11D8E6C970E81C60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60T → S in BAC34053 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008804 mRNA Translation: BAE43212.1
AK050053 mRNA Translation: BAC34053.1
BC064093 mRNA Translation: AAH64093.1
CCDSiCCDS27182.1
RefSeqiNP_796311.2, NM_177337.3
XP_011243330.1, XM_011245028.1
UniGeneiMm.206566

Genome annotation databases

EnsembliENSMUST00000055159; ENSMUSP00000055447; ENSMUSG00000043157
ENSMUST00000224727; ENSMUSP00000153531; ENSMUSG00000043157
GeneIDi219144
KEGGimmu:219144
UCSCiuc007ufu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008804 mRNA Translation: BAE43212.1
AK050053 mRNA Translation: BAC34053.1
BC064093 mRNA Translation: AAH64093.1
CCDSiCCDS27182.1
RefSeqiNP_796311.2, NM_177337.3
XP_011243330.1, XM_011245028.1
UniGeneiMm.206566

3D structure databases

ProteinModelPortaliQ6P3A9
SMRiQ6P3A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000055447

PTM databases

iPTMnetiQ6P3A9
PhosphoSitePlusiQ6P3A9

Proteomic databases

MaxQBiQ6P3A9
PaxDbiQ6P3A9
PRIDEiQ6P3A9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055159; ENSMUSP00000055447; ENSMUSG00000043157
ENSMUST00000224727; ENSMUSP00000153531; ENSMUSG00000043157
GeneIDi219144
KEGGimmu:219144
UCSCiuc007ufu.1 mouse

Organism-specific databases

CTDi115761
MGIiMGI:2444054 Arl11

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00930000150892
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ6P3A9
KOiK07959
OMAiWELRACS
OrthoDBiEOG091G0O0X
PhylomeDBiQ6P3A9
TreeFamiTF105471

Miscellaneous databases

ChiTaRSiArl11 mouse
PROiPR:Q6P3A9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043157 Expressed in 24 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_ARL11

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARL11_MOUSE
AccessioniPrimary (citable) accession number: Q6P3A9
Secondary accession number(s): Q8C7K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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