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UniProtKB - Q6P2S7 (TTC41_HUMAN)

Entry version 99 (18 Sep 2019)
Sequence version 3 (01 Jul 2008)
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Protein

Putative tetratricopeptide repeat protein 41

Gene

TTC41P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein uncertaini <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Could be the product of a pseudogene.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative tetratricopeptide repeat protein 41By similarity
Short name:
TPR repeat protein 41By similarity
Alternative name(s):
Grp94-neighboring nucleotidaseBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC41PCurated
Synonyms:GNNBy similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:49210 TTC41P

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P2S7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		253724

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P2S7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HGNC:49210

Domain mapping of disease mutations (DMDM)

More...DMDMi		193806376

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003259401 – 1318Putative tetratricopeptide repeat protein 41Add BLAST1318

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P2S7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P2S7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P2S7

PRoteomics IDEntifications database

More...PRIDEi		Q6P2S7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66919 [Q6P2S7-1]
66920 [Q6P2S7-2]
66921 [Q6P2S7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P2S7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P2S7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q6P2S7, 2 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P2S7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati399 – 432TPR 1Add BLAST34
Repeati653 – 684TPR 2Add BLAST32
Repeati817 – 850TPR 3Add BLAST34
Repeati858 – 891TPR 4Add BLAST34
Repeati991 – 1027TPR 5Add BLAST37
Repeati1045 – 1082TPR 6Add BLAST38

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P2S7

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P2S7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025139 DUF4062
IPR027417 P-loop_NTPase
IPR011990 TPR-like_helical_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13271 DUF4062, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P2S7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQKTNENVE RYTQFLQKPQ KPIQPYICST LNDFQEERDF LANNIFPQLN 
        60         70         80         90        100
ELCNSWGTYF KAVDLSWSAL KAPKSLPTHL FRQYSCLRSQ RLKLCLDYVN 
       110        120        130        140        150
SCFPFFICML GQTYGDFLPD YSHFMTSKVT RLSSLSKVEN LYVAAKNGYP 
       160        170        180        190        200
WVLENPSCSL TEFEIIQAAF LNESQFQYFY FRTGTTLLKA LDDEKKGERL 
       210        220        230        240        250
PSSSSTNEEE TLRIGKLKAK IISKGLPVRF YSDLHELGEL VFKDWSVVIE 
       260        270        280        290        300
KLHPATLMIE NIDYKHSFER FYHEEFTEKC KQMCVISKES DRTFEILEKF 
       310        320        330        340        350
ALKDVELDFN NVAADSSLDS VPRFFRINPT PTYKSILLLS REHGCGKSTL 
       360        370        380        390        400
IANWVNYFKK KHPSMLLIPH FVGSTCESSY IMSVIHYFIT ELQYRNYGTQ 
       410        420        430        440        450
LETDILNEDS DGLVFSFLVE VFIASISLKP CILVLDGIEE LIGIYGISGQ 
       460        470        480        490        500
KVKDFSWLPH SLSPHCKFIM STVSSSLSYK SLCARPDVRT VELISTGDEE 
       510        520        530        540        550
TKLNIFRKHL SIPMMDPFEQ STQALRKKPD LSPLKLTILA NELKEYRINH 
       560        570        580        590        600
NEFQCMKEYL EAVSVQELWE LVLKRWIEDY SWTFQPKRAN SDTVASGEGL 
       610        620        630        640        650
DSWVADALCL LCLSHGGLAE DELLQLLDML GYRNHYKVTA LHWAAFRNAT 
       660        670        680        690        700
KQWVQEKPNG LLYFWHQSLS AVEHKLLGVI TPVESSPCSF QTPMNHKKTH 
       710        720        730        740        750
FHQVLIRYFQ RQTSFWRVYQ ELPWHMKMSG CLRGLCGFLS SPTITDFISK 
       760        770        780        790        800
IQSLGFWTRL HLIHFWNVLL EAGYDVSEAY LLSVAKIKAD QCHTMRKSGT 
       810        820        830        840        850
LSVLQCRLIE LTVLDKCRLM FFIGSFLKFM GKTNEAEELF LSVEDMLVQS 
       860        870        880        890        900
QSMTDMLLKV QNAIGELYLE TGMTQEGFQY FQKAWSSMLR LSLSDLEDSR 
       910        920        930        940        950
DLVKQKVRVL DNLAKSASEE YLKENHILEY ATEISNLLDN NPRDQATMKY 
       960        970        980        990       1000
IEGVLMFVAG NTSLAKMKLR ECLNIRKSLF GKKNMLVGEV MEFLADLLFF 
      1010       1020       1030       1040       1050
PQRDSKKSQR KQVLKYYKQV IKIKENAETL AKSSLLRKQL SISLSDTLCK 
      1060       1070       1080       1090       1100
LAGHLLASDS CHHVMIEAVG YLYRSVDLRV IHLGSSHSSI HGIHGILHLL 
      1110       1120       1130       1140       1150
REIEWIRSRR YWPQGMSQQH SEGSRNGFSL WEHLVKLNYH SAQSSNTVSS 
      1160       1170       1180       1190       1200
AMCMNADKLH RARRMDLAPQ TISDKSKCAP GKGKKKPIIC ISAEEKIQRK 
      1210       1220       1230       1240       1250
TQNNAEIWNG SGKEASKKKT DYSSNILSLG KMNGLIKLSR QRILLAKSES 
      1260       1270       1280       1290       1300
GEGEITTIYH HPLPWPVSTK NPGESEFISE KWLFHSPDYI SISQKSFLQR 
      1310 
RLHIETKLLK TSNDINKE
Length:1,318
Mass (Da):151,684
Last modified:July 1, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i846F27FF035FEAC5
GO
Isoform 2 (identifier: Q6P2S7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1053-1053: G → F
     1054-1318: Missing.

Note: No experimental confirmation available.
Show »
Length:1,053
Mass (Da):121,665
Checksum:i4E5B662EA2790501
GO
Isoform 3 (identifier: Q6P2S7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     140-1318: Missing.

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):16,321
Checksum:iAEF044EA3BD8A091
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034494140 – 1318Missing in isoform 3. 1 PublicationAdd BLAST1179
Alternative sequenceiVSP_0344951053G → F in isoform 2. 1 Publication1
Alternative sequenceiVSP_0344961054 – 1318Missing in isoform 2. 1 PublicationAdd BLAST265

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC012386 Genomic DNA No translation available.
AC012555 Genomic DNA No translation available.
AC084199 Genomic DNA No translation available.
BC016335 mRNA No translation available.
BC064342 mRNA No translation available.

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012386 Genomic DNA No translation available.
AC012555 Genomic DNA No translation available.
AC084199 Genomic DNA No translation available.
BC016335 mRNA No translation available.
BC064342 mRNA No translation available.

3D structure databases

SMRiQ6P2S7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6P2S7, 2 interactors

PTM databases

iPTMnetiQ6P2S7
PhosphoSitePlusiQ6P2S7

Polymorphism and mutation databases

BioMutaiHGNC:49210
DMDMi193806376

Proteomic databases

EPDiQ6P2S7
jPOSTiQ6P2S7
MassIVEiQ6P2S7
PRIDEiQ6P2S7
ProteomicsDBi66919 [Q6P2S7-1]
66920 [Q6P2S7-2]
66921 [Q6P2S7-3]

Organism-specific databases

DisGeNETi253724

GeneCards: human genes, protein and diseases

More...GeneCardsi		TTC41P
HGNCiHGNC:49210 TTC41P
neXtProtiNX_Q6P2S7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

InParanoidiQ6P2S7
PhylomeDBiQ6P2S7

Miscellaneous databases

PharosiQ6P2S7

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR025139 DUF4062
IPR027417 P-loop_NTPase
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF13271 DUF4062, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC41_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2S7
Secondary accession number(s): Q05DD4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 1, 2008
Last modified: September 18, 2019
This is version 99 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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