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Protein

Calcium/calmodulin-dependent protein kinase type 1B

Gene

PNCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Activated by Ca2+/calmodulin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44ATPPROSITE-ProRule annotation1
Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi21 – 29ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calmodulin binding Source: GO_Central
  • calmodulin-dependent protein kinase activity Source: GO_Central

Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ6P2M8
SIGNORiQ6P2M8

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type 1B (EC:2.7.11.17)
Alternative name(s):
CaM kinase I beta
Short name:
CaM kinase IB
Short name:
CaM-KI beta
Short name:
CaMKI-beta
Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
Gene namesi
Name:PNCK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000130822.15
HGNCiHGNC:13415 PNCK
MIMi300680 gene
neXtProtiNX_Q6P2M8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi139728
OpenTargetsiENSG00000130822
PharmGKBiPA134988711

Chemistry databases

ChEMBLiCHEMBL3627592

Polymorphism and mutation databases

BioMutaiPNCK
DMDMi67466915

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860791 – 343Calcium/calmodulin-dependent protein kinase type 1BAdd BLAST343

Post-translational modificationi

Phosphorylated by CAMKK1.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P2M8
PeptideAtlasiQ6P2M8
PRIDEiQ6P2M8
ProteomicsDBi66908
66909 [Q6P2M8-2]
66910 [Q6P2M8-3]
66911 [Q6P2M8-5]
66912 [Q6P2M8-6]

PTM databases

iPTMnetiQ6P2M8
PhosphoSitePlusiQ6P2M8

Expressioni

Gene expression databases

BgeeiENSG00000130822 Expressed in 122 organ(s), highest expression level in lower esophagus
CleanExiHS_PNCK
ExpressionAtlasiQ6P2M8 baseline and differential
GenevisibleiQ6P2M8 HS

Organism-specific databases

HPAiHPA007458

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126582, 1 interactor
STRINGi9606.ENSP00000405950

Chemistry databases

BindingDBiQ6P2M8

Structurei

3D structure databases

ProteinModelPortaliQ6P2M8
SMRiQ6P2M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 270Protein kinasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 311Calmodulin-bindingBy similarityAdd BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ6P2M8
KOiK08795
OMAiGDAAFDK
OrthoDBiEOG091G0HK9
PhylomeDBiQ6P2M8
TreeFamiTF314166

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA
60 70 80 90 100
LRGKEALVEN EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD
110 120 130 140 150
RIMERGSYTE KDASHLVGQV LGAVSYLHSL GIVHRDLKPE NLLYATPFED
160 170 180 190 200
SKIMVSDFGL SKIQAGNMLG TACGTPGYVA PELLEQKPYG KAVDVWALGV
210 220 230 240 250
ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS ESAKDFIRHL
260 270 280 290 300
LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA
310 320 330 340
FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW
Note: Gene prediction based on similarity to mouse ortholog.
Length:343
Mass (Da):38,500
Last modified:February 1, 2005 - v2
Checksum:iE954AEE89DE608C9
GO
Isoform 2 (identifier: Q6P2M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: V → AEPVTLSGMAACVPVRASVCLWPP

Show »
Length:366
Mass (Da):40,838
Checksum:iF9F61FA92579FDE9
GO
Isoform 3 (identifier: Q6P2M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:241
Mass (Da):27,161
Checksum:i6AA7E6AFE0CEB409
GO
Isoform 4 (identifier: Q6P2M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEAAFGQVAG...RIPAIALQDM

Show »
Length:426
Mass (Da):46,957
Checksum:iA2958437908C9C67
GO
Isoform 5 (identifier: Q6P2M8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWRRVCGGLAGRRPSGDM

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):40,356
Checksum:iD27E099934F3A64A
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB09C9JB09_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
224Annotation score:
C9JJ18C9JJ18_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
226Annotation score:
C9JEC5C9JEC5_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
86Annotation score:
C9J8P0C9J8P0_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
94Annotation score:
F8WAQ5F8WAQ5_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
99Annotation score:
H7BZQ5H7BZQ5_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
81Annotation score:
F8WBU7F8WBU7_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
82Annotation score:
C9J2B9C9J2B9_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
42Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127L → P in BAG58930 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040598262Q → H1 PublicationCorresponds to variant dbSNP:rs56060609Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0126341 – 102Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_0390911M → MEAAFGQVAGSACPRRGGEG RDWKAESLADLWPKSSPGDS HRWCKGPGAGPAGPQLREAA RASSGLGGGGRHPSRIPAIA LQDM in isoform 4. 1 Publication1
Alternative sequenceiVSP_0433731M → MWRRVCGGLAGRRPSGDM in isoform 5. 1 Publication1
Alternative sequenceiVSP_012635179V → AEPVTLSGMAACVPVRASVC LWPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296203 mRNA Translation: BAG58930.1
AK303746 mRNA Translation: BAG64718.1
CR611192 mRNA No translation available.
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72838.1
CH471172 Genomic DNA Translation: EAW72839.1
CH471172 Genomic DNA Translation: EAW72841.1
CH471172 Genomic DNA Translation: EAW72842.1
CH471172 Genomic DNA Translation: EAW72843.1
CH471172 Genomic DNA Translation: EAW72845.1
BC064422 mRNA Translation: AAH64422.1
CCDSiCCDS35503.2 [Q6P2M8-5]
CCDS48189.1 [Q6P2M8-6]
RefSeqiNP_001034671.3, NM_001039582.3 [Q6P2M8-5]
NP_001129212.1, NM_001135740.1 [Q6P2M8-6]
XP_005274708.1, XM_005274651.2 [Q6P2M8-1]
XP_006724872.1, XM_006724809.3 [Q6P2M8-1]
XP_011529409.2, XM_011531107.2 [Q6P2M8-1]
XP_011529412.1, XM_011531110.2 [Q6P2M8-1]
XP_011529413.1, XM_011531111.2 [Q6P2M8-1]
XP_011529414.1, XM_011531112.2 [Q6P2M8-1]
XP_016884766.1, XM_017029277.1
XP_016884767.1, XM_017029278.1
XP_016884768.1, XM_017029279.1 [Q6P2M8-1]
UniGeneiHs.436667

Genome annotation databases

EnsembliENST00000340888; ENSP00000340586; ENSG00000130822 [Q6P2M8-1]
ENST00000370142; ENSP00000359161; ENSG00000130822 [Q6P2M8-2]
ENST00000370145; ENSP00000359164; ENSG00000130822 [Q6P2M8-6]
ENST00000370150; ENSP00000359169; ENSG00000130822 [Q6P2M8-1]
ENST00000447676; ENSP00000405950; ENSG00000130822 [Q6P2M8-5]
GeneIDi139728
KEGGihsa:139728
UCSCiuc011myt.3 human [Q6P2M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296203 mRNA Translation: BAG58930.1
AK303746 mRNA Translation: BAG64718.1
CR611192 mRNA No translation available.
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72838.1
CH471172 Genomic DNA Translation: EAW72839.1
CH471172 Genomic DNA Translation: EAW72841.1
CH471172 Genomic DNA Translation: EAW72842.1
CH471172 Genomic DNA Translation: EAW72843.1
CH471172 Genomic DNA Translation: EAW72845.1
BC064422 mRNA Translation: AAH64422.1
CCDSiCCDS35503.2 [Q6P2M8-5]
CCDS48189.1 [Q6P2M8-6]
RefSeqiNP_001034671.3, NM_001039582.3 [Q6P2M8-5]
NP_001129212.1, NM_001135740.1 [Q6P2M8-6]
XP_005274708.1, XM_005274651.2 [Q6P2M8-1]
XP_006724872.1, XM_006724809.3 [Q6P2M8-1]
XP_011529409.2, XM_011531107.2 [Q6P2M8-1]
XP_011529412.1, XM_011531110.2 [Q6P2M8-1]
XP_011529413.1, XM_011531111.2 [Q6P2M8-1]
XP_011529414.1, XM_011531112.2 [Q6P2M8-1]
XP_016884766.1, XM_017029277.1
XP_016884767.1, XM_017029278.1
XP_016884768.1, XM_017029279.1 [Q6P2M8-1]
UniGeneiHs.436667

3D structure databases

ProteinModelPortaliQ6P2M8
SMRiQ6P2M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126582, 1 interactor
STRINGi9606.ENSP00000405950

Chemistry databases

BindingDBiQ6P2M8
ChEMBLiCHEMBL3627592

PTM databases

iPTMnetiQ6P2M8
PhosphoSitePlusiQ6P2M8

Polymorphism and mutation databases

BioMutaiPNCK
DMDMi67466915

Proteomic databases

PaxDbiQ6P2M8
PeptideAtlasiQ6P2M8
PRIDEiQ6P2M8
ProteomicsDBi66908
66909 [Q6P2M8-2]
66910 [Q6P2M8-3]
66911 [Q6P2M8-5]
66912 [Q6P2M8-6]

Protocols and materials databases

DNASUi139728
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340888; ENSP00000340586; ENSG00000130822 [Q6P2M8-1]
ENST00000370142; ENSP00000359161; ENSG00000130822 [Q6P2M8-2]
ENST00000370145; ENSP00000359164; ENSG00000130822 [Q6P2M8-6]
ENST00000370150; ENSP00000359169; ENSG00000130822 [Q6P2M8-1]
ENST00000447676; ENSP00000405950; ENSG00000130822 [Q6P2M8-5]
GeneIDi139728
KEGGihsa:139728
UCSCiuc011myt.3 human [Q6P2M8-1]

Organism-specific databases

CTDi139728
DisGeNETi139728
EuPathDBiHostDB:ENSG00000130822.15
GeneCardsiPNCK
HGNCiHGNC:13415 PNCK
HPAiHPA007458
MIMi300680 gene
neXtProtiNX_Q6P2M8
OpenTargetsiENSG00000130822
PharmGKBiPA134988711
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00760000118944
HOGENOMiHOG000233016
HOVERGENiHBG108055
InParanoidiQ6P2M8
KOiK08795
OMAiGDAAFDK
OrthoDBiEOG091G0HK9
PhylomeDBiQ6P2M8
TreeFamiTF314166

Enzyme and pathway databases

SignaLinkiQ6P2M8
SIGNORiQ6P2M8

Miscellaneous databases

ChiTaRSiPNCK human
GenomeRNAii139728
PROiPR:Q6P2M8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130822 Expressed in 122 organ(s), highest expression level in lower esophagus
CleanExiHS_PNCK
ExpressionAtlasiQ6P2M8 baseline and differential
GenevisibleiQ6P2M8 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCC1B_HUMAN
AccessioniPrimary (citable) accession number: Q6P2M8
Secondary accession number(s): B4DJR8
, B4E1A6, B7WPG0, D3DWU7, Q8N4R0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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