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Entry version 143 (16 Oct 2019)
Sequence version 2 (01 Feb 2005)
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Protein

Calcium/calmodulin-dependent protein kinase type 1B

Gene

PNCK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by Ca2+/calmodulin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei44ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei136Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi21 – 29ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Calcium, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6P2M8

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6P2M8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase type 1B (EC:2.7.11.17)
Alternative name(s):
CaM kinase I beta
Short name:
CaM kinase IB
Short name:
CaM-KI beta
Short name:
CaMKI-beta
Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PNCK
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:13415 PNCK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P2M8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
139728

Open Targets

More...
OpenTargetsi
ENSG00000130822

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988711

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P2M8

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3627592

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PNCK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67466915

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860791 – 343Calcium/calmodulin-dependent protein kinase type 1BAdd BLAST343

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by CAMKK1.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P2M8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6P2M8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P2M8

PeptideAtlas

More...
PeptideAtlasi
Q6P2M8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P2M8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66908 [Q6P2M8-1]
66909 [Q6P2M8-2]
66910 [Q6P2M8-3]
66911 [Q6P2M8-5]
66912 [Q6P2M8-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P2M8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P2M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000130822 Expressed in 122 organ(s), highest expression level in lower esophagus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6P2M8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6P2M8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007458

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
126582, 1 interactor

Protein interaction database and analysis system

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IntActi
Q6P2M8, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000405950

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6P2M8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P2M8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 270Protein kinasePROSITE-ProRule annotationAdd BLAST256

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni290 – 311Calmodulin-bindingBy similarityAdd BLAST22

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0032 Eukaryota
ENOG410XRMJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162187

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000233016

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6P2M8

KEGG Orthology (KO)

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KOi
K08795

Identification of Orthologs from Complete Genome Data

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OMAi
MTRHSHP

Database of Orthologous Groups

More...
OrthoDBi
330091at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P2M8

TreeFam database of animal gene trees

More...
TreeFami
TF314166

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14169 STKc_CaMKI_beta, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042696 CaMKI_beta_STKc
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P2M8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLLKKHTED ISSVYEIRER LGSGAFSEVV LAQERGSAHL VALKCIPKKA
60 70 80 90 100
LRGKEALVEN EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD
110 120 130 140 150
RIMERGSYTE KDASHLVGQV LGAVSYLHSL GIVHRDLKPE NLLYATPFED
160 170 180 190 200
SKIMVSDFGL SKIQAGNMLG TACGTPGYVA PELLEQKPYG KAVDVWALGV
210 220 230 240 250
ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS ESAKDFIRHL
260 270 280 290 300
LERDPQKRFT CQQALRHLWI SGDTAFDRDI LGSVSEQIRK NFARTHWKRA
310 320 330 340
FNATSFLRHI RKLGQIPEGE GASEQGMARH SHSGLRAGQP PKW
Note: Gene prediction based on similarity to mouse ortholog.
Length:343
Mass (Da):38,500
Last modified:February 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE954AEE89DE608C9
GO
Isoform 2 (identifier: Q6P2M8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: V → AEPVTLSGMAACVPVRASVCLWPP

Show »
Length:366
Mass (Da):40,838
Checksum:iF9F61FA92579FDE9
GO
Isoform 3 (identifier: Q6P2M8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.

Show »
Length:241
Mass (Da):27,161
Checksum:i6AA7E6AFE0CEB409
GO
Isoform 4 (identifier: Q6P2M8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEAAFGQVAG...RIPAIALQDM

Show »
Length:426
Mass (Da):46,957
Checksum:iA2958437908C9C67
GO
Isoform 5 (identifier: Q6P2M8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWRRVCGGLAGRRPSGDM

Note: No experimental confirmation available.
Show »
Length:360
Mass (Da):40,356
Checksum:iD27E099934F3A64A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JB09C9JB09_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
224Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JJ18C9JJ18_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J8P0C9J8P0_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JEC5C9JEC5_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAQ5F8WAQ5_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBU7F8WBU7_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2B9C9J2B9_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZQ5H7BZQ5_HUMAN
Calcium/calmodulin-dependent protei...
PNCK
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127L → P in BAG58930 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040598262Q → H1 PublicationCorresponds to variant dbSNP:rs56060609Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0126341 – 102Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_0390911M → MEAAFGQVAGSACPRRGGEG RDWKAESLADLWPKSSPGDS HRWCKGPGAGPAGPQLREAA RASSGLGGGGRHPSRIPAIA LQDM in isoform 4. 1 Publication1
Alternative sequenceiVSP_0433731M → MWRRVCGGLAGRRPSGDM in isoform 5. 1 Publication1
Alternative sequenceiVSP_012635179V → AEPVTLSGMAACVPVRASVC LWPP in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK296203 mRNA Translation: BAG58930.1
AK303746 mRNA Translation: BAG64718.1
CR611192 mRNA No translation available.
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72838.1
CH471172 Genomic DNA Translation: EAW72839.1
CH471172 Genomic DNA Translation: EAW72841.1
CH471172 Genomic DNA Translation: EAW72842.1
CH471172 Genomic DNA Translation: EAW72843.1
CH471172 Genomic DNA Translation: EAW72845.1
BC064422 mRNA Translation: AAH64422.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS35503.2 [Q6P2M8-5]
CCDS48189.1 [Q6P2M8-6]

NCBI Reference Sequences

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RefSeqi
NP_001034671.3, NM_001039582.3 [Q6P2M8-5]
NP_001129212.1, NM_001135740.1 [Q6P2M8-6]
XP_005274708.1, XM_005274651.2
XP_006724872.1, XM_006724809.3 [Q6P2M8-1]
XP_011529409.2, XM_011531107.2 [Q6P2M8-1]
XP_011529412.1, XM_011531110.2
XP_011529413.1, XM_011531111.2 [Q6P2M8-1]
XP_011529414.1, XM_011531112.2 [Q6P2M8-1]
XP_016884766.1, XM_017029277.1
XP_016884767.1, XM_017029278.1
XP_016884768.1, XM_017029279.1 [Q6P2M8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000340888; ENSP00000340586; ENSG00000130822 [Q6P2M8-1]
ENST00000370142; ENSP00000359161; ENSG00000130822 [Q6P2M8-2]
ENST00000370145; ENSP00000359164; ENSG00000130822 [Q6P2M8-6]
ENST00000370150; ENSP00000359169; ENSG00000130822 [Q6P2M8-1]
ENST00000447676; ENSP00000405950; ENSG00000130822 [Q6P2M8-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
139728

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:139728

UCSC genome browser

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UCSCi
uc011myt.3 human [Q6P2M8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296203 mRNA Translation: BAG58930.1
AK303746 mRNA Translation: BAG64718.1
CR611192 mRNA No translation available.
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72838.1
CH471172 Genomic DNA Translation: EAW72839.1
CH471172 Genomic DNA Translation: EAW72841.1
CH471172 Genomic DNA Translation: EAW72842.1
CH471172 Genomic DNA Translation: EAW72843.1
CH471172 Genomic DNA Translation: EAW72845.1
BC064422 mRNA Translation: AAH64422.1
CCDSiCCDS35503.2 [Q6P2M8-5]
CCDS48189.1 [Q6P2M8-6]
RefSeqiNP_001034671.3, NM_001039582.3 [Q6P2M8-5]
NP_001129212.1, NM_001135740.1 [Q6P2M8-6]
XP_005274708.1, XM_005274651.2
XP_006724872.1, XM_006724809.3 [Q6P2M8-1]
XP_011529409.2, XM_011531107.2 [Q6P2M8-1]
XP_011529412.1, XM_011531110.2
XP_011529413.1, XM_011531111.2 [Q6P2M8-1]
XP_011529414.1, XM_011531112.2 [Q6P2M8-1]
XP_016884766.1, XM_017029277.1
XP_016884767.1, XM_017029278.1
XP_016884768.1, XM_017029279.1 [Q6P2M8-1]

3D structure databases

SMRiQ6P2M8
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126582, 1 interactor
IntActiQ6P2M8, 1 interactor
STRINGi9606.ENSP00000405950

Chemistry databases

BindingDBiQ6P2M8
ChEMBLiCHEMBL3627592

PTM databases

iPTMnetiQ6P2M8
PhosphoSitePlusiQ6P2M8

Polymorphism and mutation databases

BioMutaiPNCK
DMDMi67466915

Proteomic databases

jPOSTiQ6P2M8
MassIVEiQ6P2M8
PaxDbiQ6P2M8
PeptideAtlasiQ6P2M8
PRIDEiQ6P2M8
ProteomicsDBi66908 [Q6P2M8-1]
66909 [Q6P2M8-2]
66910 [Q6P2M8-3]
66911 [Q6P2M8-5]
66912 [Q6P2M8-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
139728

Genome annotation databases

EnsembliENST00000340888; ENSP00000340586; ENSG00000130822 [Q6P2M8-1]
ENST00000370142; ENSP00000359161; ENSG00000130822 [Q6P2M8-2]
ENST00000370145; ENSP00000359164; ENSG00000130822 [Q6P2M8-6]
ENST00000370150; ENSP00000359169; ENSG00000130822 [Q6P2M8-1]
ENST00000447676; ENSP00000405950; ENSG00000130822 [Q6P2M8-5]
GeneIDi139728
KEGGihsa:139728
UCSCiuc011myt.3 human [Q6P2M8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
139728
DisGeNETi139728

GeneCards: human genes, protein and diseases

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GeneCardsi
PNCK
HGNCiHGNC:13415 PNCK
HPAiHPA007458
MIMi300680 gene
neXtProtiNX_Q6P2M8
OpenTargetsiENSG00000130822
PharmGKBiPA134988711

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0032 Eukaryota
ENOG410XRMJ LUCA
GeneTreeiENSGT00940000162187
HOGENOMiHOG000233016
InParanoidiQ6P2M8
KOiK08795
OMAiMTRHSHP
OrthoDBi330091at2759
PhylomeDBiQ6P2M8
TreeFamiTF314166

Enzyme and pathway databases

SignaLinkiQ6P2M8
SIGNORiQ6P2M8

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PNCK human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
139728
PharosiQ6P2M8

Protein Ontology

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PROi
PR:Q6P2M8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000130822 Expressed in 122 organ(s), highest expression level in lower esophagus
ExpressionAtlasiQ6P2M8 baseline and differential
GenevisibleiQ6P2M8 HS

Family and domain databases

CDDicd14169 STKc_CaMKI_beta, 1 hit
InterProiView protein in InterPro
IPR042696 CaMKI_beta_STKc
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCC1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2M8
Secondary accession number(s): B4DJR8
, B4E1A6, B7WPG0, D3DWU7, Q8N4R0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: February 1, 2005
Last modified: October 16, 2019
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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