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Entry version 139 (07 Oct 2020)
Sequence version 2 (31 Oct 2006)
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Protein

Histone-lysine N-methyltransferase NSD3

Gene

Nsd3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri701 – 748PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri749 – 805PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri862 – 955PHD-type 3PROSITE-ProRule annotationAdd BLAST94
Zinc fingeri1323 – 1370PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-3214841, PKMTs methylate histone lysines

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferase NSD3 (EC:2.1.1.-By similarity)
Alternative name(s):
Nuclear SET domain-containing protein 3
Wolf-Hirschhorn syndrome candidate 1-like protein 1 homolog
Short name:
WHSC1-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nsd3
Synonyms:Whsc1l1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2142581, Nsd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595221 – 1439Histone-lysine N-methyltransferase NSD3Add BLAST1439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei150PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei457PhosphoserineBy similarity1
Cross-linki502Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki532Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei585PhosphoserineBy similarity1
Modified residuei587PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Cross-linki628Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei655PhosphoserineBy similarity1
Modified residuei790N6-acetyllysineCombined sources1
Cross-linki1154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P2L6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P2L6

PeptideAtlas

More...
PeptideAtlasi
Q6P2L6

PRoteomics IDEntifications database

More...
PRIDEi
Q6P2L6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P2L6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P2L6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000054823, Expressed in bone marrow and 267 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P2L6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P2L6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BRD4.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
231497, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6P2L6, 2 interactors

Molecular INTeraction database

More...
MINTi
Q6P2L6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000115470

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P2L6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P2L6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini270 – 333PWWP 1PROSITE-ProRule annotationAdd BLAST64
Domaini960 – 1025PWWP 2PROSITE-ProRule annotationAdd BLAST66
Domaini1096 – 1146AWSPROSITE-ProRule annotationAdd BLAST51
Domaini1148 – 1265SETPROSITE-ProRule annotationAdd BLAST118
Domaini1272 – 1288Post-SETPROSITE-ProRule annotationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1036 – 1065Sequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri701 – 748PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri749 – 805PHD-type 2PROSITE-ProRule annotationAdd BLAST57
Zinc fingeri862 – 955PHD-type 3PROSITE-ProRule annotationAdd BLAST94
Zinc fingeri1323 – 1370PHD-type 4; atypicalPROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1081, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155355

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_488831_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P2L6

KEGG Orthology (KO)

More...
KOi
K11425

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006560, AWS_dom
IPR041306, C5HCH
IPR003616, Post-SET_dom
IPR000313, PWWP_dom
IPR001214, SET_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17907, AWS, 1 hit
PF17982, C5HCH, 1 hit
PF00855, PWWP, 2 hits
PF00856, SET, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00570, AWS, 1 hit
SM00249, PHD, 5 hits
SM00508, PostSET, 1 hit
SM00293, PWWP, 2 hits
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57903, SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51215, AWS, 1 hit
PS50868, POST_SET, 1 hit
PS50812, PWWP, 2 hits
PS50280, SET, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P2L6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFSFSFMQG IMGNTIQQPP QLIDSANIRQ EDAFDNHSDI VEDGGPTPFE
60 70 80 90 100
ATLQQGFQYP PTTEDLPPLT NGYPPSISLY ETQTKYPPYN QYPNGSANGF
110 120 130 140 150
GAVRNFSPTD YYHSEIPNTR PHEILEKPSP PQPPPPPSVP QTVIPKKTGS
160 170 180 190 200
PEIKLKITKT IQNGRELFES SLCGDLLNEV QASEHTKSKH ESRKEKRKKS
210 220 230 240 250
NRHESSRSEE RRSHKIPKLE PEGQNRPNER VDTAPEKPRE EPVLKEAIPV
260 270 280 290 300
QPILSSVPTT ETSTGVKFQV GDLVWSKVGT YPWWPCMVSS DPQLEVHSKI
310 320 330 340 350
NTRGAREYHV QFFSNQPERA WVHEKRVREY KGHEQYEELL AEAAKQASNH
360 370 380 390 400
SEKQKIRKPR PQRERAQWDI GIAHAEKALK MTREERVEQY TFIYIDKQPE
410 420 430 440 450
EASSQAKKNV TSKTEVKKPR RPRSVLNSQP EQTNAGEVAS SQSSTDLRRQ
460 470 480 490 500
SQRRHTSLEE EEPPPVKIAW KTAAARKSLP ASITMHKGSL DLQKCNMSPV
510 520 530 540 550
VKIEQVFALQ NATGDGKFID QFVYSTKGIG NKTEISVRGQ DRLIISSPSQ
560 570 580 590 600
RSEKPAQSAS SPEATSGSAG PVEKKQQRRS IRTRSESEKS AEVVPKKKIK
610 620 630 640 650
KEQVETAPQA SLKTGLQKGA SEISDSCKPL KKRSRASTDV ETASCTYRDT
660 670 680 690 700
SDSDSRGLSD GQVGFGKQVD SPSATADADA SDAQSVDSSL SRRGVGTSKK
710 720 730 740 750
DTVCQVCEKA GDCLVACEGE CCRHFHVECL GLTAVPEGHF TCEECETGQH
760 770 780 790 800
PCFSCKVSGK DVKRCSVSVC GKFYHEACVR KFPTAIFESK GFRCPQHCCS
810 820 830 840 850
SCSMEKDIHK ASKGRMMRCL RCPVAYHVGD ACVAAGSVSV SSHILICSNH
860 870 880 890 900
SKRSSQSAAI NVGFCFVCAR GLIVQDHSDP MFSSYAYKSH YLLSESNRAE
910 920 930 940 950
LMKLPMIPSS SASKKRCEKG GRLLCCESCP ASFHPECLSI DMPEGCWNCN
960 970 980 990 1000
DCKAGKKLHY KQIVWVKLGN YRQVLWWPAE ICSPRSVPLN IQGLKHDLGD
1010 1020 1030 1040 1050
FPVFFFGSHD YYWVHQGRVF PYVEGDKHFA EGQTSINKTF KKALEEAAKR
1060 1070 1080 1090 1100
FQELKAQRES KEALEMERTS RKPPPYKHIK ANKVIGKVQV QVADLSEIPR
1110 1120 1130 1140 1150
CNCKPGDENP CGLESQCLNR MSQYECHPQV CPAGDRCQNQ CFTKRLYPDA
1160 1170 1180 1190 1200
EVIKTERRGW GLRTKRSIKK GEFVNEYVGE LIDEEECRLR IKRAHENSVT
1210 1220 1230 1240 1250
NFYMLTVTKD RIIDAGPKGN YSRFMNHSCN PNCETQKWTV NGDVRVGLFA
1260 1270 1280 1290 1300
LCDIPAGMEL TFNYNLDCLG NGRTVCHCGA DNCSGFLGVR PKSACTSAVD
1310 1320 1330 1340 1350
EKTKNAKLKK RRKVKAEAKP IHEDYCFQCG DGGELVMCDK KDCPKAYHLL
1360 1370 1380 1390 1400
CLNLTQPPHG KWECPWHRCD ECGSVAVSFC EFCPHSFCKA HGKGALVPSA
1410 1420 1430
LEGRLCCSSH DPASPVSPEY WSKIRCKWES QDSGEEVKE
Length:1,439
Mass (Da):161,002
Last modified:October 31, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i917C7ADCD1248525
GO
Isoform 2 (identifier: Q6P2L6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: P → PLPPPPPPPPP
     620-645: ASEISDSCKPLKKRSRASTDVETASC → SADRGAQGSVRFSDSSVSAAKEETVD
     646-1439: Missing.

Show »
Length:655
Mass (Da):73,380
Checksum:i358CBD840A5A47C6
GO
Isoform 3 (identifier: Q6P2L6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-941: Missing.
     973-975: Missing.
     1199-1209: Missing.

Show »
Length:484
Mass (Da):54,977
Checksum:i562572C7B3100FD4
GO
Isoform 4 (identifier: Q6P2L6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     135-135: P → PLPPPPPPPPP
     603-611: QVETAPQAS → QVGFLHVES
     612-1439: Missing.

Show »
Length:621
Mass (Da):70,000
Checksum:i5553A83F48BF9B16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z357D3Z357_MOUSE
Histone-lysine N-methyltransferase ...
Nsd3 Whsc1l1
1,446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z197D3Z197_MOUSE
Histone-lysine N-methyltransferase ...
Nsd3 Whsc1l1
1,397Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GSG3A0A1B0GSG3_MOUSE
Histone-lysine N-methyltransferase ...
Nsd3 Whsc1l1
542Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti122H → R in BAE33834 (PubMed:16141072).Curated1
Sequence conflicti950N → K in BAE21322 (PubMed:16141072).Curated1
Sequence conflicti1149D → N in BAE21322 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0214311 – 941Missing in isoform 3. 1 PublicationAdd BLAST941
Alternative sequenceiVSP_021432135P → PLPPPPPPPPP in isoform 2 and isoform 4. 2 Publications1
Alternative sequenceiVSP_021433603 – 611QVETAPQAS → QVGFLHVES in isoform 4. 1 Publication9
Alternative sequenceiVSP_021434612 – 1439Missing in isoform 4. 1 PublicationAdd BLAST828
Alternative sequenceiVSP_021435620 – 645ASEIS…ETASC → SADRGAQGSVRFSDSSVSAA KEETVD in isoform 2. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_021436646 – 1439Missing in isoform 2. 2 PublicationsAdd BLAST794
Alternative sequenceiVSP_021437973 – 975Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_0214381199 – 1209Missing in isoform 3. 1 PublicationAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK079952 mRNA Translation: BAC37792.1
AK132725 mRNA Translation: BAE21322.1
AK156746 mRNA Translation: BAE33834.1
AK170040 mRNA Translation: BAE41526.1
AC156990 Genomic DNA No translation available.
AC162367 Genomic DNA No translation available.
BC064447 mRNA Translation: AAH64447.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS40305.1 [Q6P2L6-2]
CCDS85518.1 [Q6P2L6-4]

NCBI Reference Sequences

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RefSeqi
NP_001001735.1, NM_001001735.2 [Q6P2L6-2]
NP_001295410.1, NM_001308481.1 [Q6P2L6-2]
NP_001295411.1, NM_001308482.1 [Q6P2L6-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000136107; ENSMUSP00000147840; ENSMUSG00000054823 [Q6P2L6-4]
ENSMUST00000146919; ENSMUSP00000115470; ENSMUSG00000054823 [Q6P2L6-2]
ENSMUST00000153597; ENSMUSP00000123028; ENSMUSG00000054823 [Q6P2L6-3]
ENSMUST00000155861; ENSMUSP00000117596; ENSMUSG00000054823 [Q6P2L6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
234135

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:234135

UCSC genome browser

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UCSCi
uc009lgk.1, mouse [Q6P2L6-4]
uc009lgm.1, mouse [Q6P2L6-2]
uc009lgp.1, mouse [Q6P2L6-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK079952 mRNA Translation: BAC37792.1
AK132725 mRNA Translation: BAE21322.1
AK156746 mRNA Translation: BAE33834.1
AK170040 mRNA Translation: BAE41526.1
AC156990 Genomic DNA No translation available.
AC162367 Genomic DNA No translation available.
BC064447 mRNA Translation: AAH64447.1
CCDSiCCDS40305.1 [Q6P2L6-2]
CCDS85518.1 [Q6P2L6-4]
RefSeqiNP_001001735.1, NM_001001735.2 [Q6P2L6-2]
NP_001295410.1, NM_001308481.1 [Q6P2L6-2]
NP_001295411.1, NM_001308482.1 [Q6P2L6-4]

3D structure databases

SMRiQ6P2L6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi231497, 1 interactor
IntActiQ6P2L6, 2 interactors
MINTiQ6P2L6
STRINGi10090.ENSMUSP00000115470

PTM databases

iPTMnetiQ6P2L6
PhosphoSitePlusiQ6P2L6

Proteomic databases

jPOSTiQ6P2L6
PaxDbiQ6P2L6
PeptideAtlasiQ6P2L6
PRIDEiQ6P2L6

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q6P2L6, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
984, 334 antibodies

The DNASU plasmid repository

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DNASUi
234135

Genome annotation databases

EnsembliENSMUST00000136107; ENSMUSP00000147840; ENSMUSG00000054823 [Q6P2L6-4]
ENSMUST00000146919; ENSMUSP00000115470; ENSMUSG00000054823 [Q6P2L6-2]
ENSMUST00000153597; ENSMUSP00000123028; ENSMUSG00000054823 [Q6P2L6-3]
ENSMUST00000155861; ENSMUSP00000117596; ENSMUSG00000054823 [Q6P2L6-2]
GeneIDi234135
KEGGimmu:234135
UCSCiuc009lgk.1, mouse [Q6P2L6-4]
uc009lgm.1, mouse [Q6P2L6-2]
uc009lgp.1, mouse [Q6P2L6-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54904
MGIiMGI:2142581, Nsd3

Phylogenomic databases

eggNOGiKOG1081, Eukaryota
GeneTreeiENSGT00940000155355
HOGENOMiCLU_488831_0_0_1
InParanoidiQ6P2L6
KOiK11425

Enzyme and pathway databases

ReactomeiR-MMU-3214841, PKMTs methylate histone lysines

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
234135, 5 hits in 22 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Whsc1l1, mouse

Protein Ontology

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PROi
PR:Q6P2L6
RNActiQ6P2L6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000054823, Expressed in bone marrow and 267 other tissues
ExpressionAtlasiQ6P2L6, baseline and differential
GenevisibleiQ6P2L6, MM

Family and domain databases

Gene3Di3.30.40.10, 4 hits
InterProiView protein in InterPro
IPR006560, AWS_dom
IPR041306, C5HCH
IPR003616, Post-SET_dom
IPR000313, PWWP_dom
IPR001214, SET_dom
IPR019786, Zinc_finger_PHD-type_CS
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF17907, AWS, 1 hit
PF17982, C5HCH, 1 hit
PF00855, PWWP, 2 hits
PF00856, SET, 1 hit
SMARTiView protein in SMART
SM00570, AWS, 1 hit
SM00249, PHD, 5 hits
SM00508, PostSET, 1 hit
SM00293, PWWP, 2 hits
SM00317, SET, 1 hit
SUPFAMiSSF57903, SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS51215, AWS, 1 hit
PS50868, POST_SET, 1 hit
PS50812, PWWP, 2 hits
PS50280, SET, 1 hit
PS01359, ZF_PHD_1, 1 hit
PS50016, ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSD3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2L6
Secondary accession number(s): Q3TDS4
, Q3U0L8, Q3V131, Q8BJT3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: October 31, 2006
Last modified: October 7, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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