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UniProtKB - Q6P2K6 (P4R3A_MOUSE)

Entry version 133 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Gene

Ppp4r3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 regulatory subunit 3ABy similarity
Alternative name(s):
SMEK homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppp4r3aBy similarity
Synonyms:Kiaa2010, Pp4r3a, Smek1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1915984, Ppp4r3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002545991 – 820Serine/threonine-protein phosphatase 4 regulatory subunit 3AAdd BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei117PhosphoserineCombined sources1
Modified residuei127PhosphoserineBy similarity1
Modified residuei642N6-acetyllysineCombined sources1
Modified residuei685PhosphoserineBy similarity1
Modified residuei728PhosphoserineCombined sources1
Modified residuei755PhosphoserineCombined sources1
Modified residuei758PhosphoserineCombined sources1
Modified residuei761PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei767PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P2K6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P2K6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P2K6

PeptideAtlas

More...PeptideAtlasi		Q6P2K6

PRoteomics IDEntifications database

More...PRIDEi		Q6P2K6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P2K6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P2K6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000041846, Expressed in forelimb bud and 278 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P2K6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P2K6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.

Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A.

Interacts with PPP4C; the interaction requires PPP4R2 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		213022, 25 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-158, PPP4C-PPP4R2-PPP4R3A protein phosphatase 4 complex

Protein interaction database and analysis system

More...IntActi		Q6P2K6, 18 interactors

Molecular INTeraction database

More...MINTi		Q6P2K6

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000129654

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P2K6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 100WH1Add BLAST100

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMEK family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2175, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018199

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004909_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P2K6

Database of Orthologous Groups

More...OrthoDBi		388216at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P2K6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR006887, DUF625
IPR011993, PH-like_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04802, SMK-1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P2K6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL 
        60         70         80         90        100
LLESKINPNT AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV 
       110        120        130        140        150
QGKDPSVDIT QDLVDESEEE RFDDMSSPGL ELPSCELSRL EEIAELVASS 
       160        170        180        190        200
LPSPLRREKL ALALENEGYI KKLLELFHVC EDLENIEGLH HLYEIIKGIF 
       210        220        230        240        250
LLNRTALFEV MFSEECIMDV IGCLEYDPTL SQPRKHREFL TKTAKFKEVI 
       260        270        280        290        300
PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI 
       310        320        330        340        350
VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR 
       360        370        380        390        400
DAFFKTLSNM GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV 
       410        420        430        440        450
MQEAQQNDDD ILLINLIIEH MICDTDPELG GAVQLMGLLR TLVDPENMLA 
       460        470        480        490        500
TANKTEKTEF LGFFYKHCMH VLTAPLLANT TEDKPSKDDF QTAQLLALVL 
       510        520        530        540        550
ELLTFCVEHH TYHIKNYIIN KDILRRVLVL MASKHAFLAL CALRFKRKII 
       560        570        580        590        600
GLKDEFYNRY IMKSFLFEPV VKAFLNNGSR YNLMNSAIIE MFEFIRVEDI 
       610        620        630        640        650
KSLTAHVIEN YWKALEDVDY VQTFKGLKLR FEQQRERQDN PKLDSMRSIL 
       660        670        680        690        700
RNHRYRRDAR TLEDEEEMWF NTDEDDMEDG EAVVSPSDKT KNDDDIMDPI 
       710        720        730        740        750
SKFMERKKLK ESEEKEVLLK TNLSGRQSPS FKLSLSSGTK TNLTSQSSAT 
       760        770        780        790        800
SLPGSPGSPG SPGSPGSPGS VPKSTSQTAA ITTKGGLVGL VDYPDDDEDD 
       810        820
DEDEDKEDTL PVSKKAKFES
Length:820
Mass (Da):93,842
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20D6E184C89E6015
GO
Isoform 2 (identifier: Q6P2K6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-561: Missing.

Show »
Length:259
Mass (Da):29,181
Checksum:i93C8B59E82554A3E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q481E9Q481_MOUSE
Serine/threonine-protein phosphatas...
Ppp4r3a Smek1
833Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJG9A0A1Y7VJG9_MOUSE
Serine/threonine-protein phosphatas...
Ppp4r3a
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VMI3A0A1Y7VMI3_MOUSE
Serine/threonine-protein phosphatas...
Ppp4r3a
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32609 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0212571 – 561Missing in isoform 2. 1 PublicationAdd BLAST561

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK173331 Transcribed RNA Translation: BAD32609.1 Different initiation.
AK051239 mRNA Translation: BAC34569.2
AK148868 mRNA Translation: BAE28682.1
AK156272 mRNA Translation: BAE33651.1
BC044817 mRNA Translation: AAH44817.1
BC064465 mRNA Translation: AAH64465.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS26111.1 [Q6P2K6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001153686.1, NM_001160214.1
NP_997594.1, NM_211355.2 [Q6P2K6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000048305; ENSMUSP00000041667; ENSMUSG00000041846 [Q6P2K6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		68734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:68734

UCSC genome browser

More...UCSCi		uc007oti.2, mouse [Q6P2K6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173331 Transcribed RNA Translation: BAD32609.1 Different initiation.
AK051239 mRNA Translation: BAC34569.2
AK148868 mRNA Translation: BAE28682.1
AK156272 mRNA Translation: BAE33651.1
BC044817 mRNA Translation: AAH44817.1
BC064465 mRNA Translation: AAH64465.1
CCDSiCCDS26111.1 [Q6P2K6-1]
RefSeqiNP_001153686.1, NM_001160214.1
NP_997594.1, NM_211355.2 [Q6P2K6-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi213022, 25 interactors
ComplexPortaliCPX-158, PPP4C-PPP4R2-PPP4R3A protein phosphatase 4 complex
IntActiQ6P2K6, 18 interactors
MINTiQ6P2K6
STRINGi10090.ENSMUSP00000129654

PTM databases

iPTMnetiQ6P2K6
PhosphoSitePlusiQ6P2K6

Proteomic databases

EPDiQ6P2K6
jPOSTiQ6P2K6
PaxDbiQ6P2K6
PeptideAtlasiQ6P2K6
PRIDEiQ6P2K6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		119, 91 antibodies

Genome annotation databases

EnsembliENSMUST00000048305; ENSMUSP00000041667; ENSMUSG00000041846 [Q6P2K6-1]
GeneIDi68734
KEGGimmu:68734
UCSCiuc007oti.2, mouse [Q6P2K6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55671
MGIiMGI:1915984, Ppp4r3a

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG2175, Eukaryota
GeneTreeiENSGT00390000018199
HOGENOMiCLU_004909_3_0_1
InParanoidiQ6P2K6
OrthoDBi388216at2759
PhylomeDBiQ6P2K6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		68734, 2 hits in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Smek1, mouse

Protein Ontology

More...PROi		PR:Q6P2K6
RNActiQ6P2K6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000041846, Expressed in forelimb bud and 278 other tissues
ExpressionAtlasiQ6P2K6, baseline and differential
GenevisibleiQ6P2K6, MM

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR006887, DUF625
IPR011993, PH-like_dom_sf
PfamiView protein in Pfam
PF04802, SMK-1, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP4R3A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2K6
Secondary accession number(s): Q3UF79
, Q69Z35, Q80VS2, Q8BKP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 133 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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