UniProtKB - Q6P2K6 (P4R3A_MOUSE)
Serine/threonine-protein phosphatase 4 regulatory subunit 3A
Ppp4r3a
Functioni
GO - Biological processi
- positive regulation of gluconeogenesis Source: MGI
- protein dephosphorylation Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 4 regulatory subunit 3ABy similarityAlternative name(s): SMEK homolog 1 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915984, Ppp4r3a |
Subcellular locationi
Cytoskeleton
- centrosome By similarity
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Note: In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions (By similarity).By similarity
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear speck Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- protein phosphatase 4 complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000254599 | 1 – 820 | Serine/threonine-protein phosphatase 4 regulatory subunit 3AAdd BLAST | 820 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 117 | PhosphoserineCombined sources | 1 | |
Modified residuei | 127 | PhosphoserineBy similarity | 1 | |
Modified residuei | 642 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 685 | PhosphoserineBy similarity | 1 | |
Modified residuei | 728 | PhosphoserineCombined sources | 1 | |
Modified residuei | 755 | PhosphoserineCombined sources | 1 | |
Modified residuei | 758 | PhosphoserineCombined sources | 1 | |
Modified residuei | 761 | PhosphoserineCombined sources | 1 | |
Modified residuei | 764 | PhosphoserineCombined sources | 1 | |
Modified residuei | 767 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q6P2K6 |
jPOSTi | Q6P2K6 |
PaxDbi | Q6P2K6 |
PeptideAtlasi | Q6P2K6 |
PRIDEi | Q6P2K6 |
PTM databases
iPTMneti | Q6P2K6 |
PhosphoSitePlusi | Q6P2K6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000041846, Expressed in forelimb bud and 278 other tissues |
ExpressionAtlasi | Q6P2K6, baseline and differential |
Genevisiblei | Q6P2K6, MM |
Interactioni
Subunit structurei
Serine/threonine-protein phosphatase 4 (PP4) occurs in different assemblies of the catalytic and one or more regulatory subunits.
Component of the PP4 complex PPP4C-PPP4R2-PPP4R3A.
Interacts with PPP4C; the interaction requires PPP4R2 (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 213022, 25 interactors |
ComplexPortali | CPX-158, PPP4C-PPP4R2-PPP4R3A protein phosphatase 4 complex |
IntActi | Q6P2K6, 18 interactors |
MINTi | Q6P2K6 |
STRINGi | 10090.ENSMUSP00000129654 |
Miscellaneous databases
RNActi | Q6P2K6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 100 | WH1Add BLAST | 100 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2175, Eukaryota |
GeneTreei | ENSGT00390000018199 |
HOGENOMi | CLU_004909_3_0_1 |
InParanoidi | Q6P2K6 |
OrthoDBi | 388216at2759 |
PhylomeDBi | Q6P2K6 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR006887, DUF625 IPR011993, PH-like_dom_sf |
Pfami | View protein in Pfam PF04802, SMK-1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTDTRRRVKV YTLNEDRQWD DRGTGHVSSG YVERLKGMSL LVRAESDGSL
60 70 80 90 100
LLESKINPNT AYQKQQDTLI VWSEAENYDL ALSFQEKAGC DEIWEKICQV
110 120 130 140 150
QGKDPSVDIT QDLVDESEEE RFDDMSSPGL ELPSCELSRL EEIAELVASS
160 170 180 190 200
LPSPLRREKL ALALENEGYI KKLLELFHVC EDLENIEGLH HLYEIIKGIF
210 220 230 240 250
LLNRTALFEV MFSEECIMDV IGCLEYDPTL SQPRKHREFL TKTAKFKEVI
260 270 280 290 300
PISDPELKQK IHQTYRVQYI QDMVLPTPSV FEENMLSTLH SFIFFNKVEI
310 320 330 340 350
VGMLQEDEKF LTDLFAQLTD EATDEEKRQE LVNFLKEFCA FSQTLQPQNR
360 370 380 390 400
DAFFKTLSNM GILPALEVIL GMDDTQVRSA ATDIFSYLVE YNPSMVREFV
410 420 430 440 450
MQEAQQNDDD ILLINLIIEH MICDTDPELG GAVQLMGLLR TLVDPENMLA
460 470 480 490 500
TANKTEKTEF LGFFYKHCMH VLTAPLLANT TEDKPSKDDF QTAQLLALVL
510 520 530 540 550
ELLTFCVEHH TYHIKNYIIN KDILRRVLVL MASKHAFLAL CALRFKRKII
560 570 580 590 600
GLKDEFYNRY IMKSFLFEPV VKAFLNNGSR YNLMNSAIIE MFEFIRVEDI
610 620 630 640 650
KSLTAHVIEN YWKALEDVDY VQTFKGLKLR FEQQRERQDN PKLDSMRSIL
660 670 680 690 700
RNHRYRRDAR TLEDEEEMWF NTDEDDMEDG EAVVSPSDKT KNDDDIMDPI
710 720 730 740 750
SKFMERKKLK ESEEKEVLLK TNLSGRQSPS FKLSLSSGTK TNLTSQSSAT
760 770 780 790 800
SLPGSPGSPG SPGSPGSPGS VPKSTSQTAA ITTKGGLVGL VDYPDDDEDD
810 820
DEDEDKEDTL PVSKKAKFES
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9Q481 | E9Q481_MOUSE | Serine/threonine-protein phosphatas... | Ppp4r3a Smek1 | 833 | Annotation score: | ||
A0A1Y7VJG9 | A0A1Y7VJG9_MOUSE | Serine/threonine-protein phosphatas... | Ppp4r3a | 148 | Annotation score: | ||
A0A1Y7VMI3 | A0A1Y7VMI3_MOUSE | Serine/threonine-protein phosphatas... | Ppp4r3a | 77 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021257 | 1 – 561 | Missing in isoform 2. 1 PublicationAdd BLAST | 561 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173331 Transcribed RNA Translation: BAD32609.1 Different initiation. AK051239 mRNA Translation: BAC34569.2 AK148868 mRNA Translation: BAE28682.1 AK156272 mRNA Translation: BAE33651.1 BC044817 mRNA Translation: AAH44817.1 BC064465 mRNA Translation: AAH64465.1 |
CCDSi | CCDS26111.1 [Q6P2K6-1] |
RefSeqi | NP_001153686.1, NM_001160214.1 NP_997594.1, NM_211355.2 [Q6P2K6-1] |
Genome annotation databases
Ensembli | ENSMUST00000048305; ENSMUSP00000041667; ENSMUSG00000041846 [Q6P2K6-1] |
GeneIDi | 68734 |
KEGGi | mmu:68734 |
UCSCi | uc007oti.2, mouse [Q6P2K6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK173331 Transcribed RNA Translation: BAD32609.1 Different initiation. AK051239 mRNA Translation: BAC34569.2 AK148868 mRNA Translation: BAE28682.1 AK156272 mRNA Translation: BAE33651.1 BC044817 mRNA Translation: AAH44817.1 BC064465 mRNA Translation: AAH64465.1 |
CCDSi | CCDS26111.1 [Q6P2K6-1] |
RefSeqi | NP_001153686.1, NM_001160214.1 NP_997594.1, NM_211355.2 [Q6P2K6-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 213022, 25 interactors |
ComplexPortali | CPX-158, PPP4C-PPP4R2-PPP4R3A protein phosphatase 4 complex |
IntActi | Q6P2K6, 18 interactors |
MINTi | Q6P2K6 |
STRINGi | 10090.ENSMUSP00000129654 |
PTM databases
iPTMneti | Q6P2K6 |
PhosphoSitePlusi | Q6P2K6 |
Proteomic databases
EPDi | Q6P2K6 |
jPOSTi | Q6P2K6 |
PaxDbi | Q6P2K6 |
PeptideAtlasi | Q6P2K6 |
PRIDEi | Q6P2K6 |
Protocols and materials databases
Antibodypediai | 119, 91 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000048305; ENSMUSP00000041667; ENSMUSG00000041846 [Q6P2K6-1] |
GeneIDi | 68734 |
KEGGi | mmu:68734 |
UCSCi | uc007oti.2, mouse [Q6P2K6-1] |
Organism-specific databases
CTDi | 55671 |
MGIi | MGI:1915984, Ppp4r3a |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG2175, Eukaryota |
GeneTreei | ENSGT00390000018199 |
HOGENOMi | CLU_004909_3_0_1 |
InParanoidi | Q6P2K6 |
OrthoDBi | 388216at2759 |
PhylomeDBi | Q6P2K6 |
Miscellaneous databases
BioGRID-ORCSi | 68734, 2 hits in 18 CRISPR screens |
ChiTaRSi | Smek1, mouse |
PROi | PR:Q6P2K6 |
RNActi | Q6P2K6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000041846, Expressed in forelimb bud and 278 other tissues |
ExpressionAtlasi | Q6P2K6, baseline and differential |
Genevisiblei | Q6P2K6, MM |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR006887, DUF625 IPR011993, PH-like_dom_sf |
Pfami | View protein in Pfam PF04802, SMK-1, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P4R3A_MOUSE | |
Accessioni | Q6P2K6Primary (citable) accession number: Q6P2K6 Secondary accession number(s): Q3UF79 Q8BKP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families