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Protein

Endogenous Bornavirus-like nucleoprotein 2

Gene

EBLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 2
Alternative name(s):
Endogenous Borna-like N element-2
Short name:
EBLN-2
Gene namesi
Name:EBLN2
ORF Names:GK006
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000255423.1
HGNCiHGNC:25493 EBLN2
MIMi613250 gene
neXtProtiNX_Q6P2I7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255423

Polymorphism and mutation databases

BioMutaiEBLN2
DMDMi74737218

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003587161 – 272Endogenous Bornavirus-like nucleoprotein 2Add BLAST272

Proteomic databases

PaxDbiQ6P2I7
PeptideAtlasiQ6P2I7
PRIDEiQ6P2I7
ProteomicsDBi66907

PTM databases

iPTMnetiQ6P2I7
PhosphoSitePlusiQ6P2I7

Expressioni

Gene expression databases

BgeeiENSG00000255423
GenevisibleiQ6P2I7 HS

Organism-specific databases

HPAiHPA062510
HPA068795

Interactioni

Protein-protein interaction databases

BioGridi120408, 7 interactors
IntActiQ6P2I7, 8 interactors
STRINGi9606.ENSP00000432104

Structurei

3D structure databases

ProteinModelPortaliQ6P2I7
SMRiQ6P2I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410ISC0 Eukaryota
ENOG4110Q08 LUCA
GeneTreeiENSGT00490000044176
OMAiMMASIGR
OrthoDBiEOG091G08P6
PhylomeDBiQ6P2I7

Family and domain databases

Gene3Di1.10.3040.10, 1 hit
InterProiView protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir
PfamiView protein in Pfam
PF06407 BDV_P40, 1 hit
SUPFAMiSSF101399 SSF101399, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P2I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH
60 70 80 90 100
LRKDSQPSSP GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI
110 120 130 140 150
KDIKKAAKSM LDPAHKSHFH PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN
160 170 180 190 200
TVVGNENEER GTPYASRFKD MPNFIALEKS SVLRHCCDLL IGIAAGSSDK
210 220 230 240 250
ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI GWISSRPWVG
260 270
ELMFTLLFGD FESPLHKLRK SS
Length:272
Mass (Da):30,450
Last modified:July 5, 2004 - v1
Checksum:i7937378569396D7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176A → G in AAK83528 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036895 mRNA Translation: AAK83528.1
AC103559 Genomic DNA No translation available.
BC051316 mRNA Translation: AAH51316.1
BC064501 mRNA Translation: AAH64501.1
AK001075 mRNA Translation: BAA91494.1
CCDSiCCDS54608.1
RefSeqiNP_060499.3, NM_018029.4
UniGeneiHs.658858

Genome annotation databases

EnsembliENST00000533473; ENSP00000432104; ENSG00000255423
GeneIDi55096
KEGGihsa:55096
UCSCiuc003dpj.4 human

Similar proteinsi

Entry informationi

Entry nameiEBLN2_HUMAN
AccessioniPrimary (citable) accession number: Q6P2I7
Secondary accession number(s): Q8WWH3, Q9NW89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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