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Entry version 103 (13 Nov 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Endogenous Bornavirus-like nucleoprotein 2

Gene

EBLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an RNA-binding protein. The C-terminal region is highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes. The viral protein also possesses a nuclear import and a nuclear export signal. These 2 signals seem absent in EBLN-2 supporting an unrelated function in Human.

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-2 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 2
Alternative name(s):
Endogenous Borna-like N element-2
Short name:
EBLN-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EBLN2
ORF Names:GK006
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:25493 EBLN2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
613250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P2I7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000255423

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P2I7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EBLN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737218

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003587161 – 272Endogenous Bornavirus-like nucleoprotein 2Add BLAST272

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P2I7

PeptideAtlas

More...
PeptideAtlasi
Q6P2I7

PRoteomics IDEntifications database

More...
PRIDEi
Q6P2I7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66907

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6P2I7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P2I7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255423 Expressed in 201 organ(s), highest expression level in endometrium

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P2I7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA062510
HPA068795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120408, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000432104

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410ISC0 Eukaryota
ENOG4110Q08 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00490000044176

Identification of Orthologs from Complete Genome Data

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OMAi
KSHFHPV

Database of Orthologous Groups

More...
OrthoDBi
684241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P2I7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3040.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06407 BDV_P40, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101399 SSF101399, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P2I7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGYFLKLYAY VNSHSLFVWV CDRSYKRSFR PMILNKIKEL SRNQFSTMSH
60 70 80 90 100
LRKDSQPSSP GDDAMDRSGL PDLQGRFELS GKNRQYPLDA LEPQPSIGDI
110 120 130 140 150
KDIKKAAKSM LDPAHKSHFH PVTPSLVFLC FIFDGLHQAL LSVGVSKRSN
160 170 180 190 200
TVVGNENEER GTPYASRFKD MPNFIALEKS SVLRHCCDLL IGIAAGSSDK
210 220 230 240 250
ICTSSLQVQR RFKAMMASIG RLSHGESADL LISCNAESAI GWISSRPWVG
260 270
ELMFTLLFGD FESPLHKLRK SS
Length:272
Mass (Da):30,450
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7937378569396D7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176A → G in AAK83528 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY036895 mRNA Translation: AAK83528.1
AC103559 Genomic DNA No translation available.
BC051316 mRNA Translation: AAH51316.1
BC064501 mRNA Translation: AAH64501.1
AK001075 mRNA Translation: BAA91494.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54608.1

NCBI Reference Sequences

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RefSeqi
NP_060499.3, NM_018029.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000533473; ENSP00000432104; ENSG00000255423

Database of genes from NCBI RefSeq genomes

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GeneIDi
55096

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55096

UCSC genome browser

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UCSCi
uc003dpj.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY036895 mRNA Translation: AAK83528.1
AC103559 Genomic DNA No translation available.
BC051316 mRNA Translation: AAH51316.1
BC064501 mRNA Translation: AAH64501.1
AK001075 mRNA Translation: BAA91494.1
CCDSiCCDS54608.1
RefSeqiNP_060499.3, NM_018029.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120408, 7 interactors
STRINGi9606.ENSP00000432104

PTM databases

iPTMnetiQ6P2I7
PhosphoSitePlusiQ6P2I7

Polymorphism and mutation databases

BioMutaiEBLN2
DMDMi74737218

Proteomic databases

PaxDbiQ6P2I7
PeptideAtlasiQ6P2I7
PRIDEiQ6P2I7
ProteomicsDBi66907

Genome annotation databases

EnsembliENST00000533473; ENSP00000432104; ENSG00000255423
GeneIDi55096
KEGGihsa:55096
UCSCiuc003dpj.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55096

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EBLN2
HGNCiHGNC:25493 EBLN2
HPAiHPA062510
HPA068795
MIMi613250 gene
neXtProtiNX_Q6P2I7
OpenTargetsiENSG00000255423

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410ISC0 Eukaryota
ENOG4110Q08 LUCA
GeneTreeiENSGT00490000044176
OMAiKSHFHPV
OrthoDBi684241at2759
PhylomeDBiQ6P2I7

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55096
PharosiQ6P2I7

Protein Ontology

More...
PROi
PR:Q6P2I7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000255423 Expressed in 201 organ(s), highest expression level in endometrium
GenevisibleiQ6P2I7 HS

Family and domain databases

Gene3Di1.10.3040.10, 1 hit
InterProiView protein in InterPro
IPR009441 P40_nucleoprot_BD-vir
IPR036260 P40_nucleoprot_sf_BD-vir
IPR015969 P40_nucleoprot_sub1_BD-vir
PfamiView protein in Pfam
PF06407 BDV_P40, 1 hit
SUPFAMiSSF101399 SSF101399, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEBLN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2I7
Secondary accession number(s): Q8WWH3, Q9NW89
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: November 13, 2019
This is version 103 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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