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Entry version 135 (12 Aug 2020)
Sequence version 2 (05 Feb 2008)
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Protein

X-ray radiation resistance-associated protein 1

Gene

XRRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the response of cells to X-ray radiation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • response to X-ray Source: UniProtKB

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P2D8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
X-ray radiation resistance-associated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRRA1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000166435.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18868, XRRA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609788, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P2D8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
143570

Open Targets

More...
OpenTargetsi
ENSG00000166435

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988069

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P2D8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XRRA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166919153

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003181301 – 792X-ray radiation resistance-associated protein 1Add BLAST792

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P2D8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P2D8

PeptideAtlas

More...
PeptideAtlasi
Q6P2D8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P2D8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66891 [Q6P2D8-1]
66892 [Q6P2D8-2]
66893 [Q6P2D8-3]
66894 [Q6P2D8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P2D8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P2D8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in testis followed by prostate and ovary. Low levels found in other tissues including peripheral blood leukocytes, spleen, thymus, small intestine and colon. Also expressed in neuroblastoma, glioma, breast, lung, leukemia, renal, ovarian, prostate and colorectal cancer cell lines.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By X-ray irradiation immediately after exposure and is then down-regulated two-fold in an X-ray radiation-resistant cell clone. Responds differently to X-ray radiation in clones of varying radiation responses.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166435, Expressed in testis and 153 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P2D8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P2D8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166435, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126811, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P2D8, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339918

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P2D8, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati104 – 125LRR 1Add BLAST22
Repeati141 – 155LRR 2Add BLAST15
Repeati164 – 184LRR 3Add BLAST21
Repeati188 – 209LRR 4Add BLAST22
Repeati229 – 250LRR 5Add BLAST22
Repeati254 – 275LRR 6Add BLAST22

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili723 – 745Sequence analysisAdd BLAST23

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016048

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015169_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P2D8

Identification of Orthologs from Complete Genome Data

More...
OMAi
SETTKVC

Database of Orthologous Groups

More...
OrthoDBi
799626at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P2D8

TreeFam database of animal gene trees

More...
TreeFami
TF329758

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR038894, XRRA1

The PANTHER Classification System

More...
PANTHERi
PTHR22710, PTHR22710, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369, LRR_TYP, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q6P2D8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFSGIYKLD DGKPYLNNCF PARNLLRVPE EGQGHWLVVQ KGNLKKKPKG
60 70 80 90 100
LVGAQAERRE SLKATSFEFK GKKESRRENQ VDLPGHILDQ AFLLKHHCVR
110 120 130 140 150
KPSDLCTINA KENDFKHFHS VIYINASENL LPLEAFHTFP ALKELDLAFN
160 170 180 190 200
GIKTIYVKYG DFKLLEFLDL SFNSLTVEAI CDLGILPHLR VLLLTGNGLT
210 220 230 240 250
SLPPNLAVAE QEASVTSLTS KRYILRFPAL ETLMLDDNRL SNPSCFASLA
260 270 280 290 300
GLRRLKKLSL DENRIIRIPY LQQVQLYDES VDWNGGRGSP HKEPQFMLQS
310 320 330 340 350
KPRMLEDSDE QLDYTVLPMK KDVDRTEVVF SSYPGFSTSE TTKICSLPPI
360 370 380 390 400
FEILPVKSLK ARNQTLAPPF PELRYLSLAY NKIAKEDAVL PVALFPSLCE
410 420 430 440 450
FVFHNNPLVA HTRGVPPLLK SFLQERLGIH LIRRKIVKPK HHVLMSRKES
460 470 480 490 500
WKVKSEIPKV PKQPLVLHHP RMTTTKSPSK DMLEPEAELA EDLPTTKSTS
510 520 530 540 550
VESEMPTENL EGHSPSCRTF VPLPPICSNS TVHSEETLSH LSDTTVRLSP
560 570 580 590 600
ERPSDEDSKS TESIFLTQVS ELPSSVIHKD DLELKEKDQK KPPTAPREVK
610 620 630 640 650
GTRRKLPTAF LPSKYHGYEE LLTAKPDPAF IEPKGIQKNA QALQQMLKHP
660 670 680 690 700
LLCHSSKPKL DTLQKPYVHK EKRAQRIPIP PPKKTRAQLL DDIFIRLRDP
710 720 730 740 750
RNITEAPLGA VLHQWTERRL VNHKQYLEAK RLLKEFQARY RQLVSGSLRT
760 770 780 790
VFGTTPLPMA CPALSESQPK FGHFLEFMDE FCQEPTASDS QG
Note: Gene model based on mouse cDNA data.Curated
Length:792
Mass (Da):89,864
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EBEDF9540535BC2
GO
Isoform 21 Publication (identifier: Q6P2D8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-413: Missing.
     674-685: AQRIPIPPPKKT → VLSCTSGQNGGW
     686-792: Missing.

Show »
Length:598
Mass (Da):67,681
Checksum:i419CCB0A1EF88BE6
GO
Isoform 31 Publication (identifier: Q6P2D8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-340: Missing.

Show »
Length:778
Mass (Da):88,346
Checksum:i8FE7939B3252DF38
GO
Isoform 4 (identifier: Q6P2D8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-382: Missing.

Show »
Length:736
Mass (Da):83,591
Checksum:iE73447E1D6D28B08
GO
Isoform 5 (identifier: Q6P2D8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: Missing.
     341-382: Missing.

Show »
Length:517
Mass (Da):58,896
Checksum:i595372A542C8C506
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PP69E9PP69_HUMAN
X-ray radiation resistance-associat...
XRRA1
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMT6E9PMT6_HUMAN
X-ray radiation resistance-associat...
XRRA1
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ58E9PJ58_HUMAN
X-ray radiation resistance-associat...
XRRA1
55Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PL06E9PL06_HUMAN
X-ray radiation resistance-associat...
XRRA1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIR2E9PIR2_HUMAN
X-ray radiation resistance-associat...
XRRA1
19Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YD10H0YD10_HUMAN
X-ray radiation resistance-associat...
XRRA1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO23657 differs from that shown. Reason: Frameshift.Curated
The sequence AAP97315 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3F → L in AAH64584 (PubMed:15489334).Curated1
Sequence conflicti356V → M in AAO23657 (PubMed:12908878).Curated1
Sequence conflicti778M → V in BC037294 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038693473T → R1 PublicationCorresponds to variant dbSNP:rs4944960Ensembl.1
Natural variantiVAR_051492480K → E. Corresponds to variant dbSNP:rs12291445Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0449881 – 233Missing in isoform 5. 1 PublicationAdd BLAST233
Alternative sequenceiVSP_052670327 – 413Missing in isoform 2. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_052671327 – 382Missing in isoform 4. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_052672327 – 340Missing in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_044989341 – 382Missing in isoform 5. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_052673674 – 685AQRIP…PPKKT → VLSCTSGQNGGW in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_052674686 – 792Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AP000560 Genomic DNA No translation available.
AP001992 Genomic DNA No translation available.
BC037294 mRNA No translation available.
BC064584 mRNA Translation: AAH64584.1
AY163836 mRNA Translation: AAO23657.1 Frameshift.
AF439934 mRNA Translation: AAP97315.1 Frameshift.
BK000541 mRNA Translation: DAA00367.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44680.1 [Q6P2D8-1]
CCDS58159.1 [Q6P2D8-5]
CCDS58160.1 [Q6P2D8-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001257309.1, NM_001270380.1 [Q6P2D8-2]
NP_001257310.1, NM_001270381.1 [Q6P2D8-5]
NP_892014.1, NM_182969.2 [Q6P2D8-1]
XP_016872722.1, XM_017017233.1
XP_016872723.1, XM_017017234.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000321448; ENSP00000319303; ENSG00000166435 [Q6P2D8-5]
ENST00000340360; ENSP00000339918; ENSG00000166435 [Q6P2D8-1]
ENST00000527087; ENSP00000435838; ENSG00000166435 [Q6P2D8-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
143570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:143570

UCSC genome browser

More...
UCSCi
uc001ovp.5, human [Q6P2D8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP000560 Genomic DNA No translation available.
AP001992 Genomic DNA No translation available.
BC037294 mRNA No translation available.
BC064584 mRNA Translation: AAH64584.1
AY163836 mRNA Translation: AAO23657.1 Frameshift.
AF439934 mRNA Translation: AAP97315.1 Frameshift.
BK000541 mRNA Translation: DAA00367.1
CCDSiCCDS44680.1 [Q6P2D8-1]
CCDS58159.1 [Q6P2D8-5]
CCDS58160.1 [Q6P2D8-2]
RefSeqiNP_001257309.1, NM_001270380.1 [Q6P2D8-2]
NP_001257310.1, NM_001270381.1 [Q6P2D8-5]
NP_892014.1, NM_182969.2 [Q6P2D8-1]
XP_016872722.1, XM_017017233.1
XP_016872723.1, XM_017017234.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi126811, 6 interactors
IntActiQ6P2D8, 3 interactors
STRINGi9606.ENSP00000339918

PTM databases

iPTMnetiQ6P2D8
PhosphoSitePlusiQ6P2D8

Polymorphism and mutation databases

BioMutaiXRRA1
DMDMi166919153

Proteomic databases

MassIVEiQ6P2D8
PaxDbiQ6P2D8
PeptideAtlasiQ6P2D8
PRIDEiQ6P2D8
ProteomicsDBi66891 [Q6P2D8-1]
66892 [Q6P2D8-2]
66893 [Q6P2D8-3]
66894 [Q6P2D8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
45035, 49 antibodies

Genome annotation databases

EnsembliENST00000321448; ENSP00000319303; ENSG00000166435 [Q6P2D8-5]
ENST00000340360; ENSP00000339918; ENSG00000166435 [Q6P2D8-1]
ENST00000527087; ENSP00000435838; ENSG00000166435 [Q6P2D8-2]
GeneIDi143570
KEGGihsa:143570
UCSCiuc001ovp.5, human [Q6P2D8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
143570
DisGeNETi143570
EuPathDBiHostDB:ENSG00000166435.15

GeneCards: human genes, protein and diseases

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GeneCardsi
XRRA1
HGNCiHGNC:18868, XRRA1
HPAiENSG00000166435, Low tissue specificity
MIMi609788, gene
neXtProtiNX_Q6P2D8
OpenTargetsiENSG00000166435
PharmGKBiPA134988069

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
GeneTreeiENSGT00390000016048
HOGENOMiCLU_015169_0_0_1
InParanoidiQ6P2D8
OMAiSETTKVC
OrthoDBi799626at2759
PhylomeDBiQ6P2D8
TreeFamiTF329758

Enzyme and pathway databases

PathwayCommonsiQ6P2D8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
143570, 6 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
XRRA1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
143570
PharosiQ6P2D8, Tdark

Protein Ontology

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PROi
PR:Q6P2D8
RNActiQ6P2D8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166435, Expressed in testis and 153 other tissues
ExpressionAtlasiQ6P2D8, baseline and differential
GenevisibleiQ6P2D8, HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR038894, XRRA1
PANTHERiPTHR22710, PTHR22710, 1 hit
SMARTiView protein in SMART
SM00369, LRR_TYP, 4 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRRA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2D8
Secondary accession number(s): B5MD90
, J3KNJ1, Q7RTT7, Q7Z463, Q7Z4U0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: August 12, 2020
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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