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Entry version 136 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Mediator of RNA polymerase II transcription subunit 27

Gene

MED27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 27
Alternative name(s):
Cofactor required for Sp1 transcriptional activation subunit 8
Short name:
CRSP complex subunit 8
Mediator complex subunit 27
P37 TRAP/SMCC/PC2 subunit
Transcriptional coactivator CRSP34
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED27
Synonyms:CRSP34Imported, CRSP8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160563.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2377 MED27

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605044 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P2C8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9442

Open Targets

More...
OpenTargetsi
ENSG00000160563

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162395634

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P2C8 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MED27

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737195

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000793611 – 311Mediator of RNA polymerase II transcription subunit 27Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei132PhosphoserineCombined sources1
Modified residuei134N6-methyllysineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P2C8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P2C8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P2C8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P2C8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P2C8

PeptideAtlas

More...
PeptideAtlasi
Q6P2C8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P2C8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66886 [Q6P2C8-1]
66887 [Q6P2C8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P2C8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P2C8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160563 Expressed in 204 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P2C8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P2C8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007002

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114832, 49 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3227 Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6P2C8

Database of interacting proteins

More...
DIPi
DIP-31465N

Protein interaction database and analysis system

More...
IntActi
Q6P2C8, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000292035

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P2C8 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 27 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFPB Eukaryota
ENOG410ZHQY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012207

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P2C8

KEGG Orthology (KO)

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KOi
K15170

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSQKRQR

Database of Orthologous Groups

More...
OrthoDBi
1256412at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P2C8

TreeFam database of animal gene trees

More...
TreeFami
TF323728

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021627 Mediator_Med27

The PANTHER Classification System

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PANTHERi
PTHR13130 PTHR13130, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF11571 Med27, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 PublicationCurated2 Publications (identifier: Q6P2C8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADVINVSVN LEAFSQAISA IQALRSSVSR VFDCLKDGMR NKETLEGREK
60 70 80 90 100
AFIAHFQDNL HSVNRDLNEL ERLSNLVGKP SENHPLHNSG LLSLDPVQDK
110 120 130 140 150
TPLYSQLLQA YKWSNKLQYH AGLASGLLNQ QSLKRSANQM GVSAKRRPKA
160 170 180 190 200
QPTTLVLPPQ YVDDVISRID RMFPEMSIHL SRPNGTSAML LVTLGKVLKV
210 220 230 240 250
IVVMRSLFID RTIVKGYNEN VYTEDGKLDI WSKSNYQVFQ KVTDHATTAL
260 270 280 290 300
LHYQLPQMPD VVVRSFMTWL RSYIKLFQAP CQRCGKFLQD GLPPTWRDFR
310
TLEAFHDTCR Q
Length:311
Mass (Da):35,432
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i996D675993E393CB
GO
Isoform 21 Publication (identifier: Q6P2C8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-227: Missing.

Show »
Length:275
Mass (Da):31,351
Checksum:i375CDE48668D429F
GO
Isoform 3 (identifier: Q6P2C8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-130: LQYHAGLASGLLNQ → KEQLSIPRIFHWKV
     131-311: Missing.

Show »
Length:130
Mass (Da):14,826
Checksum:iA6882C84B5148C53
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A494C0K7A0A494C0K7_HUMAN
Mediator of RNA polymerase II trans...
MED27
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0P0A0A494C0P0_HUMAN
Mediator of RNA polymerase II trans...
MED27
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02878 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH02878 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64N → D in AAZ13763 (Ref. 6) Curated1
Sequence conflicti79K → E in AAZ13763 (Ref. 6) Curated1
Sequence conflicti94L → S in AAD12721 (PubMed:9989412).Curated1
Sequence conflicti207L → C in AAD12721 (PubMed:9989412).Curated1
Sequence conflicti235N → D in AAZ13763 (Ref. 6) Curated1
Sequence conflicti279A → G in AAD12721 (PubMed:9989412).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_055411117 – 130LQYHA…GLLNQ → KEQLSIPRIFHWKV in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_055412131 – 311Missing in isoform 3. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_051869192 – 227Missing in isoform 2. 3 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BQ189678 Genomic DNA No translation available.
AL603649 Genomic DNA No translation available.
AL513102 Genomic DNA No translation available.
AL160271 Genomic DNA No translation available.
AL713892 Genomic DNA No translation available.
BC002878 mRNA Translation: AAH02878.1 Sequence problems.
BC064608 mRNA Translation: AAH64608.1
AF104252 mRNA Translation: AAD12721.1
AF230382 mRNA Translation: AAF37290.1
DQ099387 mRNA Translation: AAZ13763.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59153.1 [Q6P2C8-2]
CCDS6945.1 [Q6P2C8-1]
CCDS69689.1 [Q6P2C8-4]

NCBI Reference Sequences

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RefSeqi
NP_001240810.1, NM_001253881.1 [Q6P2C8-2]
NP_001240811.1, NM_001253882.1 [Q6P2C8-4]
NP_004260.2, NM_004269.3 [Q6P2C8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000292035; ENSP00000292035; ENSG00000160563 [Q6P2C8-1]
ENST00000357028; ENSP00000349530; ENSG00000160563 [Q6P2C8-2]
ENST00000474263; ENSP00000477136; ENSG00000160563 [Q6P2C8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9442

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9442

UCSC genome browser

More...
UCSCi
uc004cbe.3 human [Q6P2C8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BQ189678 Genomic DNA No translation available.
AL603649 Genomic DNA No translation available.
AL513102 Genomic DNA No translation available.
AL160271 Genomic DNA No translation available.
AL713892 Genomic DNA No translation available.
BC002878 mRNA Translation: AAH02878.1 Sequence problems.
BC064608 mRNA Translation: AAH64608.1
AF104252 mRNA Translation: AAD12721.1
AF230382 mRNA Translation: AAF37290.1
DQ099387 mRNA Translation: AAZ13763.1
CCDSiCCDS59153.1 [Q6P2C8-2]
CCDS6945.1 [Q6P2C8-1]
CCDS69689.1 [Q6P2C8-4]
RefSeqiNP_001240810.1, NM_001253881.1 [Q6P2C8-2]
NP_001240811.1, NM_001253882.1 [Q6P2C8-4]
NP_004260.2, NM_004269.3 [Q6P2C8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi114832, 49 interactors
ComplexPortaliCPX-3227 Core mediator complex
CORUMiQ6P2C8
DIPiDIP-31465N
IntActiQ6P2C8, 36 interactors
STRINGi9606.ENSP00000292035

PTM databases

iPTMnetiQ6P2C8
PhosphoSitePlusiQ6P2C8

Polymorphism and mutation databases

BioMutaiMED27
DMDMi74737195

Proteomic databases

EPDiQ6P2C8
jPOSTiQ6P2C8
MassIVEiQ6P2C8
MaxQBiQ6P2C8
PaxDbiQ6P2C8
PeptideAtlasiQ6P2C8
PRIDEiQ6P2C8
ProteomicsDBi66886 [Q6P2C8-1]
66887 [Q6P2C8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9442

Genome annotation databases

EnsembliENST00000292035; ENSP00000292035; ENSG00000160563 [Q6P2C8-1]
ENST00000357028; ENSP00000349530; ENSG00000160563 [Q6P2C8-2]
ENST00000474263; ENSP00000477136; ENSG00000160563 [Q6P2C8-4]
GeneIDi9442
KEGGihsa:9442
UCSCiuc004cbe.3 human [Q6P2C8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9442
DisGeNETi9442
EuPathDBiHostDB:ENSG00000160563.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MED27
HGNCiHGNC:2377 MED27
HPAiHPA007002
MIMi605044 gene
neXtProtiNX_Q6P2C8
OpenTargetsiENSG00000160563
PharmGKBiPA162395634

GenAtlas: human gene database

More...
GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFPB Eukaryota
ENOG410ZHQY LUCA
GeneTreeiENSGT00390000012207
InParanoidiQ6P2C8
KOiK15170
OMAiCSQKRQR
OrthoDBi1256412at2759
PhylomeDBiQ6P2C8
TreeFamiTF323728

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-212436 Generic Transcription Pathway
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MED27 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MED27

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9442
PharosiQ6P2C8 Tbio

Protein Ontology

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PROi
PR:Q6P2C8
RNActiQ6P2C8 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160563 Expressed in 204 organ(s), highest expression level in oocyte
ExpressionAtlasiQ6P2C8 baseline and differential
GenevisibleiQ6P2C8 HS

Family and domain databases

InterProiView protein in InterPro
IPR021627 Mediator_Med27
PANTHERiPTHR13130 PTHR13130, 1 hit
PfamiView protein in Pfam
PF11571 Med27, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED27_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P2C8
Secondary accession number(s): O95401
, Q4F964, Q5VTA4, Q5VTA5, Q9BU57, Q9NYR4, V9GYV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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