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Protein

Zinc finger protein 529

Gene

ZNF529

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 529
Gene namesi
Name:ZNF529
Synonyms:KIAA1615
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000186020.12
HGNCiHGNC:29328 ZNF529
neXtProtiNX_Q6P280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186020
PharmGKBiPA134910867

Polymorphism and mutation databases

BioMutaiZNF529
DMDMi519668652

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804191 – 563Zinc finger protein 529Add BLAST563

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ6P280
PaxDbiQ6P280
PeptideAtlasiQ6P280
PRIDEiQ6P280
ProteomicsDBi66882

PTM databases

iPTMnetiQ6P280
PhosphoSitePlusiQ6P280

Expressioni

Gene expression databases

BgeeiENSG00000186020 Expressed in 210 organ(s), highest expression level in forebrain
CleanExiHS_ZNF529
ExpressionAtlasiQ6P280 baseline and differential
GenevisibleiQ6P280 HS

Organism-specific databases

HPAiHPA031311

Interactioni

Protein-protein interaction databases

BioGridi121735, 2 interactors
IntActiQ6P280, 1 interactor
STRINGi9606.ENSP00000465578

Structurei

3D structure databases

ProteinModelPortaliQ6P280
SMRiQ6P280
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 119KRABPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri199 – 221C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri254 – 276C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri282 – 304C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri310 – 332C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri338 – 360C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri394 – 416C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri422 – 444C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri450 – 472C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri478 – 500C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri506 – 528C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri534 – 556C2H2-type 12; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144318
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P280
KOiK09228
OMAiGGKNYEC
OrthoDBiEOG091G02KC
PhylomeDBiQ6P280
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6P280-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANSSFIGDH VHGAPHAVMP EVEFPDQFFT VLTMDHELVT LRDVVINFSQ
60 70 80 90 100
EEWEYLDSAQ RNLYWDVMME NYSNLLSLDL ESRNETKHLS VGKDIIQNTG
110 120 130 140 150
SQWEVMESSK LCGLEGSIFR NDWQSKSKID LQGPEVGYFS QMKIISENVP
160 170 180 190 200
SYKTHESLTL PRRTHDSEKP YEYKEYEKVF SCDLEFDEYQ KIHTGGKNYE
210 220 230 240 250
CNQCWKTFGI DNSSMLQLNI HTGVKPCKYM EYGNTCSFYK DFNVYQKIHN
260 270 280 290 300
EKFYKCKEYR RTFERVGKVT PLQRVHDGEK HFECSFCGKS FRVHAQLTRH
310 320 330 340 350
QKIHTDEKTY KCMECGKDFR FHSQLTEHQR IHTGEKPYKC MHCEKVFRIS
360 370 380 390 400
SQLIEHQRIH TGEKPYACKE CGKAFGVCRE LARHQRIHTG KKPYECKACG
410 420 430 440 450
KVFRNSSSLT RHQRIHTGEK PYKCKECEKA FGVGSELTRH ERIHSGQKPY
460 470 480 490 500
ECKECGKFFR LTSALIQHQR IHSGEKPYEC KVCGKAFRHS SALTEHQRIH
510 520 530 540 550
TGEKPYECKA CGKAFRHSSS FTKHQRIHTD DKPYECKECG NSFSVVGHLT
560
CQPKIYTGEK SFD
Length:563
Mass (Da):65,865
Last modified:June 26, 2013 - v2
Checksum:iF59AA85D249C1A9E
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ESA1K7ESA1_HUMAN
Zinc finger protein 529
ZNF529
110Annotation score:
K7ELR0K7ELR0_HUMAN
Zinc finger protein 529
ZNF529
92Annotation score:
A0A0C4DFR4A0A0C4DFR4_HUMAN
Zinc finger protein 529
ZNF529
458Annotation score:
K7EL49K7EL49_HUMAN
Zinc finger protein 529
ZNF529
112Annotation score:
K7ES80K7ES80_HUMAN
Zinc finger protein 529
ZNF529
72Annotation score:
K7EKM0K7EKM0_HUMAN
Zinc finger protein 529
ZNF529
85Annotation score:

Sequence cautioni

The sequence AAH64690 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15068 differs from that shown. Reason: Frameshift at position 78.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79D → N in BAB15068 (PubMed:14702039).Curated1
Sequence conflicti101S → P in BAB13441 (PubMed:15057824).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031147131L → V2 PublicationsCorresponds to variant dbSNP:rs2912444Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025110 mRNA Translation: BAB15068.1 Frameshift.
AC092295 Genomic DNA No translation available.
BC064690 mRNA Translation: AAH64690.1 Different initiation.
AB046835 mRNA Translation: BAB13441.1
CCDSiCCDS54256.1
RefSeqiNP_001139121.1, NM_001145649.1
NP_001308280.1, NM_001321351.1
NP_066002.3, NM_020951.4
XP_006723365.1, XM_006723302.3
XP_011525466.1, XM_011527164.2
XP_011525469.1, XM_011527167.2
XP_016882530.1, XM_017027041.1
XP_016882531.1, XM_017027042.1
XP_016882532.1, XM_017027043.1
XP_016882533.1, XM_017027044.1
UniGeneiHs.654960

Genome annotation databases

EnsembliENST00000591340; ENSP00000465578; ENSG00000186020
GeneIDi57711
KEGGihsa:57711
UCSCiuc002oeg.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025110 mRNA Translation: BAB15068.1 Frameshift.
AC092295 Genomic DNA No translation available.
BC064690 mRNA Translation: AAH64690.1 Different initiation.
AB046835 mRNA Translation: BAB13441.1
CCDSiCCDS54256.1
RefSeqiNP_001139121.1, NM_001145649.1
NP_001308280.1, NM_001321351.1
NP_066002.3, NM_020951.4
XP_006723365.1, XM_006723302.3
XP_011525466.1, XM_011527164.2
XP_011525469.1, XM_011527167.2
XP_016882530.1, XM_017027041.1
XP_016882531.1, XM_017027042.1
XP_016882532.1, XM_017027043.1
XP_016882533.1, XM_017027044.1
UniGeneiHs.654960

3D structure databases

ProteinModelPortaliQ6P280
SMRiQ6P280
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121735, 2 interactors
IntActiQ6P280, 1 interactor
STRINGi9606.ENSP00000465578

PTM databases

iPTMnetiQ6P280
PhosphoSitePlusiQ6P280

Polymorphism and mutation databases

BioMutaiZNF529
DMDMi519668652

Proteomic databases

MaxQBiQ6P280
PaxDbiQ6P280
PeptideAtlasiQ6P280
PRIDEiQ6P280
ProteomicsDBi66882

Protocols and materials databases

DNASUi57711
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000591340; ENSP00000465578; ENSG00000186020
GeneIDi57711
KEGGihsa:57711
UCSCiuc002oeg.5 human

Organism-specific databases

CTDi57711
EuPathDBiHostDB:ENSG00000186020.12
GeneCardsiZNF529
HGNCiHGNC:29328 ZNF529
HPAiHPA031311
neXtProtiNX_Q6P280
OpenTargetsiENSG00000186020
PharmGKBiPA134910867
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144318
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6P280
KOiK09228
OMAiGGKNYEC
OrthoDBiEOG091G02KC
PhylomeDBiQ6P280
TreeFamiTF341817

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF529 human
GenomeRNAii57711
PROiPR:Q6P280

Gene expression databases

BgeeiENSG00000186020 Expressed in 210 organ(s), highest expression level in forebrain
CleanExiHS_ZNF529
ExpressionAtlasiQ6P280 baseline and differential
GenevisibleiQ6P280 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 9 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN529_HUMAN
AccessioniPrimary (citable) accession number: Q6P280
Secondary accession number(s): K7EKE1, Q9H731, Q9HCF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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