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UniProtKB - Q6P1X6 (CH082_HUMAN)

Entry version 108 (17 Jun 2020)
Sequence version 2 (10 Jun 2008)
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Protein

UPF0598 protein C8orf82

Gene

C8orf82

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0598 protein C8orf82
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C8orf82
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000213563.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:33826 C8orf82

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6P1X6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000213563

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162380827

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6P1X6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C8orf82

Domain mapping of disease mutations (DMDM)

More...DMDMi		190411564

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003406691 – 216UPF0598 protein C8orf82Add BLAST216

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6P1X6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6P1X6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6P1X6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6P1X6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P1X6

PeptideAtlas

More...PeptideAtlasi		Q6P1X6

PRoteomics IDEntifications database

More...PRIDEi		Q6P1X6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66878 [Q6P1X6-1]
66879 [Q6P1X6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P1X6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P1X6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q6P1X6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213563 Expressed in heart left ventricle and 173 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P1X6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P1X6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213563 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		136099, 10 interactors

Protein interaction database and analysis system

More...IntActi		Q6P1X6, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000436621

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P1X6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6P1X6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0598 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IW92 Eukaryota
ENOG4111JQE LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011521

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069446_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P1X6

Identification of Orthologs from Complete Genome Data

More...OMAi		RVYHPAT

Database of Orthologous Groups

More...OrthoDBi		1570646at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P1X6

TreeFam database of animal gene trees

More...TreeFami		TF323959

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028108 DUF4505

The PANTHER Classification System

More...PANTHERi		PTHR31449 PTHR31449, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14956 DUF4505, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P1X6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWPPCGTLRT LALARSRGAR ACSGDGGVSY TQGQSPEPRT REYFYYVDHQ 
        60         70         80         90        100
GQLFLDDSKM KNFITCFKDP QFLVTFFSRL RPNRSGRYEA AFPFLSPCGR 
       110        120        130        140        150
ERNFLRCEDR PVVFTHLLTA DHGPPRLSYC GGGEALAVPF EPARLLPLAA 
       160        170        180        190        200
NGRLYHPAPE RAGGVGLVRS ALAFELSACF EYGPGAPALP SHVRWQGRRL 
       210 
ALTMDLAPLL LAARSP
Length:216
Mass (Da):23,889
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79F2F20E81701640
GO
Isoform 2 (identifier: Q6P1X6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-68: MWPPCGTLRT...KMKNFITCFK → MGSPTLPTGP...ALSTRTLHPP

Show »
Length:208
Mass (Da):22,808
Checksum:i32637636A68C2FD7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEK9H0YEK9_HUMAN
UPF0598 protein C8orf82
C8orf82
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF29H0YF29_HUMAN
UPF0598 protein C8orf82
C8orf82
261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KNI2J3KNI2_HUMAN
UPF0598 protein C8orf82
C8orf82
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti37E → D in AAH64829 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0342151 – 68MWPPC…ITCFK → MGSPTLPTGPAHQGVGVLRS GAPLSEARRTSYRRRLPSVW SWARRPWEPSALSTRTLHPP in isoform 2. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471162 Genomic DNA Translation: EAW82063.1
BC064373 mRNA Translation: AAH64373.1
BC064829 mRNA Translation: AAH64829.1
BC073936 mRNA Translation: AAH73936.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS34970.1 [Q6P1X6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001001795.1, NM_001001795.1 [Q6P1X6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000524821; ENSP00000436621; ENSG00000213563 [Q6P1X6-1]
ENST00000534680; ENSP00000434593; ENSG00000213563 [Q6P1X6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		414919

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:414919

UCSC genome browser

More...UCSCi		uc003zdp.2 human [Q6P1X6-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471162 Genomic DNA Translation: EAW82063.1
BC064373 mRNA Translation: AAH64373.1
BC064829 mRNA Translation: AAH64829.1
BC073936 mRNA Translation: AAH73936.1
CCDSiCCDS34970.1 [Q6P1X6-1]
RefSeqiNP_001001795.1, NM_001001795.1 [Q6P1X6-1]

3D structure databases

SMRiQ6P1X6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi136099, 10 interactors
IntActiQ6P1X6, 6 interactors
STRINGi9606.ENSP00000436621

PTM databases

iPTMnetiQ6P1X6
PhosphoSitePlusiQ6P1X6
SwissPalmiQ6P1X6

Polymorphism and mutation databases

BioMutaiC8orf82
DMDMi190411564

Proteomic databases

EPDiQ6P1X6
jPOSTiQ6P1X6
MassIVEiQ6P1X6
MaxQBiQ6P1X6
PaxDbiQ6P1X6
PeptideAtlasiQ6P1X6
PRIDEiQ6P1X6
ProteomicsDBi66878 [Q6P1X6-1]
66879 [Q6P1X6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		70565 11 antibodies

Genome annotation databases

EnsembliENST00000524821; ENSP00000436621; ENSG00000213563 [Q6P1X6-1]
ENST00000534680; ENSP00000434593; ENSG00000213563 [Q6P1X6-1]
GeneIDi414919
KEGGihsa:414919
UCSCiuc003zdp.2 human [Q6P1X6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		414919
EuPathDBiHostDB:ENSG00000213563.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		C8orf82
HGNCiHGNC:33826 C8orf82
HPAiENSG00000213563 Low tissue specificity
neXtProtiNX_Q6P1X6
OpenTargetsiENSG00000213563
PharmGKBiPA162380827

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IW92 Eukaryota
ENOG4111JQE LUCA
GeneTreeiENSGT00390000011521
HOGENOMiCLU_069446_2_0_1
InParanoidiQ6P1X6
OMAiRVYHPAT
OrthoDBi1570646at2759
PhylomeDBiQ6P1X6
TreeFamiTF323959

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		414919 6 hits in 791 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C8orf82 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		414919
PharosiQ6P1X6 Tdark

Protein Ontology

More...PROi		PR:Q6P1X6
RNActiQ6P1X6 protein

Gene expression databases

BgeeiENSG00000213563 Expressed in heart left ventricle and 173 other tissues
ExpressionAtlasiQ6P1X6 baseline and differential
GenevisibleiQ6P1X6 HS

Family and domain databases

InterProiView protein in InterPro
IPR028108 DUF4505
PANTHERiPTHR31449 PTHR31449, 1 hit
PfamiView protein in Pfam
PF14956 DUF4505, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCH082_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1X6
Secondary accession number(s): Q6GMR2, Q6P2Q7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: June 17, 2020
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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