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Protein

Transcription initiation factor TFIID subunit 2

Gene

TAF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.2 Publications

Miscellaneous

PubMed:9418870 was unable to show an association between TAF2 and TFIID.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Protein family/group databases

MEROPSiM01.972

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 2
Alternative name(s):
150 kDa cofactor of initiator function
RNA polymerase II TBP-associated factor subunit B
TBP-associated factor 150 kDa
Transcription initiation factor TFIID 150 kDa subunit
Short name:
TAF(II)150
Short name:
TAFII-150
Short name:
TAFII150
Gene namesi
Name:TAF2
Synonyms:CIF150, TAF2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000064313.11
HGNCiHGNC:11536 TAF2
MIMi604912 gene
neXtProtiNX_Q6P1X5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal recessive 40 (MRT40)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs.
See also OMIM:615599
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_070945186T → R in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124656EnsemblClinVar.1
Natural variantiVAR_070946416P → H in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124655EnsemblClinVar.1
Natural variantiVAR_070947649W → R in MRT40. Corresponds to variant dbSNP:rs398124645EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNETi6873
MalaCardsiTAF2
MIMi615599 phenotype
OpenTargetsiENSG00000064313
Orphaneti397951 Microcephaly-thin corpus callosum-intellectual disability syndrome
PharmGKBiPA36311

Polymorphism and mutation databases

BioMutaiTAF2
DMDMi145559533

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002524241 – 1199Transcription initiation factor TFIID subunit 2Add BLAST1199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1185PhosphoserineCombined sources1
Modified residuei1188PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1198PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P1X5
MaxQBiQ6P1X5
PaxDbiQ6P1X5
PeptideAtlasiQ6P1X5
PRIDEiQ6P1X5
ProteomicsDBi66877

PTM databases

iPTMnetiQ6P1X5
PhosphoSitePlusiQ6P1X5

Expressioni

Tissue specificityi

Expressed in all tissues tested.1 Publication

Gene expression databases

BgeeiENSG00000064313 Expressed in 228 organ(s), highest expression level in forebrain
CleanExiHS_TAF2
ExpressionAtlasiQ6P1X5 baseline and differential
GenevisibleiQ6P1X5 HS

Interactioni

Subunit structurei

Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors. Interacts with TAF2C1. Component of the TFTC-HAT complex.3 Publications

Protein-protein interaction databases

BioGridi112736, 32 interactors
ComplexPortaliCPX-900 SAGA complex
CPX-903 TFTC histone acetylation complex
CPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant
CORUMiQ6P1X5
DIPiDIP-38921N
IntActiQ6P1X5, 12 interactors
STRINGi9606.ENSP00000367406

Structurei

3D structure databases

ProteinModelPortaliQ6P1X5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi600 – 603Poly-Lys4
Compositional biasi1143 – 1171His-richAdd BLAST29
Compositional biasi1155 – 1178Lys-richAdd BLAST24

Sequence similaritiesi

Belongs to the TAF2 family.Curated

Phylogenomic databases

eggNOGiKOG1932 Eukaryota
ENOG410XS52 LUCA
GeneTreeiENSGT00390000000420
HOVERGENiHBG094022
InParanoidiQ6P1X5
KOiK03128
OMAiSHGICPP
OrthoDBiEOG091G00Z3
PhylomeDBiQ6P1X5
TreeFamiTF315208

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037813 TAF2
PANTHERiPTHR15137 PTHR15137, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6P1X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLTGVEPAR MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE
60 70 80 90 100
LTIFPTVANL NRIKLNSKQC RIYRVRINDL EAAFIYNDPT LEVCHSESKQ
110 120 130 140 150
RNLNYFSNAY AAAVSAVDPD AGNGELCIKV PSELWKHVDE LKVLKIHINF
160 170 180 190 200
SLDQPKGGLH FVVPSVEGSM AERGAHVFSC GYQNSTRFWF PCVDSYSELC
210 220 230 240 250
TWKLEFTVDA AMVAVSNGDL VETVYTHDMR KKTFHYMLTI PTAASNISLA
260 270 280 290 300
IGPFEILVDP YMHEVTHFCL PQLLPLLKHT TSYLHEVFEF YEEILTCRYP
310 320 330 340 350
YSCFKTVFID EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQSL
360 370 380 390 400
AQQFFGCFIS RMSWSDEWVL KGISGYIYGL WMKKTFGVNE YRHWIKEELD
410 420 430 440 450
KIVAYELKTG GVLLHPIFGG GKEKDNPASH LHFSIKHPHT LSWEYYSMFQ
460 470 480 490 500
CKAHLVMRLI ENRISMEFML QVFNKLLSLA STASSQKFQS HMWSQMLVST
510 520 530 540 550
SGFLKSISNV SGKDIQPLIK QWVDQSGVVK FYGSFAFNRK RNVLELEIKQ
560 570 580 590 600
DYTSPGTQKY VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK
610 620 630 640 650
KKKIPLMNGE EVDMDLSAMD ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ
660 670 680 690 700
YQLRYERDVV AQQESILALE KFPTPASRLA LTDILEQEQC FYRVRMSACF
710 720 730 740 750
CLAKIANSMV STWTGPPAMK SLFTRMFCCK SCPNIVKTNN FMSFQSYFLQ
760 770 780 790 800
KTMPVAMALL RDVHNLCPKE VLTFILDLIK YNDNRKNKFS DNYYRAEMID
810 820 830 840 850
ALANSVTPAV SVNNEVRTLD NLNPDVRLIL EEITRFLNME KLLPSYRHTI
860 870 880 890 900
TVSCLRAIRV LQKNGHVPSD PALFKSYAEY GHFVDIRIAA LEAVVDYTKV
910 920 930 940 950
DRSYEELQWL LNMIQNDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV
960 970 980 990 1000
DQLWKLMNSG TSHDWRLRCG AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE
1010 1020 1030 1040 1050
KKAVLNPTII PESVAGNQEA ANNPSSHPQL VGFQNPFSSS QDEEEIDMDT
1060 1070 1080 1090 1100
VHDSQAFISH HLNMLERPST PGLSKYRPAS SRSALIPQHS AGCDSTPTTK
1110 1120 1130 1140 1150
PQWSLELARK GTGKEQAPLE MSMHPAASAP LSVFTKESTA SKHSDHHHHH
1160 1170 1180 1190
HHEHKKKKKK HKHKHKHKHK HDSKEKDKEP FTFSSPASGR SIRSPSLSD
Length:1,199
Mass (Da):136,971
Last modified:April 17, 2007 - v3
Checksum:i169DA4A3878CFD59
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEX2H0YEX2_HUMAN
Transcription initiation factor TFI...
TAF2
375Annotation score:
H0YC37H0YC37_HUMAN
Transcription initiation factor TFI...
TAF2
285Annotation score:
E5RI28E5RI28_HUMAN
Transcription initiation factor TFI...
TAF2
60Annotation score:
H0YB55H0YB55_HUMAN
Transcription initiation factor TFI...
TAF2
67Annotation score:

Sequence cautioni

The sequence AAC68502 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH64830 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → R in AAC68502 (PubMed:9774672).Curated1
Sequence conflicti41Q → H in AAC02966 (PubMed:9418870).Curated1
Sequence conflicti131P → L in AAH47732 (PubMed:15489334).Curated1
Sequence conflicti158G → C in AAH64830 (PubMed:15489334).Curated1
Sequence conflicti604I → K in AAH35673 (PubMed:15489334).Curated1
Sequence conflicti604I → K in AAH47732 (PubMed:15489334).Curated1
Sequence conflicti785R → G in AAC68502 (PubMed:9774672).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0278548P → L. Corresponds to variant dbSNP:rs17818842Ensembl.1
Natural variantiVAR_070945186T → R in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124656EnsemblClinVar.1
Natural variantiVAR_070946416P → H in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124655EnsemblClinVar.1
Natural variantiVAR_027855447S → T4 PublicationsCorresponds to variant dbSNP:rs9297605Ensembl.1
Natural variantiVAR_070947649W → R in MRT40. Corresponds to variant dbSNP:rs398124645EnsemblClinVar.1
Natural variantiVAR_057263686E → K. Corresponds to variant dbSNP:rs34154779Ensembl.1
Natural variantiVAR_0278561122S → N. Corresponds to variant dbSNP:rs956749Ensembl.1
Natural variantiVAR_0278571139T → A. Corresponds to variant dbSNP:rs956748Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026445 mRNA Translation: AAC02966.1
AF040701 mRNA Translation: AAC68502.1 Different initiation.
AF057694 mRNA Translation: AAC13540.1
AK316592 mRNA Translation: BAG38179.1
AC107960 Genomic DNA No translation available.
AC021945 Genomic DNA No translation available.
BC035673 mRNA Translation: AAH35673.1
BC047732 mRNA Translation: AAH47732.1
BC064830 mRNA Translation: AAH64830.1 Sequence problems.
CCDSiCCDS34937.1
RefSeqiNP_003175.1, NM_003184.3
UniGeneiHs.122752

Genome annotation databases

EnsembliENST00000378164; ENSP00000367406; ENSG00000064313
GeneIDi6873
KEGGihsa:6873
UCSCiuc003you.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026445 mRNA Translation: AAC02966.1
AF040701 mRNA Translation: AAC68502.1 Different initiation.
AF057694 mRNA Translation: AAC13540.1
AK316592 mRNA Translation: BAG38179.1
AC107960 Genomic DNA No translation available.
AC021945 Genomic DNA No translation available.
BC035673 mRNA Translation: AAH35673.1
BC047732 mRNA Translation: AAH47732.1
BC064830 mRNA Translation: AAH64830.1 Sequence problems.
CCDSiCCDS34937.1
RefSeqiNP_003175.1, NM_003184.3
UniGeneiHs.122752

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FURelectron microscopy8.50I1-1199[»]
ProteinModelPortaliQ6P1X5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112736, 32 interactors
ComplexPortaliCPX-900 SAGA complex
CPX-903 TFTC histone acetylation complex
CPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant
CORUMiQ6P1X5
DIPiDIP-38921N
IntActiQ6P1X5, 12 interactors
STRINGi9606.ENSP00000367406

Protein family/group databases

MEROPSiM01.972

PTM databases

iPTMnetiQ6P1X5
PhosphoSitePlusiQ6P1X5

Polymorphism and mutation databases

BioMutaiTAF2
DMDMi145559533

Proteomic databases

EPDiQ6P1X5
MaxQBiQ6P1X5
PaxDbiQ6P1X5
PeptideAtlasiQ6P1X5
PRIDEiQ6P1X5
ProteomicsDBi66877

Protocols and materials databases

DNASUi6873
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378164; ENSP00000367406; ENSG00000064313
GeneIDi6873
KEGGihsa:6873
UCSCiuc003you.4 human

Organism-specific databases

CTDi6873
DisGeNETi6873
EuPathDBiHostDB:ENSG00000064313.11
GeneCardsiTAF2
HGNCiHGNC:11536 TAF2
MalaCardsiTAF2
MIMi604912 gene
615599 phenotype
neXtProtiNX_Q6P1X5
OpenTargetsiENSG00000064313
Orphaneti397951 Microcephaly-thin corpus callosum-intellectual disability syndrome
PharmGKBiPA36311
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1932 Eukaryota
ENOG410XS52 LUCA
GeneTreeiENSGT00390000000420
HOVERGENiHBG094022
InParanoidiQ6P1X5
KOiK03128
OMAiSHGICPP
OrthoDBiEOG091G00Z3
PhylomeDBiQ6P1X5
TreeFamiTF315208

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

ChiTaRSiTAF2 human
GeneWikiiTAF2
GenomeRNAii6873
PROiPR:Q6P1X5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064313 Expressed in 228 organ(s), highest expression level in forebrain
CleanExiHS_TAF2
ExpressionAtlasiQ6P1X5 baseline and differential
GenevisibleiQ6P1X5 HS

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037813 TAF2
PANTHERiPTHR15137 PTHR15137, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAF2_HUMAN
AccessioniPrimary (citable) accession number: Q6P1X5
Secondary accession number(s): B2RE82
, O43487, O43604, O60668, Q86WW7, Q8IWK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 17, 2007
Last modified: September 12, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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