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Entry version 133 (13 Nov 2019)
Sequence version 3 (17 Apr 2007)
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Protein

Transcription initiation factor TFIID subunit 2

Gene

TAF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter.2 Publications

Miscellaneous

PubMed:9418870 was unable to show an association between TAF2 and TFIID.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M01.972

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 2
Alternative name(s):
150 kDa cofactor of initiator function
RNA polymerase II TBP-associated factor subunit B
TBP-associated factor 150 kDa
Transcription initiation factor TFIID 150 kDa subunit
Short name:
TAF(II)150
Short name:
TAFII-150
Short name:
TAFII150
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TAF2
Synonyms:CIF150, TAF2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11536 TAF2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604912 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P1X5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 40 (MRT40)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT40 affected individuals also show microcephaly, spasticity, thin corpus callosum, pyramidal signs.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070945186T → R in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124656EnsemblClinVar.1
Natural variantiVAR_070946416P → H in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124655EnsemblClinVar.1
Natural variantiVAR_070947649W → R in MRT40. Corresponds to variant dbSNP:rs398124645EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6873

MalaCards human disease database

More...
MalaCardsi
TAF2
MIMi615599 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000064313

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
397951 Microcephaly-thin corpus callosum-intellectual disability syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36311

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P1X5

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TAF2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002524241 – 1199Transcription initiation factor TFIID subunit 2Add BLAST1199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1185PhosphoserineCombined sources1
Modified residuei1188PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1196PhosphoserineCombined sources1
Modified residuei1198PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P1X5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P1X5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P1X5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P1X5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P1X5

PeptideAtlas

More...
PeptideAtlasi
Q6P1X5

PRoteomics IDEntifications database

More...
PRIDEi
Q6P1X5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66877

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P1X5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P1X5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues tested.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064313 Expressed in 228 organ(s), highest expression level in forebrain

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P1X5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P1X5 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors.

Interacts with TAF2C1.

Component of the TFTC-HAT complex.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112736, 91 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-900 SAGA complex
CPX-903 TFTC histone acetylation complex
CPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6P1X5

Database of interacting proteins

More...
DIPi
DIP-38921N

Protein interaction database and analysis system

More...
IntActi
Q6P1X5, 18 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367406

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P1X5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi600 – 603Poly-Lys4
Compositional biasi1143 – 1171His-richAdd BLAST29
Compositional biasi1155 – 1178Lys-richAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TAF2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1932 Eukaryota
ENOG410XS52 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000420

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P1X5

KEGG Orthology (KO)

More...
KOi
K03128

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHGICPP

Database of Orthologous Groups

More...
OrthoDBi
142542at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P1X5

TreeFam database of animal gene trees

More...
TreeFami
TF315208

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.1730, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042097 Aminopeptidase_N-like_N
IPR016024 ARM-type_fold
IPR037813 TAF2

The PANTHER Classification System

More...
PANTHERi
PTHR15137 PTHR15137, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF63737 SSF63737, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q6P1X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLTGVEPAR MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE
60 70 80 90 100
LTIFPTVANL NRIKLNSKQC RIYRVRINDL EAAFIYNDPT LEVCHSESKQ
110 120 130 140 150
RNLNYFSNAY AAAVSAVDPD AGNGELCIKV PSELWKHVDE LKVLKIHINF
160 170 180 190 200
SLDQPKGGLH FVVPSVEGSM AERGAHVFSC GYQNSTRFWF PCVDSYSELC
210 220 230 240 250
TWKLEFTVDA AMVAVSNGDL VETVYTHDMR KKTFHYMLTI PTAASNISLA
260 270 280 290 300
IGPFEILVDP YMHEVTHFCL PQLLPLLKHT TSYLHEVFEF YEEILTCRYP
310 320 330 340 350
YSCFKTVFID EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQSL
360 370 380 390 400
AQQFFGCFIS RMSWSDEWVL KGISGYIYGL WMKKTFGVNE YRHWIKEELD
410 420 430 440 450
KIVAYELKTG GVLLHPIFGG GKEKDNPASH LHFSIKHPHT LSWEYYSMFQ
460 470 480 490 500
CKAHLVMRLI ENRISMEFML QVFNKLLSLA STASSQKFQS HMWSQMLVST
510 520 530 540 550
SGFLKSISNV SGKDIQPLIK QWVDQSGVVK FYGSFAFNRK RNVLELEIKQ
560 570 580 590 600
DYTSPGTQKY VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK
610 620 630 640 650
KKKIPLMNGE EVDMDLSAMD ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ
660 670 680 690 700
YQLRYERDVV AQQESILALE KFPTPASRLA LTDILEQEQC FYRVRMSACF
710 720 730 740 750
CLAKIANSMV STWTGPPAMK SLFTRMFCCK SCPNIVKTNN FMSFQSYFLQ
760 770 780 790 800
KTMPVAMALL RDVHNLCPKE VLTFILDLIK YNDNRKNKFS DNYYRAEMID
810 820 830 840 850
ALANSVTPAV SVNNEVRTLD NLNPDVRLIL EEITRFLNME KLLPSYRHTI
860 870 880 890 900
TVSCLRAIRV LQKNGHVPSD PALFKSYAEY GHFVDIRIAA LEAVVDYTKV
910 920 930 940 950
DRSYEELQWL LNMIQNDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV
960 970 980 990 1000
DQLWKLMNSG TSHDWRLRCG AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE
1010 1020 1030 1040 1050
KKAVLNPTII PESVAGNQEA ANNPSSHPQL VGFQNPFSSS QDEEEIDMDT
1060 1070 1080 1090 1100
VHDSQAFISH HLNMLERPST PGLSKYRPAS SRSALIPQHS AGCDSTPTTK
1110 1120 1130 1140 1150
PQWSLELARK GTGKEQAPLE MSMHPAASAP LSVFTKESTA SKHSDHHHHH
1160 1170 1180 1190
HHEHKKKKKK HKHKHKHKHK HDSKEKDKEP FTFSSPASGR SIRSPSLSD
Length:1,199
Mass (Da):136,971
Last modified:April 17, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i169DA4A3878CFD59
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YEX2H0YEX2_HUMAN
Transcription initiation factor TFI...
TAF2
375Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC37H0YC37_HUMAN
Transcription initiation factor TFI...
TAF2
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RI28E5RI28_HUMAN
Transcription initiation factor TFI...
TAF2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB55H0YB55_HUMAN
Transcription initiation factor TFI...
TAF2
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC68502 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH64830 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → R in AAC68502 (PubMed:9774672).Curated1
Sequence conflicti41Q → H in AAC02966 (PubMed:9418870).Curated1
Sequence conflicti131P → L in AAH47732 (PubMed:15489334).Curated1
Sequence conflicti158G → C in AAH64830 (PubMed:15489334).Curated1
Sequence conflicti604I → K in AAH35673 (PubMed:15489334).Curated1
Sequence conflicti604I → K in AAH47732 (PubMed:15489334).Curated1
Sequence conflicti785R → G in AAC68502 (PubMed:9774672).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0278548P → L. Corresponds to variant dbSNP:rs17818842Ensembl.1
Natural variantiVAR_070945186T → R in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124656EnsemblClinVar.1
Natural variantiVAR_070946416P → H in MRT40; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs398124655EnsemblClinVar.1
Natural variantiVAR_027855447S → T4 PublicationsCorresponds to variant dbSNP:rs9297605Ensembl.1
Natural variantiVAR_070947649W → R in MRT40. Corresponds to variant dbSNP:rs398124645EnsemblClinVar.1
Natural variantiVAR_057263686E → K. Corresponds to variant dbSNP:rs34154779Ensembl.1
Natural variantiVAR_0278561122S → N. Corresponds to variant dbSNP:rs956749Ensembl.1
Natural variantiVAR_0278571139T → A. Corresponds to variant dbSNP:rs956748Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF026445 mRNA Translation: AAC02966.1
AF040701 mRNA Translation: AAC68502.1 Different initiation.
AF057694 mRNA Translation: AAC13540.1
AK316592 mRNA Translation: BAG38179.1
AC107960 Genomic DNA No translation available.
AC021945 Genomic DNA No translation available.
BC035673 mRNA Translation: AAH35673.1
BC047732 mRNA Translation: AAH47732.1
BC064830 mRNA Translation: AAH64830.1 Sequence problems.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34937.1

NCBI Reference Sequences

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RefSeqi
NP_003175.1, NM_003184.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378164; ENSP00000367406; ENSG00000064313

Database of genes from NCBI RefSeq genomes

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GeneIDi
6873

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6873

UCSC genome browser

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UCSCi
uc003you.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026445 mRNA Translation: AAC02966.1
AF040701 mRNA Translation: AAC68502.1 Different initiation.
AF057694 mRNA Translation: AAC13540.1
AK316592 mRNA Translation: BAG38179.1
AC107960 Genomic DNA No translation available.
AC021945 Genomic DNA No translation available.
BC035673 mRNA Translation: AAH35673.1
BC047732 mRNA Translation: AAH47732.1
BC064830 mRNA Translation: AAH64830.1 Sequence problems.
CCDSiCCDS34937.1
RefSeqiNP_003175.1, NM_003184.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5FURelectron microscopy8.50I1-1199[»]
6MZCelectron microscopy4.50B1-1199[»]
6MZLelectron microscopy23.00B1-1199[»]
6MZMelectron microscopy7.50B1-1199[»]
SMRiQ6P1X5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi112736, 91 interactors
ComplexPortaliCPX-900 SAGA complex
CPX-903 TFTC histone acetylation complex
CPX-915 General transcription factor complex TFIID
CPX-930 General transcription factor complex TFIID, TAF4B variant
CORUMiQ6P1X5
DIPiDIP-38921N
IntActiQ6P1X5, 18 interactors
STRINGi9606.ENSP00000367406

Protein family/group databases

MEROPSiM01.972

PTM databases

iPTMnetiQ6P1X5
PhosphoSitePlusiQ6P1X5

Polymorphism and mutation databases

BioMutaiTAF2
DMDMi145559533

Proteomic databases

EPDiQ6P1X5
jPOSTiQ6P1X5
MassIVEiQ6P1X5
MaxQBiQ6P1X5
PaxDbiQ6P1X5
PeptideAtlasiQ6P1X5
PRIDEiQ6P1X5
ProteomicsDBi66877

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6873

Genome annotation databases

EnsembliENST00000378164; ENSP00000367406; ENSG00000064313
GeneIDi6873
KEGGihsa:6873
UCSCiuc003you.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6873
DisGeNETi6873

GeneCards: human genes, protein and diseases

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GeneCardsi
TAF2
HGNCiHGNC:11536 TAF2
MalaCardsiTAF2
MIMi604912 gene
615599 phenotype
neXtProtiNX_Q6P1X5
OpenTargetsiENSG00000064313
Orphaneti397951 Microcephaly-thin corpus callosum-intellectual disability syndrome
PharmGKBiPA36311

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1932 Eukaryota
ENOG410XS52 LUCA
GeneTreeiENSGT00390000000420
InParanoidiQ6P1X5
KOiK03128
OMAiSHGICPP
OrthoDBi142542at2759
PhylomeDBiQ6P1X5
TreeFamiTF315208

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TAF2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TAF2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6873
PharosiQ6P1X5

Protein Ontology

More...
PROi
PR:Q6P1X5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064313 Expressed in 228 organ(s), highest expression level in forebrain
ExpressionAtlasiQ6P1X5 baseline and differential
GenevisibleiQ6P1X5 HS

Family and domain databases

Gene3Di2.60.40.1730, 1 hit
InterProiView protein in InterPro
IPR042097 Aminopeptidase_N-like_N
IPR016024 ARM-type_fold
IPR037813 TAF2
PANTHERiPTHR15137 PTHR15137, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF63737 SSF63737, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAF2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1X5
Secondary accession number(s): B2RE82
, O43487, O43604, O60668, Q86WW7, Q8IWK4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: April 17, 2007
Last modified: November 13, 2019
This is version 133 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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