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Protein

tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Gene

DUS1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79FMNBy similarity1
Active sitei108Proton donorBy similarity1
Binding sitei147FMNBy similarity1
Binding sitei175FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 25FMNBy similarity3
Nucleotide bindingi208 – 210FMNBy similarity3
Nucleotide bindingi232 – 233FMNBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processtRNA processing
LigandFlavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC:1.3.1.-)
Alternative name(s):
tRNA-dihydrouridine synthase 1-like
Gene namesi
Name:DUS1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000169718.17
HGNCiHGNC:30086 DUS1L
neXtProtiNX_Q6P1R4

Pathology & Biotechi

Organism-specific databases

DisGeNETi64118
OpenTargetsiENSG00000169718
PharmGKBiPA142671936

Polymorphism and mutation databases

BioMutaiDUS1L
DMDMi74749069

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472261 – 473tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-likeAdd BLAST473

Proteomic databases

EPDiQ6P1R4
MaxQBiQ6P1R4
PaxDbiQ6P1R4
PeptideAtlasiQ6P1R4
PRIDEiQ6P1R4
ProteomicsDBi66872

PTM databases

iPTMnetiQ6P1R4
PhosphoSitePlusiQ6P1R4

Expressioni

Gene expression databases

BgeeiENSG00000169718
CleanExiHS_DUS1L
ExpressionAtlasiQ6P1R4 baseline and differential
GenevisibleiQ6P1R4 HS

Organism-specific databases

HPAiHPA023384

Interactioni

Protein-protein interaction databases

BioGridi122073, 1 interactor
IntActiQ6P1R4, 4 interactors
STRINGi9606.ENSP00000303515

Structurei

3D structure databases

ProteinModelPortaliQ6P1R4
SMRiQ6P1R4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family. Dus1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2335 Eukaryota
COG0042 LUCA
GeneTreeiENSGT00550000075089
HOGENOMiHOG000203649
HOVERGENiHBG061241
InParanoidiQ6P1R4
KOiK05542
OMAiCYSPMYH
OrthoDBiEOG091G05BU
PhylomeDBiQ6P1R4
TreeFamiTF313398

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
PANTHERiPTHR11082 PTHR11082, 1 hit
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P1R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLQGFEFW SRTLRGARHV VAPMVDQSEL AWRLLSRRHG AQLCYTPMLH
60 70 80 90 100
AQVFVRDANY RKENLYCEVC PEDRPLIVQF CANDPEVFVQ AALLAQDYCD
110 120 130 140 150
AIDLNLGCPQ MIAKRGHYGA FLQDEWDLLQ RMILLAHEKL SVPVTCKIRV
160 170 180 190 200
FPEIDKTVRY AQMLEKAGCQ LLTVHGRTKE QKGPLSGAAS WEHIKAVRKA
210 220 230 240 250
VAIPVFANGN IQCLQDVERC LRDTGVQGVM SAEGNLHNPA LFEGRSPAVW
260 270 280 290 300
ELAEEYLDIV REHPCPLSYV RAHLFKLWHH TLQVHQELRE ELAKVKTLEG
310 320 330 340 350
IAAVSQELKL RCQEEISRQE GAKPTGDLPF HWICQPYIRP GPREGSKEKA
360 370 380 390 400
GARSKRALEE EEGGTEVLSK NKQKKQLRNP HKTFDPSLKP KYAKCDQCGN
410 420 430 440 450
PKGNRCVFSL CRGCCKKRAS KETADCPGHG LLFKTKLEKS LAWKEAQPEL
460 470
QEPQPAAPGT PGGFSEVMGS ALA
Length:473
Mass (Da):53,230
Last modified:July 5, 2004 - v1
Checksum:i9765C2BD7B0C6157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC135056 Genomic DNA No translation available.
BC017081 mRNA Translation: AAH17081.4
BC062566 mRNA Translation: AAH62566.1
BC064918 mRNA Translation: AAH64918.1
CCDSiCCDS32775.1
RefSeqiNP_071439.3, NM_022156.4
UniGeneiHs.514599
Hs.741994

Genome annotation databases

EnsembliENST00000306796; ENSP00000303515; ENSG00000169718
ENST00000354321; ENSP00000346280; ENSG00000169718
GeneIDi64118
KEGGihsa:64118
UCSCiuc002kdq.5 human

Similar proteinsi

Entry informationi

Entry nameiDUS1L_HUMAN
AccessioniPrimary (citable) accession number: Q6P1R4
Secondary accession number(s): A6NHV4, Q96AI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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