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Protein

Myb/SANT-like DNA-binding domain-containing protein 2

Gene

MSANTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Myb/SANT-like DNA-binding domain-containing protein 2
Gene namesi
Name:MSANTD2
Synonyms:C11orf61
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000120458.10
HGNCiHGNC:26266 MSANTD2
neXtProtiNX_Q6P1R3

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120458
PharmGKBiPA143485356

Polymorphism and mutation databases

BioMutaiMSANTD2
DMDMi74737168

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002743011 – 559Myb/SANT-like DNA-binding domain-containing protein 2Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13PhosphoserineCombined sources1
Modified residuei24PhosphoserineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei32PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki343Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei436PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ6P1R3
MaxQBiQ6P1R3
PeptideAtlasiQ6P1R3
PRIDEiQ6P1R3
ProteomicsDBi66869
66870 [Q6P1R3-2]
66871 [Q6P1R3-3]

PTM databases

iPTMnetiQ6P1R3
PhosphoSitePlusiQ6P1R3

Expressioni

Gene expression databases

BgeeiENSG00000120458
CleanExiHS_C11orf61
ExpressionAtlasiQ6P1R3 baseline and differential
GenevisibleiQ6P1R3 HS

Organism-specific databases

HPAiHPA038694
HPA038695

Interactioni

Protein-protein interaction databases

BioGridi122807, 2 interactors
IntActiQ6P1R3, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliQ6P1R3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini103 – 173Myb-likeAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 90Gly-richAdd BLAST62

Phylogenomic databases

GeneTreeiENSGT00390000013593
HOGENOMiHOG000111736
HOVERGENiHBG081219
InParanoidiQ6P1R3
OMAiTRITYCY
OrthoDBiEOG091G03YM
PhylomeDBiQ6P1R3
TreeFamiTF331593

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P1R3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPCGSELP ANSPLKIPKM EVLSPASPGG LSDGNPSLSD PSTPRGASPL
60 70 80 90 100
GPGSAAGSGA AASGGLGLGL GGRSAASSSV SFSPGGGGGG AAAAAAAACR
110 120 130 140 150
GMSWTPAETN ALIAVWGNER LVEARYQQLE GAGTVFGSKA PGPAMYERVS
160 170 180 190 200
RALAELGYER TPSQCRERIK TLRRCYSRVK EHGVGKRKSS YTFEQLEQVF
210 220 230 240 250
GQGGWDAQPC QPVLINSSGL YQELESDGST MEDYSQEDWG NHSQDLHGYP
260 270 280 290 300
TDQELDEIPV TKRTLKIKQE SSEEAQKRDI MQNIVQILES VQLKWELFQS
310 320 330 340 350
WTDFSRLHLS NKLAIFGIGY NTRWKEDIRY HYAEISSQVP LGKRLREYFN
360 370 380 390 400
SEKPEGRIIM TRVQKMNWKN VYYKFLEITI SEARCLELHM EIDWIPIAHS
410 420 430 440 450
KPTGGNVVQY LLPGGIPKSP GLYAIGYEEC IERPLSPHME QSSLDPGKEG
460 470 480 490 500
RVDLETLSAQ ASLQVEIEPT RIIYCYLGIA EVRTLQQCLF LHFQANTKTF
510 520 530 540 550
SKDWVGINGF LSQNCIVDPG VSPKSIYIKF VEVERDFLSA GSLVECLEKA

IGYPLKFNN
Length:559
Mass (Da):61,319
Last modified:July 5, 2004 - v1
Checksum:i92063815ADDE0E5F
GO
Isoform 2 (identifier: Q6P1R3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-230: Missing.

Show »
Length:329
Mass (Da):38,005
Checksum:i8D6573495E0AB744
GO
Isoform 3 (identifier: Q6P1R3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     171-222: Missing.

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):55,404
Checksum:i4C76D23E6CD84709
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti370N → D in BAB15618 (PubMed:14702039).Curated1
Sequence conflicti382E → K in BAB15618 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0227051 – 230Missing in isoform 2. 2 PublicationsAdd BLAST230
Alternative sequenceiVSP_022706171 – 222Missing in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026995 mRNA Translation: BAB15618.1
AK092413 mRNA Translation: BAG52548.1
AL512691 mRNA Translation: CAC21648.1
BC064919 mRNA Translation: AAH64919.1
CCDSiCCDS73408.1 [Q6P1R3-2]
CCDS76491.1 [Q6P1R3-1]
CCDS8454.1 [Q6P1R3-3]
RefSeqiNP_001294956.1, NM_001308027.1 [Q6P1R3-1]
NP_001299848.1, NM_001312919.1
NP_001299849.1, NM_001312920.1 [Q6P1R3-2]
NP_001299850.1, NM_001312921.1 [Q6P1R3-2]
NP_078907.2, NM_024631.3 [Q6P1R3-3]
XP_006718968.1, XM_006718905.1 [Q6P1R3-2]
XP_006718969.1, XM_006718906.3 [Q6P1R3-2]
XP_016873784.1, XM_017018295.1 [Q6P1R3-2]
XP_016873785.1, XM_017018296.1 [Q6P1R3-2]
XP_016873786.1, XM_017018297.1 [Q6P1R3-2]
XP_016873787.1, XM_017018298.1 [Q6P1R3-2]
XP_016873788.1, XM_017018299.1
UniGeneiHs.146079

Genome annotation databases

EnsembliENST00000239614; ENSP00000239614; ENSG00000120458 [Q6P1R3-3]
ENST00000374979; ENSP00000364118; ENSG00000120458 [Q6P1R3-1]
ENST00000526629; ENSP00000435705; ENSG00000120458 [Q6P1R3-2]
GeneIDi79684
KEGGihsa:79684
UCSCiuc001qay.2 human [Q6P1R3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMSD2_HUMAN
AccessioniPrimary (citable) accession number: Q6P1R3
Secondary accession number(s): B3KRY6, Q9H042, Q9H5K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM

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