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Protein

LETM1 domain-containing protein 1

Gene

LETMD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.1 Publication

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
LETM1 domain-containing protein 1
Alternative name(s):
Cervical cancer 1 proto-oncogene protein p40
Cervical cancer proto-oncogene 2 protein
HCCR-1
HCRR-2
Gene namesi
Name:LETMD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000050426.15
HGNCiHGNC:24241 LETMD1
neXtProtiNX_Q6P1Q0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 137CytoplasmicSequence analysisAdd BLAST137
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 360Mitochondrial intermembraneSequence analysisAdd BLAST202

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi25875
OpenTargetsiENSG00000050426
PharmGKBiPA134914870

Polymorphism and mutation databases

BioMutaiLETMD1
DMDMi74737159

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104191 – 360LETM1 domain-containing protein 1Add BLAST360

Proteomic databases

EPDiQ6P1Q0
MaxQBiQ6P1Q0
PaxDbiQ6P1Q0
PeptideAtlasiQ6P1Q0
PRIDEiQ6P1Q0
ProteomicsDBi66860
66861 [Q6P1Q0-2]
66862 [Q6P1Q0-3]
66863 [Q6P1Q0-4]
66864 [Q6P1Q0-5]
66865 [Q6P1Q0-6]

PTM databases

iPTMnetiQ6P1Q0
PhosphoSitePlusiQ6P1Q0

Expressioni

Tissue specificityi

Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.1 Publication

Gene expression databases

BgeeiENSG00000050426 Expressed in 224 organ(s), highest expression level in body of pancreas
CleanExiHS_LETMD1
ExpressionAtlasiQ6P1Q0 baseline and differential
GenevisibleiQ6P1Q0 HS

Organism-specific databases

HPAiHPA074361

Interactioni

Subunit structurei

Interacts with BRI3BP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
REEP5Q007653EBI-1549822,EBI-1549827

Protein-protein interaction databases

BioGridi117390, 41 interactors
IntActiQ6P1Q0, 20 interactors
MINTiQ6P1Q0
STRINGi9606.ENSP00000262055

Structurei

3D structure databases

ProteinModelPortaliQ6P1Q0
SMRiQ6P1Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 360Letm1 RBDPROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 110Required and sufficient for mitochondrial importAdd BLAST110

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4263 Eukaryota
ENOG410ZXCM LUCA
GeneTreeiENSGT00390000018328
HOGENOMiHOG000037443
HOVERGENiHBG108107
InParanoidiQ6P1Q0
OMAiVFRCLQA
OrthoDBiEOG091G0GD0
PhylomeDBiQ6P1Q0
TreeFamiTF314047

Family and domain databases

InterProiView protein in InterPro
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF07766 LETM1, 1 hit
PROSITEiView protein in PROSITE
PS51758 LETM1_RBD, 1 hit

Sequences (7+)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 19 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P1Q0-1) [UniParc]FASTAAdd to basket
Also known as: HCCR-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALSRVCWAR SAVWGSAVTP GHFVTRRLQL GRSGLAWGAP RSSKLHLSPK
60 70 80 90 100
ADVKNLMSYV VTKTKAINGK YHRFLGRHFP RFYVLYTIFM KGLQMLWADA
110 120 130 140 150
KKARRIKTNM WKHNIKFHQL PYREMEHLRQ FRQDVTKCLF LGIISIPPFA
160 170 180 190 200
NYLVFLLMYL FPRQLLIRHF WTPKQQTDFL DIYHAFRKQS HPEIISYLEK
210 220 230 240 250
VIPLISDAGL RWRLTDLCTK IQRGTHPAIH DILALRECFS NHPLGMNQLQ
260 270 280 290 300
ALHVKALSRA MLLTSYLPPP LLRHRLKTHT TVIHQLDKAL AKLGIGQLTA
310 320 330 340 350
QEVKSACYLR GLNSTHIGED RCRTWLGEWL QISCSLKEAE LSLLLHNVVL
360
LSTNYLGTRR
Length:360
Mass (Da):41,790
Last modified:July 5, 2004 - v1
Checksum:iEC50BEFB0E4A6DF5
GO
Isoform 2 (identifier: Q6P1Q0-2) [UniParc]FASTAAdd to basket
Also known as: HCRR-2

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:304
Mass (Da):35,723
Checksum:iE42CDAB0CEBAAA44
GO
Isoform 3 (identifier: Q6P1Q0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-155: GLQMLWADAK...IPPFANYLVF → ESLEPGHASH...SPWPEFYAYW
     156-360: Missing.

Show »
Length:155
Mass (Da):17,258
Checksum:iD059023F1D465080
GO
Isoform 4 (identifier: Q6P1Q0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-157: Missing.

Show »
Length:203
Mass (Da):23,429
Checksum:i8ED05540B421D63A
GO
Isoform 5 (identifier: Q6P1Q0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.

Show »
Length:100
Mass (Da):11,318
Checksum:i4C5179D6F75156C7
GO
Isoform 6 (identifier: Q6P1Q0-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-99: LQMLWAD → TCFPGNY
     100-360: Missing.

Show »
Length:99
Mass (Da):11,221
Checksum:i3E00BF9104FCFCFF
GO
Isoform 7 (identifier: Q6P1Q0-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     130-130: Q → QVWARGRYPEVHGE

Show »
Length:373
Mass (Da):43,328
Checksum:i4DAF71CBE878FAAB
GO

Computationally mapped potential isoform sequencesi

There are 19 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZA2F8VZA2_HUMAN
LETM1 domain-containing protein 1
LETMD1
290Annotation score:
F8VVQ3F8VVQ3_HUMAN
LETM1 domain-containing protein 1
LETMD1
260Annotation score:
F8VP71F8VP71_HUMAN
LETM1 domain-containing protein 1
LETMD1
243Annotation score:
F8W1Z2F8W1Z2_HUMAN
LETM1 domain-containing protein 1
LETMD1
236Annotation score:
F8VR33F8VR33_HUMAN
LETM1 domain-containing protein 1
LETMD1
109Annotation score:
F8VS60F8VS60_HUMAN
LETM1 domain-containing protein 1
LETMD1
158Annotation score:
F8W0R0F8W0R0_HUMAN
LETM1 domain-containing protein 1
LETMD1
184Annotation score:
H0YIV5H0YIV5_HUMAN
LETM1 domain-containing protein 1
LETMD1
144Annotation score:
F8VPY5F8VPY5_HUMAN
LETM1 domain-containing protein 1
LETMD1
179Annotation score:
H0YHF4H0YHF4_HUMAN
LETM1 domain-containing protein 1
LETMD1
98Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88I → T in AAP85625 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03703384V → I3 PublicationsCorresponds to variant dbSNP:rs12379Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0292731 – 260Missing in isoform 5. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_0292741 – 157Missing in isoform 4. 1 PublicationAdd BLAST157
Alternative sequenceiVSP_0292751 – 56Missing in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_02927692 – 155GLQML…NYLVF → ESLEPGHASHILPASSLVET SFEDSYNCDSPTGQGFGKAG DWPADCSGSKIGLLSPWPEF YAYW in isoform 3. 2 PublicationsAdd BLAST64
Alternative sequenceiVSP_02927793 – 99LQMLWAD → TCFPGNY in isoform 6. 1 Publication7
Alternative sequenceiVSP_029278100 – 360Missing in isoform 6. 1 PublicationAdd BLAST261
Alternative sequenceiVSP_045299130Q → QVWARGRYPEVHGE in isoform 7. 1 Publication1
Alternative sequenceiVSP_029279156 – 360Missing in isoform 3. 2 PublicationsAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195651 mRNA Translation: AAK34885.1
AF315598 mRNA Translation: AAL26878.1
AY259835 mRNA Translation: AAP85624.1
AY259836 mRNA Translation: AAP85625.1
AF329277 mRNA Translation: AAL56993.1
AK127540 mRNA Translation: BAG54519.1
AC087884 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58167.1
CH471111 Genomic DNA Translation: EAW58169.1
CH471111 Genomic DNA Translation: EAW58170.1
BC000395 mRNA Translation: AAH00395.2
BC019274 mRNA Translation: AAH19274.1
BC064943 mRNA Translation: AAH64943.1
AL050286 mRNA Translation: CAB43387.2
CCDSiCCDS44883.1 [Q6P1Q0-2]
CCDS58231.1 [Q6P1Q0-7]
CCDS8806.1 [Q6P1Q0-1]
PIRiT08763
RefSeqiNP_001230618.1, NM_001243689.1 [Q6P1Q0-7]
NP_056231.3, NM_015416.4 [Q6P1Q0-1]
XP_006719402.1, XM_006719339.1
XP_006719403.1, XM_006719340.1 [Q6P1Q0-4]
UniGeneiHs.655272

Genome annotation databases

EnsembliENST00000262055; ENSP00000262055; ENSG00000050426 [Q6P1Q0-1]
ENST00000418425; ENSP00000389903; ENSG00000050426 [Q6P1Q0-7]
ENST00000550100; ENSP00000447047; ENSG00000050426 [Q6P1Q0-3]
ENST00000550929; ENSP00000450163; ENSG00000050426 [Q6P1Q0-2]
GeneIDi25875
KEGGihsa:25875
UCSCiuc001rxl.4 human [Q6P1Q0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195651 mRNA Translation: AAK34885.1
AF315598 mRNA Translation: AAL26878.1
AY259835 mRNA Translation: AAP85624.1
AY259836 mRNA Translation: AAP85625.1
AF329277 mRNA Translation: AAL56993.1
AK127540 mRNA Translation: BAG54519.1
AC087884 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58167.1
CH471111 Genomic DNA Translation: EAW58169.1
CH471111 Genomic DNA Translation: EAW58170.1
BC000395 mRNA Translation: AAH00395.2
BC019274 mRNA Translation: AAH19274.1
BC064943 mRNA Translation: AAH64943.1
AL050286 mRNA Translation: CAB43387.2
CCDSiCCDS44883.1 [Q6P1Q0-2]
CCDS58231.1 [Q6P1Q0-7]
CCDS8806.1 [Q6P1Q0-1]
PIRiT08763
RefSeqiNP_001230618.1, NM_001243689.1 [Q6P1Q0-7]
NP_056231.3, NM_015416.4 [Q6P1Q0-1]
XP_006719402.1, XM_006719339.1
XP_006719403.1, XM_006719340.1 [Q6P1Q0-4]
UniGeneiHs.655272

3D structure databases

ProteinModelPortaliQ6P1Q0
SMRiQ6P1Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117390, 41 interactors
IntActiQ6P1Q0, 20 interactors
MINTiQ6P1Q0
STRINGi9606.ENSP00000262055

PTM databases

iPTMnetiQ6P1Q0
PhosphoSitePlusiQ6P1Q0

Polymorphism and mutation databases

BioMutaiLETMD1
DMDMi74737159

Proteomic databases

EPDiQ6P1Q0
MaxQBiQ6P1Q0
PaxDbiQ6P1Q0
PeptideAtlasiQ6P1Q0
PRIDEiQ6P1Q0
ProteomicsDBi66860
66861 [Q6P1Q0-2]
66862 [Q6P1Q0-3]
66863 [Q6P1Q0-4]
66864 [Q6P1Q0-5]
66865 [Q6P1Q0-6]

Protocols and materials databases

DNASUi25875
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262055; ENSP00000262055; ENSG00000050426 [Q6P1Q0-1]
ENST00000418425; ENSP00000389903; ENSG00000050426 [Q6P1Q0-7]
ENST00000550100; ENSP00000447047; ENSG00000050426 [Q6P1Q0-3]
ENST00000550929; ENSP00000450163; ENSG00000050426 [Q6P1Q0-2]
GeneIDi25875
KEGGihsa:25875
UCSCiuc001rxl.4 human [Q6P1Q0-1]

Organism-specific databases

CTDi25875
DisGeNETi25875
EuPathDBiHostDB:ENSG00000050426.15
GeneCardsiLETMD1
HGNCiHGNC:24241 LETMD1
HPAiHPA074361
neXtProtiNX_Q6P1Q0
OpenTargetsiENSG00000050426
PharmGKBiPA134914870
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4263 Eukaryota
ENOG410ZXCM LUCA
GeneTreeiENSGT00390000018328
HOGENOMiHOG000037443
HOVERGENiHBG108107
InParanoidiQ6P1Q0
OMAiVFRCLQA
OrthoDBiEOG091G0GD0
PhylomeDBiQ6P1Q0
TreeFamiTF314047

Miscellaneous databases

ChiTaRSiLETMD1 human
GeneWikiiLETMD1
GenomeRNAii25875
PROiPR:Q6P1Q0

Gene expression databases

BgeeiENSG00000050426 Expressed in 224 organ(s), highest expression level in body of pancreas
CleanExiHS_LETMD1
ExpressionAtlasiQ6P1Q0 baseline and differential
GenevisibleiQ6P1Q0 HS

Family and domain databases

InterProiView protein in InterPro
IPR011685 LETM1
IPR033122 LETM1_RBD
PfamiView protein in Pfam
PF07766 LETM1, 1 hit
PROSITEiView protein in PROSITE
PS51758 LETM1_RBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTMD1_HUMAN
AccessioniPrimary (citable) accession number: Q6P1Q0
Secondary accession number(s): A6NER7
, B3KXK7, Q6X2E4, Q6X2E5, Q7L2G9, Q7L690, Q8WXW6, Q96PK7, Q9BY59, Q9Y3X3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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