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Entry version 152 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Long-chain fatty acid transport protein 4

Gene

SLC27A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones (By similarity).By similarity

Miscellaneous

SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with acquired obesity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi243 – 254AMPSequence analysisAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism, Lipid transport, Transport
LigandNucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.2.1.3 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
R-HSA-804914 Transport of fatty acids

Protein family/group databases

Transport Classification Database

More...
TCDBi
4.C.1.1.10 the fatty acid transporter (fat) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000451

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Long-chain fatty acid transport protein 4 (EC:6.2.1.-)
Short name:
FATP-4
Short name:
Fatty acid transport protein 4
Alternative name(s):
Solute carrier family 27 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC27A4
Synonyms:ACSVL4, FATP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10998 SLC27A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604194 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P1M0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei139 – 156HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ichthyosis prematurity syndrome (IPS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA keratinization disorder characterized by complications in the second trimester of pregnancy resulting from polyhydramnion, with premature birth of a child with thick caseous desquamating epidermis, respiratory complications and transient eosinophilia. After recovery during the first months of life, the symptoms are relatively benign and the patients suffer from a lifelong non-scaly ichthyosis with atopic manifestations.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06319292A → T in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853132EnsemblClinVar.1
Natural variantiVAR_063193247S → P in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853133EnsemblClinVar.1
Natural variantiVAR_063194300Q → R in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853134EnsemblClinVar.1
Natural variantiVAR_064500374R → C in IPS. 1 PublicationCorresponds to variant dbSNP:rs768495407Ensembl.1
Natural variantiVAR_063195583R → H in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853135EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
10999

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC27A4

MalaCards human disease database

More...
MalaCardsi
SLC27A4
MIMi608649 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167114

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
88621 Ichthyosis-prematurity syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35872

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P1M0

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4327

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1111

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC27A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749065

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001932091 – 643Long-chain fatty acid transport protein 4Add BLAST643

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6P1M0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P1M0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P1M0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P1M0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P1M0

PeptideAtlas

More...
PeptideAtlasi
Q6P1M0

PRoteomics IDEntifications database

More...
PRIDEi
Q6P1M0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66849 [Q6P1M0-1]
76596

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P1M0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P1M0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6P1M0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167114 Expressed in 169 organ(s), highest expression level in esophagus mucosa

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P1M0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P1M0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009771
HPA007293

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116192, 35 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P1M0, 25 interactors

Molecular INTeraction database

More...
MINTi
Q6P1M0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000300456

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q6P1M0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1179 Eukaryota
ENOG410XQ8T LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158646

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293292

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P1M0

KEGG Orthology (KO)

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KOi
K08745

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPCQPGQ

Database of Orthologous Groups

More...
OrthoDBi
698464at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P1M0

TreeFam database of animal gene trees

More...
TreeFami
TF313430

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR030304 FATP4
IPR022272 Lipocalin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR43107:SF11 PTHR43107:SF11, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P1M0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLGASLVGV LLFSKLVLKL PWTQVGFSLL FLYLGSGGWR FIRVFIKTIR
60 70 80 90 100
RDIFGGLVLL KVKAKVRQCL QERRTVPILF ASTVRRHPDK TALIFEGTDT
110 120 130 140 150
HWTFRQLDEY SSSVANFLQA RGLASGDVAA IFMENRNEFV GLWLGMAKLG
160 170 180 190 200
VEAALINTNL RRDALLHCLT TSRARALVFG SEMASAICEV HASLDPSLSL
210 220 230 240 250
FCSGSWEPGA VPPSTEHLDP LLKDAPKHLP SCPDKGFTDK LFYIYTSGTT
260 270 280 290 300
GLPKAAIVVH SRYYRMAALV YYGFRMRPND IVYDCLPLYH SAGNIVGIGQ
310 320 330 340 350
CLLHGMTVVI RKKFSASRFW DDCIKYNCTI VQYIGELCRY LLNQPPREAE
360 370 380 390 400
NQHQVRMALG NGLRQSIWTN FSSRFHIPQV AEFYGATECN CSLGNFDSQV
410 420 430 440 450
GACGFNSRIL SFVYPIRLVR VNEDTMELIR GPDGVCIPCQ PGEPGQLVGR
460 470 480 490 500
IIQKDPLRRF DGYLNQGANN KKIAKDVFKK GDQAYLTGDV LVMDELGYLY
510 520 530 540 550
FRDRTGDTFR WKGENVSTTE VEGTLSRLLD MADVAVYGVE VPGTEGRAGM
560 570 580 590 600
AAVASPTGNC DLERFAQVLE KELPLYARPI FLRLLPELHK TGTYKFQKTE
610 620 630 640
LRKEGFDPAI VKDPLFYLDA QKGRYVPLDQ EAYSRIQAGE EKL
Length:643
Mass (Da):72,064
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i95E677DB3CEB9A14
GO
Isoform 2 (identifier: Q6P1M0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MLLGASLVGV...RQCLQERRTV → MPLTLSTLLQ...ALHPGLHQDH
     77-482: Missing.

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):26,001
Checksum:i28E743004702E708
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD11623 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti194L → P in AAD11623 (PubMed:9878842).Curated1
Sequence conflicti605G → A in AAD11623 (PubMed:9878842).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06319292A → T in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853132EnsemblClinVar.1
Natural variantiVAR_023783209G → S Correlates with lower body mass index, triglyceride concentrations, systolic blood pressure, insulin concentrations and homeostasis model assessment index. 1 PublicationCorresponds to variant dbSNP:rs2240953Ensembl.1
Natural variantiVAR_063193247S → P in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853133EnsemblClinVar.1
Natural variantiVAR_063194300Q → R in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853134EnsemblClinVar.1
Natural variantiVAR_064500374R → C in IPS. 1 PublicationCorresponds to variant dbSNP:rs768495407Ensembl.1
Natural variantiVAR_063195583R → H in IPS. 1 PublicationCorresponds to variant dbSNP:rs137853135EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0558081 – 76MLLGA…ERRTV → MPLTLSTLLQPGRIWTGRRA AEPTPGHNAAWSLSGGGAAV LQAGAETALDPGGILPVVPL LGIWRLALHPGLHQDH in isoform 2. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_05580977 – 482Missing in isoform 2. 1 PublicationAdd BLAST406

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF055899 mRNA Translation: AAD11623.1 Frameshift.
AK290222 mRNA Translation: BAF82911.1
AL359091 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87779.1
BC009959 mRNA Translation: AAH09959.1
BC065003 mRNA Translation: AAH65003.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6899.1 [Q6P1M0-1]

NCBI Reference Sequences

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RefSeqi
NP_005085.2, NM_005094.3 [Q6P1M0-1]
XP_016869711.1, XM_017014222.1 [Q6P1M0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000300456; ENSP00000300456; ENSG00000167114 [Q6P1M0-1]
ENST00000372870; ENSP00000361961; ENSG00000167114 [Q6P1M0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10999

UCSC genome browser

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UCSCi
uc004but.4 human [Q6P1M0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055899 mRNA Translation: AAD11623.1 Frameshift.
AK290222 mRNA Translation: BAF82911.1
AL359091 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87779.1
BC009959 mRNA Translation: AAH09959.1
BC065003 mRNA Translation: AAH65003.1
CCDSiCCDS6899.1 [Q6P1M0-1]
RefSeqiNP_005085.2, NM_005094.3 [Q6P1M0-1]
XP_016869711.1, XM_017014222.1 [Q6P1M0-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116192, 35 interactors
IntActiQ6P1M0, 25 interactors
MINTiQ6P1M0
STRINGi9606.ENSP00000300456

Chemistry databases

BindingDBiQ6P1M0
ChEMBLiCHEMBL4327
GuidetoPHARMACOLOGYi1111
SwissLipidsiSLP:000000451

Protein family/group databases

TCDBi4.C.1.1.10 the fatty acid transporter (fat) family

PTM databases

iPTMnetiQ6P1M0
PhosphoSitePlusiQ6P1M0
SwissPalmiQ6P1M0

Polymorphism and mutation databases

BioMutaiSLC27A4
DMDMi74749065

Proteomic databases

EPDiQ6P1M0
jPOSTiQ6P1M0
MassIVEiQ6P1M0
MaxQBiQ6P1M0
PaxDbiQ6P1M0
PeptideAtlasiQ6P1M0
PRIDEiQ6P1M0
ProteomicsDBi66849 [Q6P1M0-1]
76596

Genome annotation databases

EnsembliENST00000300456; ENSP00000300456; ENSG00000167114 [Q6P1M0-1]
ENST00000372870; ENSP00000361961; ENSG00000167114 [Q6P1M0-2]
GeneIDi10999
KEGGihsa:10999
UCSCiuc004but.4 human [Q6P1M0-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10999
DisGeNETi10999

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC27A4
GeneReviewsiSLC27A4
HGNCiHGNC:10998 SLC27A4
HPAiCAB009771
HPA007293
MalaCardsiSLC27A4
MIMi604194 gene
608649 phenotype
neXtProtiNX_Q6P1M0
OpenTargetsiENSG00000167114
Orphaneti88621 Ichthyosis-prematurity syndrome
PharmGKBiPA35872

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1179 Eukaryota
ENOG410XQ8T LUCA
GeneTreeiENSGT00940000158646
HOGENOMiHOG000293292
InParanoidiQ6P1M0
KOiK08745
OMAiIPCQPGQ
OrthoDBi698464at2759
PhylomeDBiQ6P1M0
TreeFamiTF313430

Enzyme and pathway databases

BRENDAi6.2.1.3 2681
ReactomeiR-HSA-5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)
R-HSA-804914 Transport of fatty acids

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC27A4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC27A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10999
PharosiQ6P1M0

Protein Ontology

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PROi
PR:Q6P1M0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000167114 Expressed in 169 organ(s), highest expression level in esophagus mucosa
ExpressionAtlasiQ6P1M0 baseline and differential
GenevisibleiQ6P1M0 HS

Family and domain databases

Gene3Di3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR030304 FATP4
IPR022272 Lipocalin_CS
PANTHERiPTHR43107:SF11 PTHR43107:SF11, 1 hit
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS27A4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1M0
Secondary accession number(s): A8K2F7, O95186, Q96G53
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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