UniProtKB - Q6P1L8 (RM14_HUMAN)
39S ribosomal protein L14, mitochondrial
MRPL14
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- mitochondrial translational elongation Source: Reactome
- mitochondrial translational termination Source: Reactome
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q6P1L8 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q6P1L8 |
Names & Taxonomyi
Protein namesi | Recommended name: 39S ribosomal protein L14, mitochondrialShort name: L14mt Short name: MRP-L14 Alternative name(s): 39S ribosomal protein L32, mitochondrial Short name: L32mt Short name: MRP-L32 Mitochondrial large ribosomal subunit protein uL14m1 Publication |
Gene namesi | Name:MRPL14 Synonyms:MRPL32, RPML32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14279, MRPL14 |
MIMi | 611827, gene |
neXtProti | NX_Q6P1L8 |
VEuPathDBi | HostDB:ENSG00000180992.6 |
Subcellular locationi
Mitochondrion
- Mitochondrion 5 Publications
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial large ribosomal subunit Source: UniProtKB
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 64928 |
OpenTargetsi | ENSG00000180992 |
PharmGKBi | PA30943 |
Miscellaneous databases
Pharosi | Q6P1L8, Tdark |
Genetic variation databases
BioMutai | MRPL14 |
DMDMi | 74749064 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 30 | MitochondrionBy similarityAdd BLAST | 30 | |
ChainiPRO_0000261134 | 31 – 145 | 39S ribosomal protein L14, mitochondrialAdd BLAST | 115 |
Proteomic databases
EPDi | Q6P1L8 |
jPOSTi | Q6P1L8 |
MassIVEi | Q6P1L8 |
MaxQBi | Q6P1L8 |
PaxDbi | Q6P1L8 |
PeptideAtlasi | Q6P1L8 |
PRIDEi | Q6P1L8 |
ProteomicsDBi | 66848 |
TopDownProteomicsi | Q6P1L8 |
PTM databases
iPTMneti | Q6P1L8 |
PhosphoSitePlusi | Q6P1L8 |
SwissPalmi | Q6P1L8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180992, Expressed in quadriceps femoris and 212 other tissues |
ExpressionAtlasi | Q6P1L8, baseline and differential |
Genevisiblei | Q6P1L8, HS |
Organism-specific databases
HPAi | ENSG00000180992, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379).
Interacts with MALSU1 (PubMed:22829778).
4 PublicationsProtein-protein interaction databases
BioGRIDi | 122350, 93 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q6P1L8 |
IntActi | Q6P1L8, 31 interactors |
MINTi | Q6P1L8 |
STRINGi | 9606.ENSP00000361084 |
Miscellaneous databases
RNActi | Q6P1L8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q6P1L8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3441, Eukaryota |
GeneTreei | ENSGT00390000001121 |
HOGENOMi | CLU_128925_1_0_1 |
InParanoidi | Q6P1L8 |
OMAi | HKMPGER |
OrthoDBi | 1547267at2759 |
PhylomeDBi | Q6P1L8 |
TreeFami | TF324586 |
Family and domain databases
Gene3Di | 2.40.150.20, 1 hit |
HAMAPi | MF_01367, Ribosomal_L14, 1 hit |
InterProi | View protein in InterPro IPR036853, Ribosomal_L14_sf IPR000218, Ribosomal_L14P |
Pfami | View protein in Pfam PF00238, Ribosomal_L14, 1 hit |
SMARTi | View protein in SMART SM01374, Ribosomal_L14, 1 hit |
SUPFAMi | SSF50193, SSF50193, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP
60 70 80 90 100
YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF
110 120 130 140
DSNNVVLIED NGNPVGTRIK TPIPTSLRKR EGEYSKVLAI AQNFV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312086 mRNA Translation: BAG35022.1 AL109615 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04243.1 BC065005 mRNA Translation: AAH65005.1 AB051339 Genomic DNA Translation: BAB54929.2 |
CCDSi | CCDS34460.1 |
RefSeqi | NP_001305696.1, NM_001318767.1 NP_001305697.1, NM_001318768.1 NP_115487.2, NM_032111.3 |
Genome annotation databases
Ensembli | ENST00000372014; ENSP00000361084; ENSG00000180992 |
GeneIDi | 64928 |
KEGGi | hsa:64928 |
UCSCi | uc003owp.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK312086 mRNA Translation: BAG35022.1 AL109615 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04243.1 BC065005 mRNA Translation: AAH65005.1 AB051339 Genomic DNA Translation: BAB54929.2 |
CCDSi | CCDS34460.1 |
RefSeqi | NP_001305696.1, NM_001318767.1 NP_001305697.1, NM_001318768.1 NP_115487.2, NM_032111.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J7Y | electron microscopy | 3.40 | L | 1-145 | [»] | |
3J9M | electron microscopy | 3.50 | L | 1-145 | [»] | |
5OOL | electron microscopy | 3.06 | L | 1-145 | [»] | |
5OOM | electron microscopy | 3.03 | L | 1-145 | [»] | |
6I9R | electron microscopy | 3.90 | L | 1-145 | [»] | |
6NU2 | electron microscopy | 3.90 | L | 31-145 | [»] | |
6NU3 | electron microscopy | 4.40 | L | 1-145 | [»] | |
6VLZ | electron microscopy | 2.97 | L | 1-145 | [»] | |
6VMI | electron microscopy | 2.96 | L | 1-145 | [»] | |
6ZM5 | electron microscopy | 2.89 | L | 1-145 | [»] | |
6ZM6 | electron microscopy | 2.59 | L | 1-145 | [»] | |
6ZS9 | electron microscopy | 4.00 | XL | 1-145 | [»] | |
6ZSA | electron microscopy | 4.00 | XL | 1-145 | [»] | |
6ZSB | electron microscopy | 4.50 | XL | 1-145 | [»] | |
6ZSC | electron microscopy | 3.50 | XL | 1-145 | [»] | |
6ZSD | electron microscopy | 3.70 | XL | 1-145 | [»] | |
6ZSE | electron microscopy | 5.00 | XL | 1-145 | [»] | |
6ZSG | electron microscopy | 4.00 | XL | 1-145 | [»] | |
7A5F | electron microscopy | 4.40 | L3 | 1-145 | [»] | |
7A5G | electron microscopy | 4.33 | L3 | 1-145 | [»] | |
7A5H | electron microscopy | 3.30 | L | 1-145 | [»] | |
7A5I | electron microscopy | 3.70 | L3 | 1-145 | [»] | |
7A5J | electron microscopy | 3.10 | L | 1-145 | [»] | |
7A5K | electron microscopy | 3.70 | L3 | 1-145 | [»] | |
SMRi | Q6P1L8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 122350, 93 interactors |
ComplexPortali | CPX-5226, 39S mitochondrial large ribosomal subunit |
CORUMi | Q6P1L8 |
IntActi | Q6P1L8, 31 interactors |
MINTi | Q6P1L8 |
STRINGi | 9606.ENSP00000361084 |
PTM databases
iPTMneti | Q6P1L8 |
PhosphoSitePlusi | Q6P1L8 |
SwissPalmi | Q6P1L8 |
Genetic variation databases
BioMutai | MRPL14 |
DMDMi | 74749064 |
Proteomic databases
EPDi | Q6P1L8 |
jPOSTi | Q6P1L8 |
MassIVEi | Q6P1L8 |
MaxQBi | Q6P1L8 |
PaxDbi | Q6P1L8 |
PeptideAtlasi | Q6P1L8 |
PRIDEi | Q6P1L8 |
ProteomicsDBi | 66848 |
TopDownProteomicsi | Q6P1L8 |
Protocols and materials databases
Antibodypediai | 49263, 117 antibodies |
DNASUi | 64928 |
Genome annotation databases
Ensembli | ENST00000372014; ENSP00000361084; ENSG00000180992 |
GeneIDi | 64928 |
KEGGi | hsa:64928 |
UCSCi | uc003owp.4, human |
Organism-specific databases
CTDi | 64928 |
DisGeNETi | 64928 |
GeneCardsi | MRPL14 |
HGNCi | HGNC:14279, MRPL14 |
HPAi | ENSG00000180992, Low tissue specificity |
MIMi | 611827, gene |
neXtProti | NX_Q6P1L8 |
OpenTargetsi | ENSG00000180992 |
PharmGKBi | PA30943 |
VEuPathDBi | HostDB:ENSG00000180992.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3441, Eukaryota |
GeneTreei | ENSGT00390000001121 |
HOGENOMi | CLU_128925_1_0_1 |
InParanoidi | Q6P1L8 |
OMAi | HKMPGER |
OrthoDBi | 1547267at2759 |
PhylomeDBi | Q6P1L8 |
TreeFami | TF324586 |
Enzyme and pathway databases
PathwayCommonsi | Q6P1L8 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SIGNORi | Q6P1L8 |
Miscellaneous databases
BioGRID-ORCSi | 64928, 339 hits in 993 CRISPR screens |
ChiTaRSi | MRPL14, human |
GenomeRNAii | 64928 |
Pharosi | Q6P1L8, Tdark |
PROi | PR:Q6P1L8 |
RNActi | Q6P1L8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180992, Expressed in quadriceps femoris and 212 other tissues |
ExpressionAtlasi | Q6P1L8, baseline and differential |
Genevisiblei | Q6P1L8, HS |
Family and domain databases
Gene3Di | 2.40.150.20, 1 hit |
HAMAPi | MF_01367, Ribosomal_L14, 1 hit |
InterProi | View protein in InterPro IPR036853, Ribosomal_L14_sf IPR000218, Ribosomal_L14P |
Pfami | View protein in Pfam PF00238, Ribosomal_L14, 1 hit |
SMARTi | View protein in SMART SM01374, Ribosomal_L14, 1 hit |
SUPFAMi | SSF50193, SSF50193, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RM14_HUMAN | |
Accessioni | Q6P1L8Primary (citable) accession number: Q6P1L8 Secondary accession number(s): B2R575, Q96Q72 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families