MRPL14

Functionⁱ

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
structural constituent of ribosome Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 39S ribosomal protein L14, mitochondrial Short name: L14mt Short name: MRP-L14 Alternative name(s): 39S ribosomal protein L32, mitochondrial Short name: L32mt Short name: MRP-L32 Mitochondrial large ribosomal subunit protein uL14m1 Publication
Gene namesⁱ	Name:MRPL14 Synonyms:MRPL32, RPML32
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000180992.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:14279 MRPL14
MIMⁱ	611827 gene
neXtProtⁱ	NX_Q6P1L8

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000180992
PharmGKBⁱ	PA30943

Polymorphism and mutation databases

BioMutaⁱ	MRPL14
DMDMⁱ	74749064

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 30	MitochondrionBy similarityAdd BLAST		30
ChainⁱPRO_0000261134	31 – 145	39S ribosomal protein L14, mitochondrialAdd BLAST		115

Proteomic databases

EPDⁱ	Q6P1L8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q6P1L8
PaxDbⁱ	Q6P1L8
PeptideAtlas More...PeptideAtlasⁱ	Q6P1L8
PRIDEⁱ	Q6P1L8
ProteomicsDBⁱ	66848
TopDownProteomicsⁱ	Q6P1L8

PTM databases

iPTMnetⁱ	Q6P1L8
PhosphoSitePlusⁱ	Q6P1L8
SwissPalmⁱ	Q6P1L8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000180992 Expressed in 199 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MRPL14 HS_MRPL32
ExpressionAtlasⁱ	Q6P1L8 baseline and differential
Genevisibleⁱ	Q6P1L8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038769 HPA076790

HPAⁱ

HPA038769
HPA076790

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with MALSU1 (PubMed:22829778).4 Publications

Protein-protein interaction databases

BioGridⁱ	122350, 50 interactors
CORUMⁱ	Q6P1L8
IntActⁱ	Q6P1L8, 18 interactors
Molecular INTeraction database More...MINTⁱ	Q6P1L8
STRINGⁱ	9606.ENSP00000361084

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	45 – 48	Combined sources	4
Beta strandⁱ	56 – 65	Combined sources	10
Beta strandⁱ	72 – 77	Combined sources	6
Beta strandⁱ	80 – 86	Combined sources	7
Beta strandⁱ	94 – 102	Combined sources	9
Beta strandⁱ	104 – 107	Combined sources	4
Beta strandⁱ	110 – 112	Combined sources	3
Beta strandⁱ	119 – 123	Combined sources	5
Helixⁱ	125 – 127	Combined sources	3
Beta strandⁱ	130 – 133	Combined sources	4
Turnⁱ	135 – 140	Combined sources	6
Beta strandⁱ	141 – 144	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q6P1L8
SMRⁱ	Q6P1L8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL14 family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3441 Eukaryota ENOG4111JDP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001121
HOGENOMⁱ	HOG000183701
HOVERGENⁱ	HBG088508
InParanoidⁱ	Q6P1L8
KEGG Orthology (KO) More...KOⁱ	K02874
OMAⁱ	AIRGQKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G1144
PhylomeDBⁱ	Q6P1L8
TreeFamⁱ	TF324586

Family and domain databases

Gene3Dⁱ	2.40.150.20, 1 hit
HAMAPⁱ	MF_01367 Ribosomal_L14, 1 hit
InterProⁱ	View protein in InterPro IPR036853 Ribosomal_L14_sf IPR000218 Ribosomal_L14P
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00238 Ribosomal_L14, 1 hit
SMARTⁱ	View protein in SMART SM01374 Ribosomal_L14, 1 hit
SUPFAMⁱ	SSF50193 SSF50193, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q6P1L8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP 
        60         70         80         90        100
YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF 
       110        120        130        140 
DSNNVVLIED NGNPVGTRIK TPIPTSLRKR EGEYSKVLAI AQNFV

Length:145

Mass (Da):15,948

Last modified:July 5, 2004 - v1

Checksum:ⁱ841360D2E84071A4

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK312086 mRNA Translation: BAG35022.1 AL109615 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04243.1 BC065005 mRNA Translation: AAH65005.1 AB051339 Genomic DNA Translation: BAB54929.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34460.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305696.1, NM_001318767.1 NP_001305697.1, NM_001318768.1 NP_115487.2, NM_032111.3
UniGeneⁱ	Hs.311190

Genome annotation databases

Ensemblⁱ	ENST00000372014; ENSP00000361084; ENSG00000180992
GeneIDⁱ	64928
KEGGⁱ	hsa:64928
UCSC genome browser More...UCSCⁱ	uc003owp.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P1L8	Mitochondrial ribosomal protein L14, isoform CRA_b		HUMAN		145	UniRef100_Q6P1L8
UPI000020DDFA		HUMAN		198
UPI000020DDF9		HUMAN		111

Protein	Similar proteins		Species	Score	Length	Source
Q6P1L8	Mitochondrial ribosomal protein L14, isoform CRA_b		HUMAN		145	UniRef90_Q6P1L8
MRPL14 isoform 1		PANTR		145
Uncharacterized protein		PANPA		145
Mitochondrial ribosomal protein L14		GORGO		145
39S ribosomal protein L14, mitochondrial		CALJA		145
+8

Protein	Similar proteins		Species	Score	Length	Source
Q6P1L8	39S ribosomal protein L14, mitochondrial		BOVIN		145	UniRef50_Q6P1L8
Mitochondrial ribosomal protein L14, isoform CRA_b		HUMAN		145
39S ribosomal protein L14, mitochondrial		CALJA		145
Uncharacterized protein		Cebus capucinus imitator		145
Uncharacterized protein		AOTNA		145
+197

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK312086 mRNA Translation: BAG35022.1 AL109615 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX04243.1 BC065005 mRNA Translation: AAH65005.1 AB051339 Genomic DNA Translation: BAB54929.2
CCDSⁱ	CCDS34460.1
RefSeqⁱ	NP_001305696.1, NM_001318767.1 NP_001305697.1, NM_001318768.1 NP_115487.2, NM_032111.3
UniGeneⁱ	Hs.311190

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J7Y	electron microscopy	3.40	L	1-145	[»]
	3J9M	electron microscopy	3.50	L	1-145	[»]
	5OOL	electron microscopy	3.06	L	1-145	[»]
	5OOM	electron microscopy	3.03	L	1-145	[»]
ProteinModelPortalⁱ	Q6P1L8
SMRⁱ	Q6P1L8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122350, 50 interactors
CORUMⁱ	Q6P1L8
IntActⁱ	Q6P1L8, 18 interactors
MINTⁱ	Q6P1L8
STRINGⁱ	9606.ENSP00000361084

PTM databases

iPTMnetⁱ	Q6P1L8
PhosphoSitePlusⁱ	Q6P1L8
SwissPalmⁱ	Q6P1L8

Polymorphism and mutation databases

BioMutaⁱ	MRPL14
DMDMⁱ	74749064

Proteomic databases

EPDⁱ	Q6P1L8
MaxQBⁱ	Q6P1L8
PaxDbⁱ	Q6P1L8
PeptideAtlasⁱ	Q6P1L8
PRIDEⁱ	Q6P1L8
ProteomicsDBⁱ	66848
TopDownProteomicsⁱ	Q6P1L8

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64928
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000372014; ENSP00000361084; ENSG00000180992
GeneIDⁱ	64928
KEGGⁱ	hsa:64928
UCSCⁱ	uc003owp.4 human

Organism-specific databases

CTDⁱ	64928
EuPathDBⁱ	HostDB:ENSG00000180992.6
GeneCardsⁱ	MRPL14
HGNCⁱ	HGNC:14279 MRPL14
HPAⁱ	HPA038769 HPA076790
MIMⁱ	611827 gene
neXtProtⁱ	NX_Q6P1L8
OpenTargetsⁱ	ENSG00000180992
PharmGKBⁱ	PA30943
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3441 Eukaryota ENOG4111JDP LUCA
GeneTreeⁱ	ENSGT00390000001121
HOGENOMⁱ	HOG000183701
HOVERGENⁱ	HBG088508
InParanoidⁱ	Q6P1L8
KOⁱ	K02874
OMAⁱ	AIRGQKK
OrthoDBⁱ	EOG091G1144
PhylomeDBⁱ	Q6P1L8
TreeFamⁱ	TF324586

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPL14 human
GenomeRNAiⁱ	64928
Protein Ontology More...PROⁱ	PR:Q6P1L8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000180992 Expressed in 199 organ(s), highest expression level in quadriceps femoris
CleanExⁱ	HS_MRPL14 HS_MRPL32
ExpressionAtlasⁱ	Q6P1L8 baseline and differential
Genevisibleⁱ	Q6P1L8 HS

Family and domain databases

Gene3Dⁱ	2.40.150.20, 1 hit
HAMAPⁱ	MF_01367 Ribosomal_L14, 1 hit
InterProⁱ	View protein in InterPro IPR036853 Ribosomal_L14_sf IPR000218 Ribosomal_L14P
Pfamⁱ	View protein in Pfam PF00238 Ribosomal_L14, 1 hit
SMARTⁱ	View protein in SMART SM01374 Ribosomal_L14, 1 hit
SUPFAMⁱ	SSF50193 SSF50193, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RM14_HUMAN
Accessionⁱ	Q6P1L8Primary (citable) accession number: Q6P1L8 Secondary accession number(s): B2R575, Q96Q72
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Ribosomal proteins
Ribosomal proteins families and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

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UniProtKB - Q6P1L8 (RM14_HUMAN)

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39S ribosomal protein L14, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ