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Protein

39S ribosomal protein L14, mitochondrial

Gene

MRPL14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L14, mitochondrial
Short name:
L14mt
Short name:
MRP-L14
Alternative name(s):
39S ribosomal protein L32, mitochondrial
Short name:
L32mt
Short name:
MRP-L32
Mitochondrial large ribosomal subunit protein uL14m1 Publication
Gene namesi
Name:MRPL14
Synonyms:MRPL32, RPML32
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000180992.6
HGNCiHGNC:14279 MRPL14
MIMi611827 gene
neXtProtiNX_Q6P1L8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180992
PharmGKBiPA30943

Polymorphism and mutation databases

BioMutaiMRPL14
DMDMi74749064

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionBy similarityAdd BLAST30
ChainiPRO_000026113431 – 14539S ribosomal protein L14, mitochondrialAdd BLAST115

Proteomic databases

EPDiQ6P1L8
MaxQBiQ6P1L8
PaxDbiQ6P1L8
PeptideAtlasiQ6P1L8
PRIDEiQ6P1L8
ProteomicsDBi66848
TopDownProteomicsiQ6P1L8

PTM databases

iPTMnetiQ6P1L8
PhosphoSitePlusiQ6P1L8
SwissPalmiQ6P1L8

Expressioni

Gene expression databases

BgeeiENSG00000180992 Expressed in 199 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL14
HS_MRPL32
ExpressionAtlasiQ6P1L8 baseline and differential
GenevisibleiQ6P1L8 HS

Organism-specific databases

HPAiHPA038769
HPA076790

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25278503, PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with MALSU1 (PubMed:22829778).4 Publications

Protein-protein interaction databases

BioGridi122350, 50 interactors
CORUMiQ6P1L8
IntActiQ6P1L8, 18 interactors
MINTiQ6P1L8
STRINGi9606.ENSP00000361084

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6P1L8
SMRiQ6P1L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3441 Eukaryota
ENOG4111JDP LUCA
GeneTreeiENSGT00390000001121
HOGENOMiHOG000183701
HOVERGENiHBG088508
InParanoidiQ6P1L8
KOiK02874
OMAiAIRGQKK
OrthoDBiEOG091G1144
PhylomeDBiQ6P1L8
TreeFamiTF324586

Family and domain databases

Gene3Di2.40.150.20, 1 hit
HAMAPiMF_01367 Ribosomal_L14, 1 hit
InterProiView protein in InterPro
IPR036853 Ribosomal_L14_sf
IPR000218 Ribosomal_L14P
PfamiView protein in Pfam
PF00238 Ribosomal_L14, 1 hit
SMARTiView protein in SMART
SM01374 Ribosomal_L14, 1 hit
SUPFAMiSSF50193 SSF50193, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P1L8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFFTGLWGP FTCVSRVLSH HCFSTTGSLS AIQKMTRVRV VDNSALGNSP
60 70 80 90 100
YHRAPRCIHV YKKNGVGKVG DQILLAIKGQ KKKALIVGHC MPGPRMTPRF
110 120 130 140
DSNNVVLIED NGNPVGTRIK TPIPTSLRKR EGEYSKVLAI AQNFV
Length:145
Mass (Da):15,948
Last modified:July 5, 2004 - v1
Checksum:i841360D2E84071A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312086 mRNA Translation: BAG35022.1
AL109615 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04243.1
BC065005 mRNA Translation: AAH65005.1
AB051339 Genomic DNA Translation: BAB54929.2
CCDSiCCDS34460.1
RefSeqiNP_001305696.1, NM_001318767.1
NP_001305697.1, NM_001318768.1
NP_115487.2, NM_032111.3
UniGeneiHs.311190

Genome annotation databases

EnsembliENST00000372014; ENSP00000361084; ENSG00000180992
GeneIDi64928
KEGGihsa:64928
UCSCiuc003owp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312086 mRNA Translation: BAG35022.1
AL109615 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04243.1
BC065005 mRNA Translation: AAH65005.1
AB051339 Genomic DNA Translation: BAB54929.2
CCDSiCCDS34460.1
RefSeqiNP_001305696.1, NM_001318767.1
NP_001305697.1, NM_001318768.1
NP_115487.2, NM_032111.3
UniGeneiHs.311190

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40L1-145[»]
3J9Melectron microscopy3.50L1-145[»]
5OOLelectron microscopy3.06L1-145[»]
5OOMelectron microscopy3.03L1-145[»]
ProteinModelPortaliQ6P1L8
SMRiQ6P1L8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122350, 50 interactors
CORUMiQ6P1L8
IntActiQ6P1L8, 18 interactors
MINTiQ6P1L8
STRINGi9606.ENSP00000361084

PTM databases

iPTMnetiQ6P1L8
PhosphoSitePlusiQ6P1L8
SwissPalmiQ6P1L8

Polymorphism and mutation databases

BioMutaiMRPL14
DMDMi74749064

Proteomic databases

EPDiQ6P1L8
MaxQBiQ6P1L8
PaxDbiQ6P1L8
PeptideAtlasiQ6P1L8
PRIDEiQ6P1L8
ProteomicsDBi66848
TopDownProteomicsiQ6P1L8

Protocols and materials databases

DNASUi64928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372014; ENSP00000361084; ENSG00000180992
GeneIDi64928
KEGGihsa:64928
UCSCiuc003owp.4 human

Organism-specific databases

CTDi64928
EuPathDBiHostDB:ENSG00000180992.6
GeneCardsiMRPL14
HGNCiHGNC:14279 MRPL14
HPAiHPA038769
HPA076790
MIMi611827 gene
neXtProtiNX_Q6P1L8
OpenTargetsiENSG00000180992
PharmGKBiPA30943
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3441 Eukaryota
ENOG4111JDP LUCA
GeneTreeiENSGT00390000001121
HOGENOMiHOG000183701
HOVERGENiHBG088508
InParanoidiQ6P1L8
KOiK02874
OMAiAIRGQKK
OrthoDBiEOG091G1144
PhylomeDBiQ6P1L8
TreeFamiTF324586

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL14 human
GenomeRNAii64928
PROiPR:Q6P1L8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180992 Expressed in 199 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MRPL14
HS_MRPL32
ExpressionAtlasiQ6P1L8 baseline and differential
GenevisibleiQ6P1L8 HS

Family and domain databases

Gene3Di2.40.150.20, 1 hit
HAMAPiMF_01367 Ribosomal_L14, 1 hit
InterProiView protein in InterPro
IPR036853 Ribosomal_L14_sf
IPR000218 Ribosomal_L14P
PfamiView protein in Pfam
PF00238 Ribosomal_L14, 1 hit
SMARTiView protein in SMART
SM01374 Ribosomal_L14, 1 hit
SUPFAMiSSF50193 SSF50193, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM14_HUMAN
AccessioniPrimary (citable) accession number: Q6P1L8
Secondary accession number(s): B2R575, Q96Q72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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