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Entry version 109 (10 Apr 2019)
Sequence version 2 (11 Sep 2007)
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Protein

Protein FAM117B

Gene

FAM117B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

ALS2CR13 is mapped in the genomic region covering the complete candidate region for Amyotrophic lateral sclerosis 2 (ALS2).

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM117B
Alternative name(s):
Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM117B
Synonyms:ALS2CR13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000138439.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14440 FAM117B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P1L5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000138439

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164719514

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM117B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
158563965

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002995331 – 589Protein FAM117BAdd BLAST589

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineCombined sources1
Modified residuei106PhosphoserineBy similarity1
Modified residuei210PhosphoserineCombined sources1
Modified residuei219PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei273PhosphoserineCombined sources1
Modified residuei345PhosphoserineBy similarity1
Modified residuei391PhosphoserineCombined sources1
Modified residuei449PhosphoserineBy similarity1
Modified residuei457PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P1L5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P1L5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P1L5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P1L5

PeptideAtlas

More...
PeptideAtlasi
Q6P1L5

PRoteomics IDEntifications database

More...
PRIDEi
Q6P1L5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66843
66844 [Q6P1L5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P1L5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P1L5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138439 Expressed in 188 organ(s), highest expression level in neocortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P1L5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA003229
HPA028746

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127329, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P1L5, 11 interactors

Molecular INTeraction database

More...
MINTi
Q6P1L5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376071

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6P1L5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 99Gly-richAdd BLAST85
Compositional biasi137 – 145Poly-Pro9

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEAU Eukaryota
ENOG4111PY2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183046

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252927

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107860

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P1L5

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGHWPRD

Database of Orthologous Groups

More...
OrthoDBi
1132072at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P1L5

TreeFam database of animal gene trees

More...
TreeFami
TF333159

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026641 FAM117B
IPR026642 Glcci1/FAM117

The PANTHER Classification System

More...
PANTHERi
PTHR14972 PTHR14972, 1 hit
PTHR14972:SF6 PTHR14972:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15388 FAM117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P1L5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQRVRRNGS PTPAGSLGGG AVATAGGPGS RLQPMRATVP FQLKQQQQQQ
60 70 80 90 100
HGSPTRSGGG GGGNNNGGCC GGASGPAGGG GGGGPRTASR STSPTRGGGN
110 120 130 140 150
AAARTSPTVA TQTGASATST RGTSPTRSAA PGARGSPPRP PPPPPLLGTV
160 170 180 190 200
SSPSSSPTHL WTGEVSAAPP PARVRHRRRS PEQSRSSPEK RSPSAPVCKA
210 220 230 240 250
GDKTRQPSSS PSSIIRRTSS LDTLAAPYLA GHWPRDSHGQ AAPCMRDKAT
260 270 280 290 300
QTESAWAEEY SEKKKGSHKR SASWGSTDQL KEIAKLRQQL QRSKHSSRHH
310 320 330 340 350
RDKERQSPFH GNHAAINQCQ APVPKSALIP VIPITKSTGS RFRNSVEGLN
360 370 380 390 400
QEIEIIIKET GEKEEQLIPQ DIPDGHRAPP PLVQRSSSTR SIDTQTPGGA
410 420 430 440 450
DRGSNNSSRS QSVSPTSFLT ISNEGSEESP CSADDLLVDP RDKENGNNSP
460 470 480 490 500
LPKYATSPKP NNSYMFKREP PEGCERVKVF EECSPKQLHE IPAFYCPDKN
510 520 530 540 550
KVNFIPKSGS AFCLVSILKP LLPTPDLTLK GSGHSLTVTT GMTTTLLQPI
560 570 580
AVASLSTNTE QDRVSRGTST VMPSASLLPP PEPIEEAEG
Length:589
Mass (Da):61,968
Last modified:September 11, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61B47F16D3E06B14
GO
Isoform 2 (identifier: Q6P1L5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     283-289: IAKLRQQ → VRKMVLR
     290-589: Missing.

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):29,428
Checksum:i1B2F767E5BECCC1D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI06907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI06908 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAX76518 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB69023 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BAB69023 differs from that shown. Reason: Frameshift at position 150.Curated
The sequence BAC04700 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti168A → V in BAB69023 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_027729283 – 289IAKLRQQ → VRKMVLR in isoform 2. 1 Publication7
Alternative sequenceiVSP_027730290 – 589Missing in isoform 2. 1 PublicationAdd BLAST300

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC009960 Genomic DNA Translation: AAX76518.1 Sequence problems.
AC098831 Genomic DNA Translation: AAY24090.1
AB053315 mRNA Translation: BAB69023.1 Sequence problems.
AK096090 mRNA Translation: BAC04700.1 Different initiation.
BC065010 mRNA Translation: AAH65010.1
BC106906 mRNA Translation: AAI06907.1 Different initiation.
BC106907 mRNA Translation: AAI06908.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33362.2 [Q6P1L5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_775782.2, NM_173511.3 [Q6P1L5-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.471130

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392238; ENSP00000376071; ENSG00000138439 [Q6P1L5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150864

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150864

UCSC genome browser

More...
UCSCi
uc010zhx.3 human [Q6P1L5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009960 Genomic DNA Translation: AAX76518.1 Sequence problems.
AC098831 Genomic DNA Translation: AAY24090.1
AB053315 mRNA Translation: BAB69023.1 Sequence problems.
AK096090 mRNA Translation: BAC04700.1 Different initiation.
BC065010 mRNA Translation: AAH65010.1
BC106906 mRNA Translation: AAI06907.1 Different initiation.
BC106907 mRNA Translation: AAI06908.1 Different initiation.
CCDSiCCDS33362.2 [Q6P1L5-1]
RefSeqiNP_775782.2, NM_173511.3 [Q6P1L5-1]
UniGeneiHs.471130

3D structure databases

ProteinModelPortaliQ6P1L5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127329, 25 interactors
IntActiQ6P1L5, 11 interactors
MINTiQ6P1L5
STRINGi9606.ENSP00000376071

PTM databases

iPTMnetiQ6P1L5
PhosphoSitePlusiQ6P1L5

Polymorphism and mutation databases

BioMutaiFAM117B
DMDMi158563965

Proteomic databases

EPDiQ6P1L5
jPOSTiQ6P1L5
MaxQBiQ6P1L5
PaxDbiQ6P1L5
PeptideAtlasiQ6P1L5
PRIDEiQ6P1L5
ProteomicsDBi66843
66844 [Q6P1L5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392238; ENSP00000376071; ENSG00000138439 [Q6P1L5-1]
GeneIDi150864
KEGGihsa:150864
UCSCiuc010zhx.3 human [Q6P1L5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150864
EuPathDBiHostDB:ENSG00000138439.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM117B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0002751
HGNCiHGNC:14440 FAM117B
HPAiHPA003229
HPA028746
neXtProtiNX_Q6P1L5
OpenTargetsiENSG00000138439
PharmGKBiPA164719514

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEAU Eukaryota
ENOG4111PY2 LUCA
GeneTreeiENSGT00950000183046
HOGENOMiHOG000252927
HOVERGENiHBG107860
InParanoidiQ6P1L5
OMAiAGHWPRD
OrthoDBi1132072at2759
PhylomeDBiQ6P1L5
TreeFamiTF333159

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM117B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
150864

Protein Ontology

More...
PROi
PR:Q6P1L5

Gene expression databases

BgeeiENSG00000138439 Expressed in 188 organ(s), highest expression level in neocortex
GenevisibleiQ6P1L5 HS

Family and domain databases

InterProiView protein in InterPro
IPR026641 FAM117B
IPR026642 Glcci1/FAM117
PANTHERiPTHR14972 PTHR14972, 1 hit
PTHR14972:SF6 PTHR14972:SF6, 1 hit
PfamiView protein in Pfam
PF15388 FAM117, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF117B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1L5
Secondary accession number(s): Q53QZ5
, Q585T9, Q8N8W1, Q96Q34
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 10, 2019
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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