Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 145 (07 Oct 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

General transcription factor IIH subunit 2-like protein

Gene

GTF2H2C

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri291 – 308C4-typeAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6P1K8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General transcription factor IIH subunit 2-like protein
Alternative name(s):
General transcription factor IIH polypeptide 2-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GTF2H2C
AND
Name:GTF2H2C_2
Synonyms:GTF2H2D
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000183474.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31394, GTF2H2C
HGNC:35418, GTF2H2C_2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P1K8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000183474

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164720349

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P1K8, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GTF2H2C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74737138

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003321321 – 395General transcription factor IIH subunit 2-like proteinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei95PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P1K8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P1K8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P1K8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P1K8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P1K8

PeptideAtlas

More...
PeptideAtlasi
Q6P1K8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P1K8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66842

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P1K8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P1K8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000183474, Expressed in testis and 221 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P1K8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P1K8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000183474, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
608768, 13 interactors
610778, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P1K8, 20 interactors

Molecular INTeraction database

More...
MINTi
Q6P1K8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000422907

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P1K8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P1K8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 236VWFAPROSITE-ProRule annotationAdd BLAST177

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GTF2H2 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri291 – 308C4-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2807, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00490000043395

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028556_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P1K8

KEGG Orthology (KO)

More...
KOi
K03142

Identification of Orthologs from Complete Genome Data

More...
OMAi
PTICECH

Database of Orthologous Groups

More...
OrthoDBi
768809at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P1K8

TreeFam database of animal gene trees

More...
TreeFami
TF314037

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01453, vWA_transcription_factor_IIH_type, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007198, Ssl1-like
IPR004595, TFIIH_C1-like_dom
IPR012170, TFIIH_SSL1/p44
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
IPR013087, Znf_C2H2_type
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07975, C1_4, 1 hit
PF04056, Ssl1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF015919, TFIIH_SSL1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01047, C1_4, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00622, ssl1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6P1K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH
60 70 80 90 100
GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP
110 120 130 140 150
ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKEAVDMTCH GEPSLYNSLS
160 170 180 190 200
MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK AAKIRVSVIG
210 220 230 240 250
LSAEVRVCTV LARETGGTYH VILDESHYKE LLTHHLSPPP ASSSSECSLI
260 270 280 290 300
RMGFPQHTIA SLSDQDAKPS FSMAHLDGNT EPGLTLGGYF CPQCRAKYCE
310 320 330 340 350
LPVECKICGL TLVSAPHLAR SYHHLFPLDA FQEIPLEEYN GERFCYGCQG
360 370 380 390
ELKDQHVYVC AVCQNVFCVD CDVFVHDSLH CCPGCIHKIP APSGV
Length:395
Mass (Da):44,452
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3BBD377500E04B9A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57M → I in BAF85050 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK292361 mRNA Translation: BAF85050.1
AK315282 mRNA Translation: BAG37691.1
AC147575 Genomic DNA No translation available.
BC064557 mRNA Translation: AAH64557.1
BC065021 mRNA Translation: AAH65021.1
BC105980 mRNA Translation: AAI05981.1
BC171860 mRNA Translation: AAI71860.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43325.1

NCBI Reference Sequences

More...
RefSeqi
NP_001035955.1, NM_001042490.3
NP_001092198.1, NM_001098728.1
XP_005248645.1, XM_005248588.4
XP_005248647.1, XM_005248590.3
XP_006714751.1, XM_006714688.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380729; ENSP00000370105; ENSG00000183474
ENST00000510979; ENSP00000422907; ENSG00000183474
ENST00000619699; ENSP00000483148; ENSG00000274675
ENST00000621406; ENSP00000480471; ENSG00000274675

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
728340
730394

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:728340
hsa:730394

UCSC genome browser

More...
UCSCi
uc003jwy.6, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292361 mRNA Translation: BAF85050.1
AK315282 mRNA Translation: BAG37691.1
AC147575 Genomic DNA No translation available.
BC064557 mRNA Translation: AAH64557.1
BC065021 mRNA Translation: AAH65021.1
BC105980 mRNA Translation: AAI05981.1
BC171860 mRNA Translation: AAI71860.1
CCDSiCCDS43325.1
RefSeqiNP_001035955.1, NM_001042490.3
NP_001092198.1, NM_001098728.1
XP_005248645.1, XM_005248588.4
XP_005248647.1, XM_005248590.3
XP_006714751.1, XM_006714688.3

3D structure databases

SMRiQ6P1K8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi608768, 13 interactors
610778, 14 interactors
IntActiQ6P1K8, 20 interactors
MINTiQ6P1K8
STRINGi9606.ENSP00000422907

PTM databases

iPTMnetiQ6P1K8
PhosphoSitePlusiQ6P1K8

Polymorphism and mutation databases

BioMutaiGTF2H2C
DMDMi74737138

Proteomic databases

EPDiQ6P1K8
jPOSTiQ6P1K8
MassIVEiQ6P1K8
MaxQBiQ6P1K8
PaxDbiQ6P1K8
PeptideAtlasiQ6P1K8
PRIDEiQ6P1K8
ProteomicsDBi66842

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
44086, 106 antibodies

Genome annotation databases

EnsembliENST00000380729; ENSP00000370105; ENSG00000183474
ENST00000510979; ENSP00000422907; ENSG00000183474
ENST00000619699; ENSP00000483148; ENSG00000274675
ENST00000621406; ENSP00000480471; ENSG00000274675
GeneIDi728340
730394
KEGGihsa:728340
hsa:730394
UCSCiuc003jwy.6, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
728340
730394
EuPathDBiHostDB:ENSG00000183474.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GTF2H2C
GTF2H2C_2
HGNCiHGNC:31394, GTF2H2C
HGNC:35418, GTF2H2C_2
HPAiENSG00000183474, Low tissue specificity
neXtProtiNX_Q6P1K8
OpenTargetsiENSG00000183474
PharmGKBiPA164720349

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2807, Eukaryota
GeneTreeiENSGT00490000043395
HOGENOMiCLU_028556_1_0_1
InParanoidiQ6P1K8
KOiK03142
OMAiPTICECH
OrthoDBi768809at2759
PhylomeDBiQ6P1K8
TreeFamiTF314037

Enzyme and pathway databases

PathwayCommonsiQ6P1K8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
728340, 583 hits in 845 CRISPR screens
730394, 16 hits in 66 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GTF2H2C, human
PharosiQ6P1K8, Tdark

Protein Ontology

More...
PROi
PR:Q6P1K8
RNActiQ6P1K8, protein

Gene expression databases

BgeeiENSG00000183474, Expressed in testis and 221 other tissues
ExpressionAtlasiQ6P1K8, baseline and differential
GenevisibleiQ6P1K8, HS

Family and domain databases

CDDicd01453, vWA_transcription_factor_IIH_type, 1 hit
Gene3Di3.30.40.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR007198, Ssl1-like
IPR004595, TFIIH_C1-like_dom
IPR012170, TFIIH_SSL1/p44
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
IPR013087, Znf_C2H2_type
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF07975, C1_4, 1 hit
PF04056, Ssl1, 1 hit
PIRSFiPIRSF015919, TFIIH_SSL1, 1 hit
SMARTiView protein in SMART
SM01047, C1_4, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
TIGRFAMsiTIGR00622, ssl1, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiT2H2L_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1K8
Secondary accession number(s): A6NED9
, A8K8J6, B2RCU4, B7ZW39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: October 7, 2020
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again