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Protein

Phospholipase B1, membrane-associated

Gene

PLB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Membrane-associated phospholipase. Exhibits a calcium-independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by diisopropyl fluorophosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei400NucleophileBy similarity1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei474Substrate; via amide nitrogenBy similarity1
Binding sitei513SubstrateBy similarity1
Active sitei1346By similarity1
Active sitei1349By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1482788 Acyl chain remodelling of PC
R-HSA-975634 Retinoid metabolism and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipase B1, membrane-associated
Short name:
Phospholipase B
Short name:
hPLB
Alternative name(s):
Phospholipase B/lipase
Short name:
PLB/LIP
Including the following 2 domains:
Phospholipase A2 (EC:3.1.1.4)
Lysophospholipase (EC:3.1.1.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLB1
Synonyms:PLB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163803.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30041 PLB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610179 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P1J6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 1417ExtracellularSequence analysisAdd BLAST1396
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1418 – 1438HelicalSequence analysisAdd BLAST21
Topological domaini1439 – 1458CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
151056

Open Targets

More...
OpenTargetsi
ENSG00000163803

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134891309

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLB1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000032438322 – 1458Phospholipase B1, membrane-associatedAdd BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi493N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi797N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes proteolytic cleavage in the ileum.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P1J6

PeptideAtlas

More...
PeptideAtlasi
Q6P1J6

PRoteomics IDEntifications database

More...
PRIDEi
Q6P1J6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66829
66830 [Q6P1J6-2]
66831 [Q6P1J6-3]
66832 [Q6P1J6-4]
66833 [Q6P1J6-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P1J6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P1J6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the epidermis (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163803 Expressed in 96 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLB1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P1J6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P1J6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014045

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127341, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P1J6, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330442

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6P1J6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati39 – 3471Add BLAST309
Repeati362 – 7072Add BLAST346
Repeati708 – 10543Add BLAST347
Repeati1064 – 14024Add BLAST339

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni39 – 14024 X 308-326 AA approximate repeatsAdd BLAST1364
Regioni1403 – 1445Necessary for membrane localizationBy similarityAdd BLAST43

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Repeat 2 contains the catalytic domain.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3670 Eukaryota
ENOG4111FH4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063883

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115574

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108263

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P1J6

KEGG Orthology (KO)

More...
KOi
K14621

Identification of Orthologs from Complete Genome Data

More...
OMAi
ENPYLFT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00VL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P1J6

TreeFam database of animal gene trees

More...
TreeFami
TF314942

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01824 Phospholipase_B_like, 4 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1110, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001087 GDSL
IPR008265 Lipase_GDSL_AS
IPR035547 Phospholipase_B
IPR038885 PLB1
IPR036514 SGNH_hydro_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21325 PTHR21325, 4 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00657 Lipase_GDSL, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01098 LIPASE_GDSL_SER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P1J6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLRPGIFLL ELLLLLGQGT PQIHTSPRKS TLEGQLWPET LKNSPFPCNP
60 70 80 90 100
NKLGVNMPSK SVHSLKPSDI KFVAAIGNLE IPPDPGTGDL EKQDWTERPQ
110 120 130 140 150
QVCMGVMTVL SDIIRYFSPS VPMPVCHTGK RVIPHDGAED LWIQAQELVR
160 170 180 190 200
NMKENLQLDF QFDWKLINVF FSNASQCYLC PSAQQNGLAA GGVDELMGVL
210 220 230 240 250
DYLQQEVPRA FVNLVDLSEV AEVSRQYHGT WLSPAPEPCN CSEETTRLAK
260 270 280 290 300
VVMQWSYQEA WNSLLASSRY SEQESFTVVF QPFFYETTPS LHSEDPRLQD
310 320 330 340 350
STTLAWHLWN RMMEPAGEKD EPLSVKHGRP MKCPSQESPY LFSYRNSNYL
360 370 380 390 400
TRLQKPQDKL EVREGAEIRC PDKDPSDTVP TSVHRLKPAD INVIGALGDS
410 420 430 440 450
LTAGNGAGST PGNVLDVLTQ YRGLSWSVGG DENIGTVTTL ANILREFNPS
460 470 480 490 500
LKGFSVGTGK ETSPNAFLNQ AVAGGRAEDL PVQARRLVDL MKNDTRIHFQ
510 520 530 540 550
EDWKIITLFI GGNDLCDFCN DLVHYSPQNF TDNIGKALDI LHAEVPRAFV
560 570 580 590 600
NLVTVLEIVN LRELYQEKKV YCPRMILRSL CPCVLKFDDN STELATLIEF
610 620 630 640 650
NKKFQEKTHQ LIESGRYDTR EDFTVVVQPF FENVDMPKTS EGLPDNSFFA
660 670 680 690 700
PDCFHFSSKS HSRAASALWN NMLEPVGQKT TRHKFENKIN ITCPNQVQPF
710 720 730 740 750
LRTYKNSMQG HGTWLPCRDR APSALHPTSV HALRPADIQV VAALGDSLTA
760 770 780 790 800
GNGIGSKPDD LPDVTTQYRG LSYSAGGDGS LENVTTLPNI LREFNRNLTG
810 820 830 840 850
YAVGTGDAND TNAFLNQAVP GAKAEDLMSQ VQTLMQKMKD DHRVNFHEDW
860 870 880 890 900
KVITVLIGGS DLCDYCTDSN LYSAANFVHH LRNALDVLHR EVPRVLVNLV
910 920 930 940 950
DFLNPTIMRQ VFLGNPDKCP VQQASVLCNC VLTLRENSQE LARLEAFSRA
960 970 980 990 1000
YRSSMRELVG SGRYDTQEDF SVVLQPFFQN IQLPVLADGL PDTSFFAPDC
1010 1020 1030 1040 1050
IHPNQKFHSQ LARALWTNML EPLGSKTETL DLRAEMPITC PTQNEPFLRT
1060 1070 1080 1090 1100
PRNSNYTYPI KPAIENWGSD FLCTEWKASN SVPTSVHQLR PADIKVVAAL
1110 1120 1130 1140 1150
GDSLTTAVGA RPNNSSDLPT SWRGLSWSIG GDGNLETHTT LPNILKKFNP
1160 1170 1180 1190 1200
YLLGFSTSTW EGTAGLNVAA EGARARDMPA QAWDLVERMK NSPDINLEKD
1210 1220 1230 1240 1250
WKLVTLFIGV NDLCHYCENP EAHLATEYVQ HIQQALDILS EELPRAFVNV
1260 1270 1280 1290 1300
VEVMELASLY QGQGGKCAML AAQNNCTCLR HSQSSLEKQE LKKVNWNLQH
1310 1320 1330 1340 1350
GISSFSYWHQ YTQREDFAVV VQPFFQNTLT PLNERGDTDL TFFSEDCFHF
1360 1370 1380 1390 1400
SDRGHAEMAI ALWNNMLEPV GRKTTSNNFT HSRAKLKCPS PESPYLYTLR
1410 1420 1430 1440 1450
NSRLLPDQAE EAPEVLYWAV PVAAGVGLVV GIIGTVVWRC RRGGRREDPP

MSLRTVAL
Length:1,458
Mass (Da):163,081
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B260E1489D8137B
GO
Isoform 2 (identifier: Q6P1J6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.
     774-800: SAGGDGSLENVTTLPNILREFNRNLTG → RESKPGFLSDSWVSKSNRKCTRKAPNP
     801-1458: Missing.

Show »
Length:488
Mass (Da):54,341
Checksum:i6BE12FF5CB0AC9C5
GO
Isoform 3 (identifier: Q6P1J6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     184-184: Q → QQAPSLSTVLLS
     523-544: Missing.

Show »
Length:1,447
Mass (Da):161,713
Checksum:i463E147644AF72B7
GO
Isoform 4 (identifier: Q6P1J6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     750-760: AGNGIGSKPDD → VRTLGPQVVWG
     761-1458: Missing.

Note: No experimental confirmation available.
Show »
Length:760
Mass (Da):85,191
Checksum:i6910E87C50726761
GO
Isoform 5 (identifier: Q6P1J6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1035: Missing.

Show »
Length:423
Mass (Da):47,341
Checksum:iA66F32D49AC1A20C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYX7H7BYX7_HUMAN
Phospholipase B1, membrane-associat...
PLB1
1,446Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1D3H7C1D3_HUMAN
Phospholipase B1, membrane-associat...
PLB1
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C012H7C012_HUMAN
Phospholipase B1, membrane-associat...
PLB1
510Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZW4H7BZW4_HUMAN
Phospholipase B1, membrane-associat...
PLB1
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYQ2C9JYQ2_HUMAN
Phospholipase B1, membrane-associat...
PLB1
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2A5H7C2A5_HUMAN
Phospholipase B1, membrane-associat...
PLB1
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB70920 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti426W → Y in BAB70920 (PubMed:14702039).Curated1
Sequence conflicti1186V → L in AAH42674 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039793212V → L. Corresponds to variant dbSNP:rs6753929Ensembl.1
Natural variantiVAR_039794708M → V. Corresponds to variant dbSNP:rs11681826Ensembl.1
Natural variantiVAR_039795821G → R. Corresponds to variant dbSNP:rs10201128Ensembl.1
Natural variantiVAR_039796879H → D. Corresponds to variant dbSNP:rs7601771Ensembl.1
Natural variantiVAR_061358987A → V. Corresponds to variant dbSNP:rs34289907Ensembl.1
Natural variantiVAR_0397971318A → V. Corresponds to variant dbSNP:rs2199619Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0322251 – 1035Missing in isoform 5. 1 PublicationAdd BLAST1035
Alternative sequenceiVSP_0322261 – 312Missing in isoform 2. 1 PublicationAdd BLAST312
Alternative sequenceiVSP_032227184Q → QQAPSLSTVLLS in isoform 3. 1 Publication1
Alternative sequenceiVSP_032228523 – 544Missing in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_032229750 – 760AGNGIGSKPDD → VRTLGPQVVWG in isoform 4. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_032230761 – 1458Missing in isoform 4. 1 PublicationAdd BLAST698
Alternative sequenceiVSP_032231774 – 800SAGGD…RNLTG → RESKPGFLSDSWVSKSNRKC TRKAPNP in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_032232801 – 1458Missing in isoform 2. 1 PublicationAdd BLAST658

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC074011 Genomic DNA Translation: AAY24081.1
AC074011 Genomic DNA Translation: AAY24082.1
AC093164 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00532.1
CH471053 Genomic DNA Translation: EAX00533.1
BC042674 mRNA Translation: AAH42674.1
BC065041 mRNA Translation: AAH65041.1
BC153864 mRNA Translation: AAI53865.1
AK055428 mRNA Translation: BAB70920.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33168.1 [Q6P1J6-1]
CCDS54340.1 [Q6P1J6-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001164056.1, NM_001170585.1 [Q6P1J6-3]
NP_694566.4, NM_153021.4 [Q6P1J6-1]
XP_016858922.1, XM_017003433.1 [Q6P1J6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.444933

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000327757; ENSP00000330442; ENSG00000163803 [Q6P1J6-1]
ENST00000422425; ENSP00000416440; ENSG00000163803 [Q6P1J6-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
151056

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:151056

UCSC genome browser

More...
UCSCi
uc002rmb.3 human [Q6P1J6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC074011 Genomic DNA Translation: AAY24081.1
AC074011 Genomic DNA Translation: AAY24082.1
AC093164 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00532.1
CH471053 Genomic DNA Translation: EAX00533.1
BC042674 mRNA Translation: AAH42674.1
BC065041 mRNA Translation: AAH65041.1
BC153864 mRNA Translation: AAI53865.1
AK055428 mRNA Translation: BAB70920.1 Different initiation.
CCDSiCCDS33168.1 [Q6P1J6-1]
CCDS54340.1 [Q6P1J6-3]
RefSeqiNP_001164056.1, NM_001170585.1 [Q6P1J6-3]
NP_694566.4, NM_153021.4 [Q6P1J6-1]
XP_016858922.1, XM_017003433.1 [Q6P1J6-1]
UniGeneiHs.444933

3D structure databases

ProteinModelPortaliQ6P1J6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127341, 13 interactors
IntActiQ6P1J6, 7 interactors
STRINGi9606.ENSP00000330442

PTM databases

iPTMnetiQ6P1J6
PhosphoSitePlusiQ6P1J6

Polymorphism and mutation databases

BioMutaiPLB1

Proteomic databases

PaxDbiQ6P1J6
PeptideAtlasiQ6P1J6
PRIDEiQ6P1J6
ProteomicsDBi66829
66830 [Q6P1J6-2]
66831 [Q6P1J6-3]
66832 [Q6P1J6-4]
66833 [Q6P1J6-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327757; ENSP00000330442; ENSG00000163803 [Q6P1J6-1]
ENST00000422425; ENSP00000416440; ENSG00000163803 [Q6P1J6-3]
GeneIDi151056
KEGGihsa:151056
UCSCiuc002rmb.3 human [Q6P1J6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
151056
DisGeNETi151056
EuPathDBiHostDB:ENSG00000163803.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PLB1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0024210
HGNCiHGNC:30041 PLB1
HPAiHPA014045
MIMi610179 gene
neXtProtiNX_Q6P1J6
OpenTargetsiENSG00000163803
PharmGKBiPA134891309

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3670 Eukaryota
ENOG4111FH4 LUCA
GeneTreeiENSGT00530000063883
HOGENOMiHOG000115574
HOVERGENiHBG108263
InParanoidiQ6P1J6
KOiK14621
OMAiENPYLFT
OrthoDBiEOG091G00VL
PhylomeDBiQ6P1J6
TreeFamiTF314942

Enzyme and pathway databases

ReactomeiR-HSA-1482788 Acyl chain remodelling of PC
R-HSA-975634 Retinoid metabolism and transport

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
151056

Protein Ontology

More...
PROi
PR:Q6P1J6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163803 Expressed in 96 organ(s), highest expression level in blood
CleanExiHS_PLB1
ExpressionAtlasiQ6P1J6 baseline and differential
GenevisibleiQ6P1J6 HS

Family and domain databases

CDDicd01824 Phospholipase_B_like, 4 hits
Gene3Di3.40.50.1110, 2 hits
InterProiView protein in InterPro
IPR001087 GDSL
IPR008265 Lipase_GDSL_AS
IPR035547 Phospholipase_B
IPR038885 PLB1
IPR036514 SGNH_hydro_sf
PANTHERiPTHR21325 PTHR21325, 4 hits
PfamiView protein in Pfam
PF00657 Lipase_GDSL, 3 hits
PROSITEiView protein in PROSITE
PS01098 LIPASE_GDSL_SER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1J6
Secondary accession number(s): A8KAX2
, Q53S03, Q8IUP7, Q96DP9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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