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Entry version 139 (12 Aug 2020)
Sequence version 2 (20 Mar 2007)
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Protein

Ankyrin repeat and LEM domain-containing protein 2

Gene

Ankle2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-2995383, Initiation of Nuclear Envelope (NE) Reformation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ankyrin repeat and LEM domain-containing protein 2
Alternative name(s):
LEM domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ankle2
Synonyms:D5Ertd585e, Kiaa0692, Lem4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1261856, Ankle2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 7ExtracellularSequence analysis7
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28Helical; Signal-anchor for type III membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 964CytoplasmicSequence analysisAdd BLAST936

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002802431 – 964Ankyrin repeat and LEM domain-containing protein 2Add BLAST964

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei266PhosphoserineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei503PhosphoserineBy similarity1
Modified residuei519PhosphoserineBy similarity1
Modified residuei535PhosphoserineBy similarity1
Modified residuei675PhosphoserineBy similarity1
Modified residuei916PhosphoserineBy similarity1
Modified residuei940PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P1H6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P1H6

PeptideAtlas

More...
PeptideAtlasi
Q6P1H6

PRoteomics IDEntifications database

More...
PRIDEi
Q6P1H6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P1H6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P1H6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029501, Expressed in pineal body and 259 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P1H6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with BAF/BANF1.

Interacts with protein phosphatase 2A (PP2A) components PPP2C (PPP2CA or PPP2CB) and PPP2R1A (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000031474

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P1H6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 115LEMPROSITE-ProRule annotationAdd BLAST45
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati419 – 448ANKAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ANKLE2 family.Curated

Keywords - Domaini

ANK repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ4Z, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016767

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_017564_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P1H6

KEGG Orthology (KO)

More...
KOi
K21412

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYIVDLY

Database of Orthologous Groups

More...
OrthoDBi
567264at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P1H6

TreeFam database of animal gene trees

More...
TreeFami
TF317729

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12944, LEM_ANKL2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.720.40, 1 hit
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035007, ANKLE2
IPR036770, Ankyrin_rpt-contain_sf
IPR011015, LEM/LEM-like_dom_sf
IPR035006, LEM_ANKL2
IPR003887, LEM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12349:SF4, PTHR12349:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03020, LEM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF63451, SSF63451, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50954, LEM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P1H6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLWQRLAVVE WAALAWELLG ASVLFIAVRW LVRRLEKRPR DLNRCGTLSS
60 70 80 90 100
PPSASEAVAA QPGEVTMDAM MARLKLLNPD DLRKEVMKAG LKCGPITSTT
110 120 130 140 150
RFIFEKKLAQ ALLEQGGLLT SSLPKPSAVT AMAFIQGTSR TPPSVDGKQT
160 170 180 190 200
QQACFSEDRD FGYSVGLNPP EEEAVASSVH PVPFSASTRN DNHKAGVTAP
210 220 230 240 250
KEPLVYYGVC PVYEDGPVRH ERIHVYEDKK EALQAAKLIK GSRFKAFRTR
260 270 280 290 300
EDAEKFARGI CDYLPSPNKT TPLLSPVKAV PLGGSDGLKA DGLCLAESET
310 320 330 340 350
VNKERANSYK NPRTQDLTAK LRKAVENGEE HTFSDLIWSN PRYLIGSGDN
360 370 380 390 400
PTIVQEGCRY NVMHVAAKEN QASMCQLTLE TLENPEFMRL MYPDDNMDML
410 420 430 440 450
QKRILYVVDL YLNTPDKVGF DTPLHFACKF GNVDVVNVLS SHPLIVKNRK
460 470 480 490 500
NKYGKTPEEV ICERSQNKSP ALKERIREYL MGHYYVPLLR AEDTSPVIGE
510 520 530 540 550
LWSSDQKAEA SNTAHCRSSP RDPVMTLRAF VGPLSPSKAE DFRKLWKTPP
560 570 580 590 600
RKKAGFFHSI RKSDPERGIE RVGRELAHEL GYPWVEYWEF LGCFVDLSSQ
610 620 630 640 650
EGLQRLEEYL IQKELSKKAQ QEIRENEGCL QDRTSDFGSG KKYSNSISVG
660 670 680 690 700
AFLDGDDDSS LEEIKNQQNT VPSQSQPTTD KFQTSKSGSL PLGQKVDPGE
710 720 730 740 750
TSVGTYPDKG RNGFCHPLNH RTADGRGLEA TNGEEALPPP VSVLTQELNK
760 770 780 790 800
LNLQSLGDSL HETPDKNGKL EDEVLPSRKG AADSDLLASP PAIASLGKKQ
810 820 830 840 850
VRTNTEVSEA MAEMSLGPKS PQLGVQAGLE PILSSATVDS TKRLFLSGEE
860 870 880 890 900
PSKLDRDVLA ALECANIDPG LYPAIHRWKS TVMCYSPSDR QSWPSPALKG
910 920 930 940 950
KFTTELVDLD CSHSCSGRCS PAGSSPSKPG HTSSSSGLHS PGRYSPAHGR
960
HFQRVAHVAR LAAL
Length:964
Mass (Da):106,198
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A2A4E480B24D4E0
GO
Isoform 2 (identifier: Q6P1H6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     290-290: Missing.

Show »
Length:963
Mass (Da):106,127
Checksum:iF510FE51AD9283F9
GO
Isoform 3 (identifier: Q6P1H6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-744: Missing.

Show »
Length:886
Mass (Da):97,986
Checksum:i6D642681E6FBC835
GO
Isoform 4 (identifier: Q6P1H6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     419-423: GFDTP → VSTPH
     424-964: Missing.

Show »
Length:423
Mass (Da):46,910
Checksum:i98B97C886BAB9A81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82L → H in BAE21022 (PubMed:16141072).Curated1
Sequence conflicti871L → R in BAE22361 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023576290Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_023577419 – 423GFDTP → VSTPH in isoform 4. 1 Publication5
Alternative sequenceiVSP_023578424 – 964Missing in isoform 4. 1 PublicationAdd BLAST541
Alternative sequenceiVSP_023579667 – 744Missing in isoform 3. 1 PublicationAdd BLAST78

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK003234 mRNA Translation: BAB22659.1
AK132187 mRNA Translation: BAE21022.1
AK043925 mRNA Translation: BAC31703.1
AK134966 mRNA Translation: BAE22361.1
AK142497 mRNA Translation: BAE25086.1
BC065071 mRNA Translation: AAH65071.1
AK129192 Transcribed RNA Translation: BAC98002.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS57372.1 [Q6P1H6-1]
CCDS80360.1 [Q6P1H6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001240743.1, NM_001253814.1 [Q6P1H6-1]
NP_082198.1, NM_027922.2 [Q6P1H6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000031474; ENSMUSP00000031474; ENSMUSG00000029501 [Q6P1H6-2]
ENSMUST00000086674; ENSMUSP00000083878; ENSMUSG00000029501 [Q6P1H6-3]
ENSMUST00000197188; ENSMUSP00000143044; ENSMUSG00000029501 [Q6P1H6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
71782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71782

UCSC genome browser

More...
UCSCi
uc008yqe.2, mouse [Q6P1H6-4]
uc008yqf.2, mouse [Q6P1H6-2]
uc008yqg.2, mouse [Q6P1H6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003234 mRNA Translation: BAB22659.1
AK132187 mRNA Translation: BAE21022.1
AK043925 mRNA Translation: BAC31703.1
AK134966 mRNA Translation: BAE22361.1
AK142497 mRNA Translation: BAE25086.1
BC065071 mRNA Translation: AAH65071.1
AK129192 Transcribed RNA Translation: BAC98002.1
CCDSiCCDS57372.1 [Q6P1H6-1]
CCDS80360.1 [Q6P1H6-2]
RefSeqiNP_001240743.1, NM_001253814.1 [Q6P1H6-1]
NP_082198.1, NM_027922.2 [Q6P1H6-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031474

PTM databases

iPTMnetiQ6P1H6
PhosphoSitePlusiQ6P1H6

Proteomic databases

EPDiQ6P1H6
PaxDbiQ6P1H6
PeptideAtlasiQ6P1H6
PRIDEiQ6P1H6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1225, 96 antibodies

Genome annotation databases

EnsembliENSMUST00000031474; ENSMUSP00000031474; ENSMUSG00000029501 [Q6P1H6-2]
ENSMUST00000086674; ENSMUSP00000083878; ENSMUSG00000029501 [Q6P1H6-3]
ENSMUST00000197188; ENSMUSP00000143044; ENSMUSG00000029501 [Q6P1H6-1]
GeneIDi71782
KEGGimmu:71782
UCSCiuc008yqe.2, mouse [Q6P1H6-4]
uc008yqf.2, mouse [Q6P1H6-2]
uc008yqg.2, mouse [Q6P1H6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23141
MGIiMGI:1261856, Ankle2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG502QQ4Z, Eukaryota
GeneTreeiENSGT00390000016767
HOGENOMiCLU_017564_0_0_1
InParanoidiQ6P1H6
KOiK21412
OMAiCYIVDLY
OrthoDBi567264at2759
PhylomeDBiQ6P1H6
TreeFamiTF317729

Enzyme and pathway databases

ReactomeiR-MMU-2995383, Initiation of Nuclear Envelope (NE) Reformation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
71782, 6 hits in 21 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ankle2, mouse

Protein Ontology

More...
PROi
PR:Q6P1H6
RNActiQ6P1H6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029501, Expressed in pineal body and 259 other tissues
GenevisibleiQ6P1H6, MM

Family and domain databases

CDDicd12944, LEM_ANKL2, 1 hit
Gene3Di1.10.720.40, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR035007, ANKLE2
IPR036770, Ankyrin_rpt-contain_sf
IPR011015, LEM/LEM-like_dom_sf
IPR035006, LEM_ANKL2
IPR003887, LEM_dom
PANTHERiPTHR12349:SF4, PTHR12349:SF4, 1 hit
PfamiView protein in Pfam
PF03020, LEM, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF63451, SSF63451, 1 hit
PROSITEiView protein in PROSITE
PS50954, LEM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANKL2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1H6
Secondary accession number(s): Q3UQF6
, Q3UY52, Q3V1X7, Q6ZQ67, Q8BRM7, Q9CTK6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: August 12, 2020
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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