UniProtKB - Q6P1E8 (EFCB6_MOUSE)

BLAST

>sp|Q6P1E8|EFCB6_MOUSE EF-hand calcium-binding domain-containing protein 6 OS=Mus musculus OX=10090 GN=Efcab6 PE=1 SV=2
MKRNGTRLNFAKANSTKSGSTRARDLMNKMSIIPEWHSLYSNTRKLPCSRPHSSPCKMQR
TIFQDLCRPSSSTTAIANPVLSYLDIERILAQKISSRRDDIKKVFQILDRNHNQMVTKGD
LKRVITAFLIPLTKDQFQDLLAQIPISSLGNVPYLEFLSRFGGGIDININGIKRVNENEV
DNRRTVKEVQLTEKIFRNMRSIRKVFQVMDVNNTGLVQPQELRRVLETFCLRMQDGDYEK
FLEQYNIDKTTAVDYNAFLKNLSVKNDASFKYLLSNAAELSRETQQGKNGKRLLDTGSSE
DVWKNYSLDDLEKTFCQEFSKSYEKIEKALSAGDPSKGGYISLNYLKVVLDTFIYRLPRR
IFIQLIRRFGLKTSTKINWKQFLTAIYERQKLEVSKTLPLKKRSSTEARNRSRKENIIKK
LFKYSEDRYTALKKTLLIISSTPSGHITWEELRHILNCMVAKLNDSEFSELKQTFDPEGT
GAVRVNSLLDVLDDSTKVRKMSPSTDTKTPLPVAWDSVEELVLDSITRNLQAFYSMLQSY
DLRDTGTIGKNNFRKVMRVFCPYLSNEHLVRFSSKFQEAGSGRILYKKFLLSIGVGIPPP
TPPLSSPKVQLSDQFQIEEPGQQDERTQPSGEKTSEINNMTKEEVIDGLKHRIQQKDPVF
RKQFLSISKEPDVKINQEEFRKVLERSGMPMNDCQYAMLASKLGFKNEEGMSYQDFTMGF
EDCMLSGLETVPLQSRTASRTNMDEHFISAEECLRIFPKKLKESFRDVYSAFFRIDLDRD
GIISMHDFHRLLQYLQLNMVDLEFERFLSLLGLRLSVTLNFREFQNLCEKRPWKSDEAPQ
RLIRCKQKVADSELACEQAHQYLIMKAKTRWADLSKNFIETDNEGNGILRRRDIKNSLYG
FDIPLTPREFEKLWQNYDTEGRGYITYQEFLHRLGIRYSPKVHRPYKEDYFNFLGHFTKP
KQVQEEIQELQQISEREKLMNHYEEISKAFNAMEKSKPVALCRVQKVLQECGCPLKEEEL
ISLLKSLDVSVHNNHIDPVEFLRALEISWASKARPKEKEESSPPPISFSKVTPDEVIKTM
QEVVESSQPALVEAFSALDKEDTGFVKAMEFGDVLRSVCQKLTDNQYHYFLRRLRLHLTP
NIHWKYFLENFSTFQDETADDWAENMPKAPPPMSPKETAHRDIVARVQKAVASHYHTIVQ
EFENFDTLKSNTVSRDEFRSICTRHIQILTDEQFDRLWSELPVNAKGRLKYQDFLSKLSI
ERVPSPPMAAGDSGESTMAQRGSSAPEFSQGTRSNLYSPPRDSRVGLKSRSHPCTPVGTP
PLQNCEPIESRLRKQIQGCWRELLRECKEKDTDKQGTISAAEFLALVEKFKLDISREESQ
QLIVKYDLKNNGKFAYCDFIQSCVLLLKAKETSLMRRMRIQNADKMKEAGMETPSFYSAL
LRIQPKIVHCWRPMRRSFKTYDKNGTGLLSVADFRKVLRQYSINLSEEEFFHVLEYYDKS
LSSKISYNDFLRAFLQ

Align

Format
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History
Entry version 116 (07 Nov 2018)
Sequence version 2 (13 Nov 2007)
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Protein

EF-hand calcium-binding domain-containing protein 6

Gene

Efcab6

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
Calcium bindingⁱ	109 – 120	1PROSITE-ProRule annotationAdd BLAST	12
Calcium bindingⁱ	210 – 221	2PROSITE-ProRule annotationAdd BLAST	12
Calcium bindingⁱ	776 – 787	7PROSITE-ProRule annotationAdd BLAST	12
Calcium bindingⁱ	1462 – 1473	14PROSITE-ProRule annotationAdd BLAST	12

GO - Molecular functionⁱ

calcium ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation
Ligand	Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: EF-hand calcium-binding domain-containing protein 6 Alternative name(s): DJ-1-binding protein Short name: DJBP
Gene namesⁱ	Name:Efcab6 Synonyms:Djbp, Kiaa1672
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1924877 Efcab6

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000246026	1 – 1516	EF-hand calcium-binding domain-containing protein 6Add BLAST		1516

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	906	PhosphothreonineCombined sources	1
Modified residueⁱ	1265	PhosphoserineCombined sources	1
Modified residueⁱ	1311	PhosphoserineCombined sources	1
Modified residueⁱ	1315	PhosphothreonineCombined sources	1
Modified residueⁱ	1319	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6P1E8
PRIDEⁱ	Q6P1E8

PTM databases

iPTMnetⁱ	Q6P1E8
PhosphoSitePlusⁱ	Q6P1E8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000022441 Expressed in 56 organ(s), highest expression level in testis
CleanExⁱ	MM_EFCAB6
ExpressionAtlasⁱ	Q6P1E8 baseline and differential
Genevisibleⁱ	Q6P1E8 MM

Interactionⁱ

Subunit structureⁱ

Binds PARK7. Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000114909

STRINGⁱ

10090.ENSMUSP00000114909

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P1E8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	96 – 131	EF-hand 1PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	197 – 232	EF-hand 2PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	321 – 356	EF-hand 3PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	427 – 462	EF-hand 4PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	528 – 563	EF-hand 5PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	655 – 690	EF-hand 6PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	763 – 798	EF-hand 7PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	905 – 940	EF-hand 8PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1086 – 1121	EF-hand 9PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1193 – 1228	EF-hand 10PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1229 – 1264	EF-hand 11PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1338 – 1373	EF-hand 12PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1374 – 1409	EF-hand 13PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1449 – 1484	EF-hand 14PROSITE-ProRule annotationAdd BLAST	36
Domainⁱ	1485 – 1516	EF-hand 15PROSITE-ProRule annotationAdd BLAST	32

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1318 – 1516	Interaction with PARK7By similarityAdd BLAST		199
Regionⁱ	1422 – 1516	Interaction with ARBy similarityAdd BLAST		95

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0027 Eukaryota COG5126 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013629
HOVERGENⁱ	HBG095997
InParanoidⁱ	Q6P1E8
OMAⁱ	QNCEPIE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0TP8
PhylomeDBⁱ	Q6P1E8
TreeFamⁱ	TF329179

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR015070 EF_hand_DJBP IPR002048 EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08976 EF-hand_11, 1 hit PF13202 EF-hand_5, 1 hit PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 11 hits
SUPFAMⁱ	SSF47473 SSF47473, 7 hits
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 15 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6P1E8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR 
        60         70         80         90        100
PHSSPCKMQR TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD 
       110        120        130        140        150
IKKVFQILDR NHNQMVTKGD LKRVITAFLI PLTKDQFQDL LAQIPISSLG 
       160        170        180        190        200
NVPYLEFLSR FGGGIDININ GIKRVNENEV DNRRTVKEVQ LTEKIFRNMR 
       210        220        230        240        250
SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK FLEQYNIDKT 
       260        270        280        290        300
TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE 
       310        320        330        340        350
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL 
       360        370        380        390        400
DTFIYRLPRR IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL 
       410        420        430        440        450
KKRSSTEARN RSRKENIIKK LFKYSEDRYT ALKKTLLIIS STPSGHITWE 
       460        470        480        490        500
ELRHILNCMV AKLNDSEFSE LKQTFDPEGT GAVRVNSLLD VLDDSTKVRK 
       510        520        530        540        550
MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY DLRDTGTIGK 
       560        570        580        590        600
NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP 
       610        620        630        640        650
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK 
       660        670        680        690        700
HRIQQKDPVF RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA 
       710        720        730        740        750
SKLGFKNEEG MSYQDFTMGF EDCMLSGLET VPLQSRTASR TNMDEHFISA 
       760        770        780        790        800
EECLRIFPKK LKESFRDVYS AFFRIDLDRD GIISMHDFHR LLQYLQLNMV 
       810        820        830        840        850
DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ RLIRCKQKVA 
       860        870        880        890        900
DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG 
       910        920        930        940        950
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY 
       960        970        980        990       1000
FNFLGHFTKP KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA 
      1010       1020       1030       1040       1050
LCRVQKVLQE CGCPLKEEEL ISLLKSLDVS VHNNHIDPVE FLRALEISWA 
      1060       1070       1080       1090       1100
SKARPKEKEE SSPPPISFSK VTPDEVIKTM QEVVESSQPA LVEAFSALDK 
      1110       1120       1130       1140       1150
EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP NIHWKYFLEN 
      1160       1170       1180       1190       1200
FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ 
      1210       1220       1230       1240       1250
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK 
      1260       1270       1280       1290       1300
YQDFLSKLSI ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP 
      1310       1320       1330       1340       1350
RDSRVGLKSR SHPCTPVGTP PLQNCEPIES RLRKQIQGCW RELLRECKEK 
      1360       1370       1380       1390       1400
DTDKQGTISA AEFLALVEKF KLDISREESQ QLIVKYDLKN NGKFAYCDFI 
      1410       1420       1430       1440       1450
QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL LRIQPKIVHC 
      1460       1470       1480       1490       1500
WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS 
      1510 
LSSKISYNDF LRAFLQ

Length:1,516

Mass (Da):175,771

Last modified:November 13, 2007 - v2

Checksum:ⁱ786C634E6CFA5CFD

Isoform 2 (identifier: Q6P1E8-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-688: Missing.

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        10         20         30         40         50
MPMNDCQYAM LASKLGFKNE EGMSYQDFTM GFEDCMLSGL ETVPLQSRTA 
        60         70         80         90        100
SRTNMDEHFI SAEECLRIFP KKLKESFRDV YSAFFRIDLD RDGIISMHDF 
       110        120        130        140        150
HRLLQYLQLN MVDLEFERFL SLLGLRLSVT LNFREFQNLC EKRPWKSDEA 
       160        170        180        190        200
PQRLIRCKQK VADSELACEQ AHQYLIMKAK TRWADLSKNF IETDNEGNGI 
       210        220        230        240        250
LRRRDIKNSL YGFDIPLTPR EFEKLWQNYD TEGRGYITYQ EFLHRLGIRY 
       260        270        280        290        300
SPKVHRPYKE DYFNFLGHFT KPKQVQEEIQ ELQQISEREK LMNHYEEISK 
       310        320        330        340        350
AFNAMEKSKP VALCRVQKVL QECGCPLKEE ELISLLKSLD VSVHNNHIDP 
       360        370        380        390        400
VEFLRALEIS WASKARPKEK EESSPPPISF SKVTPDEVIK TMQEVVESSQ 
       410        420        430        440        450
PALVEAFSAL DKEDTGFVKA MEFGDVLRSV CQKLTDNQYH YFLRRLRLHL 
       460        470        480        490        500
TPNIHWKYFL ENFSTFQDET ADDWAENMPK APPPMSPKET AHRDIVARVQ 
       510        520        530        540        550
KAVASHYHTI VQEFENFDTL KSNTVSRDEF RSICTRHIQI LTDEQFDRLW 
       560        570        580        590        600
SELPVNAKGR LKYQDFLSKL SIERVPSPPM AAGDSGESTM AQRGSSAPEF 
       610        620        630        640        650
SQGTRSNLYS PPRDSRVGLK SRSHPCTPVG TPPLQNCEPI ESRLRKQIQG 
       660        670        680        690        700
CWRELLRECK EKDTDKQGTI SAAEFLALVE KFKLDISREE SQQLIVKYDL 
       710        720        730        740        750
KNNGKFAYCD FIQSCVLLLK AKETSLMRRM RIQNADKMKE AGMETPSFYS 
       760        770        780        790        800
ALLRIQPKIV HCWRPMRRSF KTYDKNGTGL LSVADFRKVL RQYSINLSEE 
       810        820 
EFFHVLEYYD KSLSSKISYN DFLRAFLQ

Show »

Length:828

Mass (Da):96,577

Checksum:ⁱ945F0D4BC0AEB37F

Isoform 3 (identifier: Q6P1E8-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-838: Missing.
839-844: PQRLIR → MSKKHG

« Hide

        10         20         30         40         50
MSKKHGCKQK VADSELACEQ AHQYLIMKAK TRWADLSKNF IETDNEGNGI 
        60         70         80         90        100
LRRRDIKNSL YGFDIPLTPR EFEKLWQNYD TEGRGYITYQ EFLHRLGIRY 
       110        120        130        140        150
SPKVHRPYKE DYFNFLGHFT KPKQVQEEIQ ELQQISEREK LMNHYEEISK 
       160        170        180        190        200
AFNAMEKSKP VALCRVQKVL QECGCPLKEE ELISLLKSLD VSVHNNHIDP 
       210        220        230        240        250
VEFLRALEIS WASKARPKEK EESSPPPISF SKVTPDEVIK TMQEVVESSQ 
       260        270        280        290        300
PALVEAFSAL DKEDTGFVKA MEFGDVLRSV CQKLTDNQYH YFLRRLRLHL 
       310        320        330        340        350
TPNIHWKYFL ENFSTFQDET ADDWAENMPK APPPMSPKET AHRDIVARVQ 
       360        370        380        390        400
KAVASHYHTI VQEFENFDTL KSNTVSRDEF RSICTRHIQI LTDEQFDRLW 
       410        420        430        440        450
SELPVNAKGR LKYQDFLSKL SIERVPSPPM AAGDSGESTM AQRGSSAPEF 
       460        470        480        490        500
SQGTRSNLYS PPRDSRVGLK SRSHPCTPVG TPPLQNCEPI ESRLRKQIQG 
       510        520        530        540        550
CWRELLRECK EKDTDKQGTI SAAEFLALVE KFKLDISREE SQQLIVKYDL 
       560        570        580        590        600
KNNGKFAYCD FIQSCVLLLK AKETSLMRRM RIQNADKMKE AGMETPSFYS 
       610        620        630        640        650
ALLRIQPKIV HCWRPMRRSF KTYDKNGTGL LSVADFRKVL RQYSINLSEE 
       660        670 
EFFHVLEYYD KSLSSKISYN DFLRAFLQ

Note: Gene prediction based on EST data.

Show »

Length:678

Mass (Da):78,779

Checksum:ⁱ180AD60E21442E83

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F6RST1	F6RST1_MOUSE		EF-hand calcium-binding domain-cont... EF-hand calcium-binding domain-containing protein 6	Efcab6	70	Annotation score:

Sequence cautionⁱ

The sequence AAH56955 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH65111 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	632	E → K in AAH65111 (PubMed:15489334).Curated	1
Sequence conflictⁱ	1101	E → V in BAD90458 (Ref. 2) Curated	1
Sequence conflictⁱ	1181	R → K in BAD90458 (Ref. 2) Curated	1
Sequence conflictⁱ	1391	Missing in AAH56955 (PubMed:15489334).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_029427	1 – 838	Missing in isoform 3. CuratedAdd BLAST	838
Alternative sequenceⁱVSP_019814	1 – 688	Missing in isoform 2. 2 PublicationsAdd BLAST	688
Alternative sequenceⁱVSP_029428	839 – 844	PQRLIR → MSKKHG in isoform 3. Curated	6

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK019850 mRNA Translation: BAB31880.1 AK220412 mRNA Translation: BAD90458.1 AL513354, AL603867 Genomic DNA Translation: CAO78062.1 AL513354 Genomic DNA Translation: CAO78063.1 AL513354 Genomic DNA Translation: CAO78064.1 AL603867, AL513354 Genomic DNA Translation: CAO77882.1 BC056955 mRNA Translation: AAH56955.1 Different initiation. BC065111 mRNA Translation: AAH65111.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27707.2 [Q6P1E8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001155100.1, NM_001161628.1 [Q6P1E8-3] NP_001155101.1, NM_001161629.1 [Q6P1E8-4] NP_084222.4, NM_029946.4 [Q6P1E8-1] XP_006521596.1, XM_006521533.2 [Q6P1E8-1] XP_017172280.1, XM_017316791.1 [Q6P1E8-1]
UniGeneⁱ	Mm.196288

Genome annotation databases

Ensemblⁱ	ENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441 [Q6P1E8-1]
GeneIDⁱ	77627
KEGGⁱ	mmu:77627
UCSC genome browser More...UCSCⁱ	uc007xbo.1 mouse [Q6P1E8-4] uc007xbq.1 mouse [Q6P1E8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P1E8	Isoform 2 of EF-hand calcium-binding domain-containing protein 6		MOUSE		828	UniRef90_Q6P1E8
UPI000A315112		MUSCR		1516
UPI000A30A6B8		MUSPA		1489
UPI000A319C1D		MUSCR		1515
UPI0007EC64D1		MOUSE		1489
+4

Protein	Similar proteins		Species	Score	Length	Source
Q6P1E8	EF-hand calcium-binding domain-containing protein 6	)	HUMAN		1501	UniRef50_Q5THR3
EF-hand calcium-binding domain-containing protein 6		PONAB		1533
Uncharacterized protein		CHLSB		1504
Uncharacterized protein		NOMLE		1501
EF-hand calcium-binding domain-containing protein 6		MACFA		1501
+242

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK019850 mRNA Translation: BAB31880.1 AK220412 mRNA Translation: BAD90458.1 AL513354, AL603867 Genomic DNA Translation: CAO78062.1 AL513354 Genomic DNA Translation: CAO78063.1 AL513354 Genomic DNA Translation: CAO78064.1 AL603867, AL513354 Genomic DNA Translation: CAO77882.1 BC056955 mRNA Translation: AAH56955.1 Different initiation. BC065111 mRNA Translation: AAH65111.1 Different initiation.
CCDSⁱ	CCDS27707.2 [Q6P1E8-1]
RefSeqⁱ	NP_001155100.1, NM_001161628.1 [Q6P1E8-3] NP_001155101.1, NM_001161629.1 [Q6P1E8-4] NP_084222.4, NM_029946.4 [Q6P1E8-1] XP_006521596.1, XM_006521533.2 [Q6P1E8-1] XP_017172280.1, XM_017316791.1 [Q6P1E8-1]
UniGeneⁱ	Mm.196288

3D structure databases

ProteinModelPortalⁱ	Q6P1E8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000114909

STRINGⁱ

10090.ENSMUSP00000114909

PTM databases

iPTMnetⁱ	Q6P1E8
PhosphoSitePlusⁱ	Q6P1E8

Proteomic databases

PaxDbⁱ	Q6P1E8
PRIDEⁱ	Q6P1E8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441 [Q6P1E8-1]
GeneIDⁱ	77627
KEGGⁱ	mmu:77627
UCSCⁱ	uc007xbo.1 mouse [Q6P1E8-4] uc007xbq.1 mouse [Q6P1E8-1]

Organism-specific databases

CTDⁱ	64800
MGIⁱ	MGI:1924877 Efcab6
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0027 Eukaryota COG5126 LUCA
GeneTreeⁱ	ENSGT00390000013629
HOVERGENⁱ	HBG095997
InParanoidⁱ	Q6P1E8
OMAⁱ	QNCEPIE
OrthoDBⁱ	EOG091G0TP8
PhylomeDBⁱ	Q6P1E8
TreeFamⁱ	TF329179

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6P1E8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000022441 Expressed in 56 organ(s), highest expression level in testis
CleanExⁱ	MM_EFCAB6
ExpressionAtlasⁱ	Q6P1E8 baseline and differential
Genevisibleⁱ	Q6P1E8 MM

Family and domain databases

CDDⁱ	cd00051 EFh, 2 hits
InterProⁱ	View protein in InterPro IPR011992 EF-hand-dom_pair IPR018247 EF_Hand_1_Ca_BS IPR015070 EF_hand_DJBP IPR002048 EF_hand_dom
Pfamⁱ	View protein in Pfam PF08976 EF-hand_11, 1 hit PF13202 EF-hand_5, 1 hit PF13499 EF-hand_7, 1 hit PF13833 EF-hand_8, 1 hit
SMARTⁱ	View protein in SMART SM00054 EFh, 11 hits
SUPFAMⁱ	SSF47473 SSF47473, 7 hits
PROSITEⁱ	View protein in PROSITE PS00018 EF_HAND_1, 4 hits PS50222 EF_HAND_2, 15 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EFCB6_MOUSE
Accessionⁱ	Q6P1E8Primary (citable) accession number: Q6P1E8 Secondary accession number(s): A6PW10 , A6PW11, A6PW12, Q5DTV8, Q6PGK8, Q9D2D8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
	Last sequence update:	November 13, 2007
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q6P1E8 (EFCB6_MOUSE)

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EF-hand calcium-binding domain-containing protein 6

Efcab6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ