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UniProtKB - Q6P1E8 (EFCB6_MOUSE)

Entry version 132 (29 Sep 2021)
Sequence version 2 (13 Nov 2007)
Previous versions | rss
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Protein

EF-hand calcium-binding domain-containing protein 6

Gene

Efcab6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi109 – 1201PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi210 – 2212PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi776 – 7877PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi1462 – 147314PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EF-hand calcium-binding domain-containing protein 6
Alternative name(s):
DJ-1-binding protein
Short name:
DJBP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Efcab6
Synonyms:Djbp, Kiaa1672
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1924877, Efcab6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000022441

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002460261 – 1516EF-hand calcium-binding domain-containing protein 6Add BLAST1516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei906PhosphothreonineCombined sources1
Modified residuei1265PhosphoserineCombined sources1
Modified residuei1311PhosphoserineCombined sources1
Modified residuei1315PhosphothreonineCombined sources1
Modified residuei1319PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6P1E8

PRoteomics IDEntifications database

More...PRIDEi		Q6P1E8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		277445 [Q6P1E8-1]
277446 [Q6P1E8-3]
277447 [Q6P1E8-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6P1E8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6P1E8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000022441, Expressed in testis and 88 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6P1E8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6P1E8, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PARK7.

Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		218809, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000114909

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6P1E8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini96 – 131EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini197 – 232EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini321 – 356EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini427 – 462EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini528 – 563EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini655 – 690EF-hand 6PROSITE-ProRule annotationAdd BLAST36
Domaini763 – 798EF-hand 7PROSITE-ProRule annotationAdd BLAST36
Domaini905 – 940EF-hand 8PROSITE-ProRule annotationAdd BLAST36
Domaini1086 – 1121EF-hand 9PROSITE-ProRule annotationAdd BLAST36
Domaini1193 – 1228EF-hand 10PROSITE-ProRule annotationAdd BLAST36
Domaini1229 – 1264EF-hand 11PROSITE-ProRule annotationAdd BLAST36
Domaini1338 – 1373EF-hand 12PROSITE-ProRule annotationAdd BLAST36
Domaini1374 – 1409EF-hand 13PROSITE-ProRule annotationAdd BLAST36
Domaini1449 – 1484EF-hand 14PROSITE-ProRule annotationAdd BLAST36
Domaini1485 – 1516EF-hand 15PROSITE-ProRule annotationAdd BLAST32

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni618 – 638DisorderedSequence analysisAdd BLAST21
Regioni1263 – 1318DisorderedSequence analysisAdd BLAST56
Regioni1318 – 1516Interaction with PARK7By similarityAdd BLAST199
Regioni1422 – 1516Interaction with ARBy similarityAdd BLAST95

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 23Polar residuesSequence analysisAdd BLAST16
Compositional biasi1276 – 1299Polar residuesSequence analysisAdd BLAST24

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0027, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013629

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004260_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6P1E8

Identification of Orthologs from Complete Genome Data

More...OMAi		IHWKYFL

Database of Orthologous Groups

More...OrthoDBi		193070at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6P1E8

TreeFam database of animal gene trees

More...TreeFami		TF329179

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR015070, EF_hand_DJBP
IPR002048, EF_hand_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08976, EF-hand_11, 1 hit
PF13202, EF-hand_5, 2 hits
PF13499, EF-hand_7, 1 hit
PF13833, EF-hand_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P1E8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR 
        60         70         80         90        100
PHSSPCKMQR TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD 
       110        120        130        140        150
IKKVFQILDR NHNQMVTKGD LKRVITAFLI PLTKDQFQDL LAQIPISSLG 
       160        170        180        190        200
NVPYLEFLSR FGGGIDININ GIKRVNENEV DNRRTVKEVQ LTEKIFRNMR 
       210        220        230        240        250
SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK FLEQYNIDKT 
       260        270        280        290        300
TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE 
       310        320        330        340        350
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL 
       360        370        380        390        400
DTFIYRLPRR IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL 
       410        420        430        440        450
KKRSSTEARN RSRKENIIKK LFKYSEDRYT ALKKTLLIIS STPSGHITWE 
       460        470        480        490        500
ELRHILNCMV AKLNDSEFSE LKQTFDPEGT GAVRVNSLLD VLDDSTKVRK 
       510        520        530        540        550
MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY DLRDTGTIGK 
       560        570        580        590        600
NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP 
       610        620        630        640        650
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK 
       660        670        680        690        700
HRIQQKDPVF RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA 
       710        720        730        740        750
SKLGFKNEEG MSYQDFTMGF EDCMLSGLET VPLQSRTASR TNMDEHFISA 
       760        770        780        790        800
EECLRIFPKK LKESFRDVYS AFFRIDLDRD GIISMHDFHR LLQYLQLNMV 
       810        820        830        840        850
DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ RLIRCKQKVA 
       860        870        880        890        900
DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG 
       910        920        930        940        950
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY 
       960        970        980        990       1000
FNFLGHFTKP KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA 
      1010       1020       1030       1040       1050
LCRVQKVLQE CGCPLKEEEL ISLLKSLDVS VHNNHIDPVE FLRALEISWA 
      1060       1070       1080       1090       1100
SKARPKEKEE SSPPPISFSK VTPDEVIKTM QEVVESSQPA LVEAFSALDK 
      1110       1120       1130       1140       1150
EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP NIHWKYFLEN 
      1160       1170       1180       1190       1200
FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ 
      1210       1220       1230       1240       1250
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK 
      1260       1270       1280       1290       1300
YQDFLSKLSI ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP 
      1310       1320       1330       1340       1350
RDSRVGLKSR SHPCTPVGTP PLQNCEPIES RLRKQIQGCW RELLRECKEK 
      1360       1370       1380       1390       1400
DTDKQGTISA AEFLALVEKF KLDISREESQ QLIVKYDLKN NGKFAYCDFI 
      1410       1420       1430       1440       1450
QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL LRIQPKIVHC 
      1460       1470       1480       1490       1500
WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS 
      1510 
LSSKISYNDF LRAFLQ
Length:1,516
Mass (Da):175,771
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i786C634E6CFA5CFD
GO
Isoform 2 (identifier: Q6P1E8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-688: Missing.

Show »
Length:828
Mass (Da):96,577
Checksum:i945F0D4BC0AEB37F
GO
Isoform 3 (identifier: Q6P1E8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-838: Missing.
     839-844: PQRLIR → MSKKHG

Show »
Length:678
Mass (Da):78,779
Checksum:i180AD60E21442E83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RST1F6RST1_MOUSE
EF-hand calcium-binding domain-cont...
Efcab6
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH56955 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH65111 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti632E → K in AAH65111 (PubMed:15489334).Curated1
Sequence conflicti1101E → V in BAD90458 (Ref. 2) Curated1
Sequence conflicti1181R → K in BAD90458 (Ref. 2) Curated1
Sequence conflicti1391Missing in AAH56955 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0294271 – 838Missing in isoform 3. CuratedAdd BLAST838
Alternative sequenceiVSP_0198141 – 688Missing in isoform 2. 2 PublicationsAdd BLAST688
Alternative sequenceiVSP_029428839 – 844PQRLIR → MSKKHG in isoform 3. Curated6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK019850 mRNA Translation: BAB31880.1
AK220412 mRNA Translation: BAD90458.1
AL513354 Genomic DNA No translation available.
AL603867 Genomic DNA No translation available.
BC056955 mRNA Translation: AAH56955.1 Different initiation.
BC065111 mRNA Translation: AAH65111.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS27707.2 [Q6P1E8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001155100.1, NM_001161628.1 [Q6P1E8-3]
NP_001155101.1, NM_001161629.1 [Q6P1E8-4]
NP_084222.4, NM_029946.4 [Q6P1E8-1]
XP_006521596.1, XM_006521533.2 [Q6P1E8-1]
XP_017172280.1, XM_017316791.1 [Q6P1E8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441 [Q6P1E8-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		77627

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:77627

UCSC genome browser

More...UCSCi		uc007xbo.1, mouse [Q6P1E8-4]
uc007xbq.1, mouse [Q6P1E8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019850 mRNA Translation: BAB31880.1
AK220412 mRNA Translation: BAD90458.1
AL513354 Genomic DNA No translation available.
AL603867 Genomic DNA No translation available.
BC056955 mRNA Translation: AAH56955.1 Different initiation.
BC065111 mRNA Translation: AAH65111.1 Different initiation.
CCDSiCCDS27707.2 [Q6P1E8-1]
RefSeqiNP_001155100.1, NM_001161628.1 [Q6P1E8-3]
NP_001155101.1, NM_001161629.1 [Q6P1E8-4]
NP_084222.4, NM_029946.4 [Q6P1E8-1]
XP_006521596.1, XM_006521533.2 [Q6P1E8-1]
XP_017172280.1, XM_017316791.1 [Q6P1E8-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi218809, 2 interactors
STRINGi10090.ENSMUSP00000114909

PTM databases

iPTMnetiQ6P1E8
PhosphoSitePlusiQ6P1E8

Proteomic databases

PaxDbiQ6P1E8
PRIDEiQ6P1E8
ProteomicsDBi277445 [Q6P1E8-1]
277446 [Q6P1E8-3]
277447 [Q6P1E8-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		320, 28 antibodies

Genome annotation databases

EnsembliENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441 [Q6P1E8-1]
GeneIDi77627
KEGGimmu:77627
UCSCiuc007xbo.1, mouse [Q6P1E8-4]
uc007xbq.1, mouse [Q6P1E8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64800
MGIiMGI:1924877, Efcab6
VEuPathDBiHostDB:ENSMUSG00000022441

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG0027, Eukaryota
GeneTreeiENSGT00390000013629
HOGENOMiCLU_004260_0_0_1
InParanoidiQ6P1E8
OMAiIHWKYFL
OrthoDBi193070at2759
PhylomeDBiQ6P1E8
TreeFamiTF329179

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		77627, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Efcab6, mouse

Protein Ontology

More...PROi		PR:Q6P1E8
RNActiQ6P1E8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000022441, Expressed in testis and 88 other tissues
ExpressionAtlasiQ6P1E8, baseline and differential
GenevisibleiQ6P1E8, MM

Family and domain databases

CDDicd00051, EFh, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR015070, EF_hand_DJBP
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF08976, EF-hand_11, 1 hit
PF13202, EF-hand_5, 2 hits
PF13499, EF-hand_7, 1 hit
PF13833, EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 11 hits
SUPFAMiSSF47473, SSF47473, 7 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 15 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEFCB6_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P1E8
Secondary accession number(s): A6PW10
, A6PW11, A6PW12, Q5DTV8, Q6PGK8, Q9D2D8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 13, 2007
Last modified: September 29, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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