UniProtKB - Q6P1E8 (EFCB6_MOUSE)
Protein
EF-hand calcium-binding domain-containing protein 6
Gene
Efcab6
Organism
Mus musculus (Mouse)
Status
Functioni
Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 109 – 120 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 210 – 221 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 776 – 787 | 7PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 1462 – 1473 | 14PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: EF-hand calcium-binding domain-containing protein 6Alternative name(s): DJ-1-binding protein Short name: DJBP |
Gene namesi | Name:Efcab6 Synonyms:Djbp, Kiaa1672 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1924877, Efcab6 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000246026 | 1 – 1516 | EF-hand calcium-binding domain-containing protein 6Add BLAST | 1516 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 906 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1265 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1311 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1315 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1319 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q6P1E8 |
PRIDEi | Q6P1E8 |
PTM databases
iPTMneti | Q6P1E8 |
PhosphoSitePlusi | Q6P1E8 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022441, Expressed in spermatid and 76 other tissues |
ExpressionAtlasi | Q6P1E8, baseline and differential |
Genevisiblei | Q6P1E8, MM |
Interactioni
Subunit structurei
Binds PARK7.
Part of a ternary complex containing PARK7, EFCAB6/DJBP and AR (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 218809, 2 interactors |
STRINGi | 10090.ENSMUSP00000114909 |
Miscellaneous databases
RNActi | Q6P1E8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 96 – 131 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 197 – 232 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 321 – 356 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 427 – 462 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 528 – 563 | EF-hand 5PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 655 – 690 | EF-hand 6PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 763 – 798 | EF-hand 7PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 905 – 940 | EF-hand 8PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1086 – 1121 | EF-hand 9PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1193 – 1228 | EF-hand 10PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1229 – 1264 | EF-hand 11PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1338 – 1373 | EF-hand 12PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1374 – 1409 | EF-hand 13PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1449 – 1484 | EF-hand 14PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 1485 – 1516 | EF-hand 15PROSITE-ProRule annotationAdd BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1318 – 1516 | Interaction with PARK7By similarityAdd BLAST | 199 | |
Regioni | 1422 – 1516 | Interaction with ARBy similarityAdd BLAST | 95 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00390000013629 |
HOGENOMi | CLU_004260_0_0_1 |
InParanoidi | Q6P1E8 |
OMAi | IHWKYFL |
OrthoDBi | 193070at2759 |
PhylomeDBi | Q6P1E8 |
TreeFami | TF329179 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR015070, EF_hand_DJBP IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF08976, EF-hand_11, 1 hit PF13202, EF-hand_5, 2 hits PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 11 hits |
SUPFAMi | SSF47473, SSF47473, 7 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 15 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6P1E8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRNGTRLNF AKANSTKSGS TRARDLMNKM SIIPEWHSLY SNTRKLPCSR
60 70 80 90 100
PHSSPCKMQR TIFQDLCRPS SSTTAIANPV LSYLDIERIL AQKISSRRDD
110 120 130 140 150
IKKVFQILDR NHNQMVTKGD LKRVITAFLI PLTKDQFQDL LAQIPISSLG
160 170 180 190 200
NVPYLEFLSR FGGGIDININ GIKRVNENEV DNRRTVKEVQ LTEKIFRNMR
210 220 230 240 250
SIRKVFQVMD VNNTGLVQPQ ELRRVLETFC LRMQDGDYEK FLEQYNIDKT
260 270 280 290 300
TAVDYNAFLK NLSVKNDASF KYLLSNAAEL SRETQQGKNG KRLLDTGSSE
310 320 330 340 350
DVWKNYSLDD LEKTFCQEFS KSYEKIEKAL SAGDPSKGGY ISLNYLKVVL
360 370 380 390 400
DTFIYRLPRR IFIQLIRRFG LKTSTKINWK QFLTAIYERQ KLEVSKTLPL
410 420 430 440 450
KKRSSTEARN RSRKENIIKK LFKYSEDRYT ALKKTLLIIS STPSGHITWE
460 470 480 490 500
ELRHILNCMV AKLNDSEFSE LKQTFDPEGT GAVRVNSLLD VLDDSTKVRK
510 520 530 540 550
MSPSTDTKTP LPVAWDSVEE LVLDSITRNL QAFYSMLQSY DLRDTGTIGK
560 570 580 590 600
NNFRKVMRVF CPYLSNEHLV RFSSKFQEAG SGRILYKKFL LSIGVGIPPP
610 620 630 640 650
TPPLSSPKVQ LSDQFQIEEP GQQDERTQPS GEKTSEINNM TKEEVIDGLK
660 670 680 690 700
HRIQQKDPVF RKQFLSISKE PDVKINQEEF RKVLERSGMP MNDCQYAMLA
710 720 730 740 750
SKLGFKNEEG MSYQDFTMGF EDCMLSGLET VPLQSRTASR TNMDEHFISA
760 770 780 790 800
EECLRIFPKK LKESFRDVYS AFFRIDLDRD GIISMHDFHR LLQYLQLNMV
810 820 830 840 850
DLEFERFLSL LGLRLSVTLN FREFQNLCEK RPWKSDEAPQ RLIRCKQKVA
860 870 880 890 900
DSELACEQAH QYLIMKAKTR WADLSKNFIE TDNEGNGILR RRDIKNSLYG
910 920 930 940 950
FDIPLTPREF EKLWQNYDTE GRGYITYQEF LHRLGIRYSP KVHRPYKEDY
960 970 980 990 1000
FNFLGHFTKP KQVQEEIQEL QQISEREKLM NHYEEISKAF NAMEKSKPVA
1010 1020 1030 1040 1050
LCRVQKVLQE CGCPLKEEEL ISLLKSLDVS VHNNHIDPVE FLRALEISWA
1060 1070 1080 1090 1100
SKARPKEKEE SSPPPISFSK VTPDEVIKTM QEVVESSQPA LVEAFSALDK
1110 1120 1130 1140 1150
EDTGFVKAME FGDVLRSVCQ KLTDNQYHYF LRRLRLHLTP NIHWKYFLEN
1160 1170 1180 1190 1200
FSTFQDETAD DWAENMPKAP PPMSPKETAH RDIVARVQKA VASHYHTIVQ
1210 1220 1230 1240 1250
EFENFDTLKS NTVSRDEFRS ICTRHIQILT DEQFDRLWSE LPVNAKGRLK
1260 1270 1280 1290 1300
YQDFLSKLSI ERVPSPPMAA GDSGESTMAQ RGSSAPEFSQ GTRSNLYSPP
1310 1320 1330 1340 1350
RDSRVGLKSR SHPCTPVGTP PLQNCEPIES RLRKQIQGCW RELLRECKEK
1360 1370 1380 1390 1400
DTDKQGTISA AEFLALVEKF KLDISREESQ QLIVKYDLKN NGKFAYCDFI
1410 1420 1430 1440 1450
QSCVLLLKAK ETSLMRRMRI QNADKMKEAG METPSFYSAL LRIQPKIVHC
1460 1470 1480 1490 1500
WRPMRRSFKT YDKNGTGLLS VADFRKVLRQ YSINLSEEEF FHVLEYYDKS
1510
LSSKISYNDF LRAFLQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF6RST1 | F6RST1_MOUSE | EF-hand calcium-binding domain-cont... | Efcab6 | 70 | Annotation score: |
Sequence cautioni
The sequence AAH56955 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH65111 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 632 | E → K in AAH65111 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1101 | E → V in BAD90458 (Ref. 2) Curated | 1 | |
Sequence conflicti | 1181 | R → K in BAD90458 (Ref. 2) Curated | 1 | |
Sequence conflicti | 1391 | Missing in AAH56955 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029427 | 1 – 838 | Missing in isoform 3. CuratedAdd BLAST | 838 | |
Alternative sequenceiVSP_019814 | 1 – 688 | Missing in isoform 2. 2 PublicationsAdd BLAST | 688 | |
Alternative sequenceiVSP_029428 | 839 – 844 | PQRLIR → MSKKHG in isoform 3. Curated | 6 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK019850 mRNA Translation: BAB31880.1 AK220412 mRNA Translation: BAD90458.1 AL513354 Genomic DNA No translation available. AL603867 Genomic DNA No translation available. BC056955 mRNA Translation: AAH56955.1 Different initiation. BC065111 mRNA Translation: AAH65111.1 Different initiation. |
CCDSi | CCDS27707.2 [Q6P1E8-1] |
RefSeqi | NP_001155100.1, NM_001161628.1 [Q6P1E8-3] NP_001155101.1, NM_001161629.1 [Q6P1E8-4] NP_084222.4, NM_029946.4 [Q6P1E8-1] XP_006521596.1, XM_006521533.2 [Q6P1E8-1] XP_017172280.1, XM_017316791.1 [Q6P1E8-1] |
Genome annotation databases
Ensembli | ENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441 [Q6P1E8-1] |
GeneIDi | 77627 |
KEGGi | mmu:77627 |
UCSCi | uc007xbo.1, mouse [Q6P1E8-4] uc007xbq.1, mouse [Q6P1E8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK019850 mRNA Translation: BAB31880.1 AK220412 mRNA Translation: BAD90458.1 AL513354 Genomic DNA No translation available. AL603867 Genomic DNA No translation available. BC056955 mRNA Translation: AAH56955.1 Different initiation. BC065111 mRNA Translation: AAH65111.1 Different initiation. |
CCDSi | CCDS27707.2 [Q6P1E8-1] |
RefSeqi | NP_001155100.1, NM_001161628.1 [Q6P1E8-3] NP_001155101.1, NM_001161629.1 [Q6P1E8-4] NP_084222.4, NM_029946.4 [Q6P1E8-1] XP_006521596.1, XM_006521533.2 [Q6P1E8-1] XP_017172280.1, XM_017316791.1 [Q6P1E8-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 218809, 2 interactors |
STRINGi | 10090.ENSMUSP00000114909 |
PTM databases
iPTMneti | Q6P1E8 |
PhosphoSitePlusi | Q6P1E8 |
Proteomic databases
PaxDbi | Q6P1E8 |
PRIDEi | Q6P1E8 |
Protocols and materials databases
Antibodypediai | 320, 27 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000156187; ENSMUSP00000114909; ENSMUSG00000022441 [Q6P1E8-1] |
GeneIDi | 77627 |
KEGGi | mmu:77627 |
UCSCi | uc007xbo.1, mouse [Q6P1E8-4] uc007xbq.1, mouse [Q6P1E8-1] |
Organism-specific databases
CTDi | 64800 |
MGIi | MGI:1924877, Efcab6 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0027, Eukaryota |
GeneTreei | ENSGT00390000013629 |
HOGENOMi | CLU_004260_0_0_1 |
InParanoidi | Q6P1E8 |
OMAi | IHWKYFL |
OrthoDBi | 193070at2759 |
PhylomeDBi | Q6P1E8 |
TreeFami | TF329179 |
Miscellaneous databases
BioGRID-ORCSi | 77627, 0 hits in 17 CRISPR screens |
ChiTaRSi | Efcab6, mouse |
PROi | PR:Q6P1E8 |
RNActi | Q6P1E8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022441, Expressed in spermatid and 76 other tissues |
ExpressionAtlasi | Q6P1E8, baseline and differential |
Genevisiblei | Q6P1E8, MM |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR015070, EF_hand_DJBP IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF08976, EF-hand_11, 1 hit PF13202, EF-hand_5, 2 hits PF13499, EF-hand_7, 1 hit PF13833, EF-hand_8, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 11 hits |
SUPFAMi | SSF47473, SSF47473, 7 hits |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 4 hits PS50222, EF_HAND_2, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EFCB6_MOUSE | |
Accessioni | Q6P1E8Primary (citable) accession number: Q6P1E8 Secondary accession number(s): A6PW10 Q9D2D8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 10, 2021 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot