Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger MIZ domain-containing protein 1

Gene

Zmiz1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (PubMed:26522984).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri734 – 811SP-RING-typePROSITE-ProRule annotationAdd BLAST78

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger MIZ domain-containing protein 1
Alternative name(s):
PIAS-like protein Zimp10
Retinoic acid-induced protein 17
Gene namesi
Name:Zmiz1
Synonyms:Rai17, Zimp10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3040693 Zmiz1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death between 9.5-10.5 dpc. Mice are approximately half the size of wild-type littermates and display vascular and cell viability defects. Some heterozygotes also do not survive but those that do have no apparent defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002189881 – 1072Zinc finger MIZ domain-containing protein 1Add BLAST1072

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki91Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki841Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki850Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ6P1E1
PeptideAtlasiQ6P1E1
PRIDEiQ6P1E1

PTM databases

iPTMnetiQ6P1E1
PhosphoSitePlusiQ6P1E1

Expressioni

Tissue specificityi

Expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000007817 Expressed in 266 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_ZMIZ1
GenevisibleiQ6P1E1 MM

Interactioni

Subunit structurei

Interacts with AR, but not with ESR1, NR3C1, PGR, THRB nor VDR. Interacts with NOTCH1 and RBPJ (By similarity). Interacts with SMARCA4.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Smarca4Q3TKT42EBI-647033,EBI-1210244

Protein-protein interaction databases

IntActiQ6P1E1, 5 interactors
STRINGi10090.ENSMUSP00000124863

Structurei

3D structure databases

ProteinModelPortaliQ6P1E1
SMRiQ6P1E1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 120Sufficient for transactivation activity; sufficient for interaction with NOTCH1By similarityAdd BLAST120
Regioni844 – 1072Transactivation domainBy similarityAdd BLAST229

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 305Ala-richAdd BLAST26
Compositional biasi340 – 562Pro-richAdd BLAST223
Compositional biasi874 – 1007Pro-richAdd BLAST134

Domaini

The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein (By similarity).By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri734 – 811SP-RING-typePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00550000074410
HOGENOMiHOG000253014
HOVERGENiHBG056252
InParanoidiQ6P1E1
KOiK22403
OMAiHPPDMPS
OrthoDBiEOG091G01NY
PhylomeDBiQ6P1E1
TreeFamiTF316952

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044 ZF_SP_RING, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P1E1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNSMDRHIQQ TNDRLQCIKQ HLQNPANFHN AATELLDWCG DPRAFQRPFE
60 70 80 90 100
QSLMGCLTVV SRVAAQQGFD LDLGYRLLAV CAANRDKFTP KSAALLSSWC
110 120 130 140 150
EELGRLLLLR HQKSRQNDPP GKLPMQPPLS SMSSMKPTLS HSDGSFPYDS
160 170 180 190 200
VPWQQNTNQP PGSLSVVTTV WGVTNTSQSQ VLGNPMANAN NPMNPGGNPM
210 220 230 240 250
ASGMSTSNPG INSPQFAGQQ QQFSTKAGPA QPYIQPNMYG RPGYPGSGGF
260 270 280 290 300
GASYPGGPSA PAGMGIPPHT RPPADFTQPA AAAAAAAVAA AAATATATAT
310 320 330 340 350
ATVAALQETQ NKDINQYGPV CSSFQMGPTQ AYNSQFMNQP GPRGPASMGG
360 370 380 390 400
SLNPAGMAAG MTPSGMSGPP MGMNQPRPPG ISPFGTHGQR MPQQTYPGPR
410 420 430 440 450
PQSLPIQSIK RPYPGEPNYG NQQYGPNSQF PTQPGQYPTP NPPRPLTSPN
460 470 480 490 500
YPGQRMPSQP STGQYPPPTV NMGQYYKPEQ FNGQNNTFSS GSSYSSYSQG
510 520 530 540 550
SVNRPPRPVP VANYPHSPVP GNPTPPMTPG SSIPPYLSPS QDVKPPFPPD
560 570 580 590 600
IKPNMSALPP PPANHNDELR LTFPVRDGVV LEPFRLEHNL AVSNHVFHLR
610 620 630 640 650
PTVHQTLMWR SDLELQFKCY HHEDRQMNTN WPASVQVSVN ATPLTIERGD
660 670 680 690 700
NKTSHKPLHL KHVCQPGRNT IQITVTACCC SHLFVLQLVH RPSVRSVLQG
710 720 730 740 750
LLKKRLLPAE HCITKIKRNF SSVAASSGNT TLNGEDGVEQ TAIKVSLKCP
760 770 780 790 800
ITFRRIQLPA RGHDCKHVQC FDLESYLQLN CERGTWRCPV CNKTALLEGL
810 820 830 840 850
EVDQYMWGIL NAIQHSEFEE VTIDPTCSWR PVPIKSDLHI KDDPDGIPSK
860 870 880 890 900
RFKTMSPSQM IMPNVMEMIA ALGPGPSPYP LPPPPGGTSS NDYSSQGNNY
910 920 930 940 950
QGHGNFDFPH GNPGGTSMND FMHGPPQLSH PPDMPNNMAA LEKPLSHPMQ
960 970 980 990 1000
ETMPHAGSSD QPHPSIQQGL HVPHPSSQAG PPLHHSGAPP PSQPPRQPPQ
1010 1020 1030 1040 1050
AAPGNHPHSD LTFNPSSALE GQAGAQGASD MPEPSLDLLP ELTNPDELLS
1060 1070
YLDPPDLPSN SNDDLLSLFE NN
Note: No experimental confirmation available.
Length:1,072
Mass (Da):115,851
Last modified:July 5, 2004 - v1
Checksum:i53B1AF1338EBDB17
GO
Isoform 2 (identifier: Q6P1E1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-325: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:1,066
Mass (Da):115,199
Checksum:i761BA804BFE025B4
GO

Sequence cautioni

The sequence AAH57691 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC35753 differs from that shown. Intron retention.Curated
The sequence BAC35753 differs from that shown. Reason: Frameshift at position 350.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012187320 – 325Missing in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057691 mRNA Translation: AAH57691.1 Different initiation.
BC058646 mRNA Translation: AAH58646.1
BC065120 mRNA Translation: AAH65120.1
AK054366 mRNA Translation: BAC35753.1 Sequence problems.
CCDSiCCDS26873.1 [Q6P1E1-1]
CCDS79280.1 [Q6P1E1-2]
RefSeqiNP_001297595.1, NM_001310666.1 [Q6P1E1-2]
NP_899031.2, NM_183208.4 [Q6P1E1-1]
UniGeneiMm.227484
Mm.486339

Genome annotation databases

EnsembliENSMUST00000007961; ENSMUSP00000007961; ENSMUSG00000007817 [Q6P1E1-2]
ENSMUST00000162645; ENSMUSP00000124863; ENSMUSG00000007817 [Q6P1E1-1]
GeneIDi328365
KEGGimmu:328365
UCSCiuc007srn.2 mouse [Q6P1E1-1]
uc007sro.2 mouse [Q6P1E1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC057691 mRNA Translation: AAH57691.1 Different initiation.
BC058646 mRNA Translation: AAH58646.1
BC065120 mRNA Translation: AAH65120.1
AK054366 mRNA Translation: BAC35753.1 Sequence problems.
CCDSiCCDS26873.1 [Q6P1E1-1]
CCDS79280.1 [Q6P1E1-2]
RefSeqiNP_001297595.1, NM_001310666.1 [Q6P1E1-2]
NP_899031.2, NM_183208.4 [Q6P1E1-1]
UniGeneiMm.227484
Mm.486339

3D structure databases

ProteinModelPortaliQ6P1E1
SMRiQ6P1E1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P1E1, 5 interactors
STRINGi10090.ENSMUSP00000124863

PTM databases

iPTMnetiQ6P1E1
PhosphoSitePlusiQ6P1E1

Proteomic databases

PaxDbiQ6P1E1
PeptideAtlasiQ6P1E1
PRIDEiQ6P1E1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007961; ENSMUSP00000007961; ENSMUSG00000007817 [Q6P1E1-2]
ENSMUST00000162645; ENSMUSP00000124863; ENSMUSG00000007817 [Q6P1E1-1]
GeneIDi328365
KEGGimmu:328365
UCSCiuc007srn.2 mouse [Q6P1E1-1]
uc007sro.2 mouse [Q6P1E1-2]

Organism-specific databases

CTDi57178
MGIiMGI:3040693 Zmiz1

Phylogenomic databases

eggNOGiKOG2169 Eukaryota
ENOG410XQ2E LUCA
GeneTreeiENSGT00550000074410
HOGENOMiHOG000253014
HOVERGENiHBG056252
InParanoidiQ6P1E1
KOiK22403
OMAiHPPDMPS
OrthoDBiEOG091G01NY
PhylomeDBiQ6P1E1
TreeFamiTF316952

Miscellaneous databases

ChiTaRSiZmiz1 mouse
PROiPR:Q6P1E1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007817 Expressed in 266 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_ZMIZ1
GenevisibleiQ6P1E1 MM

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004181 Znf_MIZ
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF02891 zf-MIZ, 1 hit
PROSITEiView protein in PROSITE
PS51044 ZF_SP_RING, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZMIZ1_MOUSE
AccessioniPrimary (citable) accession number: Q6P1E1
Secondary accession number(s): Q6PDK9, Q6PF85, Q8BW47
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again