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Protein

Inositol-pentakisphosphate 2-kinase

Gene

Ippk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.1 Publication

Catalytic activityi

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855167 Synthesis of pyrophosphates in the cytosol
R-MMU-1855191 Synthesis of IPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-pentakisphosphate 2-kinase (EC:2.7.1.158)
Alternative name(s):
Inositol-1,3,4,5,6-pentakisphosphate 2-kinase
Ins(1,3,4,5,6)P5 2-kinase
Short name:
InsP5 2-kinase
Gene namesi
Name:Ippk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1922928 Ippk

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Death during ermbryogenesis before 8.5 dpc, suggesting that InsP6 is required for yolk sac function and development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001105301 – 489Inositol-pentakisphosphate 2-kinaseAdd BLAST489

Proteomic databases

PaxDbiQ6P1C1
PRIDEiQ6P1C1

PTM databases

iPTMnetiQ6P1C1
PhosphoSitePlusiQ6P1C1

Expressioni

Tissue specificityi

In brain, it is expressed throughout the hippocampus (CA1, CA2, CA3 and dentate gyrus), inner layers of the cerebral cortex, and Purkinje cells of the cerebellum. In heart, it is expressed in cardiomyocytes but not in interstitial cells, blood vessels, or valves. Also expressed in testis.1 Publication

Developmental stagei

In E9 embryos it is expressed in regions corresponding to the neural tube, notochord and somites. Through the neural tube, it is expressed in the ventricular zone and in migrating neuroblasts. Also expressed in the notochord and specific regions of the somite. Strongly expressed in the myotome (future skeletal muscle) of the somite. In addition to the neural tube, it is also expressed in the ventricular zone and migrating neuroblasts throughout the embryonic brain. Prominent expression is detected in the yolk sac and embryonic heart. Within the yolk sac, it is expressed in both the epithelial and endothelial layers (blood vessels) but absent from the blood islands. In the heart, it is detected in both the atrial and ventricular chambers. In the ventricular myocardium it is present in both the endocardium and myocardium. Also expressed in the cardinal vein, aorta, digestive tract, and pharyngeal arches.

Gene expression databases

BgeeiENSMUSG00000021385 Expressed in 273 organ(s), highest expression level in primary oocyte
CleanExiMM_IPPK
ExpressionAtlasiQ6P1C1 baseline and differential
GenevisibleiQ6P1C1 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021817

Structurei

Secondary structure

1489
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6P1C1
SMRiQ6P1C1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi136 – 140EXKPK motif5

Domaini

The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.

Sequence similaritiesi

Belongs to the IPK1 type 2 family.Curated

Phylogenomic databases

eggNOGiKOG4749 Eukaryota
ENOG410XSF2 LUCA
GeneTreeiENSGT00390000010053
HOGENOMiHOG000113092
HOVERGENiHBG079461
InParanoidiQ6P1C1
KOiK10572
OMAiMDEGKMD
OrthoDBiEOG091G05DL
PhylomeDBiQ6P1C1
TreeFamiTF106142

Family and domain databases

InterProiView protein in InterPro
IPR009286 Ins_P5_2-kin
PANTHERiPTHR14456 PTHR14456, 1 hit
PfamiView protein in Pfam
PF06090 Ins_P5_2-kin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P1C1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGKMDENE WSYHGEGNKS LVVAHAQRCV VLRFLKFPPN KKKTSEEILQ
60 70 80 90 100
HLQNIVDFGK NVMKDFLGEN YVHCGEVVQL PLEFVKQLCL KIQCERPESR
110 120 130 140 150
CDKDLDTFSG YAMCLPNLTR LQTFHFAEHR PILCVEIKPK CGFIPFSNDV
160 170 180 190 200
THEMKHKVCR YCMHQHLKVA TGKWKKISKY CPLDLYSGNK QRMHFALRSL
210 220 230 240 250
LQETQNNLRI FKNGELIYGC GDARSPVADL KELAHHLKPF FFPSNGLASG
260 270 280 290 300
PHCTKAVIRE LVHVITRVLL SSSEKARAGA LRLGLQGPRV CEASPFSRSL
310 320 330 340 350
HNQGKNTSEH SGLPKGCLLY KTLQVQMLDQ LDIEGLYPLY KRVEQYLEEF
360 370 380 390 400
PEERKTLQID GPYDEVFYQK LLDLSTEDDG TVAFALTKVQ QYRVAMTAKD
410 420 430 440 450
CSIMIALSPC LQGTSSDQRP VIPSSRSRLA FSVSVLDLDL KPYESIPHQY
460 470 480
KLDSKIVNYY SKTVHAKDDT VRSTRFKEHE DCTLVLHKV
Length:489
Mass (Da):55,928
Last modified:July 5, 2004 - v1
Checksum:i441839EA3F425D5A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A217FL54A0A217FL54_MOUSE
Inositol-pentakisphosphate 2-kinase
Ippk
538Annotation score:
A0A1Y7VNV4A0A1Y7VNV4_MOUSE
Inositol-pentakisphosphate 2-kinase
Ippk
68Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83E → Q in BAE20447 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029085 mRNA Translation: BAE20447.1
AK160092 mRNA Translation: BAE35623.1
AK167467 mRNA Translation: BAE39551.1
BC062167 mRNA Translation: AAH62167.1
BC065157 mRNA Translation: AAH65157.1
CCDSiCCDS26500.1
RefSeqiNP_951011.1, NM_199056.3
UniGeneiMm.390586

Genome annotation databases

EnsembliENSMUST00000220447; ENSMUSP00000152331; ENSMUSG00000021385
GeneIDi75678
KEGGimmu:75678
UCSCiuc007qjj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029085 mRNA Translation: BAE20447.1
AK160092 mRNA Translation: BAE35623.1
AK167467 mRNA Translation: BAE39551.1
BC062167 mRNA Translation: AAH62167.1
BC065157 mRNA Translation: AAH65157.1
CCDSiCCDS26500.1
RefSeqiNP_951011.1, NM_199056.3
UniGeneiMm.390586

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MW8X-ray2.40A1-468[»]
5MWLX-ray3.20A/B1-468[»]
5MWMX-ray2.60A1-468[»]
ProteinModelPortaliQ6P1C1
SMRiQ6P1C1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021817

PTM databases

iPTMnetiQ6P1C1
PhosphoSitePlusiQ6P1C1

Proteomic databases

PaxDbiQ6P1C1
PRIDEiQ6P1C1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000220447; ENSMUSP00000152331; ENSMUSG00000021385
GeneIDi75678
KEGGimmu:75678
UCSCiuc007qjj.2 mouse

Organism-specific databases

CTDi64768
MGIiMGI:1922928 Ippk

Phylogenomic databases

eggNOGiKOG4749 Eukaryota
ENOG410XSF2 LUCA
GeneTreeiENSGT00390000010053
HOGENOMiHOG000113092
HOVERGENiHBG079461
InParanoidiQ6P1C1
KOiK10572
OMAiMDEGKMD
OrthoDBiEOG091G05DL
PhylomeDBiQ6P1C1
TreeFamiTF106142

Enzyme and pathway databases

ReactomeiR-MMU-1855167 Synthesis of pyrophosphates in the cytosol
R-MMU-1855191 Synthesis of IPs in the nucleus

Miscellaneous databases

PROiPR:Q6P1C1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021385 Expressed in 273 organ(s), highest expression level in primary oocyte
CleanExiMM_IPPK
ExpressionAtlasiQ6P1C1 baseline and differential
GenevisibleiQ6P1C1 MM

Family and domain databases

InterProiView protein in InterPro
IPR009286 Ins_P5_2-kin
PANTHERiPTHR14456 PTHR14456, 1 hit
PfamiView protein in Pfam
PF06090 Ins_P5_2-kin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPPK_MOUSE
AccessioniPrimary (citable) accession number: Q6P1C1
Secondary accession number(s): Q3V3Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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