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Protein

39S ribosomal protein L54, mitochondrial

Gene

MRPL54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L54, mitochondrial
Short name:
L54mt
Short name:
MRP-L54
Alternative name(s):
Mitochondrial large ribosomal subunit protein mL541 Publication
Gene namesi
Name:MRPL54
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183617.4
HGNCiHGNC:16685 MRPL54
MIMi611858 gene
neXtProtiNX_Q6P161

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000183617
PharmGKBiPA30987

Polymorphism and mutation databases

BioMutaiMRPL54
DMDMi74737109

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 14MitochondrionSequence analysisAdd BLAST14
ChainiPRO_000027828015 – 13839S ribosomal protein L54, mitochondrialAdd BLAST124

Proteomic databases

EPDiQ6P161
MaxQBiQ6P161
PaxDbiQ6P161
PeptideAtlasiQ6P161
PRIDEiQ6P161
ProteomicsDBi66822
TopDownProteomicsiQ6P161

PTM databases

iPTMnetiQ6P161
PhosphoSitePlusiQ6P161

Expressioni

Gene expression databases

BgeeiENSG00000183617 Expressed in 194 organ(s), highest expression level in body of stomach
CleanExiHS_MRPL54
ExpressionAtlasiQ6P161 baseline and differential
GenevisibleiQ6P161 HS

Organism-specific databases

HPAiHPA042117
HPA046767

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:25838379, PubMed:28892042). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi125522, 13 interactors
CORUMiQ6P161
IntActiQ6P161, 9 interactors
MINTiQ6P161
STRINGi9606.ENSP00000331849

Structurei

Secondary structure

1138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6P161
SMRiQ6P161
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3435 Eukaryota
ENOG411244M LUCA
GeneTreeiENSGT00390000001201
HOGENOMiHOG000068097
HOVERGENiHBG093903
InParanoidiQ6P161
KOiK17435
OMAiYMKTGED
OrthoDBiEOG091G0TM2
PhylomeDBiQ6P161
TreeFamiTF314007

Family and domain databases

InterProiView protein in InterPro
IPR013870 Ribosomal_L37_mit
PANTHERiPTHR28595 PTHR28595, 1 hit
PfamiView protein in Pfam
PF08561 Ribosomal_L37, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6P161-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA
60 70 80 90 100
VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPDA EYPEWLFEMN
110 120 130
LGPPKTLEEL DPESREYWRR LRKQNIWRHN RLSKNKRL
Length:138
Mass (Da):15,819
Last modified:July 5, 2004 - v1
Checksum:i98E0FCA10592B064
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENN2K7ENN2_HUMAN
39S ribosomal protein L54, mitochon...
MRPL54
76Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065273 mRNA Translation: AAH65273.1
CCDSiCCDS12111.1
RefSeqiNP_758455.1, NM_172251.2
UniGeneiHs.356578

Genome annotation databases

EnsembliENST00000330133; ENSP00000331849; ENSG00000183617
GeneIDi116541
KEGGihsa:116541
UCSCiuc002lyq.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065273 mRNA Translation: AAH65273.1
CCDSiCCDS12111.1
RefSeqiNP_758455.1, NM_172251.2
UniGeneiHs.356578

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50l1-138[»]
5OOLelectron microscopy3.06l1-138[»]
5OOMelectron microscopy3.03l1-138[»]
ProteinModelPortaliQ6P161
SMRiQ6P161
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125522, 13 interactors
CORUMiQ6P161
IntActiQ6P161, 9 interactors
MINTiQ6P161
STRINGi9606.ENSP00000331849

PTM databases

iPTMnetiQ6P161
PhosphoSitePlusiQ6P161

Polymorphism and mutation databases

BioMutaiMRPL54
DMDMi74737109

Proteomic databases

EPDiQ6P161
MaxQBiQ6P161
PaxDbiQ6P161
PeptideAtlasiQ6P161
PRIDEiQ6P161
ProteomicsDBi66822
TopDownProteomicsiQ6P161

Protocols and materials databases

DNASUi116541
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330133; ENSP00000331849; ENSG00000183617
GeneIDi116541
KEGGihsa:116541
UCSCiuc002lyq.5 human

Organism-specific databases

CTDi116541
EuPathDBiHostDB:ENSG00000183617.4
GeneCardsiMRPL54
HGNCiHGNC:16685 MRPL54
HPAiHPA042117
HPA046767
MIMi611858 gene
neXtProtiNX_Q6P161
OpenTargetsiENSG00000183617
PharmGKBiPA30987
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3435 Eukaryota
ENOG411244M LUCA
GeneTreeiENSGT00390000001201
HOGENOMiHOG000068097
HOVERGENiHBG093903
InParanoidiQ6P161
KOiK17435
OMAiYMKTGED
OrthoDBiEOG091G0TM2
PhylomeDBiQ6P161
TreeFamiTF314007

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

GenomeRNAii116541
PROiPR:Q6P161
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183617 Expressed in 194 organ(s), highest expression level in body of stomach
CleanExiHS_MRPL54
ExpressionAtlasiQ6P161 baseline and differential
GenevisibleiQ6P161 HS

Family and domain databases

InterProiView protein in InterPro
IPR013870 Ribosomal_L37_mit
PANTHERiPTHR28595 PTHR28595, 1 hit
PfamiView protein in Pfam
PF08561 Ribosomal_L37, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM54_HUMAN
AccessioniPrimary (citable) accession number: Q6P161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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