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Entry version 152 (08 May 2019)
Sequence version 2 (02 May 2006)
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Protein

Putative ATP-dependent RNA helicase DHX57

Gene

DHX57

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-binding RNA helicase.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri299 – 326C3H1-typePROSITE-ProRule annotationAdd BLAST28
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi567 – 574ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DHX57 (EC:3.6.4.13)
Alternative name(s):
DEAH box protein 57
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHX57
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20086 DHX57

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P158

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000163214

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134919698

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DHX57

Domain mapping of disease mutations (DMDM)

More...
DMDMi
94710252

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002331511 – 1386Putative ATP-dependent RNA helicase DHX57Add BLAST1386

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei127PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei480PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P158

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P158

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P158

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P158

PeptideAtlas

More...
PeptideAtlasi
Q6P158

PRoteomics IDEntifications database

More...
PRIDEi
Q6P158

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66819
66820 [Q6P158-2]
66821 [Q6P158-3]

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q6P158

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P158

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P158

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163214 Expressed in 208 organ(s), highest expression level in sperm

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P158 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P158 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036160

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124783, 77 interactors

Protein interaction database and analysis system

More...
IntActi
Q6P158, 33 interactors

Molecular INTeraction database

More...
MINTi
Q6P158

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000405111

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P158

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini180 – 220UBAPROSITE-ProRule annotationAdd BLAST41
Domaini554 – 721Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST168
Domaini830 – 1010Helicase C-terminalPROSITE-ProRule annotationAdd BLAST181

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili101 – 125Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi668 – 671DEVH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi9 – 49Gly-richAdd BLAST41

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri299 – 326C3H1-typePROSITE-ProRule annotationAdd BLAST28

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0920 Eukaryota
COG1643 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156883

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P158

KEGG Orthology (KO)

More...
KOi
K13026

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEIICTQ

Database of Orthologous Groups

More...
OrthoDBi
278674at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P158

TreeFam database of animal gene trees

More...
TreeFami
TF324744

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00079 HELICc, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR006575 RWD-domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041367 Znf-CCCH_4
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
PF05773 RWD, 1 hit
PF18044 zf-CCCH_4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF52540 SSF52540, 1 hit
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50030 UBA, 1 hit
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P158-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSSVRRKGK PGKGGGKGSS RGGRGGRSHA SKSHGSGGGG GGGGGGGGGN
60 70 80 90 100
RKASSRIWDD GDDFCIFSES RRPSRPSNSN ISKGESRPKW KPKAKVPLQT
110 120 130 140 150
LHMTSENQEK VKALLRDLQE QDADAGSERG LSGEEEDDEP DCCNDERYWP
160 170 180 190 200
AGQEPSLVPD LDPLEYAGLA SVEPYVPEFT VSPFAVQKLS RYGFNTERCQ
210 220 230 240 250
AVLRMCDGDV GASLEHLLTQ CFSETFGERM KISEAVNQIS LDECMEQRQE
260 270 280 290 300
EAFALKSICG EKFIERIQNR VWTIGLELEY LTSRFRKSKP KESTKNVQEN
310 320 330 340 350
SLEICKFYLK GNCKFGSKCR FKHEVPPNQI VGRIERSVDD SHLNAIEDAS
360 370 380 390 400
FLYELEIRFS KDHKYPYQAP LVAFYSTNEN LPLACRLHIS EFLYDKALTF
410 420 430 440 450
AETSEPVVYS LITLLEEESE IVKLLTNTHH KYSDPPVNFL PVPSRTRINN
460 470 480 490 500
PACHKTVIPN NSFVSNQIPE VEKASESEES DEDDGPAPVI VENESYVNLK
510 520 530 540 550
KKISKRYDWQ AKSVHAENGK ICKQFRMKQA SRQFQSILQE RQSLPAWEER
560 570 580 590 600
ETILNLLRKH QVVVISGMTG CGKTTQIPQF ILDDSLNGPP EKVANIICTQ
610 620 630 640 650
PRRISAISVA ERVAKERAER VGLTVGYQIR LESVKSSATR LLYCTTGVLL
660 670 680 690 700
RRLEGDTALQ GVSHIIVDEV HERTEESDFL LLVLKDIVSQ RPGLQVILMS
710 720 730 740 750
ATLNAELFSD YFNSCPVITI PGRTFPVDQF FLEDAIAVTR YVLQDGSPYM
760 770 780 790 800
RSMKQISKEK LKARRNRTAF EEVEEDLRLS LHLQDQDSVK DAVPDQQLDF
810 820 830 840 850
KQLLARYKGV SKSVIKTMSI MDFEKVNLEL IEALLEWIVD GKHSYPPGAI
860 870 880 890 900
LVFLPGLAEI KMLYEQLQSN SLFNNRRSNR CVIHPLHSSL SSEEQQAVFV
910 920 930 940 950
KPPAGVTKII ISTNIAETSI TIDDVVYVID SGKMKEKRYD ASKGMESLED
960 970 980 990 1000
TFVSQANALQ RKGRAGRVAS GVCFHLFTSH HYNHQLLKQQ LPEIQRVPLE
1010 1020 1030 1040 1050
QLCLRIKILE MFSAHNLQSV FSRLIEPPHT DSLRASKIRL RDLGALTPDE
1060 1070 1080 1090 1100
RLTPLGYHLA SLPVDVRIGK LMLFGSIFRC LDPALTIAAS LAFKSPFVSP
1110 1120 1130 1140 1150
WDKKEEANQK KLEFAFANSD YLALLQAYKG WQLSTKEGVR ASYNYCRQNF
1160 1170 1180 1190 1200
LSGRVLQEMA SLKRQFTELL SDIGFAREGL RAREIEKRAQ GGDGVLDATG
1210 1220 1230 1240 1250
EEANSNAENP KLISAMLCAA LYPNVVQVKS PEGKFQKTST GAVRMQPKSA
1260 1270 1280 1290 1300
ELKFVTKNDG YVHIHPSSVN YQVRHFDSPY LLYHEKIKTS RVFIRDCSMV
1310 1320 1330 1340 1350
SVYPLVLFGG GQVNVQLQRG EFVVSLDDGW IRFVAASHQV AELVKELRCE
1360 1370 1380
LDQLLQDKIK NPSIDLCTCP RGSRIISTIV KLVTTQ
Length:1,386
Mass (Da):155,604
Last modified:May 2, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFFF62BD4BF4C1F4D
GO
Isoform 2 (identifier: Q6P158-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-658: SSATRLLYCTTGVLLRRLEGDTA → VCMLCLFPGNRNLWFLGIKSFGG
     659-1386: Missing.

Note: No experimental confirmation available.
Show »
Length:658
Mass (Da):73,602
Checksum:i570E49695D5B05A3
GO
Isoform 3 (identifier: Q6P158-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     530-535: ASRQFQ → VLNSHM
     536-1386: Missing.

Note: No experimental confirmation available.
Show »
Length:433
Mass (Da):49,508
Checksum:i1B83D88C94570046
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C109H7C109_HUMAN
Putative ATP-dependent RNA helicase...
DHX57
665Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ11A0A087WZ11_HUMAN
Putative ATP-dependent RNA helicase...
DHX57
472Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ23H7BZ23_HUMAN
Putative ATP-dependent RNA helicase...
DHX57
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WW12A0A087WW12_HUMAN
Putative ATP-dependent RNA helicase...
DHX57
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM73547 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAY24256 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti474A → T in BAB71479 (PubMed:14702039).Curated1
Sequence conflicti976L → V in AAM73547 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052190410S → F. Corresponds to variant dbSNP:rs11893062Ensembl.1
Natural variantiVAR_033861433S → G. Corresponds to variant dbSNP:rs35371077Ensembl.1
Natural variantiVAR_052191587N → S2 PublicationsCorresponds to variant dbSNP:rs7598922Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0180561 – 102Missing in isoform 3. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_018057530 – 535ASRQFQ → VLNSHM in isoform 3. 1 Publication6
Alternative sequenceiVSP_018058536 – 1386Missing in isoform 3. 1 PublicationAdd BLAST851
Alternative sequenceiVSP_018059636 – 658SSATR…EGDTA → VCMLCLFPGNRNLWFLGIKS FGG in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_018060659 – 1386Missing in isoform 2. 1 PublicationAdd BLAST728

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK057423 mRNA Translation: BAB71479.1
AC018693 Genomic DNA Translation: AAY24256.1 Sequence problems.
BC053623 mRNA Translation: AAH53623.1
BC060778 mRNA Translation: AAH60778.2
BC065278 mRNA Translation: AAH65278.1
BC131534 mRNA Translation: AAI31535.1
AF283512 mRNA Translation: AAM73547.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS1800.1 [Q6P158-1]

NCBI Reference Sequences

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RefSeqi
NP_945314.1, NM_198963.2 [Q6P158-1]
XP_011531456.1, XM_011533154.2 [Q6P158-1]
XP_011531457.1, XM_011533155.2 [Q6P158-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000457308; ENSP00000405111; ENSG00000163214 [Q6P158-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
90957

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:90957

UCSC genome browser

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UCSCi
uc002rrf.5 human [Q6P158-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057423 mRNA Translation: BAB71479.1
AC018693 Genomic DNA Translation: AAY24256.1 Sequence problems.
BC053623 mRNA Translation: AAH53623.1
BC060778 mRNA Translation: AAH60778.2
BC065278 mRNA Translation: AAH65278.1
BC131534 mRNA Translation: AAI31535.1
AF283512 mRNA Translation: AAM73547.1 Different initiation.
CCDSiCCDS1800.1 [Q6P158-1]
RefSeqiNP_945314.1, NM_198963.2 [Q6P158-1]
XP_011531456.1, XM_011533154.2 [Q6P158-1]
XP_011531457.1, XM_011533155.2 [Q6P158-1]

3D structure databases

SMRiQ6P158
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124783, 77 interactors
IntActiQ6P158, 33 interactors
MINTiQ6P158
STRINGi9606.ENSP00000405111

PTM databases

CarbonylDBiQ6P158
iPTMnetiQ6P158
PhosphoSitePlusiQ6P158

Polymorphism and mutation databases

BioMutaiDHX57
DMDMi94710252

Proteomic databases

EPDiQ6P158
jPOSTiQ6P158
MaxQBiQ6P158
PaxDbiQ6P158
PeptideAtlasiQ6P158
PRIDEiQ6P158
ProteomicsDBi66819
66820 [Q6P158-2]
66821 [Q6P158-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000457308; ENSP00000405111; ENSG00000163214 [Q6P158-1]
GeneIDi90957
KEGGihsa:90957
UCSCiuc002rrf.5 human [Q6P158-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
90957

GeneCards: human genes, protein and diseases

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GeneCardsi
DHX57
HGNCiHGNC:20086 DHX57
HPAiHPA036160
neXtProtiNX_Q6P158
OpenTargetsiENSG00000163214
PharmGKBiPA134919698

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0920 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00940000156883
InParanoidiQ6P158
KOiK13026
OMAiVEIICTQ
OrthoDBi278674at2759
PhylomeDBiQ6P158
TreeFamiTF324744

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DHX57 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DHX57

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90957

Protein Ontology

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PROi
PR:Q6P158

Gene expression databases

BgeeiENSG00000163214 Expressed in 208 organ(s), highest expression level in sperm
ExpressionAtlasiQ6P158 baseline and differential
GenevisibleiQ6P158 HS

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR006575 RWD-domain
IPR015940 UBA
IPR009060 UBA-like_sf
IPR041367 Znf-CCCH_4
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
PF05773 RWD, 1 hit
PF18044 zf-CCCH_4, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF52540 SSF52540, 1 hit
SSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50030 UBA, 1 hit
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHX57_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P158
Secondary accession number(s): A2RRC7
, Q53SI4, Q6P9G1, Q7Z6H3, Q8NG17, Q96M33
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 2, 2006
Last modified: May 8, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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