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Protein

DNA polymerase alpha subunit B

Gene

pola2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replicationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase alpha subunit BUniRule annotation
Gene namesi
Name:pola2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030131-778 pola2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 241Pol_alpha_B_NInterPro annotationAdd BLAST219
Domaini345 – 550DNA_pol_E_BInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the DNA polymerase alpha subunit B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1625 Eukaryota
COG5214 LUCA
HOVERGENiHBG055628
KOiK02321
PhylomeDBiQ6P0S9

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P0S9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVTAEDIK SELDTFNIAF NNDTIDKMLE QCFCHRLTGE EIVFEWFAFS
60 70 80 90 100
STRKQLPLTL ENLDQFEQEV LNKKKKPKST SKGSQINKTR DINSIQELIR
110 120 130 140 150
AEEEEENMLD SYSTPAKGSQ KRALTTPEHP QSKRGVARLA SPSLMLSPAS
160 170 180 190 200
FSPSATPSQK YGMRGGRGEV VSTFGAVQGP RWMGKGQTAV SVEMLDGGEN
210 220 230 240 250
SLISSYKYMF QRLRDVRDVL TGKIEELGEE LRTNFNIEEF APVSLPVQDS
260 270 280 290 300
ITVLGQVCCD SNGKLNAQSV LLEAGQEQGG RQVPVDLSEL KEFSLFPGQV
310 320 330 340 350
VVMEGMNPSG EKLVATKLYE GIPLPFYCPS EVKQEMDEVC EPVMVMIACG
360 370 380 390 400
PYTPSESLTY DPLLDLITII NKDRPDVCIL FGPFVDSKHE QIEKNQVTET
410 420 430 440 450
FETIFKRCMD SIVEGTKGTA CKLVFVPSQR DVHHHYIYPQ PPFNLTISKE
460 470 480 490 500
DTARVTLAPD PCTLLIGNVT FGLTSTDILF HMGAEEISSG TGTERFSRIM
510 520 530 540 550
KHMLTQRSYY PLYPPAEEVN MDYDKFQQFS QMSLTPDILL APSELRYFIK
560 570 580 590 600
DVIGCVCVNP GRLTKGQIGG TYGRLLIQPN PAVVEGKRVS PCIAGQVVKI
Length:600
Mass (Da):66,763
Last modified:July 5, 2004 - v1
Checksum:i7CDD7CA20F1E0BDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065460 mRNA Translation: AAH65460.1
RefSeqiNP_955875.2, NM_199581.2
UniGeneiDr.77094

Genome annotation databases

GeneIDi322059
KEGGidre:322059

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065460 mRNA Translation: AAH65460.1
RefSeqiNP_955875.2, NM_199581.2
UniGeneiDr.77094

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi322059
KEGGidre:322059

Organism-specific databases

CTDi23649
ZFINiZDB-GENE-030131-778 pola2

Phylogenomic databases

eggNOGiKOG1625 Eukaryota
COG5214 LUCA
HOVERGENiHBG055628
KOiK02321
PhylomeDBiQ6P0S9

Family and domain databases

InterProiView protein in InterPro
IPR007185 DNA_pol_alpha/epsilon_bsu
IPR016722 DNA_pol_alpha_bsu
IPR013627 Pol_alpha_B_N
PANTHERiPTHR23061 PTHR23061, 1 hit
PfamiView protein in Pfam
PF04042 DNA_pol_E_B, 1 hit
PF08418 Pol_alpha_B_N, 1 hit
PIRSFiPIRSF018300 DNA_pol_alph_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6P0S9_DANRE
AccessioniPrimary (citable) accession number: Q6P0S9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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