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Entry version 158 (17 Jun 2020)
Sequence version 2 (29 Mar 2005)
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Protein

Microtubule-associated serine/threonine-protein kinase 2

Gene

MAST2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei541ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei635Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi518 – 526ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q6P0Q8

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q6P0Q8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 2 (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAST2Imported
Synonyms:KIAA0807Imported, MAST205Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000086015.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19035 MAST2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612257 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P0Q8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23139

Open Targets

More...
OpenTargetsi
ENSG00000086015

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954073

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P0Q8 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2417355

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAST2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62287152

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863121 – 1798Microtubule-associated serine/threonine-protein kinase 2Add BLAST1798

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei151PhosphoserineBy similarity1
Modified residuei209PhosphoserineCombined sources1
Modified residuei290PhosphoserineCombined sources1
Modified residuei874PhosphoserineCombined sources1
Modified residuei876PhosphoserineCombined sources1
Modified residuei895PhosphoserineBy similarity1
Modified residuei900PhosphoserineCombined sources1
Modified residuei1004Omega-N-methylarginineCombined sources1
Modified residuei1032PhosphoserineCombined sources1
Modified residuei1256PhosphoserineCombined sources1
Modified residuei1337PhosphoserineBy similarity1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1447PhosphoserineCombined sources1
Modified residuei1508PhosphothreonineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P0Q8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P0Q8

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6P0Q8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P0Q8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P0Q8

PeptideAtlas

More...
PeptideAtlasi
Q6P0Q8

PRoteomics IDEntifications database

More...
PRIDEi
Q6P0Q8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66816 [Q6P0Q8-1]
66817 [Q6P0Q8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P0Q8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P0Q8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Abundant in the testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000086015 Expressed in gastrocnemius and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6P0Q8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6P0Q8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000086015 Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CDHR2.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116756, 25 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q6P0Q8

Protein interaction database and analysis system

More...
IntActi
Q6P0Q8, 20 interactors

Molecular INTeraction database

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MINTi
Q6P0Q8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354671

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P0Q8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11798
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6P0Q8

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini512 – 785Protein kinasePROSITE-ProRule annotationAdd BLAST274
Domaini786 – 854AGC-kinase C-terminalAdd BLAST69
Domaini1104 – 1192PDZPROSITE-ProRule annotationAdd BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0606 Eukaryota
ENOG410XPWX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155705

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000288_9_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6P0Q8

KEGG Orthology (KO)

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KOi
K08789

Identification of Orthologs from Complete Genome Data

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OMAi
EGFMPAI

Database of Orthologous Groups

More...
OrthoDBi
323328at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P0Q8

TreeFam database of animal gene trees

More...
TreeFami
TF313149

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05609 STKc_MAST, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.1480.20, 1 hit
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR028779 MAST2
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

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PANTHERi
PTHR24356:SF136 PTHR24356:SF136, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08926 DUF1908, 1 hit
PF17820 PDZ_6, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q6P0Q8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRSRCRDRP QPPPPDRRED GVQRAAELSQ SLPPRRRAPP GRQRLEERTG
60 70 80 90 100
PAGPEGKEQD VVTGVSPLLF RKLSNPDIFS STGKVKLQRQ LSQDDCKLWR
110 120 130 140 150
GNLASSLSGK QLLPLSSSVH SSVGQVTWQS SGEASNLVRM RNQSLGQSAP
160 170 180 190 200
SLTAGLKELS LPRRGSFCRT SNRKSLIVTS STSPTLPRPH SPLHGHTGNS
210 220 230 240 250
PLDSPRNFSP NAPAHFSFVP ARRTDGRRWS LASLPSSGYG TNTPSSTVSS
260 270 280 290 300
SCSSQEKLHQ LPFQPTADEL HFLTKHFSTE SVPDEEGRQS PAMRPRSRSL
310 320 330 340 350
SPGRSPVSFD SEIIMMNHVY KERFPKATAQ MEERLAEFIS SNTPDSVLPL
360 370 380 390 400
ADGALSFIHH QVIEMARDCL DKSRSGLITS QYFYELQDNL EKLLQDAHER
410 420 430 440 450
SESSEVAFVM QLVKKLMIII ARPARLLECL EFDPEEFYHL LEAAEGHAKE
460 470 480 490 500
GQGIKCDIPR YIVSQLGLTR DPLEEMAQLS SCDSPDTPET DDSIEGHGAS
510 520 530 540 550
LPSKKTPSEE DFETIKLISN GAYGAVFLVR HKSTRQRFAM KKINKQNLIL
560 570 580 590 600
RNQIQQAFVE RDILTFAENP FVVSMFCSFD TKRHLCMVME YVEGGDCATL
610 620 630 640 650
LKNIGALPVD MVRLYFAETV LALEYLHNYG IVHRDLKPDN LLITSMGHIK
660 670 680 690 700
LTDFGLSKIG LMSLTTNLYE GHIEKDAREF LDKQVCGTPE YIAPEVILRQ
710 720 730 740 750
GYGKPVDWWA MGIILYEFLV GCVPFFGDTP EELFGQVISD EIVWPEGDEA
760 770 780 790 800
LPPDAQDLTS KLLHQNPLER LGTGSAYEVK QHPFFTGLDW TGLLRQKAEF
810 820 830 840 850
IPQLESEDDT SYFDTRSERY HHMDSEDEEE VSEDGCLEIR QFSSCSPRFN
860 870 880 890 900
KVYSSMERLS LLEERRTPPP TKRSLSEEKE DHSDGLAGLK GRDRSWVIGS
910 920 930 940 950
PEILRKRLSV SESSHTESDS SPPMTVRRRC SGLLDAPRFP EGPEEASSTL
960 970 980 990 1000
RRQPQEGIWV LTPPSGEGVS GPVTEHSGEQ RPKLDEEAVG RSSGSSPAME
1010 1020 1030 1040 1050
TRGRGTSQLA EGATAKAISD LAVRRARHRL LSGDSTEKRT ARPVNKVIKS
1060 1070 1080 1090 1100
ASATALSLLI PSEHHTCSPL ASPMSPHSQS SNPSSRDSSP SRDFLPALGS
1110 1120 1130 1140 1150
MRPPIIIHRA GKKYGFTLRA IRVYMGDSDV YTVHHMVWHV EDGGPASEAG
1160 1170 1180 1190 1200
LRQGDLITHV NGEPVHGLVH TEVVELILKS GNKVAISTTP LENTSIKVGP
1210 1220 1230 1240 1250
ARKGSYKAKM ARRSKRSRGK DGQESRKRSS LFRKITKQAS LLHTSRSLSS
1260 1270 1280 1290 1300
LNRSLSSGES GPGSPTHSHS LSPRSPTQGY RVTPDAVHSV GGNSSQSSSP
1310 1320 1330 1340 1350
SSSVPSSPAG SGHTRPSSLH GLAPKLQRQY RSPRRKSAGS IPLSPLAHTP
1360 1370 1380 1390 1400
SPPPPTASPQ RSPSPLSGHV AQAFPTKLHL SPPLGRQLSR PKSAEPPRSP
1410 1420 1430 1440 1450
LLKRVQSAEK LAAALAASEK KLATSRKHSL DLPHSELKKE LPPREVSPLE
1460 1470 1480 1490 1500
VVGARSVLSG KGALPGKGVL QPAPSRALGT LRQDRAERRE SLQKQEAIRE
1510 1520 1530 1540 1550
VDSSEDDTEE GPENSQGAQE LSLAPHPEVS QSVAPKGAGE SGEEDPFPSR
1560 1570 1580 1590 1600
DPRSLGPMVP SLLTGITLGP PRMESPSGPH RRLGSPQAIE EAASSSSAGP
1610 1620 1630 1640 1650
NLGQSGATDP IPPEGCWKAQ HLHTQALTAL SPSTSGLTPT SSCSPPSSTS
1660 1670 1680 1690 1700
GKLSMWSWKS LIEGPDRASP SRKATMAGGL ANLQDLENTT PAQPKNLSPR
1710 1720 1730 1740 1750
EQGKTQPPSA PRLAHPSYED PSQGWLWESE CAQAVKEDPA LSITQVPDAS
1760 1770 1780 1790
GDRRQDVPCR GCPLTQKSEP SLRRGQEPGG HQKHRDLALV PDELLKQT
Length:1,798
Mass (Da):196,436
Last modified:March 29, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF5C92078A3451AF
GO
Isoform 2Curated (identifier: Q6P0Q8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-396: Missing.
     1091-1113: Missing.
     1290-1386: Missing.

Show »
Length:1,608
Mass (Da):176,132
Checksum:iE8E7D89D72A99168
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXZ1V9GXZ1_HUMAN
Microtubule-associated serine/threo...
MAST2
787Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ERL6E7ERL6_HUMAN
Microtubule-associated serine/threo...
MAST2
791Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KBJ4A0A669KBJ4_HUMAN
Microtubule-associated serine/threo...
MAST2
1,655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH15816 differs from that shown. Reason: Frameshift.Curated
The sequence AAH15816 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB40778 differs from that shown. Reason: Frameshift.Curated
The sequence CAH73245 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI16563 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI21706 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1225Missing in AAH65499 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04077169L → F1 PublicationCorresponds to variant dbSNP:rs55914403Ensembl.1
Natural variantiVAR_040772275K → E in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040773388D → E2 PublicationsCorresponds to variant dbSNP:rs11211247Ensembl.1
Natural variantiVAR_040774655G → A in a breast mucinous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040775659I → M4 PublicationsCorresponds to variant dbSNP:rs1707336Ensembl.1
Natural variantiVAR_040776991R → L1 PublicationCorresponds to variant dbSNP:rs56114653Ensembl.1
Natural variantiVAR_0407771197K → R1 PublicationCorresponds to variant dbSNP:rs1052607Ensembl.1
Natural variantiVAR_0407781221D → E1 PublicationCorresponds to variant dbSNP:rs56060730Ensembl.1
Natural variantiVAR_0407791246R → L1 PublicationCorresponds to variant dbSNP:rs56309943Ensembl.1
Natural variantiVAR_0407801304V → M1 PublicationCorresponds to variant dbSNP:rs33931638Ensembl.1
Natural variantiVAR_0407811463A → T1 PublicationCorresponds to variant dbSNP:rs3737738Ensembl.1
Natural variantiVAR_0407821468G → A1 PublicationCorresponds to variant dbSNP:rs3737737Ensembl.1
Natural variantiVAR_0407831551D → G3 PublicationsCorresponds to variant dbSNP:rs1052610Ensembl.1
Natural variantiVAR_0516451608T → I. Corresponds to variant dbSNP:rs35474583Ensembl.1
Natural variantiVAR_0407841673K → R1 PublicationCorresponds to variant dbSNP:rs34070850Ensembl.1
Natural variantiVAR_0407851703G → E1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051698327 – 396Missing in isoform 2. 1 PublicationAdd BLAST70
Alternative sequenceiVSP_0516991091 – 1113Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0517001290 – 1386Missing in isoform 2. 1 PublicationAdd BLAST97

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB047005 mRNA Translation: BAB40778.1 Frameshift.
AL645480 AL603888 Genomic DNA Translation: CAH73244.1
AL645480, AL358075, AL603888 Genomic DNA Translation: CAH73245.1 Sequence problems.
AL603882 AL645480 Genomic DNA Translation: CAI16217.1
AL603888 AL645480 Genomic DNA Translation: CAI16562.1
AL603888, AL358075, AL645480 Genomic DNA Translation: CAI16563.1 Sequence problems.
AL358075 AL645480 Genomic DNA Translation: CAI21705.1
AL358075, AL603888, AL645480 Genomic DNA Translation: CAI21706.1 Sequence problems.
BC015816 mRNA Translation: AAH15816.2 Different initiation.
BC065499 mRNA Translation: AAH65499.1
AB018350 mRNA Translation: BAA34527.2
AL833919 mRNA Translation: CAD38775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41326.1 [Q6P0Q8-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001306174.1, NM_001319245.1
NP_055927.2, NM_015112.2 [Q6P0Q8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361297; ENSP00000354671; ENSG00000086015 [Q6P0Q8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23139

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23139

UCSC genome browser

More...
UCSCi
uc001cov.3 human [Q6P0Q8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB047005 mRNA Translation: BAB40778.1 Frameshift.
AL645480 AL603888 Genomic DNA Translation: CAH73244.1
AL645480, AL358075, AL603888 Genomic DNA Translation: CAH73245.1 Sequence problems.
AL603882 AL645480 Genomic DNA Translation: CAI16217.1
AL603888 AL645480 Genomic DNA Translation: CAI16562.1
AL603888, AL358075, AL645480 Genomic DNA Translation: CAI16563.1 Sequence problems.
AL358075 AL645480 Genomic DNA Translation: CAI21705.1
AL358075, AL603888, AL645480 Genomic DNA Translation: CAI21706.1 Sequence problems.
BC015816 mRNA Translation: AAH15816.2 Different initiation.
BC065499 mRNA Translation: AAH65499.1
AB018350 mRNA Translation: BAA34527.2
AL833919 mRNA Translation: CAD38775.1
CCDSiCCDS41326.1 [Q6P0Q8-1]
RefSeqiNP_001306174.1, NM_001319245.1
NP_055927.2, NM_015112.2 [Q6P0Q8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KQFNMR-A1099-1193[»]
2KYLNMR-A1099-1193[»]
SMRiQ6P0Q8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116756, 25 interactors
ELMiQ6P0Q8
IntActiQ6P0Q8, 20 interactors
MINTiQ6P0Q8
STRINGi9606.ENSP00000354671

Chemistry databases

ChEMBLiCHEMBL2417355

PTM databases

iPTMnetiQ6P0Q8
PhosphoSitePlusiQ6P0Q8

Polymorphism and mutation databases

BioMutaiMAST2
DMDMi62287152

Proteomic databases

EPDiQ6P0Q8
jPOSTiQ6P0Q8
MassIVEiQ6P0Q8
MaxQBiQ6P0Q8
PaxDbiQ6P0Q8
PeptideAtlasiQ6P0Q8
PRIDEiQ6P0Q8
ProteomicsDBi66816 [Q6P0Q8-1]
66817 [Q6P0Q8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32722 156 antibodies

Genome annotation databases

EnsembliENST00000361297; ENSP00000354671; ENSG00000086015 [Q6P0Q8-1]
GeneIDi23139
KEGGihsa:23139
UCSCiuc001cov.3 human [Q6P0Q8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23139
DisGeNETi23139
EuPathDBiHostDB:ENSG00000086015.20

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MAST2
HGNCiHGNC:19035 MAST2
HPAiENSG00000086015 Tissue enhanced (skeletal)
MIMi612257 gene
neXtProtiNX_Q6P0Q8
OpenTargetsiENSG00000086015
PharmGKBiPA134954073

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0606 Eukaryota
ENOG410XPWX LUCA
GeneTreeiENSGT00940000155705
HOGENOMiCLU_000288_9_2_1
InParanoidiQ6P0Q8
KOiK08789
OMAiEGFMPAI
OrthoDBi323328at2759
PhylomeDBiQ6P0Q8
TreeFamiTF313149

Enzyme and pathway databases

SignaLinkiQ6P0Q8
SIGNORiQ6P0Q8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23139 9 hits in 825 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MAST2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MAST2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23139
PharosiQ6P0Q8 Tbio

Protein Ontology

More...
PROi
PR:Q6P0Q8
RNActiQ6P0Q8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000086015 Expressed in gastrocnemius and 234 other tissues
ExpressionAtlasiQ6P0Q8 baseline and differential
GenevisibleiQ6P0Q8 HS

Family and domain databases

CDDicd05609 STKc_MAST, 1 hit
Gene3Di1.20.1480.20, 1 hit
2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR028779 MAST2
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR041489 PDZ_6
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24356:SF136 PTHR24356:SF136, 1 hit
PfamiView protein in Pfam
PF08926 DUF1908, 1 hit
PF17820 PDZ_6, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAST2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P0Q8
Secondary accession number(s): O94899
, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: June 17, 2020
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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